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Search results 1 to 100 out of 1036 for Fgf7

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Hits by Strain

Type Details Score
Gene
2252 | FGF7
Type: gene
Organism: human
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Gene
496833 | fgf7
Type: gene
Organism: frog, western clawed
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Gene
29348 | Fgf7
Type: gene
Organism: rat
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Gene
403915 | FGF7
Type: gene
Organism: dog, domestic
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Gene
744975 | FGF7
Type: gene
Organism: chimpanzee
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Gene
616885 | FGF7
Type: gene
Organism: cattle
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Gene
415439 | FGF7
Type: gene
Organism: chicken
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Gene
493181 | fgf7
Type: gene
Organism: zebrafish
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Gene
574345 | FGF7
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR028247 | FGF7
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 7 (FGF7), also known as keratinocyte growth factor (KGF). This protein plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. It is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes, but not in fibroblasts and endothelial cells []. Studies of mouse and rat have implicated FGF7 in morphogenesis of epithelium, wound repair, hair development and early lung organogenesis [, , , ]. FGF7 has a high affinity for FGFR2 and has also been shown to interact with various collagens []and heparan sulfate proteoglycan 2 (perlecan) [].
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Protein Coding Gene
MGI:95521 | Fgf7
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
2915979 | J:29167
First Author: Rubin JS
Year: 1989
Journal: Proc Natl Acad Sci U S A
Title: Purification and characterization of a newly identified growth factor specific for epithelial cells.
Volume: 86
Issue: 3
Pages: 802-6
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Publication
9740653 | J:50000
First Author: Park WY
Year: 1998
Journal: Dev Biol
Title: FGF-10 is a chemotactic factor for distal epithelial buds during lung development.
Volume: 201
Issue: 2
Pages: 125-34
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Publication
15806171 | J:100761
First Author: Beer HD
Year: 2005
Journal: Oncogene
Title: The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.
Volume: 24
Issue: 34
Pages: 5269-77
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Publication
24227310 | J:207758
First Author: Kera H
Year: 2014
Journal: Dev Dyn
Title: FGF7 signals are relayed to autocrine EGF family growth factors to induce branching morphogenesis of mouse salivary epithelium.
Volume: 243
Issue: 4
Pages: 552-9
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Publication
15201220 | J:91010
First Author: Chi L
Year: 2004
Journal: Development
Title: Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development.
Volume: 131
Issue: 14
Pages: 3345-56
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Publication
23322300 | J:193313
First Author: Takase HM
Year: 2013
Journal: Genes Dev
Title: FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration.
Volume: 27
Issue: 2
Pages: 169-81
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Publication
7749227 | J:23585
First Author: Mattei MG
Year: 1995
Journal: Mamm Genome
Title: Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively.
Volume: 6
Issue: 3
Pages: 196-7
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Publication
24051090 | J:211425
First Author: Ishino R
Year: 2013
Journal: Biochem Biophys Res Commun
Title: FGF7 supports hematopoietic stem and progenitor cells and niche-dependent myeloblastoma cells via autocrine action on bone marrow stromal cells in vitro.
Volume: 440
Issue: 1
Pages: 125-31
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Publication
10541313 | -
First Author: Graeff RW
Year: 1999
Journal: Pediatr Res
Title: KGF and FGF-10 stimulate liquid secretion in human fetal lung.
Volume: 46
Issue: 5
Pages: 523-9
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Publication
17292422 | -
First Author: Pereira CT
Year: 2007
Journal: J Surg Res
Title: Liposomal gene transfer of keratinocyte growth factor improves wound healing by altering growth factor and collagen expression.
Volume: 139
Issue: 2
Pages: 222-8
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Publication
11973338 | -
First Author: Ruehl M
Year: 2002
Journal: J Biol Chem
Title: The epithelial mitogen keratinocyte growth factor binds to collagens via the consensus sequence glycine-proline-hydroxyproline.
Volume: 277
Issue: 30
Pages: 26872-8
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Publication
10702276 | -
First Author: Mongiat M
Year: 2000
Journal: J Biol Chem
Title: The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7.
Volume: 275
Issue: 10
Pages: 7095-100
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GXD Expression
GXD Expression
     
