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Search results 1 to 100 out of 408 for Fgf12

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0.081s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 12 (FGF12), also known as fibroblast growth factor homologous factor 1. It lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localisation signal. When transfected into mammalian cells, it accumulates in the nucleus, but is not secreted []. Although it currently has no known function, it is thought to be involved in nervous system development and function [, ].
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Smallwood PM
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.
Volume: 93
Issue: 18
Pages: 9850-7
Publication
First Author: Hartung H
Year: 1997
Journal: Cytogenet Cell Genet
Title: Assignment of Fgf12 to mouse chromosome bands 16B1-->B3 by in situ hybridization.
Volume: 76
Issue: 3-4
Pages: 185-6
GXD Expression      
Probe: MGI:6172857
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190261
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Fgf12
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:6172857
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190261
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Fgf12
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6172857
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190261
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Fgf12
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6172857
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190261
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Fgf12
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6172857
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190261
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Fgf12
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6172857
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190261
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Fgf12
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6172857
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190261
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Fgf12
Detected: true
Specimen Num: 7
Protein
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: false
Publication  
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
Publication
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
Publication
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
Publication
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
Publication
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
Publication
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
Publication
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
Publication
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
Publication
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
Publication
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
Publication
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
Publication
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
Publication
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
Publication
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
Publication
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
Publication
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
Publication
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
Publication
First Author: Liu Y
Year: 1997
Journal: Cytogenet Cell Genet
Title: Assignment of FGF12, the human FGF homologous factor 1 gene, to chromosome 3q29-->3qter by fluorescence in situ hybridization.
Volume: 78
Issue: 1
Pages: 48-9
Publication
First Author: Hanada Y
Year: 2018
Journal: Sci Rep
Title: Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function.
Volume: 8
Issue: 1
Pages: 11491
Publication
First Author: Song SH
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Fibroblast Growth Factor 12 Is a Novel Regulator of Vascular Smooth Muscle Cell Plasticity and Fate.
Volume: 36
Issue: 9
Pages: 1928-36
Publication
First Author: Nie X
Year: 2006
Journal: Angle Orthod
Title: Developmentally regulated expression of MSX1, MSX2 and Fgfs in the developing mouse cranial base.
Volume: 76
Issue: 6
Pages: 990-5
Publication
First Author: Hartung H
Year: 1997
Journal: Mech Dev
Title: Murine FGF-12 and FGF-13: expression in embryonic nervous system, connective tissue and heart.
Volume: 64
Issue: 1-2
Pages: 31-9
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:6394078
Assay Type: RT-PCR
Annotation Date: 2020-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:6394105
Age: embryonic day 9.5
Specimen Label: Ccm2l+/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6394078
Assay Type: RT-PCR
Annotation Date: 2020-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:6394105
Age: embryonic day 9.5
Specimen Label: Ccm2l-/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6394078
Assay Type: RT-PCR
Annotation Date: 2020-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:6394112
Age: embryonic day 9.5
Specimen Label: Ccm2l+/-;Heg+/-
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6394078
Assay Type: RT-PCR
Annotation Date: 2020-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:6394112
Age: embryonic day 9.5
Specimen Label: Ccm2l-/-;Heg+/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6394078
Assay Type: RT-PCR
Annotation Date: 2020-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:6394112
Age: embryonic day 9.5
Specimen Label: Ccm2l+/-;Heg-/-
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6394078
Assay Type: RT-PCR
Annotation Date: 2020-03-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:6394112
Age: embryonic day 9.5
Specimen Label: Ccm2l-/-;Heg-/-
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5810427
Assay Type: RT-PCR
Annotation Date: 2016-11-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718519
Stage: TS19
Assay Id: MGI:5810467
Age: embryonic day 11.5
Image: 1
Specimen Label: E11.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5810427
Assay Type: RT-PCR
Annotation Date: 2016-11-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718520
Stage: TS20
Assay Id: MGI:5810467
Age: embryonic day 12.5
Image: 1
Specimen Label: E12.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5810427
Assay Type: RT-PCR
Annotation Date: 2016-11-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718521
Stage: TS21
Assay Id: MGI:5810467
Age: embryonic day 13.5
Image: 1
Specimen Label: E13.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5810427
Assay Type: RT-PCR
Annotation Date: 2016-11-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718522
Stage: TS22
Assay Id: MGI:5810467
Age: embryonic day 14.4
Image: 1
Specimen Label: E14.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3524851
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750320
Stage: TS20
Assay Id: MGI:3525536
Age: embryonic day 12.0
Specimen Label: E12
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3524851
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750321
Stage: TS21
Assay Id: MGI:3525536
Age: embryonic day 13.0
Specimen Label: E13
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3524851
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:3525536
Age: embryonic day 14.0
Specimen Label: E14
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:3524851
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750323
Stage: TS23
Assay Id: MGI:3525536
Age: embryonic day 15.0
Specimen Label: E15
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3524851
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750324
Stage: TS24
Assay Id: MGI:3525536
Age: embryonic day 16.0
Specimen Label: E16
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:3524851
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750325
Stage: TS25
Assay Id: MGI:3525536
Age: embryonic day 17.0
Specimen Label: E17
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3524851
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750327
Stage: TS27
Assay Id: MGI:3525536
Age: postnatal day 0
Specimen Label: P0
Detected: false
Specimen Num: 7
GXD Expression      
Probe: MGI:3524852
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750320
Stage: TS20
Assay Id: MGI:3525537
Age: embryonic day 12.0
Specimen Label: E12
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3524852
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750321
Stage: TS21
Assay Id: MGI:3525537
Age: embryonic day 13.0
Specimen Label: E13
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3524852
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:3525537
Age: embryonic day 14.0
Specimen Label: E14
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:3524852
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750323
Stage: TS23
Assay Id: MGI:3525537
Age: embryonic day 15.0
Specimen Label: E15
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3524852
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750324
Stage: TS24
Assay Id: MGI:3525537
Age: embryonic day 16.0
Specimen Label: E16
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:3524852
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750325
Stage: TS25
Assay Id: MGI:3525537
Age: embryonic day 17.0
Specimen Label: E17
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3524852
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750327
Stage: TS27
Assay Id: MGI:3525537
Age: postnatal day 0
Specimen Label: P0
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:2664748
Assay Type: RT-PCR
Annotation Date: 2003-07-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1922525
Stage: TS25
Assay Id: MGI:2664792
Age: embryonic day 17.5
Image: 1
Specimen Label: Fgf-12
Detected: true
Specimen Num: 13
GXD Expression  
Probe: MGI:3766815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3516422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421739
Age: embryonic day 14.5
Image: FG53; Specimen C2004
Specimen Label: FG53; Specimen C2004
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3766815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421739
Age: embryonic day 14.5
Image: FG53; Specimen C2004
Specimen Label: FG53; Specimen C2004
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3620930
Assay Type: RNA in situ
Annotation Date: 2006-05-03
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3262622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:3621021
Age: embryonic day 14.5
Image: 2D
Note: Expression is in proliferating and early hypertrophic chondrocytes.
Specimen Label: 2D
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3766815
Assay Type: RNA in situ
Annotation Date: 2008-01-10
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760622
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3767164
Age: embryonic day 14.5
Image: FG53
Specimen Label: FG53
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3766815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421739
Age: embryonic day 14.5
Image: FG53; Specimen C2004
Specimen Label: FG53; Specimen C2004
Detected: true
Specimen Num: 1