Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 3 (FGF3), also known as heparin-binding growth factor 3 and INT-2 proto-oncogene protein. The protein plays an important role in the regulation of embryonic development, cell proliferation and differentiation, and is required for normal ear development [, ]. FGF3 has a high affinity for FGFR3 and FGFR2, but a low affinity for FGFR1 []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Riazuddin S |
Year: |
2011 |
Journal: |
BMC Med Genet |
Title: |
Variable expressivity of FGF3 mutations associated with deafness and LAMM syndrome. |
Volume: |
12 |
|
Pages: |
21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alvarez Y |
Year: |
2003 |
Journal: |
Development |
Title: |
Requirements for FGF3 and FGF10 during inner ear formation. |
Volume: |
130 |
Issue: |
25 |
Pages: |
6329-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Theil T |
Year: |
2008 |
Journal: |
Dev Dyn |
Title: |
Differential requirements for Fgf3 and Fgf8 during mouse forebrain development. |
Volume: |
237 |
Issue: |
11 |
Pages: |
3417-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Charles C |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition. |
Volume: |
106 |
Issue: |
52 |
Pages: |
22364-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wright TJ |
Year: |
2003 |
Journal: |
Development |
Title: |
Fgf3 and Fgf10 are required for mouse otic placode induction. |
Volume: |
130 |
Issue: |
15 |
Pages: |
3379-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luzzio A |
Year: |
2023 |
Journal: |
Mamm Genome |
Title: |
The spontaneous mouse mutant low set ears (Lse) is caused by tandem duplication of Fgf3 and Fgf4. |
Volume: |
34 |
Issue: |
3 |
Pages: |
453-463 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hatch EP |
Year: |
2007 |
Journal: |
Development |
Title: |
Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium. |
Volume: |
134 |
Issue: |
20 |
Pages: |
3615-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Urness LD |
Year: |
2011 |
Journal: |
Dev Biol |
Title: |
Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular development. |
Volume: |
356 |
Issue: |
2 |
Pages: |
383-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun YW |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene. |
Volume: |
12 |
Issue: |
10 |
Pages: |
e0186873 |
|
•
•
•
•
•
|
Publication |
First Author: |
Powles N |
Year: |
2004 |
Journal: |
Dev Dyn |
Title: |
Regulatory analysis of the mouse Fgf3 gene: control of embryonic expression patterns and dependence upon sonic hedgehog (Shh) signalling. |
Volume: |
230 |
Issue: |
1 |
Pages: |
44-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zelarayan L |
Year: |
2022 |
Journal: |
Dev Dyn |
Title: |
Inactivation of Fgf3 and Fgf4 within the Fgf3/Fgf4/Fgf15 gene cluster reveals their redundant requirement for mouse inner ear induction and embryonic survival. |
Volume: |
251 |
Issue: |
5 |
Pages: |
877-884 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
245
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
245
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
156
 |
Fragment?: |
true |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172880 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190269 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Fgf3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172880 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190269 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Fgf3 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172880 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190269 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Fgf3 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172880 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190269 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Fgf3 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172880 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190269 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Fgf3 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172880 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190269 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Fgf3 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172880 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190269 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Fgf3 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ornitz DM |
Year: |
1996 |
Journal: |
J Biol Chem |
Title: |
Receptor specificity of the fibroblast growth factor family. |
Volume: |
271 |
Issue: |
25 |
Pages: |
15292-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burgess WH |
Year: |
