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Search results 1 to 100 out of 507 for Flg

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Hits by Pathway

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Type Details Score
Gene
2312 | FLG
Type: gene
Organism: human
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Gene
712658 | FLG
Type: gene
Organism: macaque, rhesus
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Gene
102157111 | FLG
Type: gene
Organism: dog, domestic
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Gene
104002779 | FLG
Type: gene
Organism: chimpanzee
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Gene
24641 | Flg
Type: gene
Organism: rat
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Protein Coding Gene
MGI:95553 | Flg
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:6456167
Assay Type: Immunohistochemistry
Annotation Date: 2020-09-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3735528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6456585
Age: postnatal adult
Image: 1K FLG
Note: Expression around the granular layer.
Specimen Label: 1K FLG
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7547116
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3278626
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7547163
Age: embryonic day 18.5
Image: 3a FLG Ctip1+/+
Specimen Label: 3a FLG Ctip1+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7547116
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3278626
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7547163
Age: embryonic day 18.5
Image: 3a FLG Ctip1-/-
Note: Distribution of expression in granular layer altered compared to that of wild type.
Specimen Label: 3a FLG Ctip1-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7484219
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752826
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:7484322
Age: embryonic day 18.5
Image: 5B Flg wt
Note: Presence of profilaggrin granules.
Specimen Label: 5B Flg wt
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7484219
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752826
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:7484322
Age: embryonic day 18.5
Image: 5B Flg A135X/A135X
Note: Absence of profilaggrin granules.
Specimen Label: 5B Flg A135X/A135X
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7484219
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752826
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:7484322
Age: embryonic day 18.5
Image: 5B Flg Klk5-/-;A135X/A135X
Note: Presence of profilaggrin granules.
Specimen Label: 5B Flg Klk5-/-;A135X/A135X
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7484219
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752826
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:7484322
Age: embryonic day 18.5
Image: 5B Flg Klk7-/-;A135X/A135X
Note: Absence of profilaggrin granules.
Specimen Label: 5B Flg Klk7-/-;A135X/A135X
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7484219
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752826
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:7484322
Age: embryonic day 18.5
Image: 5B Flg Klk5-/-;Klk7-/-;A135X/A135X
Note: Presence of profilaggrin granules.
Specimen Label: 5B Flg Klk5-/-;Klk7-/-;A135X/A135X
Detected: true
Specimen Num: 5
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Publication
19349982 | J:151110
First Author: Fallon PG
Year: 2009
Journal: Nat Genet
Title: A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming.
Volume: 41
Issue: 5
Pages: 602-8
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Publication
36496196 | J:333084
     
