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Search results 1 to 100 out of 421 for Fgf16

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 16 (FGF16). The protein plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development []. In rat embryos, FGF16 is detected predominantly in brown adipose tissue, where it shows significant mitogenic activity for primary brown adipocytes, mediated by activation of FGFR4 [].
Publication
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
Publication
First Author: Yu W
Year: 2016
Journal: Development
Title: GATA4 regulates Fgf16 to promote heart repair after injury.
Volume: 143
Issue: 6
Pages: 936-49
Publication
First Author: Hotta Y
Year: 2008
Journal: Dev Dyn
Title: Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart.
Volume: 237
Issue: 10
Pages: 2947-54
Publication    
First Author: Itoh N
Year: 2000
Journal: GenBank Submission
Title: Mus musculus Fgf16 mRNA for fibroblast growth factor 16, complete cds
Pages: AB049219
GXD Expression      
Probe: MGI:6172864
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190264
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Fgf16
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6172864
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190264
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Fgf16
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6172864
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190264
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Fgf16
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6172864
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190264
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Fgf16
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:6172864
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190264
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Fgf16
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:6172864
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190264
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Fgf16
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:6172864
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190264
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Fgf16
Detected: false
Specimen Num: 7
Publication
First Author: Konishi M
Year: 2000
Journal: J Biol Chem
Title: Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes.
Volume: 275
Issue: 16
Pages: 12119-22
Protein
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
Publication
First Author: Zhang X
Year: 2006
Journal: J Biol Chem
Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
Volume: 281
Issue: 23
Pages: 15694-700
Publication  
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
Publication
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
Publication
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
Publication
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
Publication
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
Publication
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
Publication
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
Publication
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
Publication
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
Publication
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
Publication
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
Publication
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
Publication
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
Publication
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
Publication
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
Publication
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
Publication
First Author: Hatch EP
Year: 2009
Journal: Dev Dyn
Title: Fgf16(IRESCre) mice: a tool to inactivate genes expressed in inner ear cristae and spiral prominence epithelium.
Volume: 238
Issue: 2
Pages: 358-66
Publication
First Author: Lu SY
Year: 2008
Journal: Biochem Biophys Res Commun
Title: FGF-16 is required for embryonic heart development.
Volume: 373
Issue: 2
Pages: 270-4
Publication
First Author: Matsumoto E
Year: 2013
Journal: Genes Cells
Title: Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16.
Volume: 18
Issue: 7
Pages: 544-53
Publication
First Author: Rulifson IC
Year: 2017
Journal: J Biol Chem
Title: In Vitro and in Vivo Analyses Reveal Profound Effects of Fibroblast Growth Factor 16 as a Metabolic Regulator.
Volume: 292
Issue: 5
Pages: 1951-1969
Publication
First Author: Du W
Year: 2016
Journal: Gene Expr Patterns
Title: Expression of FGFs during early mouse tongue development.
Volume: 20
Issue: 2
Pages: 81-7
Publication
First Author: Wright TJ
Year: 2003
Journal: Dev Dyn
Title: Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development.
Volume: 228
Issue: 2
Pages: 267-72
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Miyake A
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family.
Volume: 243
Issue: 1
Pages: 148-52
GXD Expression    
Probe: MGI:2664756
Assay Type: RT-PCR
Annotation Date: 2003-07-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1922525
Stage: TS25
Assay Id: MGI:2664799
Age: embryonic day 17.5
Image: 1
Specimen Label: Fgf-16
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-10
Strength: Absent
Sex: Male
Emaps: EMAPS:3185815
Stage: TS15
Assay Id: MGI:3805334
Age: embryonic day 9.5
Specimen Label: Hd
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-10
Strength: Absent
Sex: Male
Emaps: EMAPS:1666915
Stage: TS15
Assay Id: MGI:3805334
Age: embryonic day 9.5
Specimen Label: Hd
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-10
Strength: Absent
Sex: Male
Emaps: EMAPS:1654315
Stage: TS15
Assay Id: MGI:3805334
