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Search results 1 to 100 out of 728 for Fgf18

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 18 (FGF18), also referred to ZFGF5. FGF18 is required for normal ossification and bone development and stimulates hepatic and intestinal proliferation [, , , ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Davidson D
Year: 2005
Journal: J Biol Chem
Title: Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis.
Volume: 280
Issue: 21
Pages: 20509-15
Publication
First Author: Hu MC
Year: 1998
Journal: Mol Cell Biol
Title: FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation.
Volume: 18
Issue: 10
Pages: 6063-74
Publication
First Author: Shimoaka T
Year: 2002
Journal: J Biol Chem
Title: Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF-10.
Volume: 277
Issue: 9
Pages: 7493-500
Publication
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
Publication
First Author: Usui H
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Fgf18 is required for embryonic lung alveolar development.
Volume: 322
Issue: 3
Pages: 887-92
Publication
First Author: Yue M
Year: 2021
Journal: Dev Dyn
Title: Tissue-specific analysis of Fgf18 gene function in palate development.
Volume: 250
Issue: 4
Pages: 562-573
Publication    
First Author: Feng J
Year: 2022
Journal: Elife
Title: TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development.
Volume: 11
Publication
First Author: Kimura-Ueki M
Year: 2012
Journal: J Invest Dermatol
Title: Hair cycle resting phase is regulated by cyclic epithelial FGF18 signaling.
Volume: 132
Issue: 5
Pages: 1338-45
Publication
First Author: Franco-Montoya ML
Year: 2011
Journal: Physiol Genomics
Title: Profiling target genes of FGF18 in the postnatal mouse lung: possible relevance for alveolar development.
Volume: 43
Issue: 21
Pages: 1226-40
Publication
First Author: Miyaoka Y
Year: 2010
Journal: Development
Title: A novel regulatory mechanism for Fgf18 signaling involving cysteine-rich FGF receptor (Cfr) and delta-like protein (Dlk).
Volume: 137
Issue: 1
Pages: 159-67
Publication
First Author: Zhao X
Year: 2010
Journal: Dev Dyn
Title: Retinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit-interdigit junction.
Volume: 239
Issue: 2
Pages: 665-71
Publication
First Author: Ohbayashi N
Year: 2002
Journal: Genes Dev
Title: FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis.
Volume: 16
Issue: 7
Pages: 870-9
Publication
First Author: Liu Z
Year: 2007
Journal: Dev Biol
Title: FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate.
Volume: 302
Issue: 1
Pages: 80-91
Publication
First Author: Liu A
Year: 2003
Journal: Development
Title: FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors.
Volume: 130
Issue: 25
Pages: 6175-85
Publication
First Author: Ito K
Year: 2018
Journal: Sci Rep
Title: Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters.
Volume: 8
Issue: 1
Pages: 434
Publication
First Author: Hung IH
Year: 2016
Journal: Dev Biol
Title: A combined series of Fgf9 and Fgf18 mutant alleles identifies unique and redundant roles in skeletal development.
Volume: 411
Issue: 1
Pages: 72-84
GXD Expression    
Probe: MGI:6172867
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190266
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Fgf18
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6172867
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190266
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Fgf18
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6172867
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190266
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Fgf18
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6172867
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190266
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Fgf18
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6172867
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190266
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Fgf18
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6172867
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190266
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Fgf18
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6172867
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190266
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Fgf18
Detected: true
Specimen Num: 7
Publication
First Author: Moore EE
Year: 2005
Journal: Osteoarthritis Cartilage
Title: Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis.
Volume: 13
Issue: 7
Pages: 623-31
Protein
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: false
Publication  
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
Publication
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
Publication
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
Publication
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
Publication
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
Publication
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
Publication
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
Publication
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
Publication
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
Publication
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
Publication
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
Publication
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
Publication
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
Publication
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
Publication
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
Publication
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
HT Experiment
Series Id: GSE29547
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
GXD Expression
Probe: MGI:2664821
Assay Type: RNA in situ
Annotation Date: 2003-07-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1901624
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:2664829
Age: embryonic day 16.5
Image: 2D
Note: Double labeling with Osteopontin indicates that Fgf18 abuts Osteopontin expression but does not colocalize with it and is not in the sutural mesenchymal cells.
