Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 10 (FGF10), also known as keratinocyte growth factor 2. This protein plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. FGF10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7 []. Studies suggest FGF10 is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of limb bud formation [, , ]. FGF10 is also implicated as a primary factor in the process of wound healing [, ]. FGF10 interacts with FGFR1, but has a higher affinity FGFR2 [, ]. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Sekine K |
Year: |
1999 |
Journal: |
Nat Genet |
Title: |
Fgf10 is essential for limb and lung formation. |
Volume: |
21 |
Issue: |
1 |
Pages: |
138-41 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3053083 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2004-09-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1775523 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:3053084 |
Age: |
embryonic day 15.5 |
Image: |
FGF10 CONT |
|
Specimen Label: |
FGF10 CONT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5561274 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-04-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3290913 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:7623198 |
Age: |
embryonic day 8.5 |
Image: |
4B Fgf10 |
Note: |
Expression in pharyngeal mesoderm. |
Specimen Label: |
4B Fgf10 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5561274 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-04-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607113 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:7623198 |
Age: |
embryonic day 8.5 |
Image: |
4Ca Fgf10 |
Note: |
Expression in mesoderm lateral and ventral to pharynx, including second heart field. |
Specimen Label: |
4Ca Fgf10 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5561274 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-04-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607113 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:7623198 |
Age: |
embryonic day 8.5 |
Image: |
4Cb Fgf10 |
Note: |
Expression in mesoderm lateral and ventral to pharynx. |
Specimen Label: |
4Cb Fgf10 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5561274 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-04-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607113 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:7623198 |
Age: |
embryonic day 8.5 |
Image: |
4Cc Fgf10 |
Note: |
Expression in mesoderm lateral and ventral to pharynx, including second heart field. |
Specimen Label: |
4Cc Fgf10 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5561274 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-04-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607113 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:7623198 |
Age: |
embryonic day 8.5 |
Image: |
4Cd Fgf10 |
Note: |
Expression in mesoderm lateral and ventral to pharynx. |
Specimen Label: |
4Cd Fgf10 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5561274 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-04-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607113 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:7623198 |
Age: |
embryonic day 8.5 |
Image: |
4Ce Fgf10 |
Note: |
Expression in mesoderm lateral and ventral to pharynx. |
Specimen Label: |
4Ce Fgf10 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5561274 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-04-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3673013 |
Pattern: |
Not Specified |
Stage: |
TS13 |
Assay Id: |
MGI:7623198 |
Age: |
embryonic day 8.5 |
Image: |
4Ca Fgf10 |
|
Specimen Label: |
4Ca Fgf10 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5561274 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-04-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3673013 |
Pattern: |
Not Specified |
Stage: |
TS13 |
Assay Id: |
MGI:7623198 |
Age: |
embryonic day 8.5 |
Image: |
4Cc Fgf10 |
|
Specimen Label: |
4Cc Fgf10 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Bagai S |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Fibroblast growth factor-10 is a mitogen for urothelial cells. |
Volume: |
277 |
Issue: |
26 |
Pages: |
23828-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Min H |
Year: |
1998 |
Journal: |
Genes Dev |
Title: |
Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. |
Volume: |
12 |
Issue: |
20 |
Pages: |
