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Search results 1 to 100 out of 911 for Fgf1

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Categories

Hits by Pathway

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Hits by Strain

Type Details Score
Gene
2246 | FGF1
Type: gene
Organism: human
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Gene
100217324 | fgf1
Type: gene
Organism: frog, western clawed
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Gene
key_31585 | FGF1
Type: gene
Organism: hamster, golden
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Gene
key_80049 | FGF1
Type: gene
Organism: cat, domestic
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Gene
25317 | Fgf1
Type: gene
Organism: rat
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Gene
607724 | FGF1
Type: gene
Organism: dog, domestic
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Gene
462158 | FGF1
Type: gene
Organism: chimpanzee
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Gene
281160 | FGF1
Type: gene
Organism: cattle
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Gene
396094 | FGF1
Type: gene
Organism: chicken
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Gene
705970 | FGF1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR028210 | FGF1
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 1 (FGF1), also known as heparin-binding growth factor 1 and acidic fibroblast growth factor. The protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, and is therefore thought to be involved in organogenesis [, , ]. In addition to interacting with FGFR1-4, FGF1 has also been shown to interact with casein kinase II subunits [], heat shock proteins []and acidic fibroblast growth factor intracellular-binding protein [].
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Protein Coding Gene
MGI:95515 | Fgf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
109113859 | LOC109113859
Type: gene
Organism: human
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Gene
109113860 | LOC109113860
Type: gene
Organism: human
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Gene
109113862 | LOC109113862
Type: gene
Organism: human
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Gene
9158 | FIBP
Type: gene
Organism: human
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Publication
17027650 | J:114977
First Author: Duarte M
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Thrombin induces rapid PAR1-mediated non-classical FGF1 release.
Volume: 350
Issue: 3
Pages: 604-9
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Publication
34358309 | J:345294
First Author: Li G
Year: 2022
Journal: Cardiovasc Res
Title: MicroRNA-27b-3p down-regulates FGF1 and aggravates pathological cardiac remodelling.
Volume: 118
Issue: 9
Pages: 2139-2151
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Publication
25043058 | J:217106
First Author: Suh JM
Year: 2014
Journal: Nature
Title: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.
Volume: 513
Issue: 7518
Pages: 436-9
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Publication
11175337 | J:66917
First Author: Chiu IM
Year: 2000
Journal: Oncogene
Title: Tumorigenesis in transgenic mice in which the SV40 T antigen is driven by the brain-specific FGF1 promoter.
Volume: 19
Issue: 54
Pages: 6229-39
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Publication
36161959 | J:340251
First Author: Nies VJM
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Autocrine FGF1 signaling promotes glucose uptake in adipocytes.
Volume: 119
Issue: 40
Pages: e2122382119
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Publication
34990928 | J:322599
 
First Author: Xiao M
Year: 2022
Journal: Redox Biol
Title: A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity.
Volume: 49
Pages: 102219
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Publication
34831221 | J:314850
 
First Author: Baguma-Nibasheka M
Year: 2021
Journal: Cells
Title: Regulation of Transplanted Cell Homing by FGF1 and PDGFB after Doxorubicin Myocardial Injury.
Volume: 10
Issue: 11
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Publication
19233122 | J:146830
First Author: Graziani I
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Protein folding does not prevent the nonclassical export of FGF1 and S100A13.
Volume: 381
Issue: 3
Pages: 350-4
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Publication
28813681 | J:254860
First Author: Huang Z
Year: 2017
Journal: Cell Rep
Title: Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability.
Volume: 20
Issue: 7
Pages: 1717-1728
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Publication
32817243 | J:296034
First Author: Yoo M
Year: 2020
Journal: J Neurosci
Title: Persistence of Fear Memory Depends on a Delayed Elevation of BAF53b and FGF1 Expression in the Lateral Amygdala.
Volume: 40
Issue: 37
Pages: 7133-7141
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GXD Expression
GXD Expression
   
Probe: MGI:6172853
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190259
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Fgf1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6172853
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190259
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Fgf1
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6172853
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190259
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Fgf1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6172853
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190259
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Fgf1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6172853
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190259
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Fgf1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6172853
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190259
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Fgf1
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6172853
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190259
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Fgf1
Detected: true
Specimen Num: 7
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Publication
18411303 | J:137316
First Author: Sørensen V
Year: 2008
Journal: Mol Cell Biol
Title: Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus.
Volume: 28
Issue: 12
Pages: 4129-41
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Publication
20145243 | -
First Author: Fernández IS
Year: 2010
Journal: J Biol Chem
Title: Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.
Volume: 285
Issue: 15
Pages: 11714-29
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Publication
10510314 | -
 
First Author: Mizukoshi E
Year: 1999
Journal: Biochem J
Title: Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin.
Volume: 343 Pt 2
Pages: 461-6
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Publication
9806903 | -
 
First Author: Kolpakova E
Year: 1998
Journal: Biochem J
Title: Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor.
Volume: 336 ( Pt 1)
Pages: 213-22
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Protein
P61148
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: false
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Protein
D6RCX9
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: false
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Protein
Q71UP6
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: true
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Protein
D3Z6H1
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: false
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Protein
O54837
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: true
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Protein
D3Z192
Organism: Mus musculus/domesticus
Length: 49  
Fragment?: true
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Protein
D3Z6E2
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
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Protein
Q6ZWS1
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: false
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Protein
A0A494BBG9
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
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Publication
12145206 | -
First Author: Skjerpen CS
Year: 2002
Journal: EMBO J
Title: Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity.
Volume: 21
Issue: 15
Pages: 4058-69
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Publication
8663044 | -
First Author: Ornitz DM
Year: 1996
Journal: J Biol Chem
Title: Receptor specificity of the fibroblast growth factor family.
Volume: 271
Issue: 25
Pages: 15292-7
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Publication
16597617 | J:153201
First Author: Zhang X
Year: 2006
Journal: J Biol Chem
Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
Volume: 281
Issue: 23
Pages: 15694-700
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Publication
2549857 | -
 
