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Search results 1 to 100 out of 4187 for Fgf8

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Type Details Score
Gene
2253 | FGF8
Type: gene
Organism: human
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Gene
326284 | FGF8
Type: gene
Organism: cattle
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Gene
101056934 | FGF8
Type: gene
Organism: chimpanzee
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Gene
396313 | FGF8
Type: gene
Organism: chicken
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Gene
722394 | FGF8
Type: gene
Organism: macaque, rhesus
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Gene
493525 | fgf8
Type: gene
Organism: frog, western clawed
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Gene
29349 | Fgf8
Type: gene
Organism: rat
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Gene
403868 | FGF8
Type: gene
Organism: dog, domestic
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Protein Domain
IPR028249 | FGF8
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 8 (FGF8), also known as androgen-induced growth factor. It plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. FGF8 is also required for normal brain, eye, ear and limb development during embryogenesis, and is required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system [, , , , ]. Fibroblast growth factor 8 also supports androgen and anchorage independent growth of mammary tumor cells []. FGF8 has an affinity for the all the growth factor receptors, but has the highest affinity with FGFR3 and FGFR4 [, ].This entry also includes the orthologous Fibroblast growth factor 8b from zebrafish.
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Protein Coding Gene
MGI:99604 | Fgf8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
9332670 | J:43312
First Author: Yoshiura K
Year: 1997
Journal: Am J Med Genet
Title: Genomic structure, sequence, and mapping of human FGF8 with no evidence for its role in craniosynostosis/limb defect syndromes.
Volume: 72
Issue: 3
Pages: 354-62
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Gene
109136576 | LOC109136576
Type: gene
Organism: human
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Publication
7768185 | J:23136
First Author: Crossley PH
Year: 1995
Journal: Development
Title: The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo.
Volume: 121
Issue: 2
Pages: 439-51
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Protein
G3DRA7
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: true
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GXD Expression
GXD Expression
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3606474
Age: embryonic day 10.5
Image: 3G, FGF8
Note: Expression is at the midbrain/hindbrain junction.
Specimen Label: 3G, FGF8
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3606474
Age: embryonic day 10.5
Image: 3H, FGF8
Note: Expression is at the midbrain/hindbrain junction.
Specimen Label: 3H, FGF8
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614814
Pattern: Regionally restricted
Stage: TS14
Assay Id: MGI:3606474
Age: embryonic day 8.5
Image: 2E, FGF8
Note: Expression is at the midbrain/hindbrain junction.
Specimen Label: 2E, FGF8
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614815
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:3606474
Age: embryonic day 9.5
Image: 2F, FGF8
Note: Expression is at the midbrain/hindbrain junction.
Specimen Label: 2F, FGF8
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697417
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3606474
Age: embryonic day 10.5
Image: 3G, FGF8
Note: Expression is at the midbrain/hindbrain junction.
Specimen Label: 3G, FGF8
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697417
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3606474
Age: embryonic day 10.5
Image: 3H, FGF8
Note: Expression is at the midbrain/hindbrain junction.
Specimen Label: 3H, FGF8
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1677817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3606474
Age: embryonic day 10.5
Image: 3G, FGF8
Specimen Label: 3G, FGF8
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:3606474
Age: embryonic day 9.5
Image: 2F, FGF8
Specimen Label: 2F, FGF8
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3606474
Age: embryonic day 10.5
Image: 3G, FGF8
Specimen Label: 3G, FGF8
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614014
Pattern: Regionally restricted
Stage: TS14
Assay Id: MGI:3606474
Age: embryonic day 8.5
Image: 2E, FGF8
Note: Expression is at the midbrain/hindbrain junction.
Specimen Label: 2E, FGF8
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614015
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:3606474
Age: embryonic day 9.5
Image: 2F, FGF8
Note: Expression is at the midbrain/hindbrain junction.
Specimen Label: 2F, FGF8
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689217
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3606474
Age: embryonic day 10.5
Image: 3G, FGF8
Specimen Label: 3G, FGF8
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1651214
Pattern: Regionally restricted
Stage: TS14
Assay Id: MGI:3606474
Age: embryonic day 8.5
Image: 2E, FGF8
Note: Expression is in the anterior forebrain.
