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Search results 1 to 100 out of 1166 for Fgf2

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Type Details Score
Gene
2247 | FGF2
Type: gene
Organism: human
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Gene
641462 | FGF2
Type: gene
Organism: chimpanzee
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Gene
403857 | FGF2
Type: gene
Organism: dog, domestic
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Gene
281161 | FGF2
Type: gene
Organism: cattle
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Gene
396413 | FGF2
Type: gene
Organism: chicken
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Gene
404231 | fgf2
Type: gene
Organism: zebrafish
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Gene
574136 | FGF2
Type: gene
Organism: macaque, rhesus
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Gene
550087 | fgf2
Type: gene
Organism: frog, western clawed
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Gene
100101279 | fgf2
Type: gene
Organism: frog, African clawed
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Gene
key_22936 | FGF2
Type: gene
Organism: sheep
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Gene
54250 | Fgf2
Type: gene
Organism: rat
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Protein
Q7TPH0
Organism: Mus musculus/domesticus
Length: 35  
Fragment?: true
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Protein Domain
IPR028223 | FGF2
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuousgrowth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 2 (FGF2), also known as heparin-binding growth factor 2 and basic fibroblast growth factor. The protein plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration and is a potent mitogen in vitro [, ]. FGF2 has a high affinity for FGFR1, FGFR2 and FGFR4, but a very low affinity with FGFR3 [, , , ]. FGF2 has also been shown to interact with casein kinase II subunit alpha []and some ribosomal proteins [, ].
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Protein Coding Gene
MGI:95516 | Fgf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
109113863 | LOC109113863
Type: gene
Organism: human
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Publication
11276432 | J:67832
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
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Publication
26466960 | J:328369
First Author: Liu X
Year: 2015
Journal: J Immunol
Title: Cytosolic Low Molecular Weight FGF2 Orchestrates RIG-I-Mediated Innate Immune Response.
Volume: 195
Issue: 10
Pages: 4943-52
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Publication
24244869 | J:227962
 
First Author: Nusayr E
Year: 2013
Journal: Physiol Rep
Title: FGF2 modulates cardiac remodeling in an isoform- and sex-specific manner.
Volume: 1
Issue: 4
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Publication
30144364 | J:322111
First Author: Burt PM
Year: 2019
Journal: J Cell Physiol
Title: Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection.
Volume: 234
Issue: 4
Pages: 4418-4431
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Publication
26320657 | J:254636
First Author: Song X
Year: 2015
Journal: Immunity
Title: Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage.
Volume: 43
Issue: 3
Pages: 488-501
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Publication
24244870 | J:227961
 
First Author: Nusayr E
Year: 2013
Journal: Physiol Rep
Title: Cardiac development and physiology are modulated by FGF2 in an isoform- and sex-specific manner.
Volume: 1
Issue: 4
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Publication
29466783 | J:274093
First Author: Liang W
Year: 2018
Journal: Cell Physiol Biochem
Title: Knockout of Low Molecular Weight FGF2 Attenuates Atherosclerosis by Reducing Macrophage Infiltration and Oxidative Stress in Mice.
Volume: 45
Issue: 4
Pages: 1434-1443
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Publication
14618271 | J:87118
First Author: Foletti A
Year: 2003
Journal: Cell Mol Life Sci
Title: Nuclear localization of mouse fibroblast growth factor 2 requires N-terminal and C-terminal sequences.
Volume: 60
Issue: 10
Pages: 2254-65
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Publication
30412444 | J:269593
First Author: Koleini N
Year: 2019
Journal: Am J Physiol Heart Circ Physiol
Title: Elimination or neutralization of endogenous high-molecular-weight FGF2 mitigates doxorubicin-induced cardiotoxicity.
Volume: 316
Issue: 2
Pages: H279-H288
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Publication
28765647 | J:256503
First Author: Shao X
Year: 2017
Journal: Sci Rep
Title: FGF2 cooperates with IL-17 to promote autoimmune inflammation.
Volume: 7
Issue: 1
Pages: 7024
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Publication
24125755 | J:203771
 
