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Search results 1 to 100 out of 338 for Fgf22

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 22 (FGF22), which plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis, and has been shown to stimulate cell proliferation in vitro [, ]. FGF22 is expressed in skin, with low expression found in brain. In mouse FGF22 is preferentially expressed in the inner root sheath of the hair follicle, which suggests a role in hair development [].
Publication
First Author: Umemori H
Year: 2004
Journal: Cell
Title: FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain.
Volume: 118
Issue: 2
Pages: 257-70
Publication
First Author: Nakatake Y
Year: 2001
Journal: Biochim Biophys Acta
Title: Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle.
Volume: 1517
Issue: 3
Pages: 460-3
Publication
First Author: Zhang X
Year: 2006
Journal: J Biol Chem
Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
Volume: 281
Issue: 23
Pages: 15694-700
Publication
First Author: Miyake A
Year: 2013
Journal: Biol Open
Title: Fgf22 regulated by Fgf3/Fgf8 signaling is required for zebrafish midbrain development.
Volume: 2
Issue: 5
Pages: 515-24
Publication
First Author: Jacobi A
Year: 2015
Journal: EMBO J
Title: FGF22 signaling regulates synapse formation during post-injury remodeling of the spinal cord.
Volume: 34
Issue: 9
Pages: 1231-43
Protein
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: false
Publication  
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
Publication
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
Publication
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
Publication
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
Publication
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
Publication
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
Publication
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
Publication
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
Publication
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
Publication
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
Publication
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
Publication
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
Publication
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
Publication
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
Publication
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
Publication
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
Publication
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
Publication
First Author: Jarosz M
Year: 2012
Journal: PLoS One
Title: Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis.
Volume: 7
Issue: 6
Pages: e39436
Publication  
First Author: Singh R
Year: 2012
Journal: Front Mol Neurosci
Title: Fibroblast growth factor 22 contributes to the development of retinal nerve terminals in the dorsal lateral geniculate nucleus.
Volume: 4
Pages: 61
Publication    
First Author: Terauchi A
Year: 2016
Journal: Elife
Title: Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain.
Volume: 5
Publication  
First Author: Terauchi A
Year: 2017
Journal: Front Synaptic Neurosci
Title: Selective Inactivation of Fibroblast Growth Factor 22 (FGF22) in CA3 Pyramidal Neurons Impairs Local Synaptogenesis and Affective Behavior Without Affecting Dentate Neurogenesis.
Volume: 9
Pages: 17
Publication  
First Author: Lee CH
Year: 2013
Journal: Front Cell Neurosci
Title: Suppression of epileptogenesis-associated changes in response to seizures in FGF22-deficient mice.
Volume: 7
Pages: 43
Publication  
First Author: Williams AJ
Year: 2016
Journal: Behav Brain Res
Title: Deletion of fibroblast growth factor 22 (FGF22) causes a depression-like phenotype in adult mice.
Volume: 307
Pages: 11-7
Publication
First Author: Terauchi A
Year: 2010
Journal: Nature
Title: Distinct FGFs promote differentiation of excitatory and inhibitory synapses.
Volume: 465
Issue: 7299
Pages: 783-7
Publication
First Author: Zhong W
Year: 2006
Journal: Mol Reprod Dev
Title: FGF ligand family mRNA expression profile for mouse preimplantation embryos, early gestation human placenta, and mouse trophoblast stem cells.
Volume: 73
Issue: 5
Pages: 540-50
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Terauchi A
Year: 2020
Journal: Neuroreport
Title: Neuronal fibroblast growth factor 22 signaling during development, but not in adults, is involved in anhedonia.
Volume: 31
Issue: 2
Pages: 125-130
GXD Expression      
Probe: MGI:3803936
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3804229
Age: embryonic day 1.5
Image: 6
Specimen Label: E1.5
Specimen Num: 2
GXD Expression    
Probe: MGI:3803936
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:3804229
Age: embryonic day 3.5
Image: 6
Specimen Label: E3.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3803936
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3804250
Age: postnatal adult
Image: 6
Specimen Label: 50ng
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3803936
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3804250
Age: postnatal adult
Image: 6
Specimen Label: 10ng
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3803936
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3804250
Age: postnatal adult
Image: 6
Specimen Label: 1ng
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3803936
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3804250
Age: postnatal adult
Image: 6
Specimen Label: 100pg
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:3803936
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3804250
Age: postnatal adult
Image: 6
Specimen Label: 10pg
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:3803936
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3804251
Age: postnatal adult
Image: 6
Specimen Label: 50ng
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3803936
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3804251
Age: postnatal adult
Image: 6
Specimen Label: 10ng
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3803936
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3804251
Age: postnatal adult
Image: 6
Specimen Label: 1ng
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:3803936
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3804251
Age: postnatal adult
Image: 6
Specimen Label: 100pg
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:3803936
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3804251
Age: postnatal adult
Image: 6
Specimen Label: 10pg
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:5810447
Assay Type: RT-PCR
Annotation Date: 2016-11-30
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1718519
Stage: TS19
Assay Id: MGI:5810453
Age: embryonic day 11.5
Image: 1
Specimen Label: E11.5
Specimen Num: 1
GXD Expression      
Probe: MGI:5810447
Assay Type: RT-PCR
Annotation Date: 2016-11-30
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1718520
Stage: TS20
Assay Id: MGI:5810453
Age: embryonic day 12.5
Image: 1
Specimen Label: E12.5
Specimen Num: 2
GXD Expression      
Probe: MGI:5810447
Assay Type: RT-PCR
Annotation Date: 2016-11-30
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1718521
Stage: TS21
Assay Id: MGI:5810453
Age: embryonic day 13.5
Image: 1
Specimen Label: E13.5
Specimen Num: 3
GXD Expression      
Probe: MGI:5810447
Assay Type: RT-PCR
Annotation Date: 2016-11-30
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1718522
Stage: TS22
Assay Id: MGI:5810453
Age: embryonic day 14.4
Image: 1
Specimen Label: E14.5
Specimen Num: 4
GXD Expression    
Probe: MGI:3803936
Assay Type: RT-PCR
Annotation Date: 2008-09-03
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:3804229
Age: postnatal week 4-5
Image: 6
Specimen Label: Unf.
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2008-01-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3766974
Age: embryonic day 14.5
Image: FG32
Specimen Label: FG32
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1646922
Stage: TS22
Assay Id: MGI:5421724
Age: embryonic day 14.5
Specimen Label: FG32; Specimen EX216
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1647022
Stage: TS22
Assay Id: MGI:5421724
Age: embryonic day 14.5
Specimen Label: FG32; Specimen EX216
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691022
Stage: TS22
Assay Id: MGI:5421724
Age: embryonic day 14.5
Specimen Label: FG32; Specimen EX216
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:5421724
Age: embryonic day 14.5
Specimen Label: FG32; Specimen EX216
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284222
Stage: TS22
Assay Id: MGI:5421724
Age: embryonic day 14.5
Specimen Label: FG32; Specimen EX216
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1777922
Stage: TS22
Assay Id: MGI:5421724
Age: embryonic day 14.5
Specimen Label: FG32; Specimen EX216
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280922
Stage: TS22
Assay Id: MGI:5421724
Age: embryonic day 14.5
Specimen Label: FG32; Specimen EX216
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276722
Stage: TS22
Assay Id: MGI:5421724
Age: embryonic day 14.5
Specimen Label: FG32; Specimen EX216
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284522
Stage: TS22
Assay Id: MGI:5421724
Age: embryonic day 14.5
Specimen Label: FG32; Specimen EX216
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3267322
Stage: TS22
Assay Id: MGI:5421724
Age: embryonic day 14.5
Specimen Label: FG32; Specimen EX216
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754922
Stage: TS22
Assay Id: MGI:5421724
Age: embryonic day 14.5
Note: Expression was not detected in the corpus striatum (lateral ganglionic eminence).
Specimen Label: FG32; Specimen EX216
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3516422
Stage: TS22
Assay Id: MGI:5421724
Age: embryonic day 14.5
Specimen Label: FG32; Specimen EX216
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3267222
Stage: TS22
Assay Id: MGI:5421724
Age: embryonic day 14.5
Specimen Label: FG32; Specimen EX216
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3283722
Stage: TS22
Assay Id: MGI:5421724
Age: embryonic day 14.5
Specimen Label: FG32; Specimen EX216
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3278022
Stage: TS22
Assay Id: MGI:5421724
Age: embryonic day 14.5
Note: Expression was not detected in the pallidum (medial ganglionic eminence).
Specimen Label: FG32; Specimen EX216
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689622
Stage: TS22
Assay Id: MGI:5421724
Age: embryonic day 14.5
Specimen Label: FG32; Specimen EX216
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3766797
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754022
Stage: TS22
Assay Id: MGI:5421724
Age: embryonic day 14.5
Specimen Label: FG32; Specimen EX216
Detected: false
Specimen Num: 1