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Search results 1 to 100 out of 502 for Fhl1

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0.026s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Protein Domain
Type: Family
Description: Four and a half LIM domains protein 1 (FHL1) play an essential role in skeletal muscle growth and differentiation, acts as a scaffolding protein in sarcomere assembly and is a regulator of skeletal muscle mass and energy metabolism []. It has been shown to bind to Myosin-binding protein C, regulating myosin filament formation and sarcomere assembly []. Mutations of the FHL1 gene cause skeletal and heart muscle myopathy [, ]. It contains an N-terminal zinc finger/half LIM domain, followed by 4 complete LIM domains.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression
Probe: MGI:5000849
Assay Type: RNA in situ
Annotation Date: 2013-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2778223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5448257
Age: embryonic day 15.5
Image: 5A Fhl1
Note: Expression was detected in part of the distal convoluted tubule.
Specimen Label: 5A Fhl1
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5000849
Assay Type: RNA in situ
Annotation Date: 2013-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2801123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5448257
Age: embryonic day 15.5
Image: 5A Fhl1
Specimen Label: 5A Fhl1
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:5000849
Assay Type: RNA in situ
Annotation Date: 2013-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2840723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5448257
Age: embryonic day 15.5
Image: 5A Fhl1
Note: Expression was detected in the collecting duct tip.
Specimen Label: 5A Fhl1
Detected: true
Specimen Num: 1
Gene
Type: gene
Organism: human
Publication
First Author: Cowling BS
Year: 2008
Journal: J Cell Biol
Title: Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy.
Volume: 183
Issue: 6
Pages: 1033-48
Publication
First Author: Wilding BR
Year: 2014
Journal: J Cell Sci
Title: FHL1 mutants that cause clinically distinct human myopathies form protein aggregates and impair myoblast differentiation.
Volume: 127
Issue: Pt 10
Pages: 2269-81
Publication
First Author: Keßler M
Year: 2018
Journal: Neuromuscul Disord
Title: A zebrafish model for FHL1-opathy reveals loss-of-function effects of human FHL1 mutations.
Volume: 28
Issue: 6
Pages: 521-531
GXD Expression    
Probe: MGI:3708471
Assay Type: RT-PCR
Annotation Date: 2007-05-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716824
Stage: TS24
Assay Id: MGI:3708876
Age: embryonic day 16.5
Image: S3 Fhl1
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3708471
Assay Type: RT-PCR
Annotation Date: 2007-05-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:3708876
Age: postnatal day 4
Image: S3 Fhl1
Specimen Label: 4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3708471
Assay Type: RT-PCR
Annotation Date: 2007-05-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:3708876
Age: postnatal month 1
Image: S3 Fhl1
Specimen Label: 7
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3708471
Assay Type: RT-PCR
Annotation Date: 2007-05-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716826
Stage: TS26
Assay Id: MGI:3708876
Age: embryonic day 18.5
Image: S3 Fhl1
Specimen Label: 2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3708471
Assay Type: RT-PCR
Annotation Date: 2007-05-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716827
Stage: TS27
Assay Id: MGI:3708876
Age: postnatal day 1
Image: S3 Fhl1
Specimen Label: 3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3708471
Assay Type: RT-PCR
Annotation Date: 2007-05-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:3708876
Age: postnatal day 7
Image: S3 Fhl1
Specimen Label: 5
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3708471
Assay Type: RT-PCR
Annotation Date: 2007-05-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:3708876
Age: postnatal day 15
Image: S3 Fhl1
Specimen Label: 6
Detected: true
Specimen Num: 6
Publication
First Author: Ding J
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Muscle death participates in myofibrillar abnormalities in FHL1 knockout mice.
Volume: 523
Issue: 1
Pages: 105-111
Publication
First Author: Meertens L
Year: 2019
Journal: Nature
Title: FHL1 is a major host factor for chikungunya virus infection.
Volume: 574
Issue: 7777
Pages: 259-263
Publication
First Author: Kubota A
Year: 2019
Journal: Hum Mol Genet
Title: Cardiomyopathy and altered integrin-actin signaling in Fhl1 mutant female mice.
Volume: 28
Issue: 2
Pages: 209-219
Publication
First Author: Christodoulou DC
Year: 2014
Journal: J Clin Invest
Title: 5'RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy.
Volume: 124
Issue: 3
Pages: 1364-70
Publication
First Author: Emmanuele V
Year: 2015
Journal: Hum Mol Genet
Title: Fhl1 W122S causes loss of protein function and late-onset mild myopathy.
Volume: 24
Issue: 3
Pages: 714-26
Publication
First Author: Morgan MJ
Year: 1999
Journal: Biochem Biophys Res Commun
Title: The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle.
Volume: 255
Issue: 2
Pages: 245-50
Publication
First Author: Krempler A
Year: 2000
Journal: Cytogenet Cell Genet
Title: Isolation and characterization of a new FHL1 variant (FHL1C) from porcine skeletal muscle.
Volume: 90
Issue: 1-2
Pages: 106-14
Publication
First Author: Friedrich FW
Year: 2012
Journal: Hum Mol Genet
Title: Evidence for FHL1 as a novel disease gene for isolated hypertrophic cardiomyopathy.
Volume: 21
Issue: 14
Pages: 3237-54
Publication
First Author: Domenighetti AA
Year: 2014
Journal: Hum Mol Genet
Title: Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice.
Volume: 23
Issue: 1
Pages: 209-25
Publication
First Author: Schessl J
Year: 2011
Journal: Semin Pediatr Neurol
Title: Reducing body myopathy and other FHL1-related muscular disorders.
Volume: 18
Issue: 4
Pages: 257-63
Publication
First Author: McGrath MJ
Year: 2006
Journal: J Biol Chem
Title: Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly.
Volume: 281
Issue: 11
Pages: 7666-83
Protein
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
Publication
First Author: Sheikh F
Year: 2008
Journal: J Clin Invest
Title: An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice.
Volume: 118
Issue: 12
Pages: 3870-80
Publication  
First Author: Xu X
Year: 2017
Journal: Nat Commun
Title: A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity.
Volume: 8
Pages: 14059
Publication
First Author: Cottle DL
Year: 2009
Journal: J Biol Chem
Title: SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis.
Volume: 284
Issue: 39
Pages: 26964-77
Publication
First Author: Chu PH
Year: 2000
Journal: Mech Dev
Title: Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular system.
Volume: 95
Issue: 1-2
Pages: 259-65
Publication
First Author: Raskin A
Year: 2012
Journal: J Biol Chem
Title: A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.
Volume: 287
Issue: 35
Pages: 29273-84
Publication
First Author: D'Arcy CE
Year: 2014
Journal: Hum Mol Genet
Title: Identification of FHL1 as a therapeutic target for Duchenne muscular dystrophy.
Volume: 23
Issue: 3
Pages: 618-36
Publication
First Author: Kudo LC
Year: 2007
Journal: Cereb Cortex
Title: Genetic analysis of anterior posterior expression gradients in the developing mammalian forebrain.
Volume: 17
Issue: 9
Pages: 2108-22
Publication
First Author: Feeney SJ
Year: 2015
Journal: PLoS One
Title: FHL1 reduces dystrophy in transgenic mice overexpressing FSHD muscular dystrophy region gene 1 (FRG1).
Volume: 10
Issue: 2
Pages: e0117665
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Veith C
Year: 2020
Journal: Basic Res Cardiol
Title: FHL-1 is not involved in pressure overload-induced maladaptive right ventricular remodeling and dysfunction.
Volume: 115
Issue: 2
Pages: 17
Publication
First Author: Qin H
Year: 2005
Journal: FEBS Lett
Title: The PcG protein HPC2 inhibits RBP-J-mediated transcription by interacting with LIM protein KyoT2.