Specimen Label: 2E, FGF8
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1658014
Pattern: Not Specified
Stage: TS14
Assay Id: MGI:3606474
Age: embryonic day 8.5
Image: 2E, FGF8
Specimen Label: 2E, FGF8
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1334951
Assay Type: RNA in situ
Annotation Date: 2018-03-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1724719
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6147812
Age: embryonic day 11.5
Image: 4A Fgf8
Specimen Label: 4A Fgf8
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1334951
Assay Type: RNA in situ
Annotation Date: 2018-03-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1724719
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6147812
Age: embryonic day 11.5
Image: 4B Fgf8
Specimen Label: 4B Fgf8
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609511
Pattern: Not Specified
Stage: TS11
Assay Id: MGI:3606474
Age: embryonic day 7.5
Image: 1C, FGF8
Specimen Label: 1C, FGF8
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270815
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:3606474
Age: embryonic day 9.5
Image: 2F, FGF8
Note: Expression is in the apical ectodermal ridge.
Specimen Label: 2F, FGF8
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611714
Pattern: Not Specified
Stage: TS14
Assay Id: MGI:3606474
Age: embryonic day 8.5
Image: 2E, FGF8
Specimen Label: 2E, FGF8
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3606474
Age: embryonic day 10.5
Image: 3G, FGF8
Specimen Label: 3G, FGF8
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:2683010
Assay Type: RNA in situ
Annotation Date: 2005-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1618415
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:3606474
Age: embryonic day 9.5
Image: 2F, FGF8
Note: Expression is in the posterior somites.
Specimen Label: 2F, FGF8
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:6116412
Assay Type: RNA in situ
Annotation Date: 2018-02-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6116448
Age: embryonic day 11.5
Image: 5 baI:in vivo Fgf8
Specimen Label: 5 baI:in vivo Fgf8
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6377687
Assay Type: RNA in situ
Annotation Date: 2019-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1760617
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6378162
Age: embryonic day 10.5
Image: 3C Fgf8 WT
Specimen Label: 3C Fgf8 WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6377687
Assay Type: RNA in situ
Annotation Date: 2019-11-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1760617
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6378162
Age: embryonic day 10.5
Image: 3C Fgf8 Six1-/-
Note: Expression pattern similar to wild type.
Specimen Label: 3C Fgf8 Six1-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:1334951
Assay Type: RNA in situ
Annotation Date: 1999-12-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614816
Pattern: Regionally restricted
Stage: TS16
Assay Id: MGI:1349189
Age: embryonic day 9.5
Image: 6K Fgf8 wild type
Note: Expression is in an anterior band. These results are shown schematically in Fig. 8.
Specimen Label: 6K Fgf8 wild type
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:1334951
Assay Type: RNA in situ
Annotation Date: 1999-12-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614812
Pattern: Not Specified
Stage: TS12
Assay Id: MGI:1349191
Age: embryonic day 8.0
Image: 7D Fgf8 wild type
Note: The rostral limit of expression marks the midbrain/hindbrain junction.
Specimen Label: 7D Fgf8 wild type
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6116412
Assay Type: RNA in situ
Annotation Date: 2018-02-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1668119
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6116448
Age: embryonic day 11.5
Image: 5 fnm:in vivo Fgf8
Specimen Label: 5 fnm:in vivo Fgf8
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7492075
Assay Type: RNA in situ
Annotation Date: 2023-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7492124
Age: embryonic day 10.5
Image: S2 FGF8 +/+
Specimen Label: S2 FGF8 +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7492075
Assay Type: RNA in situ
Annotation Date: 2023-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7492124
Age: embryonic day 10.5
Image: S2 FGF8 -/-
Note: Authors report non-aberrant expression pattern.
Specimen Label: S2 FGF8 -/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3769893
Assay Type: RNA in situ
Annotation Date: 2008-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1677817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3769895
Age: embryonic day 10.5
Image: 3 Fgf8 first
Specimen Label: 3 Fgf8 first
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:3769893
Assay Type: RNA in situ
Annotation Date: 2008-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1677817
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3769895
Age: embryonic day 10.5
Image: 3 Fgf8 second
Note: Partial loss of expression in the AER.
Specimen Label: 3 Fgf8 second
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:3769893
Assay Type: RNA in situ
Annotation Date: 2008-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1677817
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:3769895
Age: embryonic day 10.5
Image: 3 Fgf8 third
Note: Partial loss of expression in the AER.