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
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Publication
7583099 | -
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
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Publication
3072709 | -
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
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Publication
11276432 | J:67832
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
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Publication
10830168 | -
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
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Publication
8652550 | -
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
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Publication
1705486 | -
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
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Publication
8760337 | -
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
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Publication
23000357 | -
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
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Publication
15689573 | -
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
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Publication
10441498 | J:56785
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
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Publication
23108135 | -
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
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Publication
23016864 | -
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
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Publication
1649700 | -
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
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Publication
11746231 | -
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
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Publication
14745970 | -
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
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Publication
8978613 | -
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
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Gene
282837 | Fibp
Type: gene
Organism: rat
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Gene
476019 | FIBP
Type: gene
Organism: dog, domestic
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Gene
745847 | FIBP
Type: gene
Organism: chimpanzee
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Gene
510968 | FIBP
Type: gene
Organism: cattle
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Gene
715457 | FIBP
Type: gene
Organism: macaque, rhesus
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Publication
20568245 | J:161795
First Author: Okamoto K
Year: 2010
Journal: Dev Dyn
Title: Evidence of interlobular repulsion during branching morphogenesis in mouse salivary glands.
Volume: 239
Issue: 8
Pages: 2208-18
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Publication
30063763 | J:265829
First Author: Liu C
Year: 2018
Journal: PLoS One
Title: MiR-18a regulates myoblasts proliferation by targeting Fgf1.
Volume: 13
Issue: 7
Pages: e0201551
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Publication
22606265 | J:187244
First Author: Kirov A
Year: 2012
Journal: PLoS One
Title: Transgenic expression of nonclassically secreted FGF suppresses kidney repair.
Volume: 7
Issue: 5
Pages: e36485
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Publication
19561198 | J:173025
First Author: Conte C
Year: 2009
Journal: Nucleic Acids Res
Title: Fibroblast growth factor 1 induced during myogenesis by a transcription-translation coupling mechanism.
Volume: 37
Issue: 16
Pages: 5267-78
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Publication
30972920 | J:291745
First Author: Keeley T
Year: 2019
Journal: Physiol Rep
Title: Resistance to visceral obesity is associated with increased locomotion in mice expressing an endothelial cell-specific fibroblast growth factor 1 transgene.
Volume: 7
Issue: 7
Pages: e14034
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Publication
34986332 | J:325193
First Author: Sancar G
Year: 2022
Journal: Cell Metab
Title: FGF1 and insulin control lipolysis by convergent pathways.
Volume: 34
Issue: 1
Pages: 171-183.e6
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Publication
10373120 | J:67894
First Author: Jung J
Year: 1999
Journal: Science
Title: Initiation of mammalian liver development from endoderm by fibroblast growth factors.
Volume: 284
Issue: 5422
Pages: 1998-2003
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Publication
10688672 | J:60597
First Author: Miller DL
Year: 2000
Journal: Mol Cell Biol
Title: Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice.
Volume: 20
Issue: 6
Pages: 2260-8
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Publication
17090159 | J:117768
First Author: Nie X
Year: 2006
Journal: Angle Orthod
Title: Developmentally regulated expression of MSX1, MSX2 and Fgfs in the developing mouse cranial base.
Volume: 76
Issue: 6
Pages: 990-5
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Publication
38301966 | J:345705
 
First Author: Tang Q
Year: 2024
Journal: Biochem Pharmacol
Title: FGF1(ΔHBS) ameliorates retinal inflammation via suppressing TSPO signal in a type 2 diabetes mouse model.
Volume: 221
Pages: 116039
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Publication
26748348 | J:231094
First Author: Du W
Year: 2016
Journal: Gene Expr Patterns
Title: Expression of FGFs during early mouse tongue development.
Volume: 20
Issue: 2
Pages: 81-7
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Publication
15199124 | J:91594
First Author: Lamothe B
Year: 2004
Journal: Mol Cell Biol
Title: The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway.
Volume: 24
Issue: 13
Pages: 5657-66
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Publication
22522926 | J:183996
First Author: Jonker JW
Year: 2012
Journal: Nature
Title: A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis.
Volume: 485
Issue: 7398
Pages: 391-4
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Publication
25217174 | J:237455
First Author: Lodder EM
Year: 2014
Journal: Circ Cardiovasc Genet
Title: Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition.
Volume: 7
Issue: 6
Pages: 790-8
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Publication
16929488 | J:117979
First Author: Huang X
Year: 2006
Journal: Mol Carcinog
Title: Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis.
Volume: 45
Issue: 12
Pages: 934-42
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Publication
9428423 | J:44839
First Author: Bellusci S
Year: 1997
Journal: Development
Title: Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung.
Volume: 124
Issue: 23
Pages: 4867-78
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Protein Coding Gene
MGP_CAROLIEiJ_G0022215 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024367 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024334 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024303 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024334 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024100 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_95515 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024776 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023575 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024070 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024200 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024166 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024284 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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