Age: embryonic day 9.5
Specimen Label: Hd
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-10
Strength: Absent
Sex: Male
Emaps: EMAPS:1611715
Stage: TS15
Assay Id: MGI:3805334
Age: embryonic day 9.5
Specimen Label: Ph
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-10
Strength: Absent
Sex: Male
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3805334
Age: embryonic day 9.5
Specimen Label: Ht
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-10
Strength: Present
Sex: Male
Emaps: EMAPS:3185815
Stage: TS15
Assay Id: MGI:3805334
Age: embryonic day 9.5
Specimen Label: Hd
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-10
Strength: Present
Sex: Male
Emaps: EMAPS:1666915
Stage: TS15
Assay Id: MGI:3805334
Age: embryonic day 9.5
Specimen Label: Hd
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-10
Strength: Present
Sex: Male
Emaps: EMAPS:1654315
Stage: TS15
Assay Id: MGI:3805334
Age: embryonic day 9.5
Specimen Label: Hd
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-10
Strength: Present
Sex: Male
Emaps: EMAPS:1611715
Stage: TS15
Assay Id: MGI:3805334
Age: embryonic day 9.5
Specimen Label: Ph
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-10
Strength: Present
Sex: Male
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3805334
Age: embryonic day 9.5
Specimen Label: Ht
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-11
Strength: Absent
Sex: Male
Emaps: EMAPS:1680017
Stage: TS17
Assay Id: MGI:3805389
Age: embryonic day 10.5
Specimen Label: Hd
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-11
Strength: Absent
Sex: Male
Emaps: EMAPS:3185817
Stage: TS17
Assay Id: MGI:3805389
Age: embryonic day 10.5
Specimen Label: Hd
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-11
Strength: Absent
Sex: Male
Emaps: EMAPS:1666917
Stage: TS17
Assay Id: MGI:3805389
Age: embryonic day 10.5
Specimen Label: Hd
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-11
Strength: Absent
Sex: Male
Emaps: EMAPS:1611717
Stage: TS17
Assay Id: MGI:3805389
Age: embryonic day 10.5
Specimen Label: Ph
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-11
Strength: Absent
Sex: Male
Emaps: EMAPS:1610517
Stage: TS17
Assay Id: MGI:3805389
Age: embryonic day 10.5
Specimen Label: Ht
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-11
Strength: Present
Sex: Male
Emaps: EMAPS:1680017
Stage: TS17
Assay Id: MGI:3805389
Age: embryonic day 10.5
Specimen Label: Hd
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-11
Strength: Present
Sex: Male
Emaps: EMAPS:3185817
Stage: TS17
Assay Id: MGI:3805389
Age: embryonic day 10.5
Specimen Label: Hd
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-11
Strength: Present
Sex: Male
Emaps: EMAPS:1666917
Stage: TS17
Assay Id: MGI:3805389
Age: embryonic day 10.5
Specimen Label: Hd
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-11
Strength: Present
Sex: Male
Emaps: EMAPS:1611717
Stage: TS17
Assay Id: MGI:3805389
Age: embryonic day 10.5
Specimen Label: Ph
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-11
Strength: Present
Sex: Male
Emaps: EMAPS:1610517
Stage: TS17
Assay Id: MGI:3805389
Age: embryonic day 10.5
Specimen Label: Ht
Detected: true
Specimen Num: 7
GXD Expression        
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-11
Strength: Not Specified
Sex: Male
Emaps: EMAPS:1674817
Stage: TS17
Assay Id: MGI:3805389
Age: embryonic day 10.5
Specimen Label: Ta
Specimen Num: 8
GXD Expression      
Probe: MGI:3805328
Assay Type: RT-PCR
Annotation Date: 2008-09-11
Strength: Absent
Sex: Male
Emaps: EMAPS:1674817
Stage: TS17
Assay Id: MGI:3805389
Age: embryonic day 10.5
Specimen Label: Ta
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:4943672
Assay Type: RT-PCR
Annotation Date: 2011-04-04
Strength: Present
Sex: Female
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:4943673
Age: embryonic day 9.0
Image: 2
Specimen Label: +/+
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4943672
Assay Type: RT-PCR
Annotation Date: 2011-04-04
Strength: Present
Sex: Female
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:4943673
Age: embryonic day 9.0
Image: 2
Specimen Label: +/-
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4943672
Assay Type: RT-PCR
Annotation Date: 2011-04-04
Strength: Absent
Sex: Male
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:4943673
Age: embryonic day 9.0
Image: 2
Specimen Label: -/-
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:5562439
Assay Type: RT-PCR
Annotation Date: 2014-05-06
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5562452
Age: postnatal day 56
Image: 1
Specimen Label: brain
Specimen Num: 1
GXD Expression    
Probe: MGI:5562439
Assay Type: RT-PCR
Annotation Date: 2014-05-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5562452
Age: postnatal day 56
Image: 1
Specimen Label: heart
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5562439
Assay Type: RT-PCR
Annotation Date: 2014-05-06
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5562452
Age: postnatal day 56
Image: 1
Specimen Label: lung
Specimen Num: 3
GXD Expression    
Probe: MGI:5562439
Assay Type: RT-PCR
Annotation Date: 2014-05-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:5562452
Age: postnatal day 56
Image: 1
Specimen Label: thymus
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:5562439
Assay Type: RT-PCR
Annotation Date: 2014-05-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:5562452
Age: postnatal day 56
Image: 1
Specimen Label: stomach
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:5562439
Assay Type: RT-PCR
Annotation Date: 2014-05-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5562452
Age: postnatal day 56
Image: 1
Specimen Label: liver
Detected: false
Specimen Num: 6