| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
sheep |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
goat |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Slone J |
| Year: |
2018 |
| Journal: |
J Hum Genet |
| Title: |
Biallelic mutations in FDXR cause neurodegeneration associated with inflammation. |
| Volume: |
63 |
| Issue: |
12 |
| Pages: |
1211-1222 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang J |
| Year: |
2020 |
| Journal: |
J Pathol |
| Title: |
FDXR regulates TP73 tumor suppressor via IRP2 to modulate aging and tumor suppression. |
| Volume: |
251 |
| Issue: |
3 |
| Pages: |
284-296 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang L |
| Year: |
2020 |
| Journal: |
Mol Ther Methods Clin Dev |
| Title: |
Systemic Delivery of AAV-Fdxr Mitigates the Phenotypes of Mitochondrial Disorders in Fdxr Mutant Mice. |
| Volume: |
18 |
|
| Pages: |
84-97 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang Y |
| Year: |
2017 |
| Journal: |
Genes Dev |
| Title: |
Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang Y |
| Year: |
2022 |
| Journal: |
Oncogene |
| Title: |
Ferredoxin reductase and p53 are necessary for lipid homeostasis and tumor suppression through the ABCA1-SREBP pathway. |
| Volume: |
41 |
| Issue: |
12 |
| Pages: |
1718-1726 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang J |
| Year: |
2024 |
| Journal: |
Am J Pathol |
| Title: |
Ferredoxin 2 Is Critical for Tumor Suppression and Lipid Homeostasis but Dispensable for Embryonic Development. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mohibi S |
| Year: |
2024 |
| Journal: |
Elife |
| Title: |
Ferredoxin 1 is essential for embryonic development and lipid homeostasis. |
| Volume: |
13 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Slone JD |
| Year: |
2020 |
| Journal: |
Cell Death Dis |
| Title: |
Integrated analysis of the molecular pathogenesis of FDXR-associated disease. |
| Volume: |
11 |
| Issue: |
6 |
| Pages: |
423 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Peng Y |
| Year: |
2017 |
| Journal: |
Hum Mol Genet |
| Title: |
Biallelic mutations in the ferredoxin reductase gene cause novel mitochondriopathy with optic atrophy. |
| Volume: |
26 |
| Issue: |
24 |
| Pages: |
4937-4950 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dionne LA |
| Year: |
2015 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Stiffened hindquarters, a new spontaneous mutation |
|
|
|
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Furukawa A |
| Year: |
1997 |
| Journal: |
Biol Reprod |
| Title: |
Molecular cloning of sheep and goat ferredoxin reductase messenger ribonucleic acids, and identification of an alternatively spliced form of sheep ferredoxin reductase. |
| Volume: |
56 |
| Issue: |
5 |
| Pages: |
1336-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Itoh S |
| Year: |
1995 |
| Journal: |
Biochim Biophys Acta |
| Title: |
cDNA cloning of mouse ferredoxin reductase from kidney. |
| Volume: |
1264 |
| Issue: |
2 |
| Pages: |
159-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fairfield H |
| Year: |
2015 |
| Journal: |
Genome Res |
| Title: |
Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. |
| Volume: |
25 |
| Issue: |
7 |
| Pages: |
948-57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Da Cruz S |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Proteomic analysis of the mouse liver mitochondrial inner membrane. |
| Volume: |
278 |
| Issue: |
42 |
| Pages: |
41566-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mootha VK |
| Year: |
2003 |
| Journal: |
Cell |
| Title: |
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. |
| Volume: |
115 |
| Issue: |
5 |
| Pages: |
629-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pagliarini DJ |
| Year: |
2008 |
| Journal: |
Cell |
| Title: |
A mitochondrial protein compendium elucidates complex I disease biology. |
| Volume: |
134 |
| Issue: |
1 |
| Pages: |
112-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniPathway vocabulary mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GO Central curators, GOA curators, Rhea curators |
| Year: |
2020 |
|
| Title: |
Automatic Gene Ontology annotation based on Rhea mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators, MGI curators |
| Year: |
2001 |
|
| Title: |
Gene Ontology annotation based on Enzyme Commission mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI and IMPC |
| Year: |
2018 |
| Journal: |
Database Release |
| Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Velocigene |
| Year: |
2008 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
| Year: |
2014 |
| Journal: |
Database Release |
| Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Helmholtz Zentrum Muenchen GmbH |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2014 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Magdaleno S |
| Year: |
2006 |
| Journal: |
PLoS Biol |
| Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
| Volume: |
4 |
| Issue: |
4 |
| Pages: |
e86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Allele |
| Name: |
ferredoxin reductase; targeted mutation 1, Xinbin Chen |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin D |
| Year: |
1990 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Cloning and sequence of the human adrenodoxin reductase gene. |
| Volume: |
87 |
| Issue: |
21 |
| Pages: |
8516-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fischer F |
| Year: |
2002 |
| Journal: |
Eur J Biochem |
| Title: |
Mycobacterium tuberculosis FprA, a novel bacterial NADPH-ferredoxin reductase. |
| Volume: |
269 |
| Issue: |
12 |
| Pages: |
3005-13 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This family represents a group of adrenodoxin-type ferredoxin reductases, including human Fdxr (NADPH:adrenodoxin oxidoreductase, mitochondrial) []and Mycobacterium FprA []. |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Fdxr/Fdxr |
| Background: |
B6.Cg-Fdxr |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Fdxr/Fdxr<+> |
| Background: |
B6.Cg-Fdxr |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Fdxr/Fdxr<+> Trp53/Trp53<+> |
| Background: |
involves: 129S2/SvPas * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Fdxr/Fdxr<+> Trp53/Trp53 |
| Background: |
involves: 129S2/SvPas * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang Y |
| Year: |
2019 |
| Journal: |
Oncogene |
| Title: |
Iron regulatory protein 2 is a suppressor of mutant p53 in tumorigenesis. |
| Volume: |
38 |
| Issue: |
35 |
| Pages: |
6256-6269 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
494
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
499
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
494
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
521
 |
| Fragment?: |
false |
|
•
•
•
•
•
|