Specimen Label: 2D
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:2664821
Assay Type: RNA in situ
Annotation Date: 2003-07-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1801624
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:2664829
Age: embryonic day 16.5
Image: 2D
Note: Double labeling with Osteopontin indicates that Fgf18 abuts Osteopontin expression but does not colocalize with it and is not in the sutural mesenchymal cells.
Specimen Label: 2D
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:2664821
Assay Type: RNA in situ
Annotation Date: 2003-07-08
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1801624
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:2664829
Age: embryonic day 16.5
Image: 2E
Note: Expression is in the cranial cartilage lying just medial to the parietal bone and posterior to the coronal sutures. Double labeling with Osteopontin indicates that Fgf18 abuts Osteopontin expression but does not colocalize with it.
Specimen Label: 2E
Detected: true
Specimen Num: 5
GXD Expression
Probe: MGI:2664821
Assay Type: RNA in situ
Annotation Date: 2003-07-08
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1801624
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:2664829
Age: embryonic day 16.5
Image: 2F
Note: Expression is in the cranial cartilage lying just medial to the parietal bone and posterior to the coronal sutures. Double labeling with Osteopontin indicates that Fgf18 abuts Osteopontin expression but does not colocalize with it.
Specimen Label: 2F
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:2664821
Assay Type: RNA in situ
Annotation Date: 2003-07-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1801625
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:2664829
Age: embryonic day 17.5
Note: Expression is in the cranial cartilage. Double labeling with Osteopontin indicates that Fgf18 abuts Osteopontin expression but does not colocalize with it and also does not extend to the sutural mesenchymal cells between the two bones.
Specimen Label: Not Shown
Detected: true
Specimen Num: 7
GXD Expression
Probe: MGI:2664821
Assay Type: RNA in situ
Annotation Date: 2003-07-08
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1871524
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:2664829
Age: embryonic day 16.5
Image: 2D
Note: Expression is in the dorsal and ventral rims of the parietal bone. Double labeling with Osteopontin indicates that Fgf18 abuts Osteopontin expression but does not colocalize with it and is not in the sutural mesenchymal cells.
Specimen Label: 2D
Detected: true
Specimen Num: 4
Publication  
First Author: Boylan M
Year: 2020
Journal: Development
Title: The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall.
Volume: 147
Issue: 21
Publication
First Author: Hagan AS
Year: 2019
Journal: Dev Dyn
Title: Generation and validation of novel conditional flox and inducible Cre alleles targeting fibroblast growth factor 18 (Fgf18).
Volume: 248
Issue: 9
Pages: 882-893
Publication
First Author: Tsuchiya Y
Year: 2023
Journal: Nat Commun
Title: Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis.
Volume: 14
Issue: 1
Pages: 6304
Publication
First Author: Bradley EW
Year: 2015
Journal: J Biol Chem
Title: Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation.
Volume: 290
Issue: 26
Pages: 16272-80
Publication
First Author: Ohuchi H
Year: 2000
Journal: Mech Dev
Title: Involvement of fibroblast growth factor (FGF)18-FGF8 signaling in specification of left-right asymmetry and brain and limb development of the chick embryo.
Volume: 95
Issue: 1-2
Pages: 55-66
Publication
First Author: Maruoka Y
Year: 1998
Journal: Mech Dev
Title: Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo.
Volume: 74
Issue: 1-2
Pages: 175-7
Publication
First Author: Hinoi E
Year: 2006
Journal: Genes Dev
Title: Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium.
Volume: 20
Issue: 21
Pages: 2937-42
Publication
First Author: Leishman E
Year: 2013
Journal: Development
Title: Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18.
Volume: 140
Issue: 18
Pages: 3809-18
Publication
First Author: Nie X
Year: 2006
Journal: Angle Orthod
Title: Developmentally regulated expression of MSX1, MSX2 and Fgfs in the developing mouse cranial base.