First Author: Gonzalez JR
Year: 2022
Journal: J Invest Dermatol
Title: FLG Deficiency in Mice Alters the Early-Life CD4(+) T-Cell Response to Skin Commensal Bacteria.
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Publication
21654840 | J:180909
First Author: Hoste E
Year: 2011
Journal: J Invest Dermatol
Title: Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin.
Volume: 131
Issue: 11
Pages: 2233-41
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Publication
24060273 | J:202316
First Author: Sasaki T
Year: 2013
Journal: J Allergy Clin Immunol
Title: A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis.
Volume: 132
Issue: 5
Pages: 1111-1120.e4
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Publication
24084074 | J:202453
First Author: Saunders SP
Year: 2013
Journal: J Allergy Clin Immunol
Title: Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.
Volume: 132
Issue: 5
Pages: 1121-9
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Publication
27510401 | J:249530
First Author: Sehra S
Year: 2016
Journal: Eur J Immunol
Title: Increased Th2 activity and diminished skin barrier function cooperate in allergic skin inflammation.
Volume: 46
Issue: 11
Pages: 2609-2613
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Publication
23792461 | J:205734
First Author: Stout TE
Year: 2014
Journal: J Invest Dermatol
Title: Recombinant filaggrin is internalized and processed to correct filaggrin deficiency.
Volume: 134
Issue: 2
Pages: 423-429
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Publication
33894197 | J:318652
First Author: Muhandes L
Year: 2021
Journal: J Invest Dermatol
Title: Low Threshold for Cutaneous Allergen Sensitization but No Spontaneous Dermatitis or Atopy in FLG-Deficient Mice.
Volume: 141
Issue: 11
Pages: 2611-2619.e2
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Publication
19733297 | J:241766
First Author: Scharschmidt TC
Year: 2009
Journal: J Allergy Clin Immunol
Title: Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens.
Volume: 124
Issue: 3
Pages: 496-506, 506.e1-6
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Publication
28963556 | J:255508
First Author: Nakai K
Year: 2017
Journal: Sci Rep
Title: IL-17A induces heterogeneous macrophages, and it does not alter the effects of lipopolysaccharides on macrophage activation in the skin of mice.
Volume: 7
Issue: 1
Pages: 12473
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Publication
24999590 | J:217942
First Author: Wong WJ
Year: 2015
Journal: J Invest Dermatol
Title: Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function.
Volume: 135
Issue: 2
Pages: 454-461
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Publication
30828807 | J:345841
First Author: Rahrig S
Year: 2019
Journal: Allergy
Title: Transient epidermal barrier deficiency and lowered allergic threshold in filaggrin-hornerin (FlgHrnr(-/-) ) double-deficient mice.
Volume: 74
Issue: 7
Pages: 1327-1339
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Publication
31401286 | J:293209
First Author: Ding X
Year: 2020
Journal: J Allergy Clin Immunol
Title: Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation.
Volume: 145
Issue: 1
Pages: 283-300.e8
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Publication
1667382 | J:1618
First Author: Orr-Urtreger A
Year: 1991
Journal: Development
Title: Developmental expression of two murine fibroblast growth factor receptors, flg and bek.
Volume: 113
Issue: 4
Pages: 1419-34
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Publication
2161096 | J:10524
First Author: Safran A
Year: 1990
Journal: Oncogene
Title: The murine flg gene encodes a receptor for fibroblast growth factor.
Volume: 5
Issue: 5
Pages: 635-43
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Protein Coding Gene
MGP_CAROLIEiJ_G0025297 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027532 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027497 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027465 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027506 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0027244 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_95553 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027949 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026692 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0027220 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027357 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027326 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027466 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027352 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028008 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026774 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026743 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026240 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11438679 | J:70416
First Author: Layne MD
Year: 2001
Journal: Mol Cell Biol
Title: Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein.
Volume: 21
Issue: 15
Pages: 5256-61
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Publication
16837463 | J:116504
First Author: Matsui T
Year: 2006
Journal: J Biol Chem
Title: Mouse homologue of skin-specific retroviral-like aspartic protease involved in wrinkle formation.
Volume: 281
Issue: 37
Pages: 27512-25
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Publication
18802465 | J:161652
First Author: Smyth I
Year: 2008
Journal: PLoS Genet
Title: A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis.
Volume: 4
Issue: 9
Pages: e1000192
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Publication
10227293 | J:54636
First Author: Mills AA
Year: 1999
Journal: Nature
Title: p63 is a p53 homologue required for limb and epidermal morphogenesis.
Volume: 398
Issue: 6729
Pages: 708-13
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Publication
10227294 | J:54637
First Author: Yang A
Year: 1999
Journal: Nature
Title: p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development.
Volume: 398
Issue: 6729
Pages: 714-8
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Publication
24075906 | J:203995
First Author: Lee S
Year: 2013
Journal: Dev Biol
Title: Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation-differentiation decision in epidermal progenitor cells.
Volume: 383
Issue: 2
Pages: 201-13
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Publication
3680218 | J:22334
First Author: Rothnagel JA
Year: 1987
Journal: J Biol Chem
Title: The gene for mouse epidermal filaggrin precursor. Its partial characterization, expression, and sequence of a repeating filaggrin unit.
Volume: 262
Issue: 32
Pages: 15643-8
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Publication
6174530 | J:6708
First Author: Holbrook KA
Year: 1982
Journal: J Cell Biol
Title: Abnormal epidermal keratinization in the repeated epilation mutant mouse.
Volume: 92
Issue: 2
Pages: 387-97
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
17041603 | J:116077
First Author: Richardson RJ
Year: 2006
Journal: Nat Genet
Title: Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch.
Volume: 38
Issue: 11
Pages: 1329-34
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Publication
21081122 | J:168020
First Author: Boglev Y
Year: 2011
Journal: Dev Biol
Title: The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity.
Volume: 349
Issue: 2
Pages: 512-22
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Publication
16949565 | J:114626
First Author: Yu Z
Year: 2006
Journal: Dev Biol
Title: The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4.
Volume: 299
Issue: 1
Pages: 122-36
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Publication
14517554 | J:86392
First Author: Wakabayashi N
Year: 2003
Journal: Nat Genet
Title: Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.
Volume: 35
Issue: 3
Pages: 238-45
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Publication
24735878 | J:213415
First Author: Lee B
Year: 2014
Journal: Dev Cell
Title: Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells.
Volume: 29
Issue: 1
Pages: 47-58
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Publication
10195895 | J:54315
First Author: Takeda K
Year: 1999
Journal: Science
Title: Limb and skin abnormalities in mice lacking IKKalpha.
Volume: 284
Issue: 5412
Pages: 313-6
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Publication
26765568 | J:229900
   
