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Search results 1 to 100 out of 517 for Fgf6

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 6 (FGF6). This protein plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration [, , ]. It may also regulate bone metabolism, as shown by its activity on both osteoblasts and osteoclasts []. FGF6 has a high affinity for FGFR1, FGFR2 and FGFR4 [].
Publication
First Author: Armand AS
Year: 2006
Journal: Biochim Biophys Acta
Title: FGF6 in myogenesis.
Volume: 1763
Issue: 8
Pages: 773-8
Publication
First Author: Ollendorff V
Year: 1992
Journal: Biochimie
Title: Isolation and sequence of the murine Fgf6 cDNA.
Volume: 74
Issue: 11
Pages: 1035-8
Publication
First Author: Shamsi F
Year: 2020
Journal: Nat Commun
Title: FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis.
Volume: 11
Issue: 1
Pages: 1421
Publication
First Author: Armand AS
Year: 2005
Journal: J Cell Physiol
Title: FGF6 regulates muscle differentiation through a calcineurin-dependent pathway in regenerating soleus of adult mice.
Volume: 204
Issue: 1
Pages: 297-308
Publication
First Author: Pizette S
Year: 1996
Journal: Exp Cell Res
Title: FGF6 modulates the expression of fibroblast growth factor receptors and myogenic genes in muscle cells.
Volume: 224
Issue: 1
Pages: 143-51
Publication
First Author: deLapeyrière O
Year: 1993
Journal: Development
Title: Expression of the Fgf6 gene is restricted to developing skeletal muscle in the mouse embryo.
Volume: 118
Issue: 2
Pages: 601-11
GXD Expression      
Probe: MGI:6172885
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190272
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Fgf6
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6172885
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190272
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Fgf6
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6172885
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190272
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Fgf6
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6172885
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190272
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Fgf6
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:6172885
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190272
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Fgf6
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:6172885
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190272
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Fgf6
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:6172885
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190272
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Fgf6
Detected: false
Specimen Num: 7
Publication
First Author: Fiore F
Year: 1997
Journal: Int J Dev Biol
Title: Apparent normal phenotype of Fgf6-/- mice.
Volume: 41
Issue: 4
Pages: 639-42
Publication
First Author: Bosetti M
Year: 2010
Journal: J Cell Physiol
Title: Regulation of osteoblast and osteoclast functions by FGF-6.
Volume: 225
Issue: 2
Pages: 466-71
Protein
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: true
Publication
First Author: Armand AS
Year: 2004
Journal: Exp Cell Res
Title: IGF-II is up-regulated and myofibres are hypertrophied in regenerating soleus of mice lacking FGF6.
Volume: 297
Issue: 1
Pages: 27-38
Publication
First Author: Ornitz DM
Year: 1996
Journal: J Biol Chem
Title: Receptor specificity of the fibroblast growth factor family.
Volume: 271
Issue: 25
Pages: 15292-7
Publication  
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
Publication
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
Publication
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
Publication
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
Publication
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
Publication
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
Publication
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
Publication
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
Publication
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
Publication
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
Publication
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
Publication
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
Publication
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
Publication
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
Publication
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
Publication
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
Publication
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
Allele
Name: fibroblast growth factor 6; targeted mutation 1, Frederic Fiore
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
GXD Expression
Probe: MGI:9260
Assay Type: RNA in situ
Annotation Date: 2001-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1774322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:2149384
Age: embryonic day 14.5
Image: 5C, 5E
Note: Present in developing skeletal muscle. Expression in most muscles is more intense at the periphery of the muscle. Fgf6 is present in lesser amounts than Fgfr4.
Specimen Label: 5C, 5E
Detected: true
Specimen Num: 25
GXD Expression
Probe: MGI:9260
Assay Type: RNA in situ
Annotation Date: 2001-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1774322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:2149384
Age: embryonic day 14.5
Image: 5A
Note: Present in developing skeletal muscle, including those in the neck and the intercostal muscles. Expression in most muscles is more intense at the periphery of the muscle. Fgf6 is present in lesser amounts than Fgfr4.
Specimen Label: 5A
Detected: true
Specimen Num: 24
GXD Expression
Probe: MGI:9260
Assay Type: RNA in situ
Annotation Date: 2001-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1788322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:2149384
Age: embryonic day 14.5
Image: 6A, 6B
Note: Expression is present in the skeletal muscle of the tongue but absent from the superficial muscle layer and the fibers surrounding the tongue. Fgf6 is present in lesser amounts than Fgfr4.
Specimen Label: 6A, 6B
Detected: true
Specimen Num: 26
Publication
First Author: Coulier F
Year: 1994
Journal: Prog Growth Factor Res
Title: The human and mouse fibroblast growth factor 6 (FGF6) genes and their products: possible implication in muscle development.
Volume: 5
Issue: 1
Pages: 1-14
Publication
First Author: Han A
Year: 2014
Journal: Mol Cell Biol
Title: ALK5-mediated transforming growth factor β signaling in neural crest cells controls craniofacial muscle development via tissue-tissue interactions.
Volume: 34
Issue: 16
Pages: 3120-31
Publication
First Author: Neuhaus P
Year: 2003
Journal: Mol Cell Biol
Title: Reduced mobility of fibroblast growth factor (FGF)-deficient myoblasts might contribute to dystrophic changes in the musculature of FGF2/FGF6/mdx triple-mutant mice.
Volume: 23
Issue: 17
Pages: 6037-48
Publication
First Author: Grifone R
Year: 2005
Journal: Development
Title: Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo.
Volume: 132
Issue: 9
Pages: 2235-49
Publication
First Author: Han D
Year: 2012
Journal: Development
Title: A TGFβ-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development.
Volume: 139
Issue: 9
Pages: 1640-50
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Marics I
Year: 1989
Journal: Oncogene
Title: Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family.
Volume: 4
Issue: 3
Pages: 335-40
GXD Expression      
Probe: MGI:1328980
Assay Type: RT-PCR
Annotation Date: 1999-02-10
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:1329286
Age: embryonic day 14.5
Specimen Label: Fgf6-/-
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:1328980
Assay Type: RT-PCR
Annotation Date: 1999-02-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:1329286
Age: embryonic day 14.5
Specimen Label: Fgf6+/-
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:1328980
Assay Type: RT-PCR
Annotation Date: 1999-02-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:1329286
Age: embryonic day 14.5
Specimen Label: Fgf6+/+
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2178574
Assay Type: RT-PCR
Annotation Date: 2002-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185716
Stage: TS16
Assay Id: MGI:2178587
Age: embryonic day 10.0
Image: 3
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2178574
Assay Type: RT-PCR
Annotation Date: 2002-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185716
Stage: TS16
Assay Id: MGI:2178587
Age: embryonic day 10.0
Image: 3
Specimen Label: +/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2178574
Assay Type: RT-PCR
Annotation Date: 2002-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185716
Stage: TS16
Assay Id: MGI:2178587
Age: embryonic day 10.0
Image: 3
Specimen Label: -/-
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2178574
Assay Type: RT-PCR
Annotation Date: 2002-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185718
Stage: TS18
Assay Id: MGI:2178587
Age: embryonic day 11.0
Image: 3
Specimen Label: +/+
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2178574
Assay Type: RT-PCR
Annotation Date: 2002-05-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185718
Stage: TS18
Assay Id: MGI:2178587
Age: embryonic day 11.0
Image: 3
Specimen Label: -/-
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:2664736
Assay Type: RT-PCR
Annotation Date: 2003-07-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1922525
Stage: TS25
Assay Id: MGI:2664785
Age: embryonic day 17.5
Image: 1
Specimen Label: Fgf-6
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:2674910
Assay Type: RT-PCR
Annotation Date: 2003-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2674934
Age: embryonic day 17.5
Image: 1
Specimen Label: E17.5 wild-type
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2674910
Assay Type: RT-PCR
Annotation Date: 2003-09-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2674934
Age: embryonic day 17.5
Image: 1
Specimen Label: E17.5 FGF-Mut
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:2674910
Assay Type: RT-PCR
Annotation Date: 2003-09-25
Strength: Absent
Sex: Male
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2674935
Age: postnatal week 10-12
Image: 2
Specimen Label: normal, 1 cycle
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:2674910
Assay Type: RT-PCR
Annotation Date: 2003-09-25
Strength: Absent
Sex: Male
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2674935
Age: postnatal week 10-12
Image: 2
Specimen Label: normal, 15 cycles
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:2674910
Assay Type: RT-PCR
Annotation Date: 2003-09-25
Strength: Absent
Sex: Male
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2674935
Age: postnatal week 10-12
Image: 2
Specimen Label: normal, 20 cycles
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:2674910
Assay Type: RT-PCR
Annotation Date: 2003-09-25
Strength: Present
Sex: Male
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2674935
Age: postnatal week 10-12
Image: 2
Specimen Label: normal, 24 cycles
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3778414
Assay Type: RT-PCR
Annotation Date: 2008-04-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718523
Stage: TS23
Assay Id: MGI:3778500
Age: embryonic day 15.5
Image: 2
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3778414
Assay Type: RT-PCR
Annotation Date: 2008-04-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718523
Stage: TS23
Assay Id: MGI:3778500
Age: embryonic day 15.5
Image: 2
Specimen Label: None
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2664736
Assay Type: RT-PCR
Annotation Date: 2013-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691620
Stage: TS20
Assay Id: MGI:5461913
Age: embryonic day 12.0
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2664736
Assay Type: RT-PCR
Annotation Date: 2013-02-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691622
Stage: TS22
Assay Id: MGI:5461913
Age: embryonic day 14.0
Specimen Label: None
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:2664736
Assay Type: RT-PCR
Annotation Date: 2013-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691624
Stage: TS24
Assay Id: MGI:5461913
Age: embryonic day 16.0
Specimen Label: None
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2664736
Assay Type: RT-PCR
Annotation Date: 2013-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691627
Stage: TS27
Assay Id: MGI:5461913
Age: postnatal day 1
Specimen Label: None
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:2664736
Assay Type: RT-PCR
Annotation Date: 2013-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691627
Stage: TS27
Assay Id: MGI:5461913
Age: postnatal day 3
Specimen Label: None
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2664736
Assay Type: RT-PCR
Annotation Date: 2013-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691628
Stage: TS28
Assay Id: MGI:5461913
Age: postnatal day 5
Specimen Label: None
Detected: true
Specimen Num: 6
GXD Expression        
Probe: MGI:2664736
Assay Type: RT-PCR
Annotation Date: 2013-02-05
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:5461913
Age: postnatal adult
Specimen Label: None
Specimen Num: 7