Probe: MGI:6172887
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190273
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Fgf7
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6172887
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190273
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Fgf7
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6172887
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190273
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Fgf7
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6172887
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190273
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Fgf7
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6172887
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190273
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Fgf7
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6172887
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190273
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Fgf7
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6172887
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190273
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Fgf7
Detected: true
Specimen Num: 7
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Protein
P36363
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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Protein
Q544I6
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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Protein
Q8C386
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: false
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Publication
2549857 | -
 
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
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Publication
7583099 | -
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
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Publication
3072709 | -
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
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Publication
11276432 | J:67832
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
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Publication
10830168 | -
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
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Publication
8652550 | -
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
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Publication
1705486 | -
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
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Publication
8760337 | -
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
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Publication
23000357 | -
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
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Publication
15689573 | -
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
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Publication
10441498 | J:56785
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
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Publication
23108135 | -
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
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Publication
23016864 | -
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
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Publication
1649700 | -
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
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Publication
11746231 | -
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
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Publication
14745970 | -
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
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Publication
8978613 | -
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
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Publication
7681397 | J:65032
First Author: Guo L
Year: 1993
Journal: EMBO J
Title: Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice.
Volume: 12
Issue: 3
Pages: 973-86
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Publication
12492503 | J:80821
First Author: Foster BA
Year: 2002
Journal: Differentiation
Title: Enforced expression of FGF-7 promotes epithelial hyperplasia whereas a dominant negative FGFR2iiib promotes the emergence of neuroendocrine phenotype in prostate glands of transgenic mice.
Volume: 70
Issue: 9-10
Pages: 624-32
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Publication
22889808 | J:203684
First Author: Lee CH
Year: 2012
Journal: Mol Cell Neurosci
Title: Neurogenesis is enhanced and mossy fiber sprouting arises in FGF7-deficient mice during development.
Volume: 51
Issue: 3-4
Pages: 61-7
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Publication
35806092 | J:326546
 
