Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
sheep |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 5 (FGF5). This protein plays an important role in the regulation of cell proliferation and cell differentiation. It is required for normal regulation of the hair growth cycle, as it functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen, the apoptosis-induced regression phase [, ]. FGF5 has a high affinity for FGFR1 and FGFR2 []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Hébert JM |
Year: |
1994 |
Journal: |
Cell |
Title: |
FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. |
Volume: |
78 |
Issue: |
6 |
Pages: |
1017-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cho YM |
Year: |
2003 |
Journal: |
J Invest Dermatol |
Title: |
Hair-cycle-dependent expression of parathyroid hormone-related protein and its type I receptor: evidence for regulation at the anagen to catagen transition. |
Volume: |
120 |
Issue: |
5 |
Pages: |
715-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mattei MG |
Year: |
1992 |
Journal: |
Mamm Genome |
Title: |
Chromosomal localizations of mouse Fgf2 and Fgf5 genes. |
Volume: |
2 |
Issue: |
2 |
Pages: |
135-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Crozat K |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Porcupine, an ENU-induced Fgf5 mutant with long pelage hair |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Takahashi R |
Year: |
2022 |
Journal: |
Int J Mol Sci |
Title: |
Gender-Difference in Hair Length as Revealed by Crispr-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations. |
Volume: |
23 |
Issue: |
19 |
|
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172884 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6190271 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Fgf5 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172884 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
|
Stage: |
TS21 |
Assay Id: |
MGI:6190271 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Fgf5 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172884 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190271 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Fgf5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172884 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190271 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Fgf5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172884 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190271 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Fgf5 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172884 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190271 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Fgf5 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172884 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190271 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Fgf5 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
264
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
264
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Ornitz DM |
Year: |
1996 |
Journal: |
J Biol Chem |
Title: |
Receptor specificity of the fibroblast growth factor family. |
Volume: |
271 |
Issue: |
25 |
Pages: |
15292-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burgess WH |
Year: |
1989 |
Journal: |
Annu Rev Biochem |
Title: |
The heparin-binding (fibroblast) growth factor family of proteins. |
Volume: |
58 |
|
Pages: |
575-606 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilkie AO |
Year: |
1995 |
Journal: |
Curr Biol |
Title: |
Functions of fibroblast growth factors and their receptors. |
Volume: |
5 |
Issue: |
5 |
Pages: |
500-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thomas KA |
Year: |
1988 |
Journal: |
Trends Biochem Sci |
Title: |
Transforming potential of fibroblast growth factor genes. |
Volume: |
13 |
Issue: |
9 |
Pages: |
327-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ornitz DM |
Year: |
2001 |
Journal: |
Genome Biol |
Title: |
Fibroblast growth factors. |
Volume: |
2 |
Issue: |
3 |
Pages: |
REVIEWS3005 |
|
•
•
•
•
•
|
Publication |
First Author: |
Plotnikov AN |
Year: |
2000 |
Journal: |
Cell |
Title: |
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. |
Volume: |
101 |
Issue: |
4 |
Pages: |
413-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blaber M |
Year: |
1996 |
Journal: |
Biochemistry |
Title: |
X-ray crystal structure of human acidic fibroblast growth factor. |
Volume: |
35 |
Issue: |
7 |
Pages: |
2086-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vlodavsky I |
Year: |
1990 |
Journal: |
Cancer Metastasis Rev |
Title: |
Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis. |
Volume: |
9 |
Issue: |
3 |
Pages: |
203-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Green PJ |
Year: |
1996 |
Journal: |
Bioessays |
Title: |
Promiscuity of fibroblast growth factor receptors. |
Volume: |
18 |
Issue: |
8 |
Pages: |
639-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yardley N |
Year: |
2012 |
Journal: |
Dev Biol |
Title: |
FGF signaling transforms non-neural ectoderm into neural crest. |
Volume: |
372 |
Issue: |
2 |
Pages: |
166-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Böttcher RT |
Year: |
2005 |
Journal: |
Endocr Rev |
Title: |
Fibroblast growth factor signaling during early vertebrate development. |
Volume: |
26 |
Issue: |
1 |
Pages: |
63-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koga C |
Year: |
1999 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis. |
Volume: |
261 |
Issue: |
3 |
Pages: |
756-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakamizo S |
Year: |
2013 |
Journal: |
Skin Pharmacol Physiol |
Title: |
Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion. |
Volume: |
26 |
Issue: |
1 |
Pages: |
22-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kumar SB |
Year: |
2013 |
Journal: |
Curr Pharm Des |
Title: |
Fibroblast growth factor receptor inhibitors. |
Volume: |
19 |
Issue: |
4 |
Pages: |
687-701 |
|
•
•
•
•
•
|
Publication |
First Author: |
Amaya E |
Year: |
1991 |
Journal: |
Cell |
Title: |
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. |
Volume: |
66 |
Issue: |
2 |
Pages: |
257-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Borland CZ |
Year: |
2001 |
Journal: |
Bioessays |
Title: |
Fibroblast growth factor signaling in Caenorhabditis elegans. |
Volume: |
23 |
Issue: |
12 |
Pages: |
1120-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Coumoul X |
Year: |
2003 |
Journal: |
Birth Defects Res C Embryo Today |
Title: |
Roles of FGF receptors in mammalian development and congenital diseases. |
Volume: |
69 |
Issue: |
4 |
Pages: |
286-304 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sutherland D |
Year: |
1996 |
Journal: |
Cell |
Title: |
branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching. |
Volume: |
87 |
Issue: |
6 |
Pages: |
1091-101 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-26 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610811 |
|
Stage: |
TS11 |
Assay Id: |
MGI:1930524 |
Age: |
embryonic day 7.5 |
Image: |
3B,3C |
Note: |
No Fgf5 expression was detected in extraembryonic mesoderm. |
Specimen Label: |
3B,3C |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-26 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1611111 |
|
Stage: |
TS11 |
Assay Id: |
MGI:1930524 |
Age: |
embryonic day 7.5 |
Image: |
3B,3C |
Note: |
No Fgf5 expression was detected in extraembryonic mesoderm. |
Specimen Label: |
3B,3C |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-26 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1611411 |
|
Stage: |
TS11 |
Assay Id: |
MGI:1930524 |
Age: |
embryonic day 7.5 |
Image: |
3B,3C |
Note: |
No Fgf5 expression was detected in extraembryonic mesoderm. |
Specimen Label: |
3B,3C |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160428 |
Pattern: |
Regionally restricted |
Stage: |
TS08 |
Assay Id: |
MGI:1930524 |
Age: |
embryonic day 6.5 |
Image: |
1E,1F |
Note: |
Fgf5 mRNA was undetectable in the proximal extraembryonic tissue. |
Specimen Label: |
1E,1F |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-26 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1608711 |
|
Stage: |
TS11 |
Assay Id: |
MGI:1930524 |
Age: |
embryonic day 7.5 |
Image: |
3B,3C |
Note: |
No Fgf5 expression was detected in extraembryonic mesoderm. |
Specimen Label: |
3B,3C |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hanaka H |
Year: |
2014 |
Journal: |
Exp Anim |
Title: |
Fibroblast growth factor-5 participates in the progression of hepatic fibrosis. |
Volume: |
63 |
Issue: |
1 |
Pages: |
85-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mizuno S |
Year: |
2011 |
Journal: |
Exp Anim |
Title: |
Retrotransposon-mediated Fgf5(go-Utr) mutant mice with long pelage hair. |
Volume: |
60 |
Issue: |
2 |
Pages: |
161-7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-26 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1606911 |
Pattern: |
Graded |
Stage: |
TS11 |
Assay Id: |
MGI:1930524 |
Age: |
embryonic day 7.5 |
Image: |
3B,3C |
Note: |
Embryonic ectoderm expressed Fgf5 mRNA, with increasingly higher levels detectable towards the distal end. |
Specimen Label: |
3B,3C |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603910 |
Pattern: |
Regionally restricted |
Stage: |
TS10 |
