|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 442 for Fgf13

<< First    < Previous  |  Next >    Last >>
0.046s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 13 (FGF13), also known as fibroblast growth factor homologous factor 2. It is thought to be involved in nervous system development and function []. FGF13 has been shown to induce cell growth of lung fibroblasts and aortic smooth muscle cells, but has no effect on dermal vascular endothelial cells []. It also is thought to regulate voltage-gated sodium channels transport and function, and play a role in MAPK signaling []. The localisation and tissue-specific expression pattern of FGF13 has made it a possible candidate for familial cases of Borjeson-Forssman-Lehmann syndrome (BFLS) and other syndromal and nonspecific forms of X-linked mental retardation [].
Gene
Type: gene
Organism: human
Publication
First Author: Smallwood PM
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.
Volume: 93
Issue: 18
Pages: 9850-7
Publication
First Author: Yang L
Year: 2017
Journal: Neuron
Title: FGF13 Selectively Regulates Heat Nociception by Interacting with Nav1.7.
Volume: 93
Issue: 4
Pages: 806-821.e9
Publication
First Author: DeStefano GM
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Position effect on FGF13 associated with X-linked congenital generalized hypertrichosis.
Volume: 110
Issue: 19
Pages: 7790-5
Publication
First Author: Yuan B
Year: 2017
Journal: J Genet Genomics
Title: Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors.
Volume: 44
Issue: 1
Pages: 63-66
Publication
First Author: Dong F
Year: 2020
Journal: J Neurosci
Title: FGF13 Is Required for Histamine-Induced Itch Sensation by Interaction with NaV1.7.
Volume: 40
Issue: 50
Pages: 9589-9601
Publication
First Author: Puranam RS
Year: 2015
Journal: J Neurosci
Title: Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.
Volume: 35
Issue: 23
Pages: 8866-81
Publication
First Author: Yang QQ
Year: 2021
Journal: Cell Rep
Title: Nuclear isoform of FGF13 regulates post-natal neurogenesis in the hippocampus through an epigenomic mechanism.
Volume: 35
Issue: 7
Pages: 109127
Publication
First Author: Pablo JL
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 action.
Volume: 113
Issue: 19
Pages: E2665-74
Publication
First Author: Hollern DP
Year: 2019
Journal: Sci Rep
Title: E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration.
Volume: 9
Issue: 1
Pages: 10718
Publication  
First Author: Wang X
Year: 2017
Journal: J Mol Cell Cardiol
Title: Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles.
Volume: 104
Pages: 63-74
Publication
First Author: Leung KH
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Functional effects of FGF-13 on human lung fibroblasts, dermal microvascular endothelial cells, and aortic smooth muscle cells.
Volume: 250
Issue: 1
Pages: 137-42
Publication
First Author: Wittmack EK
Year: 2004
Journal: J Neurosci
Title: Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons.
Volume: 24
Issue: 30
Pages: 6765-75
Publication
First Author: Gecz J
Year: 1999
Journal: Hum Genet
Title: Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Börjeson-Forssman-Lehmann syndrome region in Xq26 delineated by a duplication breakpoint in a BFLS-like patient.
Volume: 104
Issue: 1
Pages: 56-63
Protein
Organism: Mus musculus/domesticus
Length: 69  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
Publication    
First Author: Pan X
Year: 2021
Journal: Elife
Title: 5'-UTR SNP of FGF13 causes translational defect and intellectual disability.
Volume: 10
Publication  
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
Publication
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
Publication
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
Publication
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
Publication
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
Publication
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
Publication
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
Publication
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
Publication
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
Publication
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
Publication
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
Publication
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
Publication
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
Publication
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
Publication
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
Publication
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
Publication
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
Publication
First Author: Sinden DS
Year: 2019
Journal: FASEB J
Title: Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.
Volume: 33
Issue: 10
Pages: 11579-11594
Publication
First Author: Wei EQ
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload.
Volume: 114
Issue: 20
Pages: E4010-E4019
Publication
First Author: Hennessey JA
Year: 2013
Journal: Circ Res
Title: Fibroblast growth factor homologous factors modulate cardiac calcium channels.
Volume: 113
Issue: 4
Pages: 381-8
Publication  
First Author: Wang Q
Year: 2021
Journal: J Adv Res
Title: Fibroblast growth factor 13 stabilizes microtubules to promote Na(+) channel function in nociceptive DRG neurons and modulates inflammatory pain.
Volume: 31
Pages: 97-111
Publication  
First Author: Yu Y
Year: 2021
Journal: Front Cell Neurosci
Title: Sensorineural Hearing Loss and Mitochondrial Apoptosis of Cochlear Spiral Ganglion Neurons in Fibroblast Growth Factor 13 Knockout Mice.
Volume: 15
Pages: 658586
Publication
First Author: Wu QF
Year: 2012
Journal: Cell
Title: Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration.
Volume: 149
Issue: 7
Pages: 1549-64
Publication
First Author: Wang C
Year: 2011
Journal: Circ Res
Title: Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts.