First Author: Byun MR
Year: 2014
Journal: Bone
Title: FGF2 stimulates osteogenic differentiation through ERK induced TAZ expression.
Volume: 58
Pages: 72-80
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Publication
21997191 | J:203076
First Author: Dong L
Year: 2012
Journal: Cell Death Differ
Title: FGF2 regulates melanocytes viability through the STAT3-transactivated PAX3 transcription.
Volume: 19
Issue: 4
Pages: 616-22
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Publication
23684572 | J:234762
 
First Author: Mierzwa AJ
Year: 2013
Journal: Neurosci Lett
Title: FGF2 and FGFR1 signaling regulate functional recovery following cuprizone demyelination.
Volume: 548
Pages: 280-5
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Publication
1543906 | J:1620
First Author: Mattei MG
Year: 1992
Journal: Mamm Genome
Title: Chromosomal localizations of mouse Fgf2 and Fgf5 genes.
Volume: 2
Issue: 2
Pages: 135-7
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Publication
25389287 | J:324439
First Author: Homer-Bouthiette C
Year: 2014
Journal: J Biol Chem
Title: Knockout of nuclear high molecular weight FGF2 isoforms in mice modulates bone and phosphate homeostasis.
Volume: 289
Issue: 52
Pages: 36303-14
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Publication
15578654 | J:104940
First Author: Murtie JC
Year: 2005
Journal: Glia
Title: In vivo analysis of oligodendrocyte lineage development in postnatal FGF2 null mice.
Volume: 49
Issue: 4
Pages: 542-54
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Publication
20338032 | J:222149
 
First Author: Niger C
Year: 2010
Journal: BMC Biochem
Title: Interaction of connexin43 and protein kinase C-delta during FGF2 signaling.
Volume: 11
Pages: 14
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Publication
29305908 | J:261854
First Author: Nadanaka S
Year: 2018
Journal: Biochim Biophys Acta
Title: Exostosin-like 2 regulates FGF2 signaling by controlling the endocytosis of FGF2.
Volume: 1862
Issue: 4
Pages: 791-799
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Publication
29681540 | J:319293
First Author: Masaki K
Year: 2018
Journal: Stem Cell Reports
Title: FGF2 Has Distinct Molecular Functions from GDNF in the Mouse Germline Niche.
Volume: 10
Issue: 6
Pages: 1782-1792
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Publication
11786528 | J:74222
First Author: Dono R
Year: 2002
Journal: Circ Res
Title: FGF2 signaling is required for the development of neuronal circuits regulating blood pressure.
Volume: 90
Issue: 1
Pages: E5-E10
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Publication
12665515 | J:133244
First Author: Okada Y
Year: 2003
Journal: J Biol Chem
Title: Impaired osteoclast formation in bone marrow cultures of Fgf2 null mice in response to parathyroid hormone.
Volume: 278
Issue: 23
Pages: 21258-66
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Publication
17909625 | J:127534
First Author: Nissen LJ
Year: 2007
Journal: J Clin Invest
Title: Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis.
Volume: 117
Issue: 10
Pages: 2766-77
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Publication
1721615 | -
First Author: Shimoyama Y
Year: 1991
Journal: Jpn J Cancer Res
Title: Characterization of high-molecular-mass forms of basic fibroblast growth factor produced by hepatocellular carcinoma cells: possible involvement of basic fibroblast growth factor in hepatocarcinogenesis.
Volume: 82
Issue: 11
Pages: 1263-70
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Publication
8530375 | -
First Author: Reich-Slotky R
Year: 1995
Journal: J Biol Chem
Title: Chimeric molecules between keratinocyte growth factor and basic fibroblast growth factor define domains that confer receptor binding specificities.
Volume: 270
Issue: 50
Pages: 29813-8
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Publication
9826564 | J:51038
First Author: Shen B
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Intracellular association of FGF-2 with the ribosomal protein L6/TAXREB107.
Volume: 252
Issue: 2
Pages: 524-8
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Publication
11716516 | -
First Author: Soulet F
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Fibroblast growth factor-2 interacts with free ribosomal protein S19.
Volume: 289
Issue: 2
Pages: 591-6
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Publication
27732085 | J:240777
First Author: Meo Burt P
Year: 2016
Journal: Endocrinology
Title: FGF2 High Molecular Weight Isoforms Contribute to Osteoarthropathy in Male Mice.
Volume: 157
Issue: 12
Pages: 4602-4614
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GXD Expression
GXD Expression
     
Probe: MGI:6172869
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190267
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Fgf2
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6172869
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190267
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Fgf2
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6172869
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190267
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Fgf2
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6172869
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190267
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Fgf2
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6172869
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190267
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Fgf2
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6172869
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190267
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Fgf2
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6172869
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190267
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Fgf2
Detected: false
Specimen Num: 7
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Publication
15837572 | J:105115
First Author: Murtie JC
Year: 2005
Journal: Neurobiol Dis
Title: PDGF and FGF2 pathways regulate distinct oligodendrocyte lineage responses in experimental demyelination with spontaneous remyelination.
Volume: 19
Issue: 1-2
Pages: 171-82
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Publication
26762209 | J:318782
First Author: Du E
Year: 2016
Journal: J Cell Biochem
Title: FGFR Inhibitor Ameliorates Hypophosphatemia and Impaired Engrailed-1/Wnt Signaling in FGF2 High Molecular Weight Isoform Transgenic Mice.
Volume: 117
Issue: 9
Pages: 1991-2000
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Publication
28244611 | J:321565
First Author: Vorgia E
Year: 2017
Journal: Mol Reprod Dev
Title: Suppression of Fgf2 by ETS2 repressor factor (ERF) is required for chorionic trophoblast differentiation.
Volume: 84
Issue: 4
Pages: 286-295
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Publication
22491947 | J:184010
First Author: Ishii K
Year: 2012
Journal: Development
Title: FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of Etv5 and Bcl6b through MAP2K1 activation.
Volume: 139
Issue: 10
Pages: 1734-43
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Protein
P15655
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: false
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Protein
Q925A1
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: false
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Protein
Q541T2
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: false
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Protein
Q925A2
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: false
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Protein
Q7TPG9
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: true
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Protein
Q925A3
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: false
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Publication
12145206 | -
First Author: Skjerpen CS
Year: 2002
Journal: EMBO J
Title: Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity.
Volume: 21
Issue: 15
Pages: 4058-69
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Publication
10574949 | -
First Author: Chellaiah A
Year: 1999
Journal: J Biol Chem
Title: Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity.
Volume: 274
Issue: 49
Pages: 34785-94
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Publication
20510392 | J:162103
First Author: Xiao L
Year: 2010
Journal: Bone
Title: Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells.
Volume: 47
Issue: 2
Pages: 360-70
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Publication
10942527 | J:64129
First Author: Yamada H
Year: 2000
Journal: J Cell Physiol
Title: Cell injury unmasks a latent proangiogenic phenotype in mice with increased expression of FGF2 in the retina.
Volume: 185
Issue: 1
Pages: 135-42
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Publication
12391121 | J:103383
First Author: Sullivan CJ
Year: 2002
Journal: J Appl Physiol (1985)
Title: Targeted disruption of the Fgf2 gene does not affect vascular growth in the mouse ischemic hindlimb.
Volume: 93
Issue: 6
Pages: 2009-17
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Publication
22290421 | J:318085
First Author: Zhang Y
Year: 2012
Journal: Cell Res
Title: Endogenously produced FGF2 is essential for the survival and proliferation of cultured mouse spermatogonial stem cells.
Volume: 22
Issue: 4
Pages: 773-6
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Publication
31358811 | J:286696
First Author: Thiemann RF
Year: 2019
Journal: Sci Rep
Title: Establishment of a Murine Pro-acinar Cell Line to Characterize Roles for FGF2 and α3β1 Integrins in Regulating Pro-acinar Characteristics.
Volume: 9
Issue: 1
Pages: 10984
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Publication
8663044 | -
First Author: Ornitz DM
Year: 1996
Journal: J Biol Chem
Title: Receptor specificity of the fibroblast growth factor family.
Volume: 271
Issue: 25
Pages: 15292-7
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Publication
27038343 | J:238110
First Author: Sudheer S
Year: 2016
Journal: Stem Cells
Title: Different Concentrations of FGF Ligands, FGF2 or FGF8 Determine Distinct States of WNT-Induced Presomitic Mesoderm.
Volume: 34
Issue: 7
Pages: 1790-800
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Publication
22042871 | J:180222
First Author: Kiyota T
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders.
Volume: 108
Issue: 49
Pages: E1339-48
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Publication
2549857 | -
 