Volume: 579
Issue: 5
Pages: 1220-6
GXD Expression    
Probe: MGI:2387047
Assay Type: Northern blot
Annotation Date: 2002-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2387376
Age: postnatal adult
Image: 2
Specimen Label: H
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2387047
Assay Type: Northern blot
Annotation Date: 2002-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2387376
Age: postnatal adult
Image: 2
Specimen Label: B
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2387047
Assay Type: Northern blot
Annotation Date: 2002-10-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2387376
Age: postnatal adult
Image: 2
Specimen Label: Sp
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:2387047
Assay Type: Northern blot
Annotation Date: 2002-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2387376
Age: postnatal adult
Image: 2
Specimen Label: Lu
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2387047
Assay Type: Northern blot
Annotation Date: 2002-10-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2387376
Age: postnatal adult
Image: 2
Specimen Label: Li
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:2387047
Assay Type: Northern blot
Annotation Date: 2002-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2387376
Age: postnatal adult
Image: 2
Specimen Label: Sk
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2387047
Assay Type: Northern blot
Annotation Date: 2002-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2387376
Age: postnatal adult
Image: 2
Specimen Label: K
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:2387047
Assay Type: Northern blot
Annotation Date: 2002-10-08
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2387376
Age: postnatal adult
Image: 2
Specimen Label: T
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:2387047
Assay Type: Northern blot
Annotation Date: 2002-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2387379
Age: postnatal month 6
Image: 7
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2387047
Assay Type: Northern blot
Annotation Date: 2002-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2387379
Age: postnatal month 6
Image: 7
Specimen Label: 2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2387047
Assay Type: Northern blot
Annotation Date: 2002-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2387379
Age: postnatal month 6
Image: 7
Specimen Label: 3 MLP-/MLP-
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2387047
Assay Type: Northern blot
Annotation Date: 2002-10-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2387379
Age: postnatal month 6
Image: 7
Specimen Label: 4 MLP-/MLP-
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3588071
Assay Type: RT-PCR
Annotation Date: 2005-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1741220
Stage: TS20
Assay Id: MGI:3588142
Age: embryonic day 12.5
Image: 3
Specimen Label: LB
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3588071
Assay Type: RT-PCR
Annotation Date: 2005-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2992728
Stage: TS28
Assay Id: MGI:3588142
Age: postnatal week 10
Image: 3
Specimen Label: C/V
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3588071
Assay Type: RT-PCR
Annotation Date: 2005-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1898628
Stage: TS28
Assay Id: MGI:3588142
Age: postnatal week 10
Image: 3
Specimen Label: C/V
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3588071
Assay Type: RT-PCR
Annotation Date: 2005-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1741220
Stage: TS20
Assay Id: MGI:3588159
Age: embryonic day 12.5
Specimen Label: Hoxa13+/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3588071
Assay Type: RT-PCR
Annotation Date: 2005-09-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1741220
Stage: TS20
Assay Id: MGI:3588159
Age: embryonic day 12.5
Specimen Label: Hoxa13-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6285852
Assay Type: RT-PCR
Annotation Date: 2019-04-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716821
Stage: TS21
Assay Id: MGI:6287379
Age: embryonic day 13.5
Image: 6
Specimen Label: +RT
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6285853
Assay Type: RT-PCR
Annotation Date: 2019-04-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716821
Stage: TS21
Assay Id: MGI:6287380
Age: embryonic day 13.5
Image: 6
Specimen Label: +RT
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6285854
Assay Type: RT-PCR
Annotation Date: 2019-04-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716821
Stage: TS21
Assay Id: MGI:6287381
Age: embryonic day 13.5
Image: 6
Specimen Label: +RT
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3724754
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3516422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421408
Age: embryonic day 14.5
Image: MH1102; Specimen C1626
Specimen Label: MH1102; Specimen C1626
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3724754
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716122
Stage: TS22
Assay Id: MGI:5421408
Age: embryonic day 14.5
Specimen Label: MH1102; Specimen C1626
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507193
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691621
Stage: TS21
Assay Id: MGI:3507539
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507193
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691627
Stage: TS27
Assay Id: MGI:3507539
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2