1989 |
Journal: |
Annu Rev Biochem |
Title: |
The heparin-binding (fibroblast) growth factor family of proteins. |
Volume: |
58 |
|
Pages: |
575-606 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilkie AO |
Year: |
1995 |
Journal: |
Curr Biol |
Title: |
Functions of fibroblast growth factors and their receptors. |
Volume: |
5 |
Issue: |
5 |
Pages: |
500-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thomas KA |
Year: |
1988 |
Journal: |
Trends Biochem Sci |
Title: |
Transforming potential of fibroblast growth factor genes. |
Volume: |
13 |
Issue: |
9 |
Pages: |
327-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ornitz DM |
Year: |
2001 |
Journal: |
Genome Biol |
Title: |
Fibroblast growth factors. |
Volume: |
2 |
Issue: |
3 |
Pages: |
REVIEWS3005 |
|
•
•
•
•
•
|
Publication |
First Author: |
Plotnikov AN |
Year: |
2000 |
Journal: |
Cell |
Title: |
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. |
Volume: |
101 |
Issue: |
4 |
Pages: |
413-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blaber M |
Year: |
1996 |
Journal: |
Biochemistry |
Title: |
X-ray crystal structure of human acidic fibroblast growth factor. |
Volume: |
35 |
Issue: |
7 |
Pages: |
2086-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vlodavsky I |
Year: |
1990 |
Journal: |
Cancer Metastasis Rev |
Title: |
Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis. |
Volume: |
9 |
Issue: |
3 |
Pages: |
203-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Green PJ |
Year: |
1996 |
Journal: |
Bioessays |
Title: |
Promiscuity of fibroblast growth factor receptors. |
Volume: |
18 |
Issue: |
8 |
Pages: |
639-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yardley N |
Year: |
2012 |
Journal: |
Dev Biol |
Title: |
FGF signaling transforms non-neural ectoderm into neural crest. |
Volume: |
372 |
Issue: |
2 |
Pages: |
166-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Böttcher RT |
Year: |
2005 |
Journal: |
Endocr Rev |
Title: |
Fibroblast growth factor signaling during early vertebrate development. |
Volume: |
26 |
Issue: |
1 |
Pages: |
63-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koga C |
Year: |
1999 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis. |
Volume: |
261 |
Issue: |
3 |
Pages: |
756-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakamizo S |
Year: |
2013 |
Journal: |
Skin Pharmacol Physiol |
Title: |
Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion. |
Volume: |
26 |
Issue: |
1 |
Pages: |
22-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kumar SB |
Year: |
2013 |
Journal: |
Curr Pharm Des |
Title: |
Fibroblast growth factor receptor inhibitors. |
Volume: |
19 |
Issue: |
4 |
Pages: |
687-701 |
|
•
•
•
•
•
|
Publication |
First Author: |
Amaya E |
Year: |
1991 |
Journal: |
Cell |
Title: |
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. |
Volume: |
66 |
Issue: |
2 |
Pages: |
257-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Borland CZ |
Year: |
2001 |
Journal: |
Bioessays |
Title: |
Fibroblast growth factor signaling in Caenorhabditis elegans. |
Volume: |
23 |
Issue: |
12 |
Pages: |
1120-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Coumoul X |
Year: |
2003 |
Journal: |
Birth Defects Res C Embryo Today |
Title: |
Roles of FGF receptors in mammalian development and congenital diseases. |
Volume: |
69 |
Issue: |
4 |
Pages: |
286-304 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sutherland D |
Year: |
1996 |
Journal: |
Cell |
Title: |
branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching. |
Volume: |
87 |
Issue: |
6 |
Pages: |
1091-101 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7788161 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-12-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1666917 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:7790846 |
Age: |
embryonic day 10.5 |
Image: |
S8 anterior Tbx1KO |
Note: |
The anterior-ventro-lateral expression of Fgf3 was expanded posteriorly in the Tbx1KO otocyst. |
Specimen Label: |
S8 anterior Tbx1KO |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7788161 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-12-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1666917 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:7790846 |
Age: |
embryonic day 10.5 |
Image: |
S8 mid-transverse Tbx1KO |
Note: |
The anterior-ventro-lateral expression of Fgf3 was expanded posteriorly in the Tbx1KO otocyst. |
Specimen Label: |
S8 mid-transverse Tbx1KO |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7788161 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-12-30 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1666917 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:7790846 |