Assay Id: |
MGI:1930524 |
Age: |
embryonic day 7.0 |
Image: |
2C,2D |
Note: |
Expression of Fgf5 remained restricted to the embryonic portion of the conceptus. |
Specimen Label: |
2C,2D |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-26 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1604210 |
|
Stage: |
TS10 |
Assay Id: |
MGI:1930524 |
Age: |
embryonic day 7.0 |
Image: |
2C,2D |
Note: |
Fgf5 expression remained restricted to the embryonic portion of the conceptus. |
Specimen Label: |
2C,2D |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-26 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:160508 |
Pattern: |
Uniform |
Stage: |
TS08 |
Assay Id: |
MGI:1930524 |
Age: |
embryonic day 6.5 |
Image: |
1E,1F |
Note: |
Fgf5 mRNA was readily detectable at uniformly high levels throughout the embryonic ectoderm at this stage. |
Specimen Label: |
1E,1F |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-26 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:160588 |
Pattern: |
Not Specified |
Stage: |
TS08 |
Assay Id: |
MGI:1930524 |
Age: |
embryonic day 6.5 |
Image: |
1E,1F |
Note: |
Authors state that it was difficult to determine whether Fgf5 mRNA was expressed in visceral endoderm cells. |
Specimen Label: |
1E,1F |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-26 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:160397 |
|
Stage: |
TS07 |
Assay Id: |
MGI:1930524 |
Age: |
embryonic day 5.5 |
Image: |
1B,1C |
Note: |
Authors state that "in one of the embryos removed from the uterus during this period" (i.e. one less advanced in development), Fgf5 mRNA was not detectable. |
Specimen Label: |
1B,1C |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-26 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1606211 |
Pattern: |
Not Specified |
Stage: |
TS11 |
Assay Id: |
MGI:1930524 |
Age: |
embryonic day 7.5 |
Image: |
3B,3C |
Note: |
The endoderm surrounding the embryo, a mixed population of epiblast-derived and primitive endoderm-derived cells, contains levels of Fgf5 mRNA similar to those in adjacent mesoderm. |
Specimen Label: |
3B,3C |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-26 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607210 |
Pattern: |
Regionally restricted |
Stage: |
TS10 |
Assay Id: |
MGI:1930524 |
Age: |
embryonic day 7.0 |
Image: |
2C,2D |
Note: |
Fgf5 mRNA levels were relatively high throughout the streak, with differential expression along the proximodistal axis; signal intensity in the most proximal region was 2- to 3-fold lower than in the most distal region. |
Specimen Label: |
2C,2D |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-26 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1606210 |
Pattern: |
Regionally restricted |
Stage: |
TS10 |
Assay Id: |
MGI:1930524 |
Age: |
embryonic day 7.0 |
Image: |
2C,2D |
Note: |
Observed both Fgf5-expressing (likely definitive endoderm cells) and non-expressing cells in the endodermal cell layer. Distally, Fgf5 mRNA was detected a levels similar to those in adjacent embryonic ectoderm; proximally, no Fgf5 mRNA was detectable |
Specimen Label: |
2C,2D |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-26 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1606910 |
Pattern: |
Graded |
Stage: |
TS10 |
Assay Id: |
MGI:1930524 |
Age: |
embryonic day 7.0 |
Image: |
2C,2D |
Note: |
Levels of Fgf5 mRNA appeared to be relatively high throughout the embryonic ectoderm, with evidence of differential expression along the proximodistal axis; the signal intensity in the most proximal region was lower than in the most distal region. |
Specimen Label: |
2C,2D |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-26 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603911 |
|
Stage: |
TS11 |
Assay Id: |
MGI:1930524 |
Age: |
embryonic day 7.75 |
Image: |
3D,3E |
Note: |
Fgf5 mRNA was not detected in embryos at this stage (E7.75), as determined by serial section analysis through the embryo, although it was abundant in embryos from the same litter that were not as advanced in development |
Specimen Label: |
3D,3E |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
RNA in situ |
Annotation Date: |
2001-02-26 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1607110 |
Pattern: |
Regionally restricted |
Stage: |
TS10 |
Assay Id: |
MGI:1930524 |
Age: |
embryonic day 7.0 |
Image: |
2C,2D |
Note: |
Fgf5 was not detected in cells that had migrated either proximally into the extraembryonic region or proximolaterally between embryonic ectoderm and visceral endoderm. Cells exiting the streak more distally expressed Fgf5 similarly to distal ectoderm. |
Specimen Label: |
