Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 18 (FGF18), also referred to ZFGF5. FGF18 is required for normal ossification and bone development and stimulates hepatic and intestinal proliferation [, , , ]. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Davidson D |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. |
Volume: |
280 |
Issue: |
21 |
Pages: |
20509-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu MC |
Year: |
1998 |
Journal: |
Mol Cell Biol |
Title: |
FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation. |
Volume: |
18 |
Issue: |
10 |
Pages: |
6063-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shimoaka T |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF-10. |
Volume: |
277 |
Issue: |
9 |
Pages: |
7493-500 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ornitz DM |
Year: |
2001 |
Journal: |
Genome Biol |
Title: |
Fibroblast growth factors. |
Volume: |
2 |
Issue: |
3 |
Pages: |
REVIEWS3005 |
|
•
•
•
•
•
|
Publication |
First Author: |
Usui H |
Year: |
2004 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Fgf18 is required for embryonic lung alveolar development. |
Volume: |
322 |
Issue: |
3 |
Pages: |
887-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yue M |
Year: |
2021 |
Journal: |
Dev Dyn |
Title: |
Tissue-specific analysis of Fgf18 gene function in palate development. |
Volume: |
250 |
Issue: |
4 |
Pages: |
562-573 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feng J |
Year: |
2022 |
Journal: |
Elife |
Title: |
TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development. |
Volume: |
11 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kimura-Ueki M |
Year: |
2012 |
Journal: |
J Invest Dermatol |
Title: |
Hair cycle resting phase is regulated by cyclic epithelial FGF18 signaling. |
Volume: |
132 |
Issue: |
5 |
Pages: |
1338-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Franco-Montoya ML |
Year: |
2011 |
Journal: |
Physiol Genomics |
Title: |
Profiling target genes of FGF18 in the postnatal mouse lung: possible relevance for alveolar development. |
Volume: |
43 |
Issue: |
21 |
Pages: |
1226-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miyaoka Y |
Year: |
2010 |
Journal: |
Development |
Title: |
A novel regulatory mechanism for Fgf18 signaling involving cysteine-rich FGF receptor (Cfr) and delta-like protein (Dlk). |
Volume: |
137 |
Issue: |
1 |
Pages: |
159-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao X |
Year: |
2010 |
Journal: |
Dev Dyn |
Title: |
Retinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit-interdigit junction. |
Volume: |
239 |
Issue: |
2 |
Pages: |
665-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohbayashi N |
Year: |
2002 |
Journal: |
Genes Dev |
Title: |
FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. |
Volume: |
16 |
Issue: |
7 |
Pages: |
870-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Z |
Year: |
2007 |
Journal: |
Dev Biol |
Title: |
FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate. |
Volume: |
302 |
Issue: |
1 |
Pages: |
80-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu A |
Year: |
2003 |
Journal: |
Development |
Title: |
FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors. |
Volume: |
130 |
Issue: |
25 |
Pages: |
6175-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lv Y |
Year: |
2024 |
Journal: |
Front Cell Dev Biol |
Title: |
Overexpression of Fgf18 in cranial neural crest cells recapitulates Pierre Robin sequence in mice. |
Volume: |
12 |
|
Pages: |
1376814 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hung IH |
Year: |
2016 |
Journal: |
Dev Biol |
Title: |
A combined series of Fgf9 and Fgf18 mutant alleles identifies unique and redundant roles in skeletal development. |
Volume: |
411 |
Issue: |
1 |
Pages: |
72-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ito K |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters. |
Volume: |
8 |
Issue: |
1 |
Pages: |
434 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172867 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190266 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Fgf18 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172867 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190266 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Fgf18 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172867 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190266 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Fgf18 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172867 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190266 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Fgf18 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172867 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190266 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Fgf18 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172867 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190266 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Fgf18 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172867 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190266 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Fgf18 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moore EE |
