Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
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•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
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•
•
•
•
•
|
Gene |
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•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
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•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
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•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
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•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
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•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
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•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
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•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 23 (FGF23), which is secreted by osteoblasts and osteoclasts []. FGF23 acts on kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule []. FGF23 is responsible for phosphate metabolism, decreasing the reabsorption and increasing excretion of phosphate []. FGF23 is involved in the pathogenesis of three hypophosphatemic disorders; oncogenic osteomalacia (OOM), X-linked hypophosphatemia (XLH) and autosomal dominant hypophosphatemic rickets (ADHR). These conditions are characterised by hypophosphatemia, decreased renal phosphate reabsorption, normal or low serum calcitriol concentrations and defective skeletal mineralisation [, , ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
ADHR Consortium. |
Year: |
2000 |
Journal: |
Nat Genet |
Title: |
Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. |
Volume: |
26 |
Issue: |
3 |
Pages: |
345-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ornitz DM |
Year: |
2001 |
Journal: |
Genome Biol |
Title: |
Fibroblast growth factors. |
Volume: |
2 |
Issue: |
3 |
Pages: |
REVIEWS3005 |
|
•
•
•
•
•
|
Publication |
First Author: |
Faul C |
Year: |
2011 |
Journal: |
J Clin Invest |
Title: |
FGF23 induces left ventricular hypertrophy. |
Volume: |
121 |
Issue: |
11 |
Pages: |
4393-408 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu S |
Year: |
2006 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Pathogenic role of Fgf23 in Hyp mice. |
Volume: |
291 |
Issue: |
1 |
Pages: |
E38-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu S |
Year: |
2008 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Pathogenic role of Fgf23 in Dmp1-null mice. |
Volume: |
295 |
Issue: |
2 |
Pages: |
E254-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Courbon G |
Year: |
2023 |
Journal: |
JCI Insight |
Title: |
FGF23 directly inhibits osteoprogenitor differentiation in Dmp1-knockout mice. |
Volume: |
8 |
Issue: |
24 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Meo Burt P |
Year: |
2018 |
Journal: |
Endocrinology |
Title: |
FGF23 Regulates Wnt/β-Catenin Signaling-Mediated Osteoarthritis in Mice Overexpressing High-Molecular-Weight FGF2. |
Volume: |
159 |
Issue: |
6 |
Pages: |
2386-2396 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tamamura Y |
Year: |
2019 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Notch signaling is involved in Fgf23 upregulation in osteocytes. |
Volume: |
518 |
Issue: |
2 |
Pages: |
233-238 |
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•
•
•
•
•
|
Publication |
First Author: |
Ichikawa S |
Year: |
2014 |
Journal: |
Endocrinology |
Title: |
Genetic rescue of glycosylation-deficient Fgf23 in the Galnt3 knockout mouse. |
Volume: |
155 |
Issue: |
10 |
Pages: |
3891-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu S |
Year: |
2009 |
Journal: |
Mol Endocrinol |
Title: |
Novel regulators of Fgf23 expression and mineralization in Hyp bone. |
Volume: |
23 |
Issue: |
9 |
Pages: |
1505-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Onishi T |
Year: |
2008 |
Journal: |
Arch Oral Biol |
Title: |
Phex mutation causes overexpression of FGF23 in teeth. |
Volume: |
53 |
Issue: |
2 |
Pages: |
99-104 |
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•
•
•
•
•
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Publication |
First Author: |
Umbach AT |
Year: |
2016 |
Journal: |
Kidney Blood Press Res |
Title: |
Impact of Annexin A 7 Deficiency on FGF23 Plasma Concentrations. |
Volume: |
41 |
Issue: |
6 |
Pages: |
828-836 |
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•
•
•
•
•
|
Publication |
First Author: |
Smith RC |
Year: |
2012 |
Journal: |
J Clin Invest |
Title: |
Circulating αKlotho influences phosphate handling by controlling FGF23 production. |
Volume: |
122 |
Issue: |
12 |
Pages: |
4710-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Simic P |
Year: |
2020 |
Journal: |
J Clin Invest |
Title: |
Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney. |
Volume: |
130 |
Issue: |
3 |
Pages: |
1513-1526 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiao Z |
Year: |
2019 |