2C,2D |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pennycuik PR |
Year: |
1984 |
Journal: |
Genet Res |
Title: |
The angora locus (go) in the mouse: hair morphology, duration of growth cycle and site of action. |
Volume: |
44 |
Issue: |
3 |
Pages: |
283-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
McGeachie AB |
Year: |
2001 |
Journal: |
Neuroscience |
Title: |
Fibroblast growth factor-5 is expressed in Schwann cells and is not essential for motoneurone survival. |
Volume: |
104 |
Issue: |
3 |
Pages: |
891-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sundberg JP |
Year: |
1997 |
Journal: |
Vet Pathol |
Title: |
Angora mouse mutation: altered hair cycle, follicular dystrophy, phenotypic maintenance of skin grafts, and changes in keratin expression. |
Volume: |
34 |
Issue: |
3 |
Pages: |
171-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beutler B |
Year: |
2013 |
Journal: |
MGI Direct Data Submission |
Title: |
Direct Data Submission for splinter |
Volume: |
v |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Dickie MM |
Year: |
1963 |
Journal: |
Mouse News Lett |
Title: |
Angora |
Volume: |
29 |
|
Pages: |
39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma L |
Year: |
2003 |
Journal: |
Development |
Title: |
'Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation. |
Volume: |
130 |
Issue: |
2 |
Pages: |
379-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hébert JM |
Year: |
1990 |
Journal: |
Dev Biol |
Title: |
Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis. |
Volume: |
138 |
Issue: |
2 |
Pages: |
454-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moscoso LM |
Year: |
1998 |
Journal: |
J Neurosci |
Title: |
Organization and reorganization of neuromuscular junctions in mice lacking neural cell adhesion molecule, tenascin-C, or fibroblast growth factor-5. |
Volume: |
18 |
Issue: |
4 |
Pages: |
1465-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pelton TA |
Year: |
2002 |
Journal: |
J Cell Sci |
Title: |
Transient pluripotent cell populations during primitive ectoderm formation: correlation of in vivo and in vitro pluripotent cell development. |
Volume: |
115 |
Issue: |
Pt 2 |
Pages: |
329-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rosenquist TA |
Year: |
1996 |
Journal: |
Dev Dyn |
Title: |
Fibroblast growth factor signalling in the hair growth cycle: expression of the fibroblast growth factor receptor and ligand genes in the murine hair follicle. |
Volume: |
205 |
Issue: |
4 |
Pages: |
379-86 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Haub O |
Year: |
1990 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system. |
Volume: |
87 |
Issue: |
20 |
Pages: |
8022-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ozawa K |
Year: |
1998 |
Journal: |
J Biol Chem |
Title: |
An alternatively spliced fibroblast growth factor (FGF)-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activity. |
Volume: |
273 |
Issue: |
44 |
Pages: |
29262-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koniukhov BV |
Year: |
1990 |
Journal: |
Ontogenez |
Title: |
[An analysis of the expression of the mutant angora-Y gene in the mouse]. |
Volume: |
21 |
Issue: |
5 |
Pages: |
502-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Konyukhov BV |
Year: |
1990 |
Journal: |
Mouse Genome |
Title: |
Analysis of the angora-Y gene expression |
Volume: |
87 |
|
Pages: |
94-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hébert JM |
Year: |
1991 |
Journal: |
Development |
Title: |
mRNA localization studies suggest that murine FGF-5 plays a role in gastrulation. |
Volume: |
112 |
Issue: |
2 |
Pages: |
407-15 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2664734 |
Assay Type: |
RT-PCR |
Annotation Date: |
2003-07-08 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1922525 |
|
Stage: |
TS25 |
Assay Id: |
MGI:2664784 |
Age: |
embryonic day 17.5 |
Image: |
1 |
|
Specimen Label: |
Fgf-5 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-08-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:2670173 |
Age: |
embryonic day 10.5 |
Image: |
2 |
|
Specimen Label: |
10.5 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-08-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603919 |
|
Stage: |
TS19 |
Assay Id: |
MGI:2670173 |
Age: |
embryonic day 11.5 |
Image: |
2 |
|
Specimen Label: |
11.5 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:17266 |
Assay Type: |
Northern blot |
Annotation Date: |
2003-08-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603920 |
|
Stage: |
TS20 |
Assay Id: |
MGI:2670173 |
Age: |
embryonic day 12.5 |
Image: |
2 |
|
Specimen Label: |
12.5 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|