Year: |
2005 |
Journal: |
Osteoarthritis Cartilage |
Title: |
Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis. |
Volume: |
13 |
Issue: |
7 |
Pages: |
623-31 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
207
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
207
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
98
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Burgess WH |
Year: |
1989 |
Journal: |
Annu Rev Biochem |
Title: |
The heparin-binding (fibroblast) growth factor family of proteins. |
Volume: |
58 |
|
Pages: |
575-606 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilkie AO |
Year: |
1995 |
Journal: |
Curr Biol |
Title: |
Functions of fibroblast growth factors and their receptors. |
Volume: |
5 |
Issue: |
5 |
Pages: |
500-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thomas KA |
Year: |
1988 |
Journal: |
Trends Biochem Sci |
Title: |
Transforming potential of fibroblast growth factor genes. |
Volume: |
13 |
Issue: |
9 |
Pages: |
327-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Plotnikov AN |
Year: |
2000 |
Journal: |
Cell |
Title: |
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. |
Volume: |
101 |
Issue: |
4 |
Pages: |
413-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blaber M |
Year: |
1996 |
Journal: |
Biochemistry |
Title: |
X-ray crystal structure of human acidic fibroblast growth factor. |
Volume: |
35 |
Issue: |
7 |
Pages: |
2086-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vlodavsky I |
Year: |
1990 |
Journal: |
Cancer Metastasis Rev |
Title: |
Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis. |
Volume: |
9 |
Issue: |
3 |
Pages: |
203-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Green PJ |
Year: |
1996 |
Journal: |
Bioessays |
Title: |
Promiscuity of fibroblast growth factor receptors. |
Volume: |
18 |
Issue: |
8 |
Pages: |
639-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yardley N |
Year: |
2012 |
Journal: |
Dev Biol |
Title: |
FGF signaling transforms non-neural ectoderm into neural crest. |
Volume: |
372 |
Issue: |
2 |
Pages: |
166-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Böttcher RT |
Year: |
2005 |
Journal: |
Endocr Rev |
Title: |
Fibroblast growth factor signaling during early vertebrate development. |
Volume: |
26 |
Issue: |
1 |
Pages: |
63-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koga C |
Year: |
1999 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis. |
Volume: |
261 |
Issue: |
3 |
Pages: |
756-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakamizo S |
Year: |
2013 |
Journal: |
Skin Pharmacol Physiol |
Title: |
Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion. |
Volume: |
26 |
Issue: |
1 |
Pages: |
22-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kumar SB |
Year: |
2013 |
Journal: |
Curr Pharm Des |
Title: |
Fibroblast growth factor receptor inhibitors. |
Volume: |
19 |
Issue: |
4 |
Pages: |
687-701 |
|
•
•
•
•
•
|
Publication |
First Author: |
Amaya E |
Year: |
1991 |
Journal: |
Cell |
Title: |
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. |
Volume: |
66 |
Issue: |
2 |
Pages: |
257-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Borland CZ |
Year: |
2001 |
Journal: |
Bioessays |
Title: |
Fibroblast growth factor signaling in Caenorhabditis elegans. |
Volume: |
23 |
Issue: |
12 |
Pages: |
1120-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Coumoul X |
Year: |
2003 |
Journal: |
Birth Defects Res C Embryo Today |
Title: |
Roles of FGF receptors in mammalian development and congenital diseases. |
Volume: |
69 |
Issue: |
4 |
Pages: |
286-304 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sutherland D |
Year: |
1996 |
Journal: |
Cell |
Title: |
branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching. |
Volume: |
87 |
Issue: |
6 |
Pages: |
1091-101 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE29547 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2664821 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-07-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1901624 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:2664829 |
Age: |
embryonic day 16.5 |
Image: |
2D |
Note: |
Double labeling with Osteopontin indicates that Fgf18 abuts Osteopontin expression but does not colocalize with it and is not in the sutural mesenchymal cells. |
Specimen Label: |
2D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2664821 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-07-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801624 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:2664829 |
Age: |
embryonic day 16.5 |
Image: |
2D |
Note: |
Double labeling with Osteopontin indicates that Fgf18 abuts Osteopontin expression but does not colocalize with it and is not in the sutural mesenchymal cells. |
Specimen Label: |
2D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2664821 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-07-08 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801624 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:2664829 |
Age: |