First Author: Takaya K
Year: 2022
Journal: Int J Mol Sci
Title: Fibroblast Growth Factor 7 Suppresses Fibrosis and Promotes Epithelialization during Wound Healing in Mouse Fetuses.
Volume: 23
Issue: 13
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Publication
15260994 | J:91948
First Author: Umemori H
Year: 2004
Journal: Cell
Title: FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain.
Volume: 118
Issue: 2
Pages: 257-70
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Publication
25738454 | J:220706
First Author: Koehler JA
Year: 2015
Journal: Cell Metab
Title: GLP-1R agonists promote normal and neoplastic intestinal growth through mechanisms requiring Fgf7.
Volume: 21
Issue: 3
Pages: 379-91
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Publication
9332392 | J:42985
First Author: Tagashira S
Year: 1997
Journal: Gene
Title: Cloning of mouse FGF10 and up-regulation of its gene expression during wound healing.
Volume: 197
Issue: 1-2
Pages: 399-404
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Publication
11489975 | J:70820
First Author: Revest JM
Year: 2001
Journal: J Immunol
Title: Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb.
Volume: 167
Issue: 4
Pages: 1954-61
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Publication
20505669 | J:161954
First Author: Terauchi A
Year: 2010
Journal: Nature
Title: Distinct FGFs promote differentiation of excitatory and inhibitory synapses.
Volume: 465
Issue: 7299
Pages: 783-7
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Publication
12878679 | J:84706
First Author: Assimacopoulos S
Year: 2003
Journal: J Neurosci
Title: Identification of a Pax6-dependent epidermal growth factor family signaling source at the lateral edge of the embryonic cerebral cortex.
Volume: 23
Issue: 16
Pages: 6399-403
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Publication
37838739 | J:341713
First Author: Aure MH
Year: 2023
Journal: Nat Commun
Title: FGFR2 is essential for salivary gland duct homeostasis and MAPK-dependent seromucous acinar cell differentiation.
Volume: 14
Issue: 1
Pages: 6485
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Publication
25329657 | J:278474
First Author: Zhu XJ
Year: 2014
Journal: PLoS Genet
Title: BMP-FGF signaling axis mediates Wnt-induced epidermal stratification in developing mammalian skin.
Volume: 10
Issue: 10
Pages: e1004687
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Publication
17394208 | J:120879
First Author: Metzger DE
Year: 2007
Journal: Dev Dyn
Title: Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung.
Volume: 236
Issue: 5
Pages: 1175-92
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Publication
27590203 | J:237227
First Author: May AJ
Year: 2016
Journal: Dev Biol
Title: FGF and EDA pathways control initiation and branching of distinct subsets of developing nasal glands.
Volume: 419
Issue: 2
Pages: 348-356
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Publication
9428423 | J:44839
First Author: Bellusci S
Year: 1997
Journal: Development
Title: Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung.
Volume: 124
Issue: 23
Pages: 4867-78
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Publication
18559345 | J:140258
First Author: Yamamoto S
Year: 2008
Journal: J Biol Chem
Title: Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression.
Volume: 283
Issue: 34
Pages: 23139-49
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Publication
11493558 | J:69847
First Author: Mahlapuu M
Year: 2001
Journal: Development
Title: Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations.
Volume: 128
Issue: 12
Pages: 2397-406
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Publication
35614226 | J:330284
First Author: Nusser A
Year: 2022
Journal: Nature
Title: Developmental dynamics of two bipotent thymic epithelial progenitor types.
Volume: 606
Issue: 7912
Pages: 165-171
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Publication
19934017 | J:155096
First Author: Han J
Year: 2009
Journal: Development
Title: Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice.
Volume: 136
Issue: 24
Pages: 4225-33
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Publication
16151852 | J:102993
First Author: Nie X
Year: 2005
Journal: Anat Embryol (Berl)
Title: Apoptosis, proliferation and gene expression patterns in mouse developing tongue.
Volume: 210
Issue: 2
Pages: 125-32
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Publication
12421715 | J:79832
First Author: Hoffman MP
Year: 2002
Journal: Development
Title: Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms.
Volume: 129
Issue: 24
Pages: 5767-78
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Publication
26934381 | J:231594
First Author: Kumar M
Year: 2016
Journal: Dev Biol
Title: Epithelial Wnt/βcatenin signalling is essential for epididymal coiling.
Volume: 412
Issue: 2
Pages: 234-49
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Publication
9006067 | J:38383
First Author: Bellusci S
Year: 1997
Journal: Development
Title: Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis.
Volume: 124
Issue: 1
Pages: 53-63
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Publication
8901049 | J:32251
First Author: Rosenquist TA
Year: 1996
Journal: Dev Dyn
Title: Fibroblast growth factor signalling in the hair growth cycle: expression of the fibroblast growth factor receptor and ligand genes in the murine hair follicle.
Volume: 205
Issue: 4
Pages: 379-86
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Protein Coding Gene
MGP_CAROLIEiJ_G0024235 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026437 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026400 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026376 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026412 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026156 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_95521 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0026858 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025617 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026136 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026270 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026234 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026375 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026254 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0026913 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025353 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025691 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025681 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025155 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
12376619 | J:125077
First Author: Chen Y
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Protection of the intestinal mucosa by intraepithelial gamma delta T cells.
Volume: 99
Issue: 22
Pages: 14338-43
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Publication
15592472 | J:94872
First Author: Sharp LL
Year: 2005
Journal: Nat Immunol
Title: Dendritic epidermal T cells regulate skin homeostasis through local production of insulin-like growth factor 1.
Volume: 6
Issue: 1
Pages: 73-9
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Publication
15034027 | J:88716
First Author: Yang H
Year: 2004
Journal: J Immunol
Title: Intestinal intraepithelial lymphocyte gamma delta-T cell-derived keratinocyte growth factor modulates epithelial growth in the mouse.
Volume: 172
Issue: 7
Pages: 4151-8
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First Author: Gardner JC
Year: 2016
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Keratinocyte growth factor supports pulmonary innate immune defense through maintenance of alveolar antimicrobial protein levels and macrophage function.
Volume: 310
Issue: 9
Pages: L868-79
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16304055 | J:129368
First Author: Alpdogan O
Year: 2006
Journal: Blood
Title: Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration.
Volume: 107
Issue: 6
Pages: 2453-60
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9876183 | J:53739
First Author: Qiao J
Year: 1999
Journal: Development
Title: FGF-7 modulates ureteric bud growth and nephron number in the developing kidney.
Volume: 126
Issue: 3
Pages: 547-54
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First Author: Tichelaar JW
Year: 2000
Journal: J Biol Chem
Title: Conditional expression of fibroblast growth factor-7 in the developing and mature lung.
Volume: 275
Issue: 16
Pages: 11858-64
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