First Author: Seldin L
Year: 2016
Journal: Elife
Title: NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures.
Volume: 5
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Publication
11572870 | J:73258
First Author: Makino T
Year: 2001
Journal: J Biol Chem
Title: Hornerin, a novel profilaggrin-like protein and differentiation-specific marker isolated from mouse skin.
Volume: 276
Issue: 50
Pages: 47445-52
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Publication
19956733 | J:161749
First Author: Mill P
Year: 2009
Journal: PLoS Genet
Title: Palmitoylation regulates epidermal homeostasis and hair follicle differentiation.
Volume: 5
Issue: 11
Pages: e1000748
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Publication
7713516 | J:22331
First Author: Yamanaka S
Year: 1994
Journal: Genomics
Title: The mouse gene encoding the GM2 activator protein (Gm2a): cDNA sequence, expression, and chromosome mapping.
Volume: 24
Issue: 3
Pages: 601-4
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Publication
18369314 | J:134270
First Author: Lee JH
Year: 2008
Journal: EMBO J
Title: A crucial role of WW45 in developing epithelial tissues in the mouse.
Volume: 27
Issue: 8
Pages: 1231-42
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Publication
9888996 | J:52302
First Author: Song HJ
Year: 1999
Journal: Genomics
Title: Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues.
Volume: 55
Issue: 1
Pages: 28-42
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Publication
10662549 | J:60558
First Author: Cox PR
Year: 2000
Journal: Genomics
Title: Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs.
Volume: 63
Issue: 1
Pages: 97-107
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Publication
28589954 | J:242196
 
First Author: Xu M
Year: 2017
Journal: Nat Commun
Title: WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation.
Volume: 8
Pages: 15397
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Publication
10431239 | J:56495
First Author: Segre JA
Year: 1999
Journal: Nat Genet
Title: Klf4 is a transcription factor required for establishing the barrier function of the skin.
Volume: 22
Issue: 4
Pages: 356-60
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Publication
10441742 | J:56860
First Author: Lueders KK
Year: 1999
Journal: Mamm Genome
Title: Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes.
Volume: 10
Issue: 9
Pages: 900-5
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Publication
7959006 | J:21625
First Author: Brady JP
Year: 1994
Journal: Gene
Title: A mouse cDNA encoding a protein with zinc-fingers and a KRAB domain shows similarity to human profilaggrin.
Volume: 149
Issue: 2
Pages: 299-304
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Publication
2298727 | J:10266
First Author: Rothnagel JA
Year: 1990
Journal: J Biol Chem
Title: The structure of the gene for mouse filaggrin and a comparison of the repeating units.
Volume: 265
Issue: 4
Pages: 1862-5
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Publication
7835895 | J:20819
First Author: Rothnagel JA
Year: 1994
Journal: Genomics
Title: Characterization of the mouse loricrin gene: linkage with profilaggrin and the flaky tail and soft coat mutant loci on chromosome 3.
Volume: 23
Issue: 2
Pages: 450-6
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Publication
12230510 | J:78844
First Author: Pearton DJ
Year: 2002
Journal: J Invest Dermatol
Title: Functional analysis of the profilaggrin N-terminal peptide: identification of domains that regulate nuclear and cytoplasmic distribution.
Volume: 119
Issue: 3
Pages: 661-9
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Publication
18166659 | J:131056
First Author: Sevilla LM
Year: 2007
Journal: J Cell Biol
Title: Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier.
Volume: 179
Issue: 7
Pages: 1599-612
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Publication
19461998 | J:149319
First Author: Romano RA
Year: 2009
Journal: PLoS One
Title: An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate.
Volume: 4
Issue: 5
Pages: e5623
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Publication
15922673 | J:99529
First Author: Hwang M
Year: 2005
Journal: Gene Expr Patterns
Title: The temporal and spatial expression of the novel Ca++-binding proteins, Scarf and Scarf2, during development and epidermal differentiation.
Volume: 5
Issue: 6
Pages: 801-8
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Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
16418220 | J:105239
First Author: Den Z
Year: 2006
Journal: J Cell Sci
Title: Desmocollin 3 is required for pre-implantation development of the mouse embryo.
Volume: 119
Issue: Pt 3
Pages: 482-9
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Publication
24198274 | J:206321
First Author: Veniaminova NA
Year: 2013
Journal: Development
Title: Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration.
Volume: 140
Issue: 24
Pages: 4870-80
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Publication
32467224 | J:297718
First Author: Szigety KM
Year: 2020
Journal: Genes Dev
Title: HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity.
Volume: 34
Issue: 13-14
Pages: 973-988
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Publication
28095415 | J:238698
First Author: Kasparek P
Year: 2017
Journal: PLoS Genet
Title: KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.
Volume: 13
Issue: 1
Pages: e1006566
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Publication
22094257 | J:178952
First Author: Darido C
Year: 2011
Journal: Cancer Cell
Title: Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis.
Volume: 20
Issue: 5
Pages: 635-48
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Publication
26975724 | J:233531
First Author: Cangkrama M
Year: 2016
Journal: J Invest Dermatol
Title: Two Ancient Gene Families Are Critical for Maintenance of the Mammalian Skin Barrier in Postnatal Life.
Volume: 136
Issue: 7
Pages: 1438-1448
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Publication
26063791 | J:225600
 
First Author: Georgy SR
Year: 2015
Journal: J Natl Cancer Inst
Title: Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma.
Volume: 107
Issue: 9
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Publication
17079689 | J:114702
First Author: Blanpain C
Year: 2006
Journal: Genes Dev
Title: Canonical notch signaling functions as a commitment switch in the epidermal lineage.
Volume: 20
Issue: 21
Pages: 3022-35
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