Age: |
embryonic day 10.5 |
Image: |
S8 posterior Tbx1KO |
Note: |
The anterior-ventro-lateral expression of Fgf3 was expanded posteriorly in the Tbx1KO otocyst. |
Specimen Label: |
S8 posterior Tbx1KO |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carlton MB |
Year: |
1998 |
Journal: |
Dev Dyn |
Title: |
Crouzon-like craniofacial dysmorphology in the mouse is caused by an insertional mutation at the Fgf3/Fgf4 locus. |
Volume: |
212 |
Issue: |
2 |
Pages: |
242-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ludwig S |
Year: |
2018 |
Journal: |
MGI Direct Data Submission |
Title: |
Mutagenetix entry for Porkchop. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mansour SL |
Year: |
1990 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination. |
Volume: |
87 |
Issue: |
19 |
Pages: |
7688-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Donjacour AA |
Year: |
1998 |
Journal: |
Differentiation |
Title: |
Enlargement of the ampullary gland and seminal vesicle, but not the prostate in int-2/Fgf-3 transgenic mice. |
Volume: |
62 |
Issue: |
5 |
Pages: |
227-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aggarwal VS |
Year: |
2006 |
Journal: |
Hum Mol Genet |
Title: |
Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy. |
Volume: |
15 |
Issue: |
21 |
Pages: |
3219-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kwan H |
Year: |
1992 |
Journal: |
Mol Cell Biol |
Title: |
Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice. |
Volume: |
12 |
Issue: |
1 |
Pages: |
147-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mansour SL |
Year: |
1993 |
Journal: |
Development |
Title: |
Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. |
Volume: |
117 |
Issue: |
1 |
Pages: |
13-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vázquez-Echeverría C |
Year: |
2008 |
Journal: |
Dev Biol |
Title: |
Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain. |
Volume: |
322 |
Issue: |
1 |
Pages: |
167-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vendrell V |
Year: |
2013 |
Journal: |
Mech Dev |
Title: |
Roles of Wnt8a during formation and patterning of the mouse inner ear. |
Volume: |
130 |
Issue: |
2-3 |
Pages: |
160-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muller WJ |
Year: |
1990 |
Journal: |
EMBO J |
Title: |
The int-2 gene product acts as an epithelial growth factor in transgenic mice. |
Volume: |
9 |
Issue: |
3 |
Pages: |
907-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zelarayan LC |
Year: |
2007 |
Journal: |
Dev Biol |
Title: |
Differential requirements for FGF3, FGF8 and FGF10 during inner ear development. |
Volume: |
308 |
Issue: |
2 |
Pages: |
379-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harada H |
Year: |
2002 |
Journal: |
Connect Tissue Res |
Title: |
FGF10 maintains stem cell population during mouse incisor development. |
Volume: |
43 |
Issue: |
2-3 |
Pages: |
201-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Antoine M |
Year: |
2005 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2. |
Volume: |
338 |
Issue: |
2 |
Pages: |
1248-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anderson MJ |
Year: |
2016 |
Journal: |
PLoS Genet |
Title: |
An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension. |
Volume: |
12 |
Issue: |
5 |
Pages: |
e1006018 |
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•
•
•
•
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HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
embryonic day 10.0 |
Stage: |
16 |
Structure . Name: |
otocyst |
Notes: |
Due to the limited amount of otic tissue in mutants, the tissue sample contained the otic vesicle and surrounding mesenchyme and neighboring hindbrain |
Curation Status: |
Curated |
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•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
embryonic day 10.0 |
Stage: |
16 |
Structure . Name: |
otocyst |
Notes: |
Due to the limited amount of otic tissue in mutants, the tissue sample contained the otic vesicle and surrounding mesenchyme and neighboring hindbrain |
Curation Status: |
Curated |
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•
•
•
•
•
|
Publication |
First Author: |
Harada H |
Year: |
2002 |
Journal: |
Development |
Title: |
FGF10 maintains stem cell compartment in developing mouse incisors. |
Volume: |
129 |
Issue: |
6 |
Pages: |
1533-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anderson MJ |
Year: |
2016 |
Journal: |
Genesis |
Title: |
Fgf3-Fgf4-cis: A new mouse line for studying Fgf functions during mouse development. |
Volume: |
54 |
Issue: |
2 |
Pages: |