Journal: |
JCI Insight |
Title: |
FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model. |
Volume: |
4 |
Issue: |
23 |
|
|
•
•
•
•
•
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Publication |
First Author: |
Li Y |
Year: |
2013 |
Journal: |
Calcif Tissue Int |
Title: |
FGF23 affects the lineage fate determination of mesenchymal stem cells. |
Volume: |
93 |
Issue: |
6 |
Pages: |
556-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andrukhova O |
Year: |
2014 |
Journal: |
EMBO J |
Title: |
FGF23 promotes renal calcium reabsorption through the TRPV5 channel. |
Volume: |
33 |
Issue: |
3 |
Pages: |
229-46 |
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•
•
•
•
•
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Publication |
First Author: |
Andrukhova O |
Year: |
2014 |
Journal: |
EMBO Mol Med |
Title: |
FGF23 regulates renal sodium handling and blood pressure. |
Volume: |
6 |
Issue: |
6 |
Pages: |
744-59 |
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•
•
•
•
•
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Publication |
First Author: |
Andrukhova O |
Year: |
2016 |
Journal: |
Mol Cell Endocrinol |
Title: |
Fgf23 and parathyroid hormone signaling interact in kidney and bone. |
Volume: |
436 |
|
Pages: |
224-39 |
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•
•
•
•
•
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Publication |
First Author: |
Bai X |
Year: |
2009 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype. |
Volume: |
296 |
Issue: |
1 |
Pages: |
E79-88 |
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•
•
•
•
•
|
Publication |
First Author: |
Shimada T |
Year: |
2004 |
Journal: |
J Clin Invest |
Title: |
Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. |
Volume: |
113 |
Issue: |
4 |
Pages: |
561-8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172877 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
|
Stage: |
TS24 |
Assay Id: |
MGI:6190268 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Fgf23 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172877 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190268 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Fgf23 |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172877 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6190268 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Fgf23 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172877 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
|
Stage: |
TS21 |
Assay Id: |
MGI:6190268 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Fgf23 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172877 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
|
Stage: |
TS26 |
Assay Id: |
MGI:6190268 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Fgf23 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172877 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190268 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Fgf23 |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172877 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190268 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Fgf23 |
Detected: |
false |
Specimen Num: |
7 |
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•
•
•
•
•
|
Publication |
First Author: |
Kaludjerovic J |
Year: |
2017 |
Journal: |
FASEB J |
Title: |
Klotho expression in long bones regulates FGF23 production during renal failure. |
Volume: |
31 |
Issue: |
5 |
Pages: |
2050-2064 |
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•
•
•
•
•
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Publication |
First Author: |
Daryadel A |
Year: |
2021 |
Journal: |
FASEB J |
Title: |
Systemic Jak1 activation provokes hepatic inflammation and imbalanced FGF23 production and cleavage. |
Volume: |
35 |
Issue: |
2 |
Pages: |
e21302 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai M |
Year: |
2014 |
Journal: |
J Biol Chem |
Title: |
Sympathetic activation induces skeletal Fgf23 expression in a circadian rhythm-dependent manner. |
Volume: |
289 |
Issue: |
3 |
Pages: |
1457-66 |
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•
•
•
•
•
|
Publication |
First Author: |
Lindberg K |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Arterial klotho expression and FGF23 effects on vascular calcification and function. |
Volume: |
8 |
Issue: |
4 |
Pages: |
e60658 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu X |
Year: |
2005 |
Journal: |
Bone |
Title: |
Genetic dissection of phosphate- and vitamin D-mediated regulation of circulating Fgf23 concentrations. |
Volume: |
36 |
Issue: |
6 |
Pages: |
971-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Karaplis AC |
Year: |
2012 |
Journal: |
Endocrinology |
Title: |
Mineralizing enthesopathy is a common feature of renal phosphate-wasting disorders attributed to FGF23 and is exacerbated by standard therapy in hyp mice. |
Volume: |
153 |
Issue: |
12 |
Pages: |
5906-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fukuda T |
Year: |
2007 |
Journal: |
