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Search results 1 to 100 out of 1011 for Fgf3

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 3 (FGF3), also known as heparin-binding growth factor 3 and INT-2 proto-oncogene protein. The protein plays an important role in the regulation of embryonic development, cell proliferation and differentiation, and is required for normal ear development [, ]. FGF3 has a high affinity for FGFR3 and FGFR2, but a low affinity for FGFR1 [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Publication
First Author: Alvarez Y
Year: 2003
Journal: Development
Title: Requirements for FGF3 and FGF10 during inner ear formation.
Volume: 130
Issue: 25
Pages: 6329-38
Publication  
First Author: Riazuddin S
Year: 2011
Journal: BMC Med Genet
Title: Variable expressivity of FGF3 mutations associated with deafness and LAMM syndrome.
Volume: 12
Pages: 21
Publication
First Author: Theil T
Year: 2008
Journal: Dev Dyn
Title: Differential requirements for Fgf3 and Fgf8 during mouse forebrain development.
Volume: 237
Issue: 11
Pages: 3417-23
Publication
First Author: Charles C
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition.
Volume: 106
Issue: 52
Pages: 22364-8
Publication
First Author: Wright TJ
Year: 2003
Journal: Development
Title: Fgf3 and Fgf10 are required for mouse otic placode induction.
Volume: 130
Issue: 15
Pages: 3379-90
Publication
First Author: Hatch EP
Year: 2007
Journal: Development
Title: Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium.
Volume: 134
Issue: 20
Pages: 3615-25
Publication
First Author: Urness LD
Year: 2011
Journal: Dev Biol
Title: Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular development.
Volume: 356
Issue: 2
Pages: 383-97
Publication
First Author: Sun YW
Year: 2017
Journal: PLoS One
Title: Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene.
Volume: 12
Issue: 10
Pages: e0186873
Publication
First Author: Powles N
Year: 2004
Journal: Dev Dyn
Title: Regulatory analysis of the mouse Fgf3 gene: control of embryonic expression patterns and dependence upon sonic hedgehog (Shh) signalling.
Volume: 230
Issue: 1
Pages: 44-56
Publication
First Author: Luzzio A
Year: 2023
Journal: Mamm Genome
Title: The spontaneous mouse mutant low set ears (Lse) is caused by tandem duplication of Fgf3 and Fgf4.
Volume: 34
Issue: 3
Pages: 453-463
Publication
First Author: Zelarayan L
Year: 2022
Journal: Dev Dyn
Title: Inactivation of Fgf3 and Fgf4 within the Fgf3/Fgf4/Fgf15 gene cluster reveals their redundant requirement for mouse inner ear induction and embryonic survival.
Volume: 251
Issue: 5
Pages: 877-884
Protein
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: true
GXD Expression    
Probe: MGI:6172880
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190269
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Fgf3
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6172880
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190269
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Fgf3
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6172880
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190269
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Fgf3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6172880
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190269
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Fgf3
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6172880
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190269
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Fgf3
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6172880
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190269
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Fgf3
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6172880
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190269
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Fgf3
Detected: true
Specimen Num: 7
Publication
First Author: Ornitz DM
Year: 1996
Journal: J Biol Chem
Title: Receptor specificity of the fibroblast growth factor family.
Volume: 271
Issue: 25
Pages: 15292-7
Publication  
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
Publication
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
Publication
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
Publication
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
Publication
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
Publication
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
Publication
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
Publication
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
Publication
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
Publication
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
Publication
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
Publication
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
Publication
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
Publication
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
Publication
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
Publication
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
Publication
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
Publication
First Author: Carlton MB
Year: 1998
Journal: Dev Dyn
Title: Crouzon-like craniofacial dysmorphology in the mouse is caused by an insertional mutation at the Fgf3/Fgf4 locus.
Volume: 212
Issue: 2
Pages: 242-9
Publication      
First Author: Ludwig S
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Porkchop.
Publication
First Author: Mansour SL
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination.
Volume: 87
Issue: 19
Pages: 7688-92
Publication
First Author: Donjacour AA
Year: 1998
Journal: Differentiation
Title: Enlargement of the ampullary gland and seminal vesicle, but not the prostate in int-2/Fgf-3 transgenic mice.
Volume: 62
Issue: 5
Pages: 227-37
Publication
First Author: Aggarwal VS
Year: 2006
Journal: Hum Mol Genet
Title: Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy.
Volume: 15
Issue: 21
Pages: 3219-28
Publication
First Author: Kwan H
Year: 1992
Journal: Mol Cell Biol
Title: Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice.
Volume: 12
Issue: 1
Pages: 147-54
Publication
First Author: Mansour SL
Year: 1993
Journal: Development
Title: Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear.
Volume: 117
Issue: 1
Pages: 13-28
Publication
First Author: Muller WJ
Year: 1990
Journal: EMBO J
Title: The int-2 gene product acts as an epithelial growth factor in transgenic mice.
Volume: 9
Issue: 3
Pages: 907-13
Publication
First Author: Vázquez-Echeverría C
Year: 2008
Journal: Dev Biol
Title: Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain.
Volume: 322
Issue: 1
Pages: 167-78
Publication
First Author: Vendrell V
Year: 2013
Journal: Mech Dev
Title: Roles of Wnt8a during formation and patterning of the mouse inner ear.
Volume: 130
Issue: 2-3
Pages: 160-8
Publication
First Author: Zelarayan LC
Year: 2007
Journal: Dev Biol
Title: Differential requirements for FGF3, FGF8 and FGF10 during inner ear development.
