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Search results 1 to 100 out of 892 for Fgf21

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 21 (FGF21), which stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression []. FGF21 has been shown to protect animals from diet-induced obesity when overexpressed in transgenic mice. It also lowers blood glucose and triglyceride levels when administered to diabetic rodents [], suggesting it may exhibit the therapeutic characteristics necessary for effective treatment of diabetes. Treatment of animals with FGF21 results in increased energy expenditure, fat utilisation and lipid excretion []. FGF21 is most abundantly expressed in the liver, and also expressed in the thymus at lower levels [].
Publication
First Author: Nishimura T
Year: 2000
Journal: Biochim Biophys Acta
Title: Identification of a novel FGF, FGF-21, preferentially expressed in the liver.
Volume: 1492
Issue: 1
Pages: 203-6
Publication
First Author: Kharitonenkov A
Year: 2005
Journal: J Clin Invest
Title: FGF-21 as a novel metabolic regulator.
Volume: 115
Issue: 6
Pages: 1627-35
Publication
First Author: Zheng Q
Year: 2020
Journal: Theranostics
Title: Lack of FGF21 promotes NASH-HCC transition via hepatocyte-TLR4-IL-17A signaling.
Volume: 10
Issue: 22
Pages: 9923-9936
Publication
First Author: Fang H
Year: 2021
Journal: Am J Physiol Renal Physiol
Title: FGF21 prevents low-protein diet-induced renal inflammation in aged mice.
Volume: 321
Issue: 3
Pages: F356-F368
Publication
First Author: Owen BM
Year: 2013
Journal: Nat Med
Title: FGF21 contributes to neuroendocrine control of female reproduction.
Volume: 19
Issue: 9
Pages: 1153-6
Publication
First Author: Hill CM
Year: 2022
Journal: Nat Commun
Title: FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice.
Volume: 13
Issue: 1
Pages: 1897
Publication
First Author: Coate KC
Year: 2017
Journal: Cell Metab
Title: FGF21 Is an Exocrine Pancreas Secretagogue.
Volume: 25
Issue: 2
Pages: 472-480
Publication
First Author: Talukdar S
Year: 2016
Journal: Cell Metab
Title: FGF21 Regulates Sweet and Alcohol Preference.
Volume: 23
Issue: 2
Pages: 344-9
Publication
First Author: Zhao C
Year: 2015
Journal: J Lipid Res
Title: FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice.
Volume: 56
Issue: 8
Pages: 1481-91
Publication
First Author: Laeger T
Year: 2014
Journal: J Clin Invest
Title: FGF21 is an endocrine signal of protein restriction.
Volume: 124
Issue: 9
Pages: 3913-22
Publication  
First Author: Wei J
Year: 2018
Journal: EMBO J
Title: HRD1-ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination.
Volume: 37
Issue: 22
Publication
First Author: Adams AC
Year: 2012
Journal: PLoS One
Title: FGF21 requires βklotho to act in vivo.
Volume: 7
Issue: 11
Pages: e49977
Publication
First Author: Zhou B
Year: 2022
Journal: Cell Rep
Title: Central FGF21 production regulates memory but not peripheral metabolism.
Volume: 40
Issue: 8
Pages: 111239
Publication
First Author: Patel R
Year: 2015
Journal: Mol Endocrinol
Title: Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop.
Volume: 29
Issue: 2
Pages: 213-23
Publication
First Author: Wanders D
Year: 2017
Journal: Diabetes
Title: FGF21 Mediates the Thermogenic and Insulin-Sensitizing Effects of Dietary Methionine Restriction but Not Its Effects on Hepatic Lipid Metabolism.
Volume: 66
Issue: 4
Pages: 858-867
Publication
First Author: Jiang X
Year: 2015
Journal: Endocrinology
Title: The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/Sirt1/PGC-1α signaling.
Volume: 156
Issue: 3
Pages: 1156-70
Publication
First Author: Hill CM
Year: 2017
Journal: Sci Rep
Title: Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints.
Volume: 7
Issue: 1
Pages: 8209
Publication
First Author: Ishida K
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Interactions between FGF21 and BMP-2 in osteogenesis.
Volume: 432
Issue: 4
Pages: 677-82
Publication
First Author: Flippo KH
Year: 2022
Journal: Cell Metab
Title: FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit.
Volume: 34
Issue: 2
Pages: 317-328.e6
Publication
First Author: Vandanmagsar B
Year: 2016
Journal: Cell Rep
Title: Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle.
Volume: 15
Issue: 8
Pages: 1686-99
Publication
First Author: De Sousa-Coelho AL
Year: 2013
Journal: J Lipid Res
Title: FGF21 mediates the lipid metabolism response to amino acid starvation.
