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Search results 1 to 100 out of 2019 for Fgf10

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 10 (FGF10), also known as keratinocyte growth factor 2. This protein plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. FGF10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7 []. Studies suggest FGF10 is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of limb bud formation [, , ]. FGF10 is also implicated as a primary factor in the process of wound healing [, ]. FGF10 interacts with FGFR1, but has a higher affinity FGFR2 [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Sekine K
Year: 1999
Journal: Nat Genet
Title: Fgf10 is essential for limb and lung formation.
Volume: 21
Issue: 1
Pages: 138-41
GXD Expression  
Probe: MGI:3053083
Assay Type: Immunohistochemistry
Annotation Date: 2004-09-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:3053084
Age: embryonic day 15.5
Image: FGF10 CONT
Specimen Label: FGF10 CONT
Detected: true
Specimen Num: 1
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Bagai S
Year: 2002
Journal: J Biol Chem
Title: Fibroblast growth factor-10 is a mitogen for urothelial cells.
Volume: 277
Issue: 26
Pages: 23828-37
Publication
First Author: Min H
Year: 1998
Journal: Genes Dev
Title: Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless.
Volume: 12
Issue: 20
Pages: 3156-61
GXD Expression      
Probe: MGI:1267329
Assay Type: RT-PCR
Annotation Date: 1998-07-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672819
Stage: TS19
Assay Id: MGI:1270056
Age: embryonic day 11.5
Specimen Label: Fgf10
Detected: true
Specimen Num: 1
Publication
First Author: Beer HD
Year: 2005
Journal: Oncogene
Title: The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.
Volume: 24
Issue: 34
Pages: 5269-77
Protein
Organism: Mus musculus/domesticus
Length: 37  
Fragment?: true
Publication
First Author: Nyeng P
Year: 2007
Journal: Dev Biol
Title: FGF10 signaling controls stomach morphogenesis.
Volume: 303
Issue: 1
Pages: 295-310
Publication
First Author: Sugimoto K
Year: 2014
Journal: Genes Cells
Title: Role of FGF10 on tumorigenesis by MS-K.
Volume: 19
Issue: 2
Pages: 112-25
Publication
First Author: Emoto H
Year: 1997
Journal: J Biol Chem
Title: Structure and expression of human fibroblast growth factor-10.
Volume: 272
Issue: 37
Pages: 23191-4
Publication
First Author: Jimenez PA
Year: 1999
Journal: J Surg Res
Title: Keratinocyte growth factor-2 accelerates wound healing in incisional wounds.
Volume: 81
Issue: 2
Pages: 238-42
Publication
First Author: May AJ
Year: 2019
Journal: Dev Biol
Title: FGF10 is an essential regulator of tracheal submucosal gland morphogenesis.
Volume: 451
Issue: 2
Pages: 158-166
Protein
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
Publication
First Author: Marguerie A
Year: 2006
Journal: Cardiovasc Res
Title: Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice.
Volume: 71
Issue: 1
Pages: 50-60
Publication
First Author: Harada H
Year: 2002
Journal: Development
Title: FGF10 maintains stem cell compartment in developing mouse incisors.
Volume: 129
Issue: 6
Pages: 1533-41
Publication
First Author: Li W
Year: 2014
Journal: Genesis
Title: Pbx1 activates Fgf10 in the mesenchyme of developing lungs.
Volume: 52
Issue: 5
Pages: 399-407
Publication
First Author: Alvarez Y
Year: 2003
Journal: Development
Title: Requirements for FGF3 and FGF10 during inner ear formation.
Volume: 130
Issue: 25
Pages: 6329-38
Publication
First Author: Harada H
Year: 2002
Journal: Connect Tissue Res
Title: FGF10 maintains stem cell population during mouse incisor development.
Volume: 43
Issue: 2-3
Pages: 201-4
Publication  
First Author: Teague WJ
Year: 2018
Journal: Front Genet
Title: FGF10 and the Mystery of Duodenal Atresia in Humans.
Volume: 9
Pages: 530
Publication
First Author: Golzio C
Year: 2012
Journal: PLoS One
Title: ISL1 directly regulates FGF10 transcription during human cardiac outflow formation.
Volume: 7
Issue: 1
Pages: e30677
Publication
First Author: Ornitz DM
Year: 1996
Journal: J Biol Chem
Title: Receptor specificity of the fibroblast growth factor family.