Specimen Label: 3 Fgf8 third
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3769893
Assay Type: RNA in situ
Annotation Date: 2008-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1677817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3769895
Age: embryonic day 10.5
Image: 3 Fgf8 fourth
Specimen Label: 3 Fgf8 fourth
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:6479761
Assay Type: RNA in situ
Annotation Date: 2020-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3285715
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6479821
Age: embryonic day 9.5
Image: 2b Fgf8 +/OG
Specimen Label: 2b Fgf8 +/OG
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6479761
Assay Type: RNA in situ
Annotation Date: 2020-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3285715
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6479821
Age: embryonic day 9.5
Image: 2b Fgf8 OG/OG weak
Note: No obvious alteration in expression pattern compared to heterozygote
Specimen Label: 2b Fgf8 OG/OG weak
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6479761
Assay Type: RNA in situ
Annotation Date: 2020-12-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3285715
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:6479821
Age: embryonic day 9.5
Image: 2b Fgf8 OG/OG strong
Note: No obvious alteration in expression pattern compared to heterozygote
Specimen Label: 2b Fgf8 OG/OG strong
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:6116412
Assay Type: RNA in situ
Annotation Date: 2018-02-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6116448
Age: embryonic day 11.5
Image: 5 flb:in vivo Fgf8
Specimen Label: 5 flb:in vivo Fgf8
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:1334951
Assay Type: RNA in situ
Annotation Date: 1999-12-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691016
Pattern: Regionally restricted
Stage: TS16
Assay Id: MGI:1349189
Age: embryonic day 9.5
Image: 6K Fgf8 wild type
Note: These results are shown schematically in Fig. 8.
Specimen Label: 6K Fgf8 wild type
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1334951
Assay Type: RNA in situ
Annotation Date: 1999-12-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3596112
Pattern: Not Specified
Stage: TS12
Assay Id: MGI:1349191
Age: embryonic day 8.0
Image: 7D Fgf8 wild type
Specimen Label: 7D Fgf8 wild type
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:1334951
Assay Type: RNA in situ
Annotation Date: 1999-12-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614412
Pattern: Regionally restricted
Stage: TS12
Assay Id: MGI:1349191
Age: embryonic day 8.0
Image: 7D Fgf8 wild type
Note: Expression is in the anterior neural ridge.
Specimen Label: 7D Fgf8 wild type
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2014-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5532320
Age: embryonic day 8.5
Image: 4D Fgf8
Specimen Label: 4D Fgf8
Detected: true
Specimen Num: 2
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Publication
15483110 | J:132550
First Author: Huffman KJ
Year: 2004
Journal: J Neurosci
Title: Fgf8 regulates the development of intra-neocortical projections.
Volume: 24
Issue: 41
Pages: 8917-23
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Publication
7687739 | -
First Author: Yan G
Year: 1993
Journal: Mol Cell Biol
Title: Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy.
Volume: 13
Issue: 8
Pages: 4513-22
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Publication
22273727 | -
First Author: Liu SB
Year: 2012
Journal: Toxicology
Title: The role of androgen-induced growth factor (FGF8) on genital tubercle development in a hypospadiac male rat model of prenatal exposure to di-n-butyl phthalate.
Volume: 293
Issue: 1-3
Pages: 53-8
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Publication
11420691 | -
First Author: Mattila MM
Year: 2001
Journal: Oncogene
Title: FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells.
Volume: 20
Issue: 22
Pages: 2791-804
•
•
•
•
•
Publication
16613831 | J:108506
First Author: Storm EE
Year: 2006
Journal: Development
Title: Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers.
Volume: 133
Issue: 9
Pages: 1831-44
•
•
•
•
•
Publication
37287454 | J:336422
 
First Author: Zbasnik N
Year: 2023
Journal: Front Cell Dev Biol
Title: Fgf8 regulates first pharyngeal arch segmentation through pouch-cleft interactions.
Volume: 11
Pages: 1186526
•
•
•
•
•
Protein
Q60757
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: true
•
•
•
•
•
Publication
16720880 | J:109474
First Author: Ilagan R
Year: 2006
Journal: Development
Title: Fgf8 is required for anterior heart field development.
Volume: 133
Issue: 12
Pages: 2435-45
•
•
•
•
•
Protein
P37237
Organism: Mus musculus/domesticus
Length: 268  
Fragment?: false
•
•
•
•
•
Protein
Q80ZL6
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: false
•
•
•
•
•
Protein
Q3V279
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
•
•
•
•
•
Protein
D3Z208
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: false
•
•
•
•
•
Protein
D3Z207
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
•
•
•
•
•
Protein
A0A7U3JW74
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: false
•
•
•
•
•
Publication
18625063 | J:160580
 
First Author: Borello U
Year: 2008
Journal: Neural Dev
Title: FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development.