Volume: 54
Issue: 7
Pages: 1786-97
Publication  
First Author: Huen SC
Year: 2021
Journal: J Exp Med
Title: Hepatic FGF21 preserves thermoregulation and cardiovascular function during bacterial inflammation.
Volume: 218
Issue: 10
Publication  
First Author: Reilly SM
Year: 2021
Journal: J Clin Invest
Title: FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition.
Volume: 131
Issue: 10
Publication
First Author: BonDurant LD
Year: 2017
Journal: Cell Metab
Title: FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms.
Volume: 25
Issue: 4
Pages: 935-944.e4
Publication
First Author: Redondo-Angulo I
Year: 2017
Journal: Cardiovasc Res
Title: Fgf21 is required for cardiac remodeling in pregnancy.
Volume: 113
Issue: 13
Pages: 1574-1584
Publication
First Author: Markan KR
Year: 2014
Journal: Diabetes
Title: Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding.
Volume: 63
Issue: 12
Pages: 4057-63
Publication
First Author: Kuroda M
Year: 2017
Journal: J Clin Invest
Title: Peripherally derived FGF21 promotes remyelination in the central nervous system.
Volume: 127
Issue: 9
Pages: 3496-3509
Publication
First Author: Keipert S
Year: 2017
Journal: Cell Metab
Title: Long-Term Cold Adaptation Does Not Require FGF21 or UCP1.
Volume: 26
Issue: 2
Pages: 437-446.e5
Publication
First Author: Jager J
Year: 2016
Journal: J Biol Chem
Title: The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling.
Volume: 291
Issue: 20
Pages: 10867-75
Publication
First Author: Maruyama R
Year: 2018
Journal: J Nutr Sci Vitaminol (Tokyo)
Title: FGF21 Alleviates Hepatic Endoplasmic Reticulum Stress under Physiological Conditions.
Volume: 64
Issue: 3
Pages: 200-208
Publication
First Author: Fu Z
Year: 2017
Journal: Cell Rep
Title: FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice.
Volume: 18
Issue: 7
Pages: 1606-1613
Publication  
First Author: Xu J
Year: 2023
Journal: Int J Mol Sci
Title: Hepatic-Specific FGF21 Knockout Abrogates Ovariectomy-Induced Obesity by Reversing Corticosterone Production.
Volume: 24
Issue: 19
Publication
First Author: Song P
Year: 2018
Journal: Cell Metab
Title: The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol.
Volume: 27
Issue: 6
Pages: 1338-1347.e4
Publication
First Author: Coskun T
Year: 2008
Journal: Endocrinology
Title: Fibroblast growth factor 21 corrects obesity in mice.
Volume: 149
Issue: 12
Pages: 6018-27
Publication
First Author: Jeanson Y
Year: 2016
Journal: Biochem J
Title: Lactate induces FGF21 expression in adipocytes through a p38-MAPK pathway.
Volume: 473
Issue: 6
Pages: 685-92
Publication
First Author: Chartoumpekis DV
Year: 2011
Journal: Diabetes
Title: Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice.
Volume: 60
Issue: 10
Pages: 2465-73
Publication
First Author: Hill CM
Year: 2019
Journal: Cell Rep
Title: FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism.
Volume: 27
Issue: 10
Pages: 2934-2947.e3
Protein
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
Publication
First Author: Potthoff MJ
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.
Volume: 106
Issue: 26
Pages: 10853-8
Publication
First Author: Nakayama Y
Year: 2017
Journal: Sci Rep
Title: Fgf21 regulates T-cell development in the neonatal and juvenile thymus.
Volume: 7
Issue: 1
Pages: 330
Publication
First Author: von Holstein-Rathlou S
Year: 2016
Journal: Cell Metab
Title: FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver.
Volume: 23
Issue: 2
Pages: 335-43
Publication
First Author: Samms RJ
Year: 2015
Journal: Cell Rep
Title: Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1.
Volume: 11
Issue: 7
Pages: 991-9
Publication
First Author: Geng L
Year: 2019
Journal: Cell Rep
Title: Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues.
Volume: 26
Issue: 10
Pages: 2738-2752.e4
Publication
First Author: Chavan R
Year: 2017
Journal: Biol Open
Title: REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6.
Volume: 6
Issue: 1
Pages: 1-7
Publication
First Author: Fisher FM
Year: 2012
Journal: Genes Dev
Title: FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis.
Volume: 26
Issue: 3
Pages: 271-81
Publication
First Author: Croon M
Year: 2022
Journal: Sci Adv
Title: FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction.
Volume: 8
Issue: 14
Pages: eabn7105
Publication
First Author: Hanzawa N
Year: 2020
Journal: Sci Rep
Title: Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing.