Biochem Biophys Res Commun |
Title: |
FGF23 induces expression of two isoforms of NAB2, which are corepressors of Egr-1. |
Volume: |
353 |
Issue: |
1 |
Pages: |
147-51 |
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•
•
•
•
•
|
Publication |
First Author: |
Lysaght AC |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
FGF23 deficiency leads to mixed hearing loss and middle ear malformation in mice. |
Volume: |
9 |
Issue: |
9 |
Pages: |
e107681 |
|
•
•
•
•
•
|
Publication |
First Author: |
Clinkenbeard EL |
Year: |
2019 |
Journal: |
JCI Insight |
Title: |
Increased FGF23 protects against detrimental cardio-renal consequences during elevated blood phosphate in CKD. |
Volume: |
4 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Quarles LD |
Year: |
2012 |
Journal: |
Nat Rev Endocrinol |
Title: |
Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism. |
Volume: |
8 |
Issue: |
5 |
Pages: |
276-86 |
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•
•
•
•
•
|
Publication |
First Author: |
Jüppner H |
Year: |
2011 |
Journal: |
Kidney Int Suppl |
Title: |
Phosphate and FGF-23. |
|
Issue: |
121 |
Pages: |
S24-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fukumoto S |
Year: |
2008 |
Journal: |
Intern Med |
Title: |
Physiological regulation and disorders of phosphate metabolism--pivotal role of fibroblast growth factor 23. |
Volume: |
47 |
Issue: |
5 |
Pages: |
337-43 |
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•
•
•
•
•
|
Publication |
First Author: |
Bowe AE |
Year: |
2001 |
Journal: |
Biochem Biophys Res Commun |
Title: |
FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate. |
Volume: |
284 |
Issue: |
4 |
Pages: |
977-81 |
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•
•
•
•
•
|
Publication |
First Author: |
Hollberg K |
Year: |
2008 |
Journal: |
Bone |
Title: |
Osteoclast polarization is not required for degradation of bone matrix in rachitic FGF23 transgenic mice. |
Volume: |
42 |
Issue: |
6 |
Pages: |
1111-21 |
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•
•
•
•
•
|
Publication |
First Author: |
Clinkenbeard EL |
Year: |
2014 |
Journal: |
J Bone Miner Res |
Title: |
Neonatal iron deficiency causes abnormal phosphate metabolism by elevating FGF23 in normal and ADHR mice. |
Volume: |
29 |
Issue: |
2 |
Pages: |
361-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aprile A |
Year: |
2023 |
Journal: |
Sci Transl Med |
Title: |
Inhibition of FGF23 is a therapeutic strategy to target hematopoietic stem cell niche defects in β-thalassemia. |
Volume: |
15 |
Issue: |
698 |
Pages: |
eabq3679 |
|
•
•
•
•
•
|
Publication |
First Author: |
Slavic S |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Genetic Ablation of Fgf23 or Klotho Does not Modulate Experimental Heart Hypertrophy Induced by Pressure Overload. |
Volume: |
7 |
Issue: |
1 |
Pages: |
11298 |
|
•
•
•
•
•
|
Publication |
First Author: |
Touchberry CD |
Year: |
2013 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy. |
Volume: |
304 |
Issue: |
8 |
Pages: |
E863-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inoue Y |
Year: |
2005 |
Journal: |
Biochem J |
Title: |
Role of the vitamin D receptor in FGF23 action on phosphate metabolism. |
Volume: |
390 |
Issue: |
Pt 1 |
Pages: |
325-31 |
|
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•
•
•
•
|
Publication |
First Author: |
Fan Y |
Year: |
2016 |
Journal: |
FASEB J |
Title: |
Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis. |
Volume: |
30 |
Issue: |
1 |
Pages: |
428-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ovejero D |
Year: |
2023 |
Journal: |
J Clin Invest |
Title: |
Murine models of HRAS-mediated cutaneous skeletal hypophosphatemia syndrome suggest bone as the FGF23 excess source. |
Volume: |
133 |
Issue: |
9 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Silswal N |
Year: |
2014 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
FGF23 directly impairs endothelium-dependent vasorelaxation by increasing superoxide levels and reducing nitric oxide bioavailability. |
Volume: |
307 |
Issue: |
5 |
Pages: |
E426-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dai B |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
A comparative transcriptome analysis identifying FGF23 regulated genes in the kidney of a mouse CKD model. |
Volume: |
7 |
Issue: |
9 |
Pages: |
e44161 |
|
•
•
•
•
•
|
Publication |
First Author: |
Masuyama R |
Year: |
2006 |
Journal: |
J Clin Invest |
Title: |
Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts. |
Volume: |
116 |
Issue: |
12 |
Pages: |
3150-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Olauson H |
Year: |
2013 |
Journal: |
PLoS Genet |
Title: |
Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion. |
Volume: |
9 |
Issue: |
12 |
Pages: |
e1003975 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matthias J |
Year: |
2020 |
Journal: |
Endocrinology |
Title: |
Extra-Large Gα Protein (XLαs) Deficiency Causes Severe Adenine-Induced Renal Injury with Massive FGF23 Elevation. |
Volume: |