embryonic day 16.5 |
Image: |
2E |
Note: |
Expression is in the cranial cartilage lying just medial to the parietal bone and posterior to the coronal sutures. Double labeling with Osteopontin indicates that Fgf18 abuts Osteopontin expression but does not colocalize with it. |
Specimen Label: |
2E |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2664821 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-07-08 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801624 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:2664829 |
Age: |
embryonic day 16.5 |
Image: |
2F |
Note: |
Expression is in the cranial cartilage lying just medial to the parietal bone and posterior to the coronal sutures. Double labeling with Osteopontin indicates that Fgf18 abuts Osteopontin expression but does not colocalize with it. |
Specimen Label: |
2F |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2664821 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-07-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1801625 |
Pattern: |
Regionally restricted |
Stage: |
TS25 |
Assay Id: |
MGI:2664829 |
Age: |
embryonic day 17.5 |
|
Note: |
Expression is in the cranial cartilage. Double labeling with Osteopontin indicates that Fgf18 abuts Osteopontin expression but does not colocalize with it and also does not extend to the sutural mesenchymal cells between the two bones. |
Specimen Label: |
Not Shown |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2664821 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-07-08 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1871524 |
Pattern: |
Regionally restricted |
Stage: |
TS24 |
Assay Id: |
MGI:2664829 |
Age: |
embryonic day 16.5 |
Image: |
2D |
Note: |
Expression is in the dorsal and ventral rims of the parietal bone. Double labeling with Osteopontin indicates that Fgf18 abuts Osteopontin expression but does not colocalize with it and is not in the sutural mesenchymal cells. |
Specimen Label: |
2D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boylan M |
Year: |
2020 |
Journal: |
Development |
Title: |
The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall. |
Volume: |
147 |
Issue: |
21 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hagan AS |
Year: |
2019 |
Journal: |
Dev Dyn |
Title: |
Generation and validation of novel conditional flox and inducible Cre alleles targeting fibroblast growth factor 18 (Fgf18). |
Volume: |
248 |
Issue: |
9 |
Pages: |
882-893 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bradley EW |
Year: |
2015 |
Journal: |
J Biol Chem |
Title: |
Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation. |
Volume: |
290 |
Issue: |
26 |
Pages: |
16272-80 |
|
•
•
•
•
•
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Publication |
First Author: |
Tsuchiya Y |
Year: |
2023 |
Journal: |
Nat Commun |
Title: |
Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis. |
Volume: |
14 |
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1 |
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6304 |
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Ohuchi H |
Year: |
2000 |
Journal: |
Mech Dev |
Title: |
Involvement of fibroblast growth factor (FGF)18-FGF8 signaling in specification of left-right asymmetry and brain and limb development of the chick embryo. |
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95 |
Issue: |
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55-66 |
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Maruoka Y |
Year: |
1998 |
Journal: |
Mech Dev |
Title: |
Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo. |
Volume: |
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Pages: |
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First Author: |
Hinoi E |
Year: |
2006 |
Journal: |
Genes Dev |
Title: |
Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. |
Volume: |
20 |
Issue: |
21 |
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2937-42 |
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Publication |
First Author: |
Leishman E |
Year: |
2013 |
Journal: |
Development |
Title: |
Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18. |
Volume: |
140 |
Issue: |
18 |
Pages: |
3809-18 |
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Publication |
First Author: |
Nie X |
Year: |
2006 |
Journal: |
Angle Orthod |
Title: |
Developmentally regulated expression of MSX1, MSX2 and Fgfs in the developing mouse cranial base. |
Volume: |
76 |
Issue: |
6 |
Pages: |
990-5 |
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Publication |
First Author: |
Charoenchaikorn K |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
Runx1 is involved in the fusion of the primary and the secondary palatal shelves. |
Volume: |
326 |
Issue: |
2 |
Pages: |
392-402 |
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Publication |
First Author: |
Gori F |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
Perichondrial expression of Wdr5 regulates chondrocyte proliferation and differentiation. |
Volume: |
329 |
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First Author: |
Hagan AS |
Year: |
2020 |
Journal: |
Development |
Title: |