3156-61 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7852706 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2025-01-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672826 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:7852808 |
Age: |
embryonic day 18.5 |
Image: |
6G Fgf10 WT |
|
Specimen Label: |
6G Fgf10 WT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7852706 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2025-01-16 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672826 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:7852808 |
Age: |
embryonic day 18.5 |
Image: |
6G Fgf10 KO |
Note: |
Increased levels of expression compared to wild type. |
Specimen Label: |
6G Fgf10 KO |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beer HD |
Year: |
2005 |
Journal: |
Oncogene |
Title: |
The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. |
Volume: |
24 |
Issue: |
34 |
Pages: |
5269-77 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1267329 |
Assay Type: |
RT-PCR |
Annotation Date: |
1998-07-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672819 |
|
Stage: |
TS19 |
Assay Id: |
MGI:1270056 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Fgf10 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
37
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Nyeng P |
Year: |
2007 |
Journal: |
Dev Biol |
Title: |
FGF10 signaling controls stomach morphogenesis. |
Volume: |
303 |
Issue: |
1 |
Pages: |
295-310 |
|
•
•
•
•
•
|
Publication |
First Author: |
Emoto H |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
Structure and expression of human fibroblast growth factor-10. |
Volume: |
272 |
Issue: |
37 |
Pages: |
23191-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jimenez PA |
Year: |
1999 |
Journal: |
J Surg Res |
Title: |
Keratinocyte growth factor-2 accelerates wound healing in incisional wounds. |
Volume: |
81 |
Issue: |
2 |
Pages: |
238-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sugimoto K |
Year: |
2014 |
Journal: |
Genes Cells |
Title: |
Role of FGF10 on tumorigenesis by MS-K. |
Volume: |
19 |
Issue: |
2 |
Pages: |
112-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
May AJ |
Year: |
2019 |
Journal: |
Dev Biol |
Title: |
FGF10 is an essential regulator of tracheal submucosal gland morphogenesis. |
Volume: |
451 |
Issue: |
2 |
Pages: |
158-166 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
209
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
260
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Marguerie A |
Year: |
2006 |
Journal: |
Cardiovasc Res |
Title: |
Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice. |
Volume: |
71 |
Issue: |
1 |
Pages: |
50-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harada H |
Year: |
2002 |
Journal: |
Development |
Title: |
FGF10 maintains stem cell compartment in developing mouse incisors. |
Volume: |
129 |
Issue: |
6 |
Pages: |
1533-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li W |
Year: |
2014 |
Journal: |
Genesis |
Title: |
Pbx1 activates Fgf10 in the mesenchyme of developing lungs. |
Volume: |
52 |
Issue: |
5 |
Pages: |
399-407 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ornitz DM |
Year: |
1996 |
Journal: |
J Biol Chem |
Title: |
Receptor specificity of the fibroblast growth factor family. |
Volume: |
271 |
Issue: |
25 |
Pages: |
15292-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang X |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. |
Volume: |
281 |
Issue: |
23 |
Pages: |
15694-700 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alvarez Y |
Year: |
2003 |
Journal: |
Development |
Title: |
Requirements for FGF3 and FGF10 during inner ear formation. |
Volume: |
130 |
Issue: |
25 |
Pages: |
6329-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harada H |
Year: |
2002 |
Journal: |
Connect Tissue Res |
Title: |
FGF10 maintains stem cell population during mouse incisor development. |
Volume: |
43 |
Issue: |
2-3 |
Pages: |
201-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Teague WJ |
Year: |
2018 |
Journal: |
Front Genet |
Title: |
FGF10 and the Mystery of Duodenal Atresia in Humans. |
Volume: |
9 |
|
Pages: |
530 |
|
•
•
•
•
•
|
Publication |
First Author: |
Golzio C |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
ISL1 directly regulates FGF10 transcription during human cardiac outflow formation. |
Volume: |
7 |
Issue: |
1 |
Pages: |
e30677 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burgess WH |
Year: |
1989 |
Journal: |
Annu Rev Biochem |
Title: |