161 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bøllehuus Hansen L |
Year: |
2020 |
Journal: |
FASEB J |
Title: |
Influence of FGF23 and Klotho on male reproduction: Systemic vs direct effects. |
Volume: |
34 |
Issue: |
9 |
Pages: |
12436-12449 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shimada T |
Year: |
2005 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism. |
Volume: |
289 |
Issue: |
5 |
Pages: |
F1088-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Radhakrishnan K |
Year: |
2021 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Orphan nuclear receptor ERR-γ regulates hepatic FGF23 production in acute kidney injury. |
Volume: |
118 |
Issue: |
16 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Jung YS |
Year: |
2024 |
Journal: |
Redox Biol |
Title: |
ERRγ-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress. |
Volume: |
71 |
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Pages: |
103107 |
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•
•
•
•
•
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Publication |
First Author: |
Murali SK |
Year: |
2016 |
Journal: |
PLoS Biol |
Title: |
Excessive Osteocytic Fgf23 Secretion Contributes to Pyrophosphate Accumulation and Mineralization Defect in Hyp Mice. |
Volume: |
14 |
Issue: |
4 |
Pages: |
e1002427 |
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•
•
•
•
•
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Publication |
First Author: |
Kawai M |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
FGF23 suppresses chondrocyte proliferation in the presence of soluble α-Klotho both in vitro and in vivo. |
Volume: |
288 |
Issue: |
4 |
Pages: |
2414-27 |
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•
•
•
•
•
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Publication |
First Author: |
Murali SK |
Year: |
2016 |
Journal: |
J Bone Miner Res |
Title: |
FGF23 Regulates Bone Mineralization in a 1,25(OH)2 D3 and Klotho-Independent Manner. |
Volume: |
31 |
Issue: |
1 |
Pages: |
129-42 |
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•
•
•
•
•
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Publication |
First Author: |
Kamiya N |
Year: |
2017 |
Journal: |
J Bone Miner Res |
Title: |
Targeted Disruption of NF1 in Osteocytes Increases FGF23 and Osteoid With Osteomalacia-like Bone Phenotype. |
Volume: |
32 |
Issue: |
8 |
Pages: |
1716-1726 |
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•
•
•
•
•
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Publication |
First Author: |
Gattineni J |
Year: |
2014 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Regulation of renal phosphate transport by FGF23 is mediated by FGFR1 and FGFR4. |
Volume: |
306 |
Issue: |
3 |
Pages: |
F351-8 |
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•
•
•
•
•
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Publication |
First Author: |
Wang X |
Year: |
2012 |
Journal: |
PLoS Genet |
Title: |
Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice. |
Volume: |
8 |
Issue: |
5 |
Pages: |
e1002708 |
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•
•
•
•
•
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Publication |
First Author: |
Flamme I |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
FGF23 expression in rodents is directly induced via erythropoietin after inhibition of hypoxia inducible factor proline hydroxylase. |
Volume: |
12 |
Issue: |
10 |
Pages: |
e0186979 |
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•
•
•
•
•
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Publication |
First Author: |
Sellars KB |
Year: |
2021 |
Journal: |
Endocrinology |
Title: |
Murine Fetal Serum Phosphorus is Set Independent of FGF23 and PTH, Except in the Presence of Maternal Phosphate Loading. |
Volume: |
162 |
Issue: |
1 |
|
|
•
•
•
•
•
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Publication |
First Author: |
Reilly AM |
Year: |
2014 |
Journal: |
Bone |
Title: |
Nicotinamide treatment in a murine model of familial tumoral calcinosis reduces serum Fgf23 and raises heart calcium. |
Volume: |
67 |
|
Pages: |
139-44 |
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•
•
•
•
•
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Publication |
First Author: |
Goetz R |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation. |
Volume: |
107 |
Issue: |
1 |
Pages: |
407-12 |
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•
•
•
•
•
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Publication |
First Author: |
Sakurai A |
Year: |
2017 |
Journal: |
Biomed Res |
Title: |
Chronological immunolocalization of sclerostin and FGF23 in the mouse metaphyseal trabecular and cortical bone. |
Volume: |
38 |
Issue: |
4 |
Pages: |
257-267 |
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•
•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
251
 |
Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
251
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
251
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu X |
Year: |
2012 |