Volume: 109
Issue: 7
Pages: 775-82
Publication
First Author: Burel S
Year: 2017
Journal: J Biol Chem
Title: C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation.
Volume: 292
Issue: 42
Pages: 17431-17448
Publication
First Author: Hartung H
Year: 1997
Journal: Mech Dev
Title: Murine FGF-12 and FGF-13: expression in embryonic nervous system, connective tissue and heart.
Volume: 64
Issue: 1-2
Pages: 31-9
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication  
First Author: Park DS
Year: 2016
Journal: Nat Commun
Title: Fhf2 gene deletion causes temperature-sensitive cardiac conduction failure.
Volume: 7
Pages: 12966
GXD Expression    
Probe: MGI:2655105
Assay Type: RT-PCR
Annotation Date: 2003-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1626220
Stage: TS20
Assay Id: MGI:2655137
Age: embryonic day 12.0
Image: 4
Specimen Label: E12
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2655105
Assay Type: RT-PCR
Annotation Date: 2003-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775121
Stage: TS21
Assay Id: MGI:2655137
Age: embryonic day 13.0
Image: 4
Specimen Label: E13
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2655105
Assay Type: RT-PCR
Annotation Date: 2003-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775122
Stage: TS22
Assay Id: MGI:2655137
Age: embryonic day 14.0
Image: 4
Specimen Label: E14
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2655105
Assay Type: RT-PCR
Annotation Date: 2003-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775125
Stage: TS25
Assay Id: MGI:2655137
Age: embryonic day 17.0
Image: 4
Specimen Label: E17
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2655105
Assay Type: RT-PCR
Annotation Date: 2003-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775127
Stage: TS27
Assay Id: MGI:2655137
Age: postnatal day 1
Image: 4
Specimen Label: D1
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:2655105
Assay Type: RT-PCR
Annotation Date: 2003-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775128
Stage: TS28
Assay Id: MGI:2655137
Age: postnatal day 5
Image: 4
Specimen Label: D5
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2655105
Assay Type: RT-PCR
Annotation Date: 2003-04-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1775128
Stage: TS28
Assay Id: MGI:2655137
Age: postnatal month 3
Image: 4
Specimen Label: Ad
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:2664751
Assay Type: RT-PCR
Annotation Date: 2003-07-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1922525
Stage: TS25
Assay Id: MGI:2664794
Age: embryonic day 17.5
Image: 1
Specimen Label: Fgf-13
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3844674
Assay Type: RT-PCR
Annotation Date: 2009-05-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3845139
Age: embryonic day 7.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3844674
Assay Type: RT-PCR
Annotation Date: 2009-05-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3845139
Age: embryonic day 7.5
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5810428
Assay Type: RT-PCR
Annotation Date: 2016-11-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718519
Stage: TS19
Assay Id: MGI:5810458
Age: embryonic day 11.5
Image: 1
Specimen Label: E11.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5810428
Assay Type: RT-PCR
Annotation Date: 2016-11-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718520
Stage: TS20
Assay Id: MGI:5810458
Age: embryonic day 12.5
Image: 1
Specimen Label: E12.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5810428
Assay Type: RT-PCR
Annotation Date: 2016-11-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718521
Stage: TS21
Assay Id: MGI:5810458
Age: embryonic day 13.5
Image: 1
Specimen Label: E13.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5810428
Assay Type: RT-PCR
Annotation Date: 2016-11-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718522
Stage: TS22
Assay Id: MGI:5810458
Age: embryonic day 14.4
Image: 1
Specimen Label: E14.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3524853
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750320
Stage: TS20
Assay Id: MGI:3525538
Age: embryonic day 12.0
Specimen Label: E12
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3524853
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750321
Stage: TS21
Assay Id: MGI:3525538
Age: embryonic day 13.0
Specimen Label: E13
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3524853
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:3525538
Age: embryonic day 14.0
Specimen Label: E14
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:3524853
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750323
Stage: TS23
Assay Id: MGI:3525538
Age: embryonic day 15.0
Specimen Label: E15
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3524853
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750324
Stage: TS24
Assay Id: MGI:3525538
Age: embryonic day 16.0
Specimen Label: E16
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:3524853
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750325
Stage: TS25
Assay Id: MGI:3525538
Age: embryonic day 17.0
Specimen Label: E17
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3524853
Assay Type: RT-PCR
Annotation Date: 2005-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750327
Stage: TS27
Assay Id: MGI:3525538
Age: postnatal day 0
Specimen Label: P0
Detected: false
Specimen Num: 7
GXD Expression  
Probe: MGI:3766793
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3516422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421720
Age: embryonic day 14.5
Image: FG21; Specimen C1210
Specimen Label: FG21; Specimen C1210
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1614051
Assay Type: RNA in situ
Annotation Date: 2024-06-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7660547
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3766793
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716122
Stage: TS22
Assay Id: MGI:5421720
Age: embryonic day 14.5
Specimen Label: FG21; Specimen C1210
Detected: false
Specimen Num: 1