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Search results 1 to 100 out of 498 for Fgf17

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 17 (FGF17). The protein plays an important role in the regulation of embryonic development and in the induction and patterning of the embryonic brain. It is required for normal brain development []. In mouse, FGF17 is localised to specific sites in the brain, the developing skeleton and developing arteries, which suggests a role in central nervous system, bone and vascular growth [, , ].
GXD Expression
Probe: MGI:4427168
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824842
Age: embryonic day 14.5
Image: S6 A/B - Fgf17
Note: Expression is present in the anterior commissure.
Specimen Label: S6 A/B - Fgf17
Detected: true
Specimen Num: 1
Publication
First Author: Xu J
Year: 1999
Journal: Mech Dev
Title: Genomic structure, mapping, activity and expression of fibroblast growth factor 17.
Volume: 83
Issue: 1-2
Pages: 165-78
Publication
First Author: Hoshikawa M
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain.
Volume: 244
Issue: 1
Pages: 187-91
Publication
First Author: Xu J
Year: 2000
Journal: Development
Title: Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures.
Volume: 127
Issue: 9
Pages: 1833-43
Publication
First Author: Maruoka Y
Year: 1998
Journal: Mech Dev
Title: Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo.
Volume: 74
Issue: 1-2
Pages: 175-7
Publication  
First Author: Boylan M
Year: 2020
Journal: Development
Title: The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall.
Volume: 147
Issue: 21
GXD Expression    
Probe: MGI:6172865
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190265
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Fgf17
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6172865
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190265
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Fgf17
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6172865
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190265
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Fgf17
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6172865
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190265
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Fgf17
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:6172865
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190265
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Fgf17
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:6172865
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190265
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Fgf17
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:6172865
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190265
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Fgf17
Detected: false
Specimen Num: 7
Publication
First Author: Greene JM
Year: 1998
Journal: Eur J Neurosci
Title: Identification and characterization of a novel member of the fibroblast growth factor family.
Volume: 10
Issue: 5
Pages: 1911-25
Protein
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
Publication
First Author: Zhang X
Year: 2006
Journal: J Biol Chem
Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
Volume: 281
Issue: 23
Pages: 15694-700
Publication  
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
Publication
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
Publication
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
Publication
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
Publication
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
Publication
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
Publication
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
Publication
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
Publication
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
Publication
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
Publication
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
Publication
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
Publication
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
Publication
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
Publication
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
Publication
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
Publication
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
Publication
First Author: Scearce-Levie K
Year: 2008
Journal: Genes Brain Behav
Title: Abnormal social behaviors in mice lacking Fgf17.
Volume: 7
Issue: 3
Pages: 344-54
Publication
First Author: Yu X
Year: 2011
Journal: Neuroimage
Title: Morphological and functional midbrain phenotypes in Fibroblast Growth Factor 17 mutant mice detected by Mn-enhanced MRI.
Volume: 56
Issue: 3
Pages: 1251-8
Publication
First Author: Cholfin JA
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Patterning of frontal cortex subdivisions by Fgf17.
Volume: 104
Issue: 18
Pages: 7652-7
Publication
First Author: Iram T
Year: 2022
Journal: Nature
Title: Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17.
Volume: 605
Issue: 7910
Pages: 509-515
Publication  
First Author: Hoch RV
Year: 2015
Journal: Neural Dev
Title: Fgf signaling controls the telencephalic distribution of Fgf-expressing progenitors generated in the rostral patterning center.
Volume: 10
Pages: 8
Publication
First Author: Zhong W
Year: 2006
Journal: Mol Reprod Dev
Title: FGF ligand family mRNA expression profile for mouse preimplantation embryos, early gestation human placenta, and mouse trophoblast stem cells.
Volume: 73
Issue: 5
Pages: 540-50
Publication
First Author: Sun X
Year: 2000
Journal: Nat Genet
Title: Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development.
Volume: 25
Issue: 1
Pages: 83-6
Publication
First Author: Hasenpusch-Theil K
Year: 2017
Journal: Cereb Cortex
Title: Direct Interactions Between Gli3, Wnt8b, and Fgfs Underlie Patterning of the Dorsal Telencephalon.
Volume: 27
Issue: 2
Pages: 1137-1148
Publication
First Author: Sato T
Year: 2009
Journal: Development
Title: The duration of Fgf8 isthmic organizer expression is key to patterning different tectal-isthmo-cerebellum structures.
Volume: 136
Issue: 21
Pages: 3617-26
Publication
First Author: Mariani FV
Year: 2008
Journal: Nature
Title: Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning.
Volume: 453
Issue: 7193
Pages: 401-5
Publication
First Author: Guo Q
Year: 2010
Journal: Dev Biol
Title: Fgf8b-containing spliceforms, but not Fgf8a, are essential for Fgf8 function during development of the midbrain and cerebellum.
Volume: 338
Issue: 2
Pages: 183-92
Publication
First Author: Zhao X
Year: 2009
Journal: Gene Expr Patterns
Title: Effect of retinoic acid signaling on Wnt/beta-catenin and FGF signaling during body axis extension.
Volume: 9
Issue: 6
Pages: 430-5
Publication
First Author: Goldman DC
Year: 2000
Journal: Development
Title: Fate and function of the ventral ectodermal ridge during mouse tail development.
Volume: 127
Issue: 10
Pages: 2113-23
Publication  
First Author: Jen YH
Year: 2009
Journal: Neural Dev
Title: Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis.
Volume: 4
Pages: 33
Publication  
First Author: Borello U
Year: 2008
Journal: Neural Dev
Title: FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development.
Volume: 3
Pages: 17
Publication
First Author: Bachler M
Year: 2001
Journal: Mech Dev
Title: Expression of members of the Fgf family and their receptors during midfacial development.
Volume: 100
Issue: 2
Pages: 313-6
Publication
First Author: Miraoui H
Year: 2013
Journal: Am J Hum Genet
Title: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.
Volume: 92
Issue: 5
Pages: 725-43
Publication
First Author: Liu A
Year: 2003
Journal: Development
Title: FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors.
Volume: 130
Issue: 25
Pages: 6175-85
Publication
First Author: Eblaghie MC
Year: 2004
Journal: J Anat
Title: Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos.
Volume: 205
Issue: 1
Pages: 1-13
Publication
First Author: Cases O
Year: 2013
Journal: J Biol Chem
Title: Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head.
Volume: 288
Issue: 23
Pages: 16655-70
Publication
First Author: Kasberg AD
Year: 2013
Journal: Dev Biol
Title: SP8 regulates signaling centers during craniofacial development.
Volume: 381
Issue: 2
Pages: 312-23
Publication
First Author: Clegg JM
Year: 2019
Journal: J Neurosci
Title: Heparan Sulfate Sulfation by Hs2st Restricts Astroglial Precursor Somal Translocation in Developing Mouse Forebrain by a Non-Cell-Autonomous Mechanism.
Volume: 39
Issue: 8
Pages: 1386-1404
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:2664757
Assay Type: RT-PCR
Annotation Date: 2003-07-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1922525
Stage: TS25
Assay Id: MGI:2664801
Age: embryonic day 17.5
Image: 1
Specimen Label: Fgf-17
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3803934
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3804226
Age: embryonic day 1.5
Image: 4
Specimen Label: E1.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3803934
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:3804226
Age: embryonic day 3.5
Image: 4
Specimen Label: E3.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3803934
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3804246
Age: postnatal adult
Image: 4
Specimen Label: 50ng
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3803934
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3804246
Age: postnatal adult
Image: 4
Specimen Label: 10ng
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3803934
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3804246
Age: postnatal adult
Image: 4
Specimen Label: 1ng
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3803934
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3804246
Age: postnatal adult
Image: 4
Specimen Label: 100pg
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3803934
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3804246
Age: postnatal adult
Image: 4
Specimen Label: 10pg
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:3803934
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3804247
Age: postnatal adult
Image: 4
Specimen Label: 50ng
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3803934
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3804247
Age: postnatal adult
Image: 4
Specimen Label: 10ng
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3803934
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3804247
Age: postnatal adult
Image: 4
Specimen Label: 1ng
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:3803934
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3804247
Age: postnatal adult
Image: 4
Specimen Label: 100pg
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:3803934
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3804247
Age: postnatal adult
Image: 4
Specimen Label: 10pg
Detected: false
Specimen Num: 5