Volume: 308
Issue: 2
Pages: 379-91
Publication
First Author: Harada H
Year: 2002
Journal: Connect Tissue Res
Title: FGF10 maintains stem cell population during mouse incisor development.
Volume: 43
Issue: 2-3
Pages: 201-4
Publication
First Author: Antoine M
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2.
Volume: 338
Issue: 2
Pages: 1248-55
Publication
First Author: Anderson MJ
Year: 2016
Journal: PLoS Genet
Title: An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension.
Volume: 12
Issue: 5
Pages: e1006018
Publication
First Author: Harada H
Year: 2002
Journal: Development
Title: FGF10 maintains stem cell compartment in developing mouse incisors.
Volume: 129
Issue: 6
Pages: 1533-41
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: embryonic day 10.0
Stage: 16
Structure . Name: otocyst
Notes: Due to the limited amount of otic tissue in mutants, the tissue sample contained the otic vesicle and surrounding mesenchyme and neighboring hindbrain
Curation Status: Curated
HT Sample
Organism Name: mouse, laboratory
Sex: Not Specified
Age: embryonic day 10.0
Stage: 16
Structure . Name: otocyst
Notes: Due to the limited amount of otic tissue in mutants, the tissue sample contained the otic vesicle and surrounding mesenchyme and neighboring hindbrain
Curation Status: Curated
Publication
First Author: Anderson MJ
Year: 2016
Journal: Genesis
Title: Fgf3-Fgf4-cis: A new mouse line for studying Fgf functions during mouse development.
Volume: 54
Issue: 2
Pages: 91-8
Publication  
First Author: Urness LD
Year: 2018
Journal: Development
Title: Spatial and temporal inhibition of FGFR2b ligands reveals continuous requirements and novel targets in mouse inner ear morphogenesis.
Volume: 145
Issue: 24
Publication
First Author: Kratochwil K
Year: 2002
Journal: Genes Dev
Title: FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice.
Volume: 16
Issue: 24
Pages: 3173-85
Publication
First Author: Liu C
Year: 2013
Journal: Development
Title: FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling.
Volume: 140
Issue: 21
Pages: 4375-85
Publication
First Author: Speer AL
Year: 2012
Journal: PLoS One
Title: Fibroblast growth factor 10-fibroblast growth factor receptor 2b mediated signaling is not required for adult glandular stomach homeostasis.
Volume: 7
Issue: 11
Pages: e49127
Publication
First Author: Pirvola U
Year: 2000
Journal: J Neurosci
Title: FGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis.
Volume: 20
Issue: 16
Pages: 6125-34
Publication
First Author: Ladher RK
Year: 2005
Journal: Genes Dev
Title: FGF8 initiates inner ear induction in chick and mouse.
Volume: 19
Issue: 5
Pages: 603-13
Publication
First Author: Jackson A
Year: 2014
Journal: Dev Dyn
Title: Endoderm-specific deletion of Tbx1 reveals an FGF-independent role for Tbx1 in pharyngeal apparatus morphogenesis.
Volume: 243
Issue: 9
Pages: 1143-51
Publication
First Author: Zhao X
Year: 2000
Journal: Mech Dev
Title: Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ.
Volume: 99
Issue: 1-2
Pages: 29-38
Publication
First Author: Domínguez-Frutos E
Year: 2009
Journal: Mech Dev
Title: Tissue-specific requirements for FGF8 during early inner ear development.
Volume: 126
Issue: 10
Pages: 873-81
Publication
First Author: Chen J
Year: 2009
Journal: Dev Biol
Title: Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development.
Volume: 334
Issue: 1
Pages: 174-85
Publication
First Author: Urness LD
Year: 2010
Journal: Dev Biol
Title: FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a.
Volume: 340
Issue: 2
Pages: 595-604
Publication
First Author: Trokovic N
Year: 2005
Journal: Int J Dev Biol
Title: Fibroblast growth factor signalling and regional specification of the pharyngeal ectoderm.
Volume: 49
Issue: 7
Pages: 797-805
Publication
First Author: Hoffman MP
Year: 2002
Journal: Development
Title: Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms.
Volume: 129
Issue: 24
Pages: 5767-78
Publication
First Author: Kwon HJ
Year: 2015
Journal: J Dent Res
Title: Deletion of Osr2 Partially Rescues Tooth Development in Runx2 Mutant Mice.
Volume: 94
Issue: 8
Pages: 1113-9
Publication
First Author: Kettunen P
Year: 2007
Journal: Mech Dev
Title: Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning.
Volume: 124
Issue: 11-12
Pages: 868-83
Publication
First Author: Gardiner JR
Year: 2012
Journal: Development
Title: Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis.
Volume: 139
Issue: 18
Pages: 3456-66
Publication
First Author: Nakatomi M
Year: 2010
Journal: Dev Biol
Title: Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis.
Volume: 340
Issue: 2
Pages: 438-49
Publication
First Author: Aberg T
Year: 2004
Journal: Dev Biol
Title: Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis.
Volume: 270
Issue: 1
Pages: 76-93
Publication
First Author: Zheng W
Year: 2003
Journal: Development
Title: The role of Six1 in mammalian auditory system development.
Volume: 130
Issue: 17
Pages: 3989-4000
Publication
First Author: Kyrylkova K
Year: 2012
Journal: PLoS One
Title: BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor.
Volume: 7
Issue: 5
Pages: e37670
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory