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Search results 1 to 100 out of 1005 for Fgf7

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Type Details Score
Gene
2252 | FGF7
Type: gene
Organism: human
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Gene
744975 | FGF7
Type: gene
Organism: chimpanzee
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Gene
616885 | FGF7
Type: gene
Organism: cattle
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Gene
415439 | FGF7
Type: gene
Organism: chicken
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Gene
493181 | fgf7
Type: gene
Organism: zebrafish
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Gene
574345 | FGF7
Type: gene
Organism: macaque, rhesus
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Gene
496833 | fgf7
Type: gene
Organism: frog, western clawed
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Gene
29348 | Fgf7
Type: gene
Organism: rat
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Gene
403915 | FGF7
Type: gene
Organism: dog, domestic
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Protein Domain
IPR028247 | FGF7
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 7 (FGF7), also known as keratinocyte growth factor (KGF). This protein plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. It is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes, but not in fibroblasts and endothelial cells []. Studies of mouse and rat have implicated FGF7 in morphogenesis of epithelium, wound repair, hair development and early lung organogenesis [, , , ]. FGF7 has a high affinity for FGFR2 and has also been shown to interact with various collagens []and heparan sulfate proteoglycan 2 (perlecan) [].
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Protein Coding Gene
MGI:95521 | Fgf7
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
2915979 | J:29167
First Author: Rubin JS
Year: 1989
Journal: Proc Natl Acad Sci U S A
Title: Purification and characterization of a newly identified growth factor specific for epithelial cells.
Volume: 86
Issue: 3
Pages: 802-6
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Publication
9740653 | J:50000
First Author: Park WY
Year: 1998
Journal: Dev Biol
Title: FGF-10 is a chemotactic factor for distal epithelial buds during lung development.
Volume: 201
Issue: 2
Pages: 125-34
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Publication
15806171 | J:100761
First Author: Beer HD
Year: 2005
Journal: Oncogene
Title: The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.
Volume: 24
Issue: 34
Pages: 5269-77
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Publication
24227310 | J:207758
First Author: Kera H
Year: 2014
Journal: Dev Dyn
Title: FGF7 signals are relayed to autocrine EGF family growth factors to induce branching morphogenesis of mouse salivary epithelium.
Volume: 243
Issue: 4
Pages: 552-9
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Publication
15201220 | J:91010
First Author: Chi L
Year: 2004
Journal: Development
Title: Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development.
Volume: 131
Issue: 14
Pages: 3345-56
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Publication
23322300 | J:193313
First Author: Takase HM
Year: 2013
Journal: Genes Dev
Title: FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration.
Volume: 27
Issue: 2
Pages: 169-81
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Publication
7749227 | J:23585
First Author: Mattei MG
Year: 1995
Journal: Mamm Genome
Title: Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively.
Volume: 6
Issue: 3
Pages: 196-7
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Publication
24051090 | J:211425
First Author: Ishino R
Year: 2013
Journal: Biochem Biophys Res Commun
Title: FGF7 supports hematopoietic stem and progenitor cells and niche-dependent myeloblastoma cells via autocrine action on bone marrow stromal cells in vitro.
Volume: 440
Issue: 1
Pages: 125-31
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Publication
10541313 | -
First Author: Graeff RW
Year: 1999
Journal: Pediatr Res
Title: KGF and FGF-10 stimulate liquid secretion in human fetal lung.
Volume: 46
Issue: 5
Pages: 523-9
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Publication
17292422 | -
First Author: Pereira CT
Year: 2007
Journal: J Surg Res
Title: Liposomal gene transfer of keratinocyte growth factor improves wound healing by altering growth factor and collagen expression.
Volume: 139
Issue: 2
Pages: 222-8
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Publication
11973338 | -
First Author: Ruehl M
Year: 2002
Journal: J Biol Chem
Title: The epithelial mitogen keratinocyte growth factor binds to collagens via the consensus sequence glycine-proline-hydroxyproline.
Volume: 277
Issue: 30
Pages: 26872-8
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Publication
10702276 | -
First Author: Mongiat M
Year: 2000
Journal: J Biol Chem
Title: The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7.
Volume: 275
Issue: 10
Pages: 7095-100
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GXD Expression
GXD Expression
     
Probe: MGI:6172887
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190273
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Fgf7
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6172887
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190273
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Fgf7
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6172887
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190273
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Fgf7
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6172887
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190273
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Fgf7
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6172887
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190273
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Fgf7
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6172887
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190273
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Fgf7
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6172887
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190273
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Fgf7
Detected: true
Specimen Num: 7
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Protein
P36363
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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Protein
Q544I6
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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Protein
Q8C386
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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Publication
2549857 | -
 
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
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Publication
7583099 | -
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
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Publication
3072709 | -
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
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Publication
11276432 | J:67832
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
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Publication
10830168 | -
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
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Publication
8652550 | -
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
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Publication
1705486 | -
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
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Publication
8760337 | -
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
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Publication
23000357 | -
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
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Publication
15689573 | -
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
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Publication
10441498 | J:56785
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
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Publication
23108135 | -
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
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Publication
23016864 | -
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
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Publication
1649700 | -
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
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Publication
11746231 | -
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
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Publication
14745970 | -
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
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Publication
8978613 | -
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
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Publication
7681397 | J:65032
First Author: Guo L
Year: 1993
Journal: EMBO J
Title: Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice.
Volume: 12
Issue: 3
Pages: 973-86
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Publication
12492503 | J:80821
First Author: Foster BA
Year: 2002
Journal: Differentiation
Title: Enforced expression of FGF-7 promotes epithelial hyperplasia whereas a dominant negative FGFR2iiib promotes the emergence of neuroendocrine phenotype in prostate glands of transgenic mice.
Volume: 70
Issue: 9-10
Pages: 624-32
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Publication
22889808 | J:203684
First Author: Lee CH
Year: 2012
Journal: Mol Cell Neurosci
Title: Neurogenesis is enhanced and mossy fiber sprouting arises in FGF7-deficient mice during development.
Volume: 51
Issue: 3-4
Pages: 61-7
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Publication
35806092 | J:326546
 
First Author: Takaya K
Year: 2022
Journal: Int J Mol Sci
Title: Fibroblast Growth Factor 7 Suppresses Fibrosis and Promotes Epithelialization during Wound Healing in Mouse Fetuses.
Volume: 23
Issue: 13
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Publication
15260994 | J:91948
First Author: Umemori H
Year: 2004
Journal: Cell
Title: FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain.
Volume: 118
Issue: 2
Pages: 257-70
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Publication
25738454 | J:220706
First Author: Koehler JA
Year: 2015
Journal: Cell Metab
Title: GLP-1R agonists promote normal and neoplastic intestinal growth through mechanisms requiring Fgf7.
Volume: 21
Issue: 3
Pages: 379-91
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Publication
9332392 | J:42985
First Author: Tagashira S
Year: 1997
Journal: Gene
Title: Cloning of mouse FGF10 and up-regulation of its gene expression during wound healing.
Volume: 197
Issue: 1-2
Pages: 399-404
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Publication
11489975 | J:70820
First Author: Revest JM
Year: 2001
Journal: J Immunol
Title: Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb.
Volume: 167
Issue: 4
Pages: 1954-61
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Publication
20505669 | J:161954
First Author: Terauchi A
Year: 2010
Journal: Nature
Title: Distinct FGFs promote differentiation of excitatory and inhibitory synapses.
Volume: 465
Issue: 7299
Pages: 783-7
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Publication
12878679 | J:84706
First Author: Assimacopoulos S
Year: 2003
Journal: J Neurosci
Title: Identification of a Pax6-dependent epidermal growth factor family signaling source at the lateral edge of the embryonic cerebral cortex.
Volume: 23
Issue: 16
Pages: 6399-403
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Publication
25329657 | J:278474
First Author: Zhu XJ
Year: 2014
Journal: PLoS Genet
Title: BMP-FGF signaling axis mediates Wnt-induced epidermal stratification in developing mammalian skin.
Volume: 10
Issue: 10
Pages: e1004687
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Publication
37838739 | J:341713
First Author: Aure MH
Year: 2023
Journal: Nat Commun
Title: FGFR2 is essential for salivary gland duct homeostasis and MAPK-dependent seromucous acinar cell differentiation.
Volume: 14
Issue: 1
Pages: 6485
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Publication
17394208 | J:120879
First Author: Metzger DE
Year: 2007
Journal: Dev Dyn
Title: Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung.
Volume: 236
Issue: 5
Pages: 1175-92
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Publication
19934017 | J:155096
First Author: Han J
Year: 2009
Journal: Development
Title: Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice.
Volume: 136
Issue: 24
Pages: 4225-33
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Publication
27590203 | J:237227
First Author: May AJ
Year: 2016
Journal: Dev Biol
Title: FGF and EDA pathways control initiation and branching of distinct subsets of developing nasal glands.
Volume: 419
Issue: 2
Pages: 348-356
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Publication
9428423 | J:44839
First Author: Bellusci S
Year: 1997
Journal: Development
Title: Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung.
Volume: 124
Issue: 23
Pages: 4867-78
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Publication
18559345 | J:140258
First Author: Yamamoto S
Year: 2008
Journal: J Biol Chem
Title: Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression.
Volume: 283
Issue: 34
Pages: 23139-49
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Publication
11493558 | J:69847
First Author: Mahlapuu M
Year: 2001
Journal: Development
Title: Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations.
Volume: 128
Issue: 12
Pages: 2397-406
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Publication
35614226 | J:330284
First Author: Nusser A
Year: 2022
Journal: Nature
Title: Developmental dynamics of two bipotent thymic epithelial progenitor types.
Volume: 606
Issue: 7912
Pages: 165-171
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Publication
16151852 | J:102993
First Author: Nie X
Year: 2005
Journal: Anat Embryol (Berl)
Title: Apoptosis, proliferation and gene expression patterns in mouse developing tongue.
Volume: 210
Issue: 2
Pages: 125-32
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Publication
26934381 | J:231594
First Author: Kumar M
Year: 2016
Journal: Dev Biol
Title: Epithelial Wnt/βcatenin signalling is essential for epididymal coiling.
Volume: 412
Issue: 2
Pages: 234-49
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Publication
12421715 | J:79832
First Author: Hoffman MP
Year: 2002
Journal: Development
Title: Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms.
Volume: 129
Issue: 24
Pages: 5767-78
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Publication
9006067 | J:38383
First Author: Bellusci S
Year: 1997
Journal: Development
Title: Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis.
Volume: 124
Issue: 1
Pages: 53-63
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Publication
8901049 | J:32251
First Author: Rosenquist TA
Year: 1996
Journal: Dev Dyn
Title: Fibroblast growth factor signalling in the hair growth cycle: expression of the fibroblast growth factor receptor and ligand genes in the murine hair follicle.
Volume: 205
Issue: 4
Pages: 379-86
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Protein Coding Gene
MGP_CAROLIEiJ_G0024235 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026437 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026400 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026376 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026412 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026156 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_95521 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0026858 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025617 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026136 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026270 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026234 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026375 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026254 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0026913 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025353 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025691 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025681 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025155 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10766812 | J:61736
First Author: Tichelaar JW
Year: 2000
Journal: J Biol Chem
Title: Conditional expression of fibroblast growth factor-7 in the developing and mature lung.
Volume: 275
Issue: 16
Pages: 11858-64
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Publication
15592472 | J:94872
First Author: Sharp LL
Year: 2005
Journal: Nat Immunol
Title: Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1.
Volume: 6
Issue: 1
Pages: 73-9
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Publication
15034027 | J:88716
First Author: Yang H
Year: 2004
Journal: J Immunol
Title: Intestinal intraepithelial lymphocyte gamma delta-T cell-derived keratinocyte growth factor modulates epithelial growth in the mouse.
Volume: 172
Issue: 7
Pages: 4151-8
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Publication
12376619 | J:125077
First Author: Chen Y
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Protection of the intestinal mucosa by intraepithelial gamma delta T cells.
Volume: 99
Issue: 22
Pages: 14338-43
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Publication
16304055 | J:129368
First Author: Alpdogan O
Year: 2006
Journal: Blood
Title: Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration.
Volume: 107
Issue: 6
Pages: 2453-60
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Publication
26919897 | J:234370
First Author: Gardner JC
Year: 2016
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Keratinocyte growth factor supports pulmonary innate immune defense through maintenance of alveolar antimicrobial protein levels and macrophage function.
Volume: 310
Issue: 9
Pages: L868-79
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Publication
9876183 | J:53739
First Author: Qiao J
Year: 1999
Journal: Development
Title: FGF-7 modulates ureteric bud growth and nephron number in the developing kidney.
Volume: 126
Issue: 3
Pages: 547-54
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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