Volume: 271
Issue: 25
Pages: 15292-7
Publication
First Author: Zhang X
Year: 2006
Journal: J Biol Chem
Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
Volume: 281
Issue: 23
Pages: 15694-700
Publication
First Author: Pauley S
Year: 2003
Journal: Dev Dyn
Title: Expression and function of FGF10 in mammalian inner ear development.
Volume: 227
Issue: 2
Pages: 203-15
Publication
First Author: Konishi M
Year: 2006
Journal: Mol Cell Endocrinol
Title: Role of Fgf10 in cell proliferation in white adipose tissue.
Volume: 249
Issue: 1-2
Pages: 71-7
Publication  
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
Publication
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
Publication
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
Publication
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
Publication
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
Publication
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
Publication
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
Publication
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
Publication
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
Publication
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
Publication
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
Publication
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
Publication
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
Publication
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
Publication
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
Publication
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
Publication
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
Publication
First Author: Li C
Year: 2005
Journal: Dev Biol
Title: Wnt5a regulates Shh and Fgf10 signaling during lung development.
Volume: 287
Issue: 1
Pages: 86-97
Publication
First Author: Rochais F
Year: 2014
Journal: Cardiovasc Res
Title: FGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry.
Volume: 104
Issue: 3
Pages: 432-42
Publication
First Author: Wright TJ
Year: 2003
Journal: Development
Title: Fgf3 and Fgf10 are required for mouse otic placode induction.
Volume: 130
Issue: 15
Pages: 3379-90
Publication
First Author: Sala FG
Year: 2011
Journal: Development
Title: FGF10 controls the patterning of the tracheal cartilage rings via Shh.
Volume: 138
Issue: 2
Pages: 273-82
Publication
First Author: Hajihosseini MK
Year: 2008
Journal: Mol Cell Neurosci
Title: Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis.
Volume: 37
Issue: 4
Pages: 857-68
Publication  
First Author: Volckaert T
Year: 2019
Journal: Development
Title: Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling.
Volume: 146
Issue: 2
Publication
First Author: Hirashima T
Year: 2009
Journal: Dev Dyn
Title: Mechanisms for split localization of Fgf10 expression in early lung development.
Volume: 238
Issue: 11
Pages: 2813-22
Publication  
First Author: Zhang S
Year: 2018
Journal: Front Physiol
Title: FGF10 Is Required for Circumvallate Papilla Morphogenesis by Maintaining Lgr5 Activity.
Volume: 9
Pages: 1192
Publication
First Author: Cho KW
Year: 2009
Journal: J Exp Zool B Mol Dev Evol
Title: ERK activation is involved in tooth development via FGF10 signaling.
Volume: 312
Issue: 8
Pages: 901-11
Publication  
First Author: Yin Y
Year: 2020
Journal: Sci Signal
Title: FGF9 and FGF10 activate distinct signaling pathways to direct lung epithelial specification and branching.
Volume: 13
Issue: 621
Publication
First Author: Mailleux AA
Year: 2005
Journal: Development
Title: Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage.
Volume: 132
Issue: 9
Pages: 2157-66
Publication
First Author: Tagashira S
Year: 1997
Journal: Gene
Title: Cloning of mouse FGF10 and up-regulation of its gene expression during wound healing.
Volume: 197
Issue: 1-2
Pages: 399-404
Publication
First Author: Chao CM
Year: 2017
Journal: J Pathol
Title: Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia.
Volume: 241
Issue: 1
Pages: 91-103
Publication
First Author: Volckaert T
Year: 2013
Journal: Development
Title: Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors.
Volume: 140
Issue: 18
Pages: 3731-42
Publication
First Author: Makarenkova HP
Year: 2000
Journal: Development
Title: FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development.
Volume: 127
Issue: 12
Pages: 2563-72
Publication
First Author: Zelarayan LC
Year: 2007
Journal: Dev Biol
Title: Differential requirements for FGF3, FGF8 and FGF10 during inner ear development.
Volume: 308
Issue: 2
Pages: 379-91
Publication
First Author: May AJ
Year: 2015
Journal: Curr Mol Med
Title: Salivary Gland Dysplasia in Fgf10 Heterozygous Mice: A New Mouse Model of Xerostomia.
Volume: 15
Issue: 7
Pages: 674-82
Publication
First Author: Lilleväli K
Year: 2006
Journal: Mech Dev
Title: Gata3 is required for early morphogenesis and Fgf10 expression during otic development.
Volume: 123
Issue: 6
Pages: 415-29
Publication
First Author: Urness LD
Year: 2011
Journal: Dev Biol
Title: Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular development.