The heparin-binding (fibroblast) growth factor family of proteins. |
Volume: |
58 |
|
Pages: |
575-606 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilkie AO |
Year: |
1995 |
Journal: |
Curr Biol |
Title: |
Functions of fibroblast growth factors and their receptors. |
Volume: |
5 |
Issue: |
5 |
Pages: |
500-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thomas KA |
Year: |
1988 |
Journal: |
Trends Biochem Sci |
Title: |
Transforming potential of fibroblast growth factor genes. |
Volume: |
13 |
Issue: |
9 |
Pages: |
327-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ornitz DM |
Year: |
2001 |
Journal: |
Genome Biol |
Title: |
Fibroblast growth factors. |
Volume: |
2 |
Issue: |
3 |
Pages: |
REVIEWS3005 |
|
•
•
•
•
•
|
Publication |
First Author: |
Plotnikov AN |
Year: |
2000 |
Journal: |
Cell |
Title: |
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. |
Volume: |
101 |
Issue: |
4 |
Pages: |
413-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blaber M |
Year: |
1996 |
Journal: |
Biochemistry |
Title: |
X-ray crystal structure of human acidic fibroblast growth factor. |
Volume: |
35 |
Issue: |
7 |
Pages: |
2086-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vlodavsky I |
Year: |
1990 |
Journal: |
Cancer Metastasis Rev |
Title: |
Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis. |
Volume: |
9 |
Issue: |
3 |
Pages: |
203-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Green PJ |
Year: |
1996 |
Journal: |
Bioessays |
Title: |
Promiscuity of fibroblast growth factor receptors. |
Volume: |
18 |
Issue: |
8 |
Pages: |
639-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yardley N |
Year: |
2012 |
Journal: |
Dev Biol |
Title: |
FGF signaling transforms non-neural ectoderm into neural crest. |
Volume: |
372 |
Issue: |
2 |
Pages: |
166-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Böttcher RT |
Year: |
2005 |
Journal: |
Endocr Rev |
Title: |
Fibroblast growth factor signaling during early vertebrate development. |
Volume: |
26 |
Issue: |
1 |
Pages: |
63-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koga C |
Year: |
1999 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis. |
Volume: |
261 |
Issue: |
3 |
Pages: |
756-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakamizo S |
Year: |
2013 |
Journal: |
Skin Pharmacol Physiol |
Title: |
Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion. |
Volume: |
26 |
Issue: |
1 |
Pages: |
22-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kumar SB |
Year: |
2013 |
Journal: |
Curr Pharm Des |
Title: |
Fibroblast growth factor receptor inhibitors. |
Volume: |
19 |
Issue: |
4 |
Pages: |
687-701 |
|
•
•
•
•
•
|
Publication |
First Author: |
Amaya E |
Year: |
1991 |
Journal: |
Cell |
Title: |
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. |
Volume: |
66 |
Issue: |
2 |
Pages: |
257-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Borland CZ |
Year: |
2001 |
Journal: |
Bioessays |
Title: |
Fibroblast growth factor signaling in Caenorhabditis elegans. |
Volume: |
23 |
Issue: |
12 |
Pages: |
1120-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Coumoul X |
Year: |
2003 |
Journal: |
Birth Defects Res C Embryo Today |
Title: |
Roles of FGF receptors in mammalian development and congenital diseases. |
Volume: |
69 |
Issue: |
4 |
Pages: |
286-304 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sutherland D |
Year: |
1996 |
Journal: |
Cell |
Title: |
branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching. |
Volume: |
87 |
Issue: |
6 |
Pages: |
1091-101 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pauley S |
Year: |
2003 |
Journal: |
Dev Dyn |
Title: |
Expression and function of FGF10 in mammalian inner ear development. |
Volume: |
227 |
Issue: |
2 |
Pages: |
203-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Konishi M |
Year: |
2006 |
Journal: |
Mol Cell Endocrinol |
Title: |
Role of Fgf10 in cell proliferation in white adipose tissue. |
Volume: |
249 |
Issue: |
1-2 |
Pages: |
71-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li C |
Year: |
2005 |
Journal: |
Dev Biol |
Title: |
Wnt5a regulates Shh and Fgf10 signaling during lung development. |
Volume: |
287 |
Issue: |
1 |
Pages: |
86-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rochais F |
Year: |
2014 |
Journal: |
Cardiovasc Res |
Title: |
FGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry. |
Volume: |
104 |
Issue: |
3 |
Pages: |
432-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wright TJ |
Year: |
2003 |
Journal: |
Development |
Title: |