Volume: 76
Issue: 6
Pages: 990-5
Publication
First Author: Charoenchaikorn K
Year: 2009
Journal: Dev Biol
Title: Runx1 is involved in the fusion of the primary and the secondary palatal shelves.
Volume: 326
Issue: 2
Pages: 392-402
Publication
First Author: Gori F
Year: 2009
Journal: Dev Biol
Title: Perichondrial expression of Wdr5 regulates chondrocyte proliferation and differentiation.
Volume: 329
Issue: 1
Pages: 36-43
Publication  
First Author: Hagan AS
Year: 2020
Journal: Development
Title: Identification of a FGF18-expressing alveolar myofibroblast that is developmentally cleared during alveologenesis.
Volume: 147
Issue: 2
Publication
First Author: Du W
Year: 2016
Journal: Gene Expr Patterns
Title: Expression of FGFs during early mouse tongue development.
Volume: 20
Issue: 2
Pages: 81-7
Publication
First Author: Zhong W
Year: 2006
Journal: Mol Reprod Dev
Title: FGF ligand family mRNA expression profile for mouse preimplantation embryos, early gestation human placenta, and mouse trophoblast stem cells.
Volume: 73
Issue: 5
Pages: 540-50
Publication
First Author: Yang Y
Year: 2020
Journal: Nucleic Acids Res
Title: Phosphorylation of Msx1 promotes cell proliferation through the Fgf9/18-MAPK signaling pathway during embryonic limb development.
Volume: 48
Issue: 20
Pages: 11452-11467
Publication
First Author: Xu J
Year: 2000
Journal: Development
Title: Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures.
Volume: 127
Issue: 9
Pages: 1833-43
Publication
First Author: Boothby IC
Year: 2021
Journal: Nature
Title: Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin.
Volume: 599
Issue: 7886
Pages: 667-672
Publication
First Author: Liu Z
Year: 2002
Journal: Genes Dev
Title: Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18.
Volume: 16
Issue: 7
Pages: 859-69
Publication
First Author: Hasegawa H
Year: 2004
Journal: J Neurosci
Title: Laminar patterning in the developing neocortex by temporally coordinated fibroblast growth factor signaling.
Volume: 24
Issue: 40
Pages: 8711-9
Publication
First Author: Zhao X
Year: 2009
Journal: Gene Expr Patterns
Title: Effect of retinoic acid signaling on Wnt/beta-catenin and FGF signaling during body axis extension.
Volume: 9
Issue: 6
Pages: 430-5
Publication
First Author: Rockel JS
Year: 2016
Journal: J Clin Invest
Title: Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis.
Volume: 126
Issue: 5
Pages: 1649-63
Publication
First Author: Elluru RG
Year: 2009
Journal: Laryngoscope
Title: Fibroblast growth factor 18 gives growth and directional cues to airway cartilage.
Volume: 119
Issue: 6
Pages: 1153-65
Publication
First Author: Miraoui H
Year: 2013
Journal: Am J Hum Genet
Title: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.
Volume: 92
Issue: 5
Pages: 725-43
Publication
First Author: Zhang H
Year: 2016
Journal: PLoS Genet
Title: Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice.
Volume: 12
Issue: 12
Pages: e1006510
Publication
First Author: Cinque L
Year: 2015
Journal: Nature
Title: FGF signalling regulates bone growth through autophagy.
Volume: 528
Issue: 7581
Pages: 272-5
Publication
First Author: Porntaveetus T
Year: 2010
Journal: Gene Expr Patterns
Title: Expression of Fgf signalling pathway related genes during palatal rugae development in the mouse.
Volume: 10
Issue: 4-5
Pages: 193-8
Publication  
First Author: Yamaguchi H
Year: 2022
Journal: Dev Biol
Title: Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice.
Volume: 482
Pages: 91-100
Publication
First Author: Xu J
Year: 2016
Journal: PLoS Genet
Title: A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development.
Volume: 12
Issue: 1
Pages: e1005769
Publication
First Author: Dichmann DS
Year: 2003
Journal: Dev Dyn
Title: Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas.
Volume: 226
Issue: 4
Pages: 663-74
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory