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Search results 1 to 100 out of 1166 for Fgf9

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Type Details Score
Gene
2254 | FGF9
Type: gene
Organism: human
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Gene
613731 | FGF9
Type: gene
Organism: cattle
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Gene
378917 | FGF9
Type: gene
Organism: chicken
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Gene
721324 | FGF9
Type: gene
Organism: macaque, rhesus
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Gene
101883614 | fgf9
Type: gene
Organism: zebrafish
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Gene
100217327 | fgf9
Type: gene
Organism: frog, western clawed
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Gene
25444 | Fgf9
Type: gene
Organism: rat
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Gene
477340 | FGF9
Type: gene
Organism: dog, domestic
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Gene
744731 | FGF9
Type: gene
Organism: chimpanzee
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Protein Domain
IPR028251 | FGF9
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].This entry represents fibroblast growth factor 9 (FGF9), also known as glia-activating factor and heparin-binding growth factor 9. This protein plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. It is involved in cyclic proliferation of uterine endometrial stroma []and can act as both a paracrine mitogen for epithelial cells and an autocrine mitogen for stromal cells []. FGF9 has also been shown to play a vital role in male development, as it is needed to carry out important masculinising developmental functions, such testicular embryogenesis [, ]. FGF9 Interacts with FGFR1, FGFR2, FGFR3 and FGFR4, but has highest affinity for FGFR3 [, ].
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Protein Coding Gene
MGI:104723 | Fgf9
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
16700629 | J:110252
First Author: Kim Y
Year: 2006
Journal: PLoS Biol
Title: Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination.
Volume: 4
Issue: 6
Pages: e187
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Publication
11290325 | J:68379
First Author: Colvin JS
Year: 2001
Journal: Cell
Title: Male-to-female sex reversal in mice lacking fibroblast growth factor 9.
Volume: 104
Issue: 6
Pages: 875-89
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Publication
8576175 | J:30894
First Author: Santos-Ocampo S
Year: 1996
Journal: J Biol Chem
Title: Expression and biological activity of mouse fibroblast growth factor-9.
Volume: 271
Issue: 3
Pages: 1726-31
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GXD Expression
GXD Expression
   
Probe: MGI:7580939
Assay Type: RNA in situ
Annotation Date: 2024-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287826
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:7580946
Age: embryonic day 18.5
Specimen Label: S1B Fgf9
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7580939
Assay Type: RNA in situ
Annotation Date: 2024-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289026
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:7580946
Age: embryonic day 18.5
Specimen Label: S1A Fgf9
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7580939
Assay Type: RNA in situ
Annotation Date: 2024-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3808526
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:7580946
Age: embryonic day 18.5
Specimen Label: S1A Fgf9
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7580939
Assay Type: RNA in situ
Annotation Date: 2024-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3808526
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:7580946
Age: embryonic day 18.5
Specimen Label: S1B Fgf9
Detected: true
Specimen Num: 2
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Publication
10362017 | -
First Author: Giri D
Year: 1999
Journal: J Cell Physiol
Title: FGF9 is an autocrine and paracrine prostatic growth factor expressed by prostatic stromal cells.
Volume: 180
Issue: 1
Pages: 53-60
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Publication
28189801 | J:254809
 
First Author: Wang L
Year: 2017
Journal: Bone
Title: Osteoblast-derived FGF9 regulates skeletal homeostasis.
Volume: 98
Pages: 18-25
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Publication
16496342 | J:106766
First Author: Lin Y
Year: 2006
Journal: Genesis
Title: Generation of an Fgf9 conditional null allele.
Volume: 44
Issue: 3
Pages: 150-4
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GXD Expression
GXD Expression
   
Probe: MGI:5817384
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610525
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5817414
Age: embryonic day 17.5
Specimen Label: 4C FGF9 WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5817384
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1610525
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5817414
Age: embryonic day 17.5
Note: Authors report decreased expression.
Specimen Label: 4C FGF9 HEXIM1 1-312
Detected: true
Specimen Num: 2
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Publication
28848153 | J:320246
First Author: Šućurović S
Year: 2017
Journal: Cell Physiol Biochem
Title: Spatial and Temporal Analyses of FGF9 Expression During Early Pregnancy.
Volume: 42
Issue: 6
Pages: 2318-2329
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Publication
33608505 | J:314447
First Author: Guo M
Year: 2021
Journal: Cell Death Dis
Title: Deletion of FGF9 in GABAergic neurons causes epilepsy.
Volume: 12
Issue: 2
Pages: 196
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Publication
18653563 | J:139005
First Author: Geske MJ
Year: 2008
Journal: Development
Title: Fgf9 signaling regulates small intestinal elongation and mesenchymal development.
Volume: 135
Issue: 17
Pages: 2959-68
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Publication
32184391 | J:286400
First Author: Shamsi F
Year: 2020
Journal: Nat Commun
Title: FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis.
Volume: 11
Issue: 1
Pages: 1421
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Publication
16540514 | J:107426
First Author: DiNapoli L
Year: 2006
Journal: Development
Title: FGF9 promotes survival of germ cells in the fetal testis.
Volume: 133
Issue: 8
Pages: 1519-27
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Publication
19219044 | J:146802
First Author: Harada M
Year: 2009
Journal: Nat Genet
Title: FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion.
Volume: 41
Issue: 3
Pages: 289-98
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Publication
15328018 | J:93155
First Author: Pirvola U
Year: 2004
Journal: Dev Biol
Title: Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions.
Volume: 273
Issue: 2
Pages: 350-60
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Publication
16504022 | J:107239
 
First Author: Govindarajan V
Year: 2006
Journal: BMC Dev Biol
Title: FGF9 can induce endochondral ossification in cranial mesenchyme.
Volume: 6
Pages: 7
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Publication
36734881 | J:341338
First Author: Ganji E
Year: 2023
Journal: FASEB J
Title: Targeted deletion of Fgf9 in tendon disrupts mineralization of the developing enthesis.
Volume: 37
Issue: 3
Pages: e22777
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Publication
28695538 | J:252502
     
First Author: Garrett L
Year: 2017
Journal: Mol Neurobiol
Title: Fgf9 Y162C Mutation Alters Information Processing and Social Memory in Mice.
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Publication
16540513 | J:107406
First Author: White AC
Year: 2006
Journal: Development
Title: FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains.
Volume: 133
Issue: 8
Pages: 1507-17
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Publication
32127497 | J:292476
 
First Author: Yin Y
Year: 2020
Journal: Sci Signal
Title: FGF9 and FGF10 activate distinct signaling pathways to direct lung epithelial specification and branching.
Volume: 13
Issue: 621
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Publication
23727932 | J:199838
First Author: Gay D
Year: 2013
Journal: Nat Med
Title: Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding.
Volume: 19
Issue: 7
Pages: 916-23
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Publication
37096042 | J:336513
First Author: Patzek S
Year: 2023
Journal: iScience
Title: Loss of Fgf9 in mice leads to pancreatic hypoplasia and asplenia.
Volume: 26
Issue: 4
Pages: 106500
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Publication
20833365 | J:164280
First Author: Bowles J
Year: 2010
Journal: Dev Cell
Title: FGF9 suppresses meiosis and promotes male germ cell fate in mice.
Volume: 19
Issue: 3
Pages: 440-9
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Publication
36358989 | J:331418
 
First Author: Sun Y
Year: 2022
Journal: Biomolecules
Title: FGF9 Promotes Expression of HAS2 in Palatal Elevation via the Wnt/β-Catenin/TCF7L2 Pathway.
Volume: 12
Issue: 11
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Publication
12072406 | -
First Author: Tsai SJ
Year: 2002
Journal: Endocrinology
Title: Fibroblast growth factor-9 is an endometrial stromal growth factor.
Volume: 143
Issue: 7
Pages: 2715-21
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Publication
26157349 | J:309134
First Author: Huang Y
Year: 2015
Journal: Int J Biol Sci
Title: Overexpression of FGF9 in prostate epithelial cells augments reactive stroma formation and promotes prostate cancer progression.
Volume: 11
Issue: 8
Pages: 948-60
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Publication
21750028 | J:175543
First Author: Yin Y
Year: 2011
Journal: Development
Title: Mesothelial- and epithelial-derived FGF9 have distinct functions in the regulation of lung development.
Volume: 138
Issue: 15
Pages: 3169-77
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Publication
15229180 | J:92065
First Author: Schmahl J
Year: 2004
Journal: Development
Title: Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination.
Volume: 131
Issue: 15
Pages: 3627-36
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Publication
26634297 | J:228317
 
First Author: Muthukrishnan SD
Year: 2015
Journal: Nat Commun
Title: Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells.
Volume: 6
Pages: 10027
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Publication
22698282 | J:185582
First Author: Barak H
Year: 2012
Journal: Dev Cell
Title: FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.
Volume: 22
Issue: 6
Pages: 1191-207
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Publication
10574949 | -
First Author: Chellaiah A
Year: 1999
Journal: J Biol Chem
Title: Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity.
Volume: 274
Issue: 49
Pages: 34785-94
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Publication
9250873 | J:42167
First Author: Mattei MG
Year: 1997
Journal: Mamm Genome
Title: Mouse fgf9 (fibroblast growth factor 9) is localized on chromosome 14.
Volume: 8
Issue: 8
Pages: 617-8
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Publication
17544391 | J:122952
First Author: Hung IH
Year: 2007
Journal: Dev Biol
Title: FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod.
Volume: 307
Issue: 2
Pages: 300-13
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Publication
16494859 | J:108388
First Author: del Moral PM
Year: 2006
Journal: Dev Biol
Title: Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung.
Volume: 293
Issue: 1
Pages: 77-89
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Publication
17881491 | J:128368
First Author: White AC
Year: 2007
Journal: Development
Title: FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network.
Volume: 134
Issue: 20
Pages: 3743-52
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Protein
P54130
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Protein
E9Q2N2
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: false
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Protein
Q3TPG0
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
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Protein
Q3TYJ7
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
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Protein
E1APJ6
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Protein
E9Q864
Organism: Mus musculus/domesticus
Length: 30  
Fragment?: true
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Protein
A0A7U3L5J2
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Publication
32452519 | J:293772
First Author: Bird AD
Year: 2020
Journal: Hum Mol Genet
Title: Ovotesticular disorders of sex development in FGF9 mouse models of human synostosis syndromes.
Volume: 29
Issue: 13
Pages: 2148-2161
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Publication
28169396 | J:241783
First Author: Tang L
Year: 2017
Journal: Hum Mol Genet
Title: A point mutation in Fgf9 impedes joint interzone formation leading to multiple synostoses syndrome.
Volume: 26
Issue: 7
Pages: 1280-1293
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Publication
20934536 | J:168653
First Author: Sylvestersen KB
Year: 2011
Journal: Gene Expr Patterns
Title: Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme.
Volume: 11
Issue: 1-2
Pages: 105-11
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Publication
35753346 | J:327362
First Author: Brandebura AN
Year: 2022
Journal: J Biol Chem
Title: Transcriptional profiling reveals roles of intercellular Fgf9 signaling in astrocyte maturation and synaptic refinement during brainstem development.
Volume: 298
Issue: 8
Pages: 102176
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Publication
20159962 | J:158581
First Author: Barrios F
Year: 2010
Journal: J Cell Sci
Title: Opposing effects of retinoic acid and FGF9 on Nanos2 expression and meiotic entry of mouse germ cells.
Volume: 123
Issue: Pt 6
Pages: 871-80
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Publication
19232523 | J:148042
First Author: Lin Y
Year: 2009
Journal: Dev Biol
Title: Neuron-derived FGF9 is essential for scaffold formation of Bergmann radial fibers and migration of granule neurons in the cerebellum.
Volume: 329
Issue: 1
Pages: 44-54
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Publication
2549857 | -
 
First Author: Burgess WH
Year: 1989
Journal: Annu Rev Biochem
Title: The heparin-binding (fibroblast) growth factor family of proteins.
Volume: 58
Pages: 575-606
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Publication
7583099 | -
First Author: Wilkie AO
Year: 1995
Journal: Curr Biol
Title: Functions of fibroblast growth factors and their receptors.
Volume: 5
Issue: 5
Pages: 500-7
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Publication
3072709 | -
First Author: Thomas KA
Year: 1988
Journal: Trends Biochem Sci
Title: Transforming potential of fibroblast growth factor genes.
Volume: 13
Issue: 9
Pages: 327-8
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Publication
11276432 | J:67832
First Author: Ornitz DM
Year: 2001
Journal: Genome Biol
Title: Fibroblast growth factors.
Volume: 2
Issue: 3
Pages: REVIEWS3005
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Publication
10830168 | -
First Author: Plotnikov AN
Year: 2000
Journal: Cell
Title: Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Volume: 101
Issue: 4
Pages: 413-24
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Publication
8652550 | -
First Author: Blaber M
Year: 1996
Journal: Biochemistry
Title: X-ray crystal structure of human acidic fibroblast growth factor.
Volume: 35
Issue: 7
Pages: 2086-94
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Publication
1705486 | -
First Author: Vlodavsky I
Year: 1990
Journal: Cancer Metastasis Rev
Title: Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis.
Volume: 9
Issue: 3
Pages: 203-26
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Publication
8760337 | -
First Author: Green PJ
Year: 1996
Journal: Bioessays
Title: Promiscuity of fibroblast growth factor receptors.
Volume: 18
Issue: 8
Pages: 639-46
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Publication
23000357 | -
First Author: Yardley N
Year: 2012
Journal: Dev Biol
Title: FGF signaling transforms non-neural ectoderm into neural crest.
Volume: 372
Issue: 2
Pages: 166-77
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Publication
15689573 | -
First Author: Böttcher RT
Year: 2005
Journal: Endocr Rev
Title: Fibroblast growth factor signaling during early vertebrate development.
Volume: 26
Issue: 1
Pages: 63-77
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Publication
10441498 | J:56785
First Author: Koga C
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis.
Volume: 261
Issue: 3
Pages: 756-65
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Publication
23108135 | -
First Author: Nakamizo S
Year: 2013
Journal: Skin Pharmacol Physiol
Title: Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion.
Volume: 26
Issue: 1
Pages: 22-9
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Publication
23016864 | -
First Author: Kumar SB
Year: 2013
Journal: Curr Pharm Des
Title: Fibroblast growth factor receptor inhibitors.
Volume: 19
Issue: 4
Pages: 687-701
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Publication
1649700 | -
First Author: Amaya E
Year: 1991
Journal: Cell
Title: Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos.
Volume: 66
Issue: 2
Pages: 257-70
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Publication
11746231 | -
First Author: Borland CZ
Year: 2001
Journal: Bioessays
Title: Fibroblast growth factor signaling in Caenorhabditis elegans.
Volume: 23
Issue: 12
Pages: 1120-30
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Publication
14745970 | -
First Author: Coumoul X
Year: 2003
Journal: Birth Defects Res C Embryo Today
Title: Roles of FGF receptors in mammalian development and congenital diseases.
Volume: 69
Issue: 4
Pages: 286-304
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Publication
8978613 | -
First Author: Sutherland D
Year: 1996
Journal: Cell
Title: branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.
Volume: 87
Issue: 6
Pages: 1091-101
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Publication
26794256 | J:231474
First Author: Hung IH
Year: 2016
Journal: Dev Biol
Title: A combined series of Fgf9 and Fgf18 mutant alleles identifies unique and redundant roles in skeletal development.
Volume: 411
Issue: 1
Pages: 72-84
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Publication
35675358 | J:326602
First Author: Hiller BE
Year: 2022
Journal: PLoS Pathog
Title: Fibroblast growth factor-9 expression in airway epithelial cells amplifies the type I interferon response and alters influenza A virus pathogenesis.
Volume: 18
Issue: 6
Pages: e1010228
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Publication
25413587 | J:218612
First Author: Arai D
Year: 2015
Journal: J Pathol
Title: Characterization of the cell of origin and propagation potential of the fibroblast growth factor 9-induced mouse model of lung adenocarcinoma.
Volume: 235
Issue: 4
Pages: 593-605
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Publication
23867472 | J:204282
First Author: Yin Y
Year: 2013
Journal: Cancer Res
Title: Rapid induction of lung adenocarcinoma by fibroblast growth factor 9 signaling through FGF receptor 3.
Volume: 73
Issue: 18
Pages: 5730-41
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Publication
25978641 | J:224791
First Author: Yin Y
Year: 2015
Journal: PLoS Genet
Title: Fibroblast Growth Factor 9 Regulation by MicroRNAs Controls Lung Development and Links DICER1 Loss to the Pathogenesis of Pleuropulmonary Blastoma.
Volume: 11
Issue: 5
Pages: e1005242
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HT Experiment
GSE210645 | The role of Fgf9 in mouse pancreas development [scRNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE210574 | The role of Fgf9 in mouse pancreas development [bulk RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
7656983 | J:28377
First Author: Seo M
Year: 1995
Journal: FEBS Lett
Title: Retinoic acid induces gene expression of fibroblast growth factor-9 during induction of neuronal differentiation of mouse embryonal carcinoma P19 cells.
Volume: 370
Issue: 3
Pages: 231-5
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Publication
28395336 | J:244125
First Author: Ulu F
Year: 2017
Journal: Biol Reprod
Title: Dose-dependent functions of fibroblast growth factor 9 regulate the fate of murine XY primordial germ cells.
Volume: 96
Issue: 1
Pages: 122-133
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Publication
33959039 | J:306390
 
First Author: Li R
Year: 2021
Journal: Front Physiol
Title: The Fibroblast Growth Factor 9 (Fgf9) Participates in Palatogenesis by Promoting Palatal Growth and Elevation.
Volume: 12
Pages: 653040
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Publication
21858205 | J:176356
First Author: Puk O
Year: 2011
Journal: PLoS One
Title: The pathologic effect of a novel neomorphic Fgf9(Y162C) allele is restricted to decreased vision and retarded lens growth.
Volume: 6
Issue: 8
Pages: e23678
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Publication
21262993 | J:181449
First Author: Korf-Klingebiel M
Year: 2011
Journal: Circulation
Title: Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction.
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First Author: Colvin JS
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Title: Skeletal dysplasia and defective chondrocyte differentiation by targeted overexpression of fibroblast growth factor 9 in transgenic mice.
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Journal: Stem Cells
Title: Core binding factor beta functions in the maintenance of stem cells and orchestrates continuous proliferation and differentiation in mouse incisors.
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Title: FGF9-Pitx2-FGF10 signaling controls cecal formation in mice.
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Title: Developmentally regulated expression of MSX1, MSX2 and Fgfs in the developing mouse cranial base.
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