91-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Urness LD |
Year: |
2018 |
Journal: |
Development |
Title: |
Spatial and temporal inhibition of FGFR2b ligands reveals continuous requirements and novel targets in mouse inner ear morphogenesis. |
Volume: |
145 |
Issue: |
24 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kratochwil K |
Year: |
2002 |
Journal: |
Genes Dev |
Title: |
FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice. |
Volume: |
16 |
Issue: |
24 |
Pages: |
3173-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu C |
Year: |
2013 |
Journal: |
Development |
Title: |
FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling. |
Volume: |
140 |
Issue: |
21 |
Pages: |
4375-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ladher RK |
Year: |
2005 |
Journal: |
Genes Dev |
Title: |
FGF8 initiates inner ear induction in chick and mouse. |
Volume: |
19 |
Issue: |
5 |
Pages: |
603-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pirvola U |
Year: |
2000 |
Journal: |
J Neurosci |
Title: |
FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis. |
Volume: |
20 |
Issue: |
16 |
Pages: |
6125-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Speer AL |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Fibroblast growth factor 10-fibroblast growth factor receptor 2b mediated signaling is not required for adult glandular stomach homeostasis. |
Volume: |
7 |
Issue: |
11 |
Pages: |
e49127 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao X |
Year: |
2000 |
Journal: |
Mech Dev |
Title: |
Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ. |
Volume: |
99 |
Issue: |
1-2 |
Pages: |
29-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jackson A |
Year: |
2014 |
Journal: |
Dev Dyn |
Title: |
Endoderm-specific deletion of Tbx1 reveals an FGF-independent role for Tbx1 in pharyngeal apparatus morphogenesis. |
Volume: |
243 |
Issue: |
9 |
Pages: |
1143-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen J |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. |
Volume: |
334 |
Issue: |
1 |
Pages: |
174-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Urness LD |
Year: |
2010 |
Journal: |
Dev Biol |
Title: |
FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a. |
Volume: |
340 |
Issue: |
2 |
Pages: |
595-604 |
|
•
•
•
•
•
|
Publication |
First Author: |
Trokovic N |
Year: |
2005 |
Journal: |
Int J Dev Biol |
Title: |
Fibroblast growth factor signalling and regional specification of the pharyngeal ectoderm. |
Volume: |
49 |
Issue: |
7 |
Pages: |
797-805 |
|
•
•
•
•
•
|
Publication |
First Author: |
Domínguez-Frutos E |
Year: |
2009 |
Journal: |
Mech Dev |
Title: |
Tissue-specific requirements for FGF8 during early inner ear development. |
Volume: |
126 |
Issue: |
10 |
Pages: |
873-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoffman MP |
Year: |
2002 |
Journal: |
Development |
Title: |
Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms. |
Volume: |
129 |
Issue: |
24 |
Pages: |
5767-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kwon HJ |
Year: |
2015 |
Journal: |
J Dent Res |
Title: |
Deletion of Osr2 Partially Rescues Tooth Development in Runx2 Mutant Mice. |
Volume: |
94 |
Issue: |
8 |
Pages: |
1113-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kettunen P |
Year: |
2007 |
Journal: |
Mech Dev |
Title: |
Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning. |
Volume: |
124 |
Issue: |
11-12 |
Pages: |
868-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gardiner JR |
Year: |
2012 |
Journal: |
Development |
Title: |
Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis. |
Volume: |
139 |
Issue: |
18 |
Pages: |
3456-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakatomi M |
Year: |
2010 |
Journal: |
Dev Biol |
Title: |
Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis. |
Volume: |
340 |
Issue: |
2 |
Pages: |
438-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aberg T |
Year: |
2004 |
Journal: |
Dev Biol |
Title: |
Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. |
Volume: |
270 |
Issue: |
1 |
Pages: |
76-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zheng W |
Year: |
2003 |
Journal: |
Development |
Title: |
The role of Six1 in mammalian auditory system development. |
Volume: |
130 |
Issue: |
17 |
Pages: |
3989-4000 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kyrylkova K |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e37670 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bei M |
Year: |
1998 |
Journal: |
Development |
Title: |
FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development. |
Volume: |
125 |
Issue: |
21 |
Pages: |
4325-33 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|