Fgf3 and Fgf10 are required for mouse otic placode induction. |
Volume: |
130 |
Issue: |
15 |
Pages: |
3379-90 |
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Publication |
First Author: |
Sala FG |
Year: |
2011 |
Journal: |
Development |
Title: |
FGF10 controls the patterning of the tracheal cartilage rings via Shh. |
Volume: |
138 |
Issue: |
2 |
Pages: |
273-82 |
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Publication |
First Author: |
Hajihosseini MK |
Year: |
2008 |
Journal: |
Mol Cell Neurosci |
Title: |
Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis. |
Volume: |
37 |
Issue: |
4 |
Pages: |
857-68 |
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Publication |
First Author: |
Volckaert T |
Year: |
2019 |
Journal: |
Development |
Title: |
Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling. |
Volume: |
146 |
Issue: |
2 |
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Publication |
First Author: |
Hirashima T |
Year: |
2009 |
Journal: |
Dev Dyn |
Title: |
Mechanisms for split localization of Fgf10 expression in early lung development. |
Volume: |
238 |
Issue: |
11 |
Pages: |
2813-22 |
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Publication |
First Author: |
Zhang S |
Year: |
2018 |
Journal: |
Front Physiol |
Title: |
FGF10 Is Required for Circumvallate Papilla Morphogenesis by Maintaining Lgr5 Activity. |
Volume: |
9 |
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Pages: |
1192 |
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Publication |
First Author: |
Cho KW |
Year: |
2009 |
Journal: |
J Exp Zool B Mol Dev Evol |
Title: |
ERK activation is involved in tooth development via FGF10 signaling. |
Volume: |
312 |
Issue: |
8 |
Pages: |
901-11 |
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Publication |
First Author: |
Yin Y |
Year: |
2020 |
Journal: |
Sci Signal |
Title: |
FGF9 and FGF10 activate distinct signaling pathways to direct lung epithelial specification and branching. |
Volume: |
13 |
Issue: |
621 |
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Publication |
First Author: |
Mailleux AA |
Year: |
2005 |
Journal: |
Development |
Title: |
Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. |
Volume: |
132 |
Issue: |
9 |
Pages: |
2157-66 |
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Publication |
First Author: |
Tagashira S |
Year: |
1997 |
Journal: |
Gene |
Title: |
Cloning of mouse FGF10 and up-regulation of its gene expression during wound healing. |
Volume: |
197 |
Issue: |
1-2 |
Pages: |
399-404 |
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Publication |
First Author: |
Chao CM |
Year: |
2017 |
Journal: |
J Pathol |
Title: |
Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia. |
Volume: |
241 |
Issue: |
1 |
Pages: |
91-103 |
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Publication |
First Author: |
Volckaert T |
Year: |
2013 |
Journal: |
Development |
Title: |
Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors. |
Volume: |
140 |
Issue: |
18 |
Pages: |
3731-42 |
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Publication |
First Author: |
Makarenkova HP |
Year: |
2000 |
Journal: |
Development |
Title: |
FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development. |
Volume: |
127 |
Issue: |
12 |
Pages: |
2563-72 |
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Publication |
First Author: |
Zelarayan LC |
Year: |
2007 |
Journal: |
Dev Biol |
Title: |
Differential requirements for FGF3, FGF8 and FGF10 during inner ear development. |
Volume: |
308 |
Issue: |
2 |
Pages: |
379-91 |
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Publication |
First Author: |
May AJ |
Year: |
2015 |
Journal: |
Curr Mol Med |
Title: |
Salivary Gland Dysplasia in Fgf10 Heterozygous Mice: A New Mouse Model of Xerostomia. |
Volume: |
15 |
Issue: |
7 |
Pages: |
674-82 |
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Publication |
First Author: |
Lilleväli K |
Year: |
2006 |
Journal: |
Mech Dev |
Title: |
Gata3 is required for early morphogenesis and Fgf10 expression during otic development. |
Volume: |
123 |
Issue: |
6 |
Pages: |
415-29 |
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Publication |
First Author: |
Urness LD |
Year: |
2011 |
Journal: |
Dev Biol |
Title: |
Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular development. |
Volume: |
356 |
Issue: |
2 |
Pages: |
383-97 |
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Publication |
First Author: |
Urness LD |
Year: |