Journal: |
J Mol Biol |
Title: |
A unique FGF23 with the ability to activate FGFR signaling through both αKlotho and βKlotho. |
Volume: |
418 |
Issue: |
1-2 |
Pages: |
82-9 |
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•
•
•
•
•
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Publication |
First Author: |
Andrukhova O |
Year: |
2012 |
Journal: |
Bone |
Title: |
FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2-SGK1 signaling pathway. |
Volume: |
51 |
Issue: |
3 |
Pages: |
621-8 |
|
•
•
•
•
•
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Publication |
First Author: |
Liu ES |
Year: |
2018 |
Journal: |
Endocrinology |
Title: |
Increased Circulating FGF23 Does Not Lead to Cardiac Hypertrophy in the Male Hyp Mouse Model of XLH. |
Volume: |
159 |
Issue: |
5 |
Pages: |
2165-2172 |
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•
•
•
•
•
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Publication |
First Author: |
Takashi Y |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation. |
Volume: |
116 |
Issue: |
23 |
Pages: |
11418-11427 |
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•
•
•
•
•
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Publication |
First Author: |
Streicher C |
Year: |
2012 |
Journal: |
Endocrinology |
Title: |
Long-term Fgf23 deficiency does not influence aging, glucose homeostasis, or fat metabolism in mice with a nonfunctioning vitamin D receptor. |
Volume: |
153 |
Issue: |
4 |
Pages: |
1795-805 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yadav PS |
Year: |
2023 |
Journal: |
Endocrinology |
Title: |
Impaired Growth Plate Maturation in XLH Is due to Both Excess FGF23 and Decreased 1,25-Dihydroxyvitamin D Signaling. |
Volume: |
165 |
Issue: |
1 |
|
|
•
•
•
•
•
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Publication |
First Author: |
Egli-Spichtig D |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
Renal Dnase1 expression is regulated by FGF23 but loss of Dnase1 does not alter renal phosphate handling. |
Volume: |
11 |
Issue: |
1 |
Pages: |
6175 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma Y |
Year: |
2014 |
Journal: |
Endocrinology |
Title: |
Neither absence nor excess of FGF23 disturbs murine fetal-placental phosphorus homeostasis or prenatal skeletal development and mineralization. |
Volume: |
155 |
Issue: |
5 |
Pages: |
1596-605 |
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•
•
•
•
•
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Publication |
First Author: |
Stubbs JR |
Year: |
2012 |
Journal: |
J Bone Miner Res |
Title: |
Longitudinal evaluation of FGF23 changes and mineral metabolism abnormalities in a mouse model of chronic kidney disease. |
Volume: |
27 |
Issue: |
1 |
Pages: |
38-46 |
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•
•
•
•
•
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Publication |
First Author: |
Li X |
Year: |
2023 |
Journal: |
Blood Adv |
Title: |
Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia. |
Volume: |
7 |
Issue: |
17 |
Pages: |
5156-5171 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiao L |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO. |
Volume: |
285 |
Issue: |
4 |
Pages: |
2834-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma Y |
Year: |
2017 |
Journal: |
Endocrinology |
Title: |
FGF23 Is Not Required to Regulate Fetal Phosphorus Metabolism but Exerts Effects Within 12 Hours After Birth. |
Volume: |
158 |
Issue: |
2 |
Pages: |
252-263 |
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•
•
•
•
•
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Publication |
First Author: |
Martin A |
Year: |
2012 |
Journal: |
Mol Endocrinol |
Title: |
Overexpression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice. |
Volume: |
26 |
Issue: |
11 |
Pages: |
1883-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ichikawa S |
Year: |
2009 |
Journal: |
Endocrinology |
Title: |
Ablation of the Galnt3 gene leads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrations and hyperphosphatemia despite increased Fgf23 expression. |
Volume: |
150 |
Issue: |
6 |
Pages: |
2543-50 |
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•
•
•
•
•
|
Publication |
First Author: |
Gattineni J |
Year: |
2009 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1. |
Volume: |
297 |
Issue: |
2 |
Pages: |
F282-91 |
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•
•
•
•
•
|
Publication |
First Author: |
Liu ES |
Year: |
2016 |
Journal: |
J Bone Miner Res |
Title: |
1,25-Dihydroxyvitamin D Alone Improves Skeletal Growth, Microarchitecture, and Strength in a Murine Model of XLH, Despite Enhanced FGF23 Expression. |
Volume: |
31 |
Issue: |
5 |
Pages: |
929-39 |
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•
•
•
•
•
|
Publication |
First Author: |
Liu S |
Year: |
2007 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice. |
Volume: |
293 |
Issue: |
6 |
Pages: |
E1636-44 |
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•
•
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