Volume: 3
Pages: 17
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5316405
Assay Type: RNA in situ
Annotation Date: 2012-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277615
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5316464
Age: embryonic day 9.5
Note: Expression was detected in the whole apical ectodermal ridge (AER) region.
Specimen Label: 5B Fgf8
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5316405
Assay Type: RNA in situ
Annotation Date: 2012-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3277615
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5316464
Age: embryonic day 9.5
Note: Expression was detected in the whole apical ectodermal ridge (AER) region.
Specimen Label: 5C Fgf8
Detected: true
Specimen Num: 2
•
•
•
•
•
Publication
8663044 | -
First Author: Ornitz DM
Year: 1996
Journal: J Biol Chem
Title: Receptor specificity of the fibroblast growth factor family.
Volume: 271
Issue: 25
Pages: 15292-7
•
•
•
•
•
Publication
16597617 | J:153201
First Author: Zhang X
Year: 2006
Journal: J Biol Chem
Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
Volume: 281
Issue: 23
Pages: 15694-700
•
•
•
•
•
Publication
2549857 | -
 
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
•
•
•
•
•
Publication
7583099 | -
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
•
•
•
•
•
Publication
3072709 | -
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
•
•
•
•
•
Publication
11276432 | J:67832
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
•
•
•
•
•
Publication
10830168 | -
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
•
•
•
•
•
Publication
8652550 | -
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
•
•
•
•
•
Publication
1705486 | -
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
•
•
•
•
•
Publication
8760337 | -
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
•
•
•
•
•
Publication
23000357 | -
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
•
•
•
•
•
Publication
15689573 | -
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
•
•
•
•
•
Publication
10441498 | J:56785
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
•
•
•
•
•
Publication
23108135 | -
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
•
•
•
•
•
Publication
23016864 | -
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
•
•
•
•
•
Publication
1649700 | -
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
•
•
•
•
•
Publication
11746231 | -
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
•
•
•
•
•
Publication
14745970 | -
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
•
•
•
•
•
Publication
8978613 | -
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
•
•
•
•
•
Publication
9462741 | J:45909
First Author: Meyers EN
Year: 1998
Journal: Nat Genet
Title: An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination.
Volume: 18
Issue: 2
Pages: 136-41
•
•
•
•
•
Publication
35618654 | J:330234
First Author: Zbasnik N
Year: 2022
Journal: Dev Dyn
Title: Fgf8 dosage regulates jaw shape and symmetry through pharyngeal-cardiac tissue relationships.
Volume: 251
Issue: 10
Pages: 1711-1727
•
•
•
•
•
Publication
12223417 | J:78687
First Author: Abu-Issa R
Year: 2002
Journal: Development
Title: Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse.
Volume: 129
Issue: 19
Pages: 4613-25
•
•
•
•
•
Publication
21266408 | J:170125
First Author: Sunmonu NA
Year: 2011
Journal: Development
Title: Gbx2 and Fgf8 are sequentially required for formation of the midbrain-hindbrain compartment boundary.
Volume: 138
Issue: 4
Pages: 725-34
•
•
•
•
•
Publication
11101845 | J:66265
First Author: Moon AM
Year: 2000
Journal: Nat Genet
Title: Fgf8 is required for outgrowth and patterning of the limbs.
Volume: 26
Issue: 4
Pages: 455-9
•
•
•
•
•
Publication
16397882 | J:105771
First Author: Beermann F
Year: 2006
Journal: Genesis
Title: Identification of evolutionarily conserved regulatory elements in the mouse Fgf8 locus.
Volume: 44
Issue: 1
Pages: 1-6
•
•
•
•
•
Publication
18942154 | J:140707
First Author: Theil T
Year: 2008
Journal: Dev Dyn
Title: Differential requirements for Fgf3 and Fgf8 during mouse forebrain development.
Volume: 237
Issue: 11
Pages: 3417-23
•
•
•
•
•
Publication
12223415 | J:78685
First Author: Frank DU
Year: 2002
Journal: Development
Title: An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome.
Volume: 129
Issue: 19
Pages: 4591-603
•
•
•
•
•
Publication
15741321 | J:96329
First Author: Ladher RK
Year: 2005
Journal: Genes Dev
Title: FGF8 initiates inner ear induction in chick and mouse.
Volume: 19
Issue: 5
Pages: 603-13
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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