2015 |
Journal: |
Dev Biol |
Title: |
Fgf10 is required for specification of non-sensory regions of the cochlear epithelium. |
Volume: |
400 |
Issue: |
1 |
Pages: |
59-71 |
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Publication |
First Author: |
He W |
Year: |
2010 |
Journal: |
J Pediatr Surg |
Title: |
Perturbation of Fgf10 signal pathway in mouse embryonic palate by dexamethasone and vitamin B12 in vivo. |
Volume: |
45 |
Issue: |
10 |
Pages: |
2030-5 |
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Publication |
First Author: |
Veltmaat JM |
Year: |
2006 |
Journal: |
Development |
Title: |
Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. |
Volume: |
133 |
Issue: |
12 |
Pages: |
2325-35 |
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Publication |
First Author: |
Hajihosseini MK |
Year: |
2009 |
Journal: |
Dev Dyn |
Title: |
Evidence that Fgf10 contributes to the skeletal and visceral defects of an Apert syndrome mouse model. |
Volume: |
238 |
Issue: |
2 |
Pages: |
376-85 |
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Publication |
First Author: |
Ohuchi H |
Year: |
2005 |
Journal: |
Dev Dyn |
Title: |
Identification of cis-element regulating expression of the mouse Fgf10 gene during inner ear development. |
Volume: |
233 |
Issue: |
1 |
Pages: |
177-87 |
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Publication |
First Author: |
Fairbanks TJ |
Year: |
2004 |
Journal: |
J Surg Res |
Title: |
A genetic mechanism for cecal atresia: the role of the Fgf10 signaling pathway. |
Volume: |
120 |
Issue: |
2 |
Pages: |
201-9 |
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Publication |
First Author: |
Suzuki K |
Year: |
2000 |
Journal: |
FEBS Lett |
Title: |
Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene. |
Volume: |
481 |
Issue: |
1 |
Pages: |
53-6 |
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Publication |
First Author: |
Yamaoka T |
Year: |
2002 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Transgenic expression of FGF8 and FGF10 induces transdifferentiation of pancreatic islet cells into hepatocytes and exocrine cells. |
Volume: |
292 |
Issue: |
1 |
Pages: |
138-43 |
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Publication |
First Author: |
Kelly RG |
Year: |
2007 |
Journal: |
Dev Dyn |
Title: |
Visualization of outflow tract development in the absence of Tbx1 using an FgF10 enhancer trap transgene. |
Volume: |
236 |
Issue: |
3 |
Pages: |
821-8 |
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Publication |
First Author: |
Patel VN |
Year: |
2007 |
Journal: |
Development |
Title: |
Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. |
Volume: |
134 |
Issue: |
23 |
Pages: |
4177-86 |
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Publication |
First Author: |
Lü J |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis. |
Volume: |
282 |
Issue: |
30 |
Pages: |
22176-84 |
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Publication |
First Author: |
Mauduit O |
Year: |
2022 |
Journal: |
Cell Rep |
Title: |
A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands. |
Volume: |
39 |
Issue: |
2 |
Pages: |
110663 |
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Publication |
First Author: |
Alappat SR |
Year: |
2005 |
Journal: |
Dev Biol |
Title: |
The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice. |
Volume: |
277 |
Issue: |
1 |
Pages: |
102-13 |
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Publication |
First Author: |
Ohuchi H |
Year: |
2000 |
Journal: |
Biochem Biophys Res Commun |
Title: |
FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development. |
Volume: |
277 |
Issue: |
3 |
Pages: |
643-9 |
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Publication |
First Author: |
Bhushan A |
Year: |
2001 |
Journal: |
Development |
Title: |
Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. |
Volume: |
128 |
Issue: |
24 |
Pages: |
5109-17 |
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Publication |
First Author: |
Tao H |
Year: |
2006 |
Journal: |
Dev Growth Differ |
Title: |
Exogenous FGF10 can rescue an eye-open at birth phenotype of Fgf10-null mice by activating activin and TGFalpha-EGFR signaling. |
Volume: |
48 |
Issue: |
5 |
Pages: |
339-46 |
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Publication |
First Author: |
Lü J |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis. |
Volume: |
280 |
Issue: |
6 |
Pages: |
4834-41 |
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