Volume: 10
Issue: 1
Pages: 5181
Publication
First Author: Ameka M
Year: 2019
Journal: Sci Rep
Title: Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure.
Volume: 9
Issue: 1
Pages: 630
Publication
First Author: Bookout AL
Year: 2013
Journal: Nat Med
Title: FGF21 regulates metabolism and circadian behavior by acting on the nervous system.
Volume: 19
Issue: 9
Pages: 1147-52
Publication
First Author: Lynch L
Year: 2016
Journal: Cell Metab
Title: iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy.
Volume: 24
Issue: 3
Pages: 510-519
Publication
First Author: Solon-Biet SM
Year: 2023
Journal: Cell Rep
Title: Toward reconciling the roles of FGF21 in protein appetite, sweet preference, and energy expenditure.
Volume: 42
Issue: 12
Pages: 113536
Publication
First Author: Watanabe M
Year: 2020
Journal: Endocrine
Title: Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis.
Volume: 67
Issue: 1
Pages: 95-108
Publication
First Author: Yaqoob U
Year: 2014
Journal: PLoS One
Title: FGF21 promotes endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway.
Volume: 9
Issue: 5
Pages: e98130
Publication
First Author: Oishi K
Year: 2008
Journal: FEBS Lett
Title: Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver.
Volume: 582
Issue: 25-26
Pages: 3639-42
Publication
First Author: Zarei M
Year: 2016
Journal: Diabetes
Title: Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency.
Volume: 65
Issue: 10
Pages: 3185-99
Publication  
First Author: Lee YK
Year: 2021
Journal: Mol Metab
Title: FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice.
Volume: 49
Pages: 101187
Publication
First Author: Joe Y
Year: 2018
Journal: FASEB J
Title: FGF21 induced by carbon monoxide mediates metabolic homeostasis via the PERK/ATF4 pathway.
Volume: 32
Issue: 5
Pages: 2630-2643
Publication
First Author: Kawakami R
Year: 2022
Journal: Sci Rep
Title: Ketone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart.
Volume: 12
Issue: 1
Pages: 7338
Publication
First Author: Youm YH
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution.
Volume: 113
Issue: 4
Pages: 1026-31
Publication
First Author: Oishi K
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice.
Volume: 412
Issue: 2
Pages: 396-400
Publication
First Author: Keipert S
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine.
Volume: 306
Issue: 5
Pages: E469-82
Publication
First Author: Zhang Y
Year: 2018
Journal: Biochem Biophys Res Commun
Title: FGF21 mediates the protective effect of fenofibrate against acetaminophen -induced hepatotoxicity via activating autophagy in mice.
Volume: 503
Issue: 2
Pages: 474-481
Publication
First Author: Li F
Year: 2018
Journal: FASEB J
Title: FGF21 is induced in cisplatin nephrotoxicity to protect against kidney tubular cell injury.
Volume: 32
Issue: 6
Pages: 3423-3433
Publication  
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
Publication
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
Publication
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
Publication
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
Publication
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
Publication
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
Publication
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
Publication
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
Publication
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
Publication
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
Publication
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
Publication
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
Publication
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
Publication
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
Publication
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
Publication
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
Publication
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
Publication
First Author: Pereira RO
Year: 2017
Journal: EMBO J
Title: OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance.
Volume: 36
Issue: 14
Pages: 2126-2145
Publication
First Author: Kang SG
Year: 2021
Journal: iScience
Title: Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response.
Volume: 24
Issue: 3
Pages: 102181
Publication
First Author: Yuan X
Year: 2018
Journal: Nat Commun
Title: Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood.
Volume: 9
Issue: 1
Pages: 636
Publication
First Author: Murata Y
Year: 2013
Journal: PLoS One
Title: Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet.
Volume: 8
Issue: 7
Pages: e69330
Publication  
First Author: Quesada-López T
Year: 2016
Journal: Nat Commun
Title: The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes.
Volume: 7
Pages: 13479
Publication
First Author: Byun S
Year: 2020
Journal: Nat Commun
Title: Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase.
Volume: 11
Issue: 1
Pages: 807
Publication
First Author: Katsumura S
Year: 2022
Journal: Cell Metab
Title: Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure.
Volume: 34
Issue: 4
Pages: 564-580.e8
Publication
First Author: Estall JL
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis.
Volume: 106
Issue: 52
Pages: 22510-5
Publication  
First Author: Klein Hazebroek M
Year: 2022
Journal: Front Endocrinol (Lausanne)
Title: Obesity-resistance of UCP1-deficient mice associates with sustained FGF21 sensitivity in inguinal adipose tissue.
Volume: 13
Pages: 909621
Publication
First Author: Wang L
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.
Volume: 116
Issue: 30
Pages: 15184-15193