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
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Publication
7583099 | -
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
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Publication
3072709 | -
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
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Publication
10830168 | -
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
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Publication
8652550 | -
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
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Publication
1705486 | -
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
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Publication
8760337 | -
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
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Publication
23000357 | -
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
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Publication
15689573 | -
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
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Publication
10441498 | J:56785
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
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Publication
23108135 | -
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
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Publication
23016864 | -
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
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Publication
1649700 | -
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
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Publication
11746231 | -
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
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Publication
14745970 | -
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
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Publication
8978613 | -
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
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Publication
21806973 | J:175755
First Author: Fei Y
Year: 2011
Journal: Biochem Biophys Res Commun
Title: The impaired bone anabolic effect of PTH in the absence of endogenous FGF2 is partially due to reduced ATF4 expression.
Volume: 412
Issue: 1
Pages: 160-4
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Publication
9010207 | J:38854
First Author: Qian X
Year: 1997
Journal: Neuron
Title: FGF2 concentration regulates the generation of neurons and glia from multipotent cortical stem cells.
Volume: 18
Issue: 1
Pages: 81-93
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Publication
10688672 | J:60597
First Author: Miller DL
Year: 2000
Journal: Mol Cell Biol
Title: Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice.
Volume: 20
Issue: 6
Pages: 2260-8
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Publication
17150229 | J:119652
First Author: Liao S
Year: 2007
Journal: J Mol Cell Cardiol
Title: The cardioprotective effect of the low molecular weight isoform of fibroblast growth factor-2: the role of JNK signaling.
Volume: 42
Issue: 1
Pages: 106-20
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Publication
19056741 | J:147213
First Author: Xiao L
Year: 2009
Journal: J Biol Chem
Title: Exported 18-kDa isoform of fibroblast growth factor-2 is a critical determinant of bone mass in mice.
Volume: 284
Issue: 5
Pages: 3170-82
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Publication
26378412 | J:227083
First Author: Yang J
Year: 2015
Journal: Cell Cycle
Title: Binding of FGF2 to FGFR2 in an autocrine mode in trophectoderm cells is indispensable for mouse blastocyst formation through PKC-p38 pathway.
Volume: 14
Issue: 20
Pages: 3318-30
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Publication
15073041 | J:94550
First Author: Garmy-Susini B
Year: 2004
Journal: Circ Res
Title: Role of fibroblast growth factor-2 isoforms in the effect of estradiol on endothelial cell migration and proliferation.
Volume: 94
Issue: 10
Pages: 1301-9
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Publication
24375670 | J:207506
First Author: Murcia-Belmonte V
Year: 2014
Journal: Glia
Title: ERK1/2 signaling is essential for the chemoattraction exerted by human FGF2 and human anosmin-1 on newborn rat and mouse OPCs via FGFR1.
Volume: 62
Issue: 3
Pages: 374-86
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Allele
Fgf2<tm2Doe> | MGI:3512180
Name: fibroblast growth factor 2; targeted mutation 2, Thomas Doetschman
Allele Type: Targeted
Attribute String: Null/knockout
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QTL
MGI:3046555 | Angfq1
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:3046557 | Angfq3
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:5811541 | Angfq7
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:3046556 | Angfq2
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:5811537 | Angfq5
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:3046558 | Angfq4
Type: QTL
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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