Identification of a FGF18-expressing alveolar myofibroblast that is developmentally cleared during alveologenesis. |
Volume: |
147 |
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2 |
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Du W |
Year: |
2016 |
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Gene Expr Patterns |
Title: |
Expression of FGFs during early mouse tongue development. |
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20 |
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Zhong W |
Year: |
2006 |
Journal: |
Mol Reprod Dev |
Title: |
FGF ligand family mRNA expression profile for mouse preimplantation embryos, early gestation human placenta, and mouse trophoblast stem cells. |
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73 |
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First Author: |
Xu J |
Year: |
2000 |
Journal: |
Development |
Title: |
Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. |
Volume: |
127 |
Issue: |
9 |
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1833-43 |
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First Author: |
Boothby IC |
Year: |
2021 |
Journal: |
Nature |
Title: |
Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin. |
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599 |
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First Author: |
Yang Y |
Year: |
2020 |
Journal: |
Nucleic Acids Res |
Title: |
Phosphorylation of Msx1 promotes cell proliferation through the Fgf9/18-MAPK signaling pathway during embryonic limb development. |
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48 |
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Liu Z |
Year: |
2002 |
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Genes Dev |
Title: |
Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. |
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16 |
Issue: |
7 |
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Hasegawa H |
Year: |
2004 |
Journal: |
J Neurosci |
Title: |
Laminar patterning in the developing neocortex by temporally coordinated fibroblast growth factor signaling. |
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24 |
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First Author: |
Zhao X |
Year: |
2009 |
Journal: |
Gene Expr Patterns |
Title: |
Effect of retinoic acid signaling on Wnt/beta-catenin and FGF signaling during body axis extension. |
Volume: |
9 |
Issue: |
6 |
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430-5 |
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Publication |
First Author: |
Rockel JS |
Year: |
2016 |
Journal: |
J Clin Invest |
Title: |
Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis. |
Volume: |
126 |
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5 |
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Elluru RG |
Year: |
2009 |
Journal: |
Laryngoscope |
Title: |
Fibroblast growth factor 18 gives growth and directional cues to airway cartilage. |
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119 |
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6 |
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First Author: |
Miraoui H |
Year: |
2013 |
Journal: |
Am J Hum Genet |
Title: |
Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. |
Volume: |
92 |
Issue: |
5 |
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725-43 |
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Cinque L |
Year: |
2015 |
Journal: |
Nature |
Title: |
FGF signalling regulates bone growth through autophagy. |
Volume: |
528 |
Issue: |
7581 |
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272-5 |
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Publication |
First Author: |
Zhang H |
Year: |
2016 |
Journal: |
PLoS Genet |
Title: |
Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice. |
Volume: |
12 |
Issue: |
12 |
Pages: |
e1006510 |
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Publication |
First Author: |
Porntaveetus T |
Year: |
2010 |
Journal: |
Gene Expr Patterns |
Title: |
Expression of Fgf signalling pathway related genes during palatal rugae development in the mouse. |
Volume: |
10 |
Issue: |
4-5 |
Pages: |
193-8 |
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Publication |
First Author: |
Yamaguchi H |
Year: |
2022 |
Journal: |
Dev Biol |
Title: |
Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice. |
Volume: |
482 |
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Pages: |
91-100 |
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Publication |
First Author: |
Xu J |
Year: |
2016 |
Journal: |
PLoS Genet |
Title: |
A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development. |
Volume: |
12 |
Issue: |
1 |
Pages: |
e1005769 |
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Publication |
First Author: |
Dichmann DS |
Year: |
2003 |
Journal: |
Dev Dyn |
Title: |
Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. |
Volume: |
226 |
Issue: |
4 |
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663-74 |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
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•
•
•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
|