Volume: 356
Issue: 2
Pages: 383-97
Publication
First Author: Urness LD
Year: 2015
Journal: Dev Biol
Title: Fgf10 is required for specification of non-sensory regions of the cochlear epithelium.
Volume: 400
Issue: 1
Pages: 59-71
Publication
First Author: He W
Year: 2010
Journal: J Pediatr Surg
Title: Perturbation of Fgf10 signal pathway in mouse embryonic palate by dexamethasone and vitamin B12 in vivo.
Volume: 45
Issue: 10
Pages: 2030-5
Publication
First Author: Veltmaat JM
Year: 2006
Journal: Development
Title: Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes.
Volume: 133
Issue: 12
Pages: 2325-35
Publication
First Author: Hajihosseini MK
Year: 2009
Journal: Dev Dyn
Title: Evidence that Fgf10 contributes to the skeletal and visceral defects of an Apert syndrome mouse model.
Volume: 238
Issue: 2
Pages: 376-85
Publication
First Author: Fairbanks TJ
Year: 2004
Journal: J Surg Res
Title: A genetic mechanism for cecal atresia: the role of the Fgf10 signaling pathway.
Volume: 120
Issue: 2
Pages: 201-9
Publication
First Author: Ohuchi H
Year: 2005
Journal: Dev Dyn
Title: Identification of cis-element regulating expression of the mouse Fgf10 gene during inner ear development.
Volume: 233
Issue: 1
Pages: 177-87
Publication
First Author: Suzuki K
Year: 2000
Journal: FEBS Lett
Title: Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene.
Volume: 481
Issue: 1
Pages: 53-6
Publication
First Author: Yamaoka T
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Transgenic expression of FGF8 and FGF10 induces transdifferentiation of pancreatic islet cells into hepatocytes and exocrine cells.
Volume: 292
Issue: 1
Pages: 138-43
Publication
First Author: Kelly RG
Year: 2007
Journal: Dev Dyn
Title: Visualization of outflow tract development in the absence of Tbx1 using an FgF10 enhancer trap transgene.
Volume: 236
Issue: 3
Pages: 821-8
Publication
First Author: Patel VN
Year: 2007
Journal: Development
Title: Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis.
Volume: 134
Issue: 23
Pages: 4177-86
GXD Expression    
Probe: MGI:6172855
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190260
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Fgf10
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6172855
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190260
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Fgf10
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6172855
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190260
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Fgf10
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6172855
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190260
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Fgf10
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6172855
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190260
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Fgf10
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6172855
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190260
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Fgf10
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6172855
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190260
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Fgf10
Detected: true
Specimen Num: 6
Publication
First Author: Lü J
Year: 2007
Journal: J Biol Chem
Title: Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis.
Volume: 282
Issue: 30
Pages: 22176-84
Publication
First Author: Alappat SR
Year: 2005
Journal: Dev Biol
Title: The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice.
Volume: 277
Issue: 1
Pages: 102-13
Publication
First Author: Bhushan A
Year: 2001
Journal: Development
Title: Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis.
Volume: 128
Issue: 24
Pages: 5109-17
Publication
First Author: Ohuchi H
Year: 2000
Journal: Biochem Biophys Res Commun
Title: FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development.
Volume: 277
Issue: 3
Pages: 643-9
Publication
First Author: Lü J
Year: 2005
Journal: J Biol Chem
Title: Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis.
Volume: 280
Issue: 6
Pages: 4834-41
Publication
First Author: Tao H
Year: 2006
Journal: Dev Growth Differ
Title: Exogenous FGF10 can rescue an eye-open at birth phenotype of Fgf10-null mice by activating activin and TGFalpha-EGFR signaling.
Volume: 48
Issue: 5
Pages: 339-46
Publication
First Author: Carroll LS
Year: 2015
Journal: Development
Title: Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/β-catenin signaling.
Volume: 142
Issue: 23
Pages: 4056-67
Publication
First Author: Yamamoto-Shiraishi Y
Year: 2014
Journal: Dev Biol
Title: Etv1 and Ewsr1 cooperatively regulate limb mesenchymal Fgf10 expression in response to apical ectodermal ridge-derived fibroblast growth factor signal.
Volume: 394
Issue: 1
Pages: 181-90
Publication
First Author: Chao CM
Year: 2019
Journal: Hum Mol Genet
Title: Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia.
Volume: 28
Issue: 9
Pages: 1429-1444
Publication
First Author: Ramasamy SK
Year: 2007
Journal: Dev Biol
Title: Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development.
Volume: 307
Issue: 2
Pages: 237-47