Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
63
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1929291 |
Assay Type: |
RT-PCR |
Annotation Date: |
2001-01-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603913 |
|
Stage: |
TS13 |
Assay Id: |
MGI:1929449 |
Age: |
embryonic day 8.5 |
Image: |
6 |
|
Specimen Label: |
-/- Flt1 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1929291 |
Assay Type: |
RT-PCR |
Annotation Date: |
2001-01-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603913 |
|
Stage: |
TS13 |
Assay Id: |
MGI:1929449 |
Age: |
embryonic day 8.5 |
Image: |
6 |
|
Specimen Label: |
+/- Flt1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nesmith JE |
Year: |
2017 |
Journal: |
Development |
Title: |
Blood vessel anastomosis is spatially regulated by Flt1 during angiogenesis. |
Volume: |
144 |
Issue: |
5 |
Pages: |
889-896 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dhondt J |
Year: |
2011 |
Journal: |
FASEB J |
Title: |
Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons. |
Volume: |
25 |
Issue: |
5 |
Pages: |
1461-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kurotsu S |
Year: |
2018 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Distinct expression patterns of Flk1 and Flt1 in the coronary vascular system during development and after myocardial infarction. |
Volume: |
495 |
Issue: |
1 |
Pages: |
884-891 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jin J |
Year: |
2012 |
Journal: |
Cell |
Title: |
Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function. |
Volume: |
151 |
Issue: |
2 |
Pages: |
384-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qian BZ |
Year: |
2015 |
Journal: |
J Exp Med |
Title: |
FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis. |
Volume: |
212 |
Issue: |
9 |
Pages: |
1433-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rosnet O |
Year: |
1993 |
Journal: |
Oncogene |
Title: |
Close physical linkage of the FLT1 and FLT3 genes on chromosome 13 in man and chromosome 5 in mouse. |
Volume: |
8 |
Issue: |
1 |
Pages: |
173-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Verma M |
Year: |
2019 |
Journal: |
PLoS Genet |
Title: |
Inhibition of FLT1 ameliorates muscular dystrophy phenotype by increased vasculature in a mouse model of Duchenne muscular dystrophy. |
Volume: |
15 |
Issue: |
12 |
Pages: |
e1008468 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sano K |
Year: |
2012 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Flt1 and Flk1 mediate regulation of intraocular pressure and their double heterozygosity causes the buphthalmia in mice. |
Volume: |
420 |
Issue: |
2 |
Pages: |
422-7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172978 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190288 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Flt1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172978 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190288 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Flt1 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172978 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190288 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Flt1 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172978 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190288 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Flt1 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172978 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190288 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Flt1 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172978 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190288 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Flt1 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6172978 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190288 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Flt1 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2023-06-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3590513 |
Pattern: |
Not Specified |
Stage: |
TS13 |
Assay Id: |
MGI:7488101 |
Age: |
embryonic day 8.75 |
Image: |
7Cc |
Note: |
The Flt1 KO; Etv2 CKO embryos had an intermediate phenotype. |
Specimen Label: |
7Cc |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2023-06-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3590513 |
Pattern: |
Not Specified |
Stage: |
TS13 |
Assay Id: |
MGI:7488101 |
Age: |
embryonic day 8.75 |
Image: |
7Cf |
Note: |
The Flt1 KO; Etv2 CKO embryos had an intermediate phenotype. |
Specimen Label: |
7Cf |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
688
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Minami T |
Year: |
2002 |
Journal: |
Blood |
Title: |
Differential regulation of the von Willebrand factor and Flt-1 promoters in the endothelium of hypoxanthine phosphoribosyltransferase-targeted mice. |
Volume: |
100 |
Issue: |
12 |
Pages: |
4019-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Apicella I |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
Full Functional Knockout of Placental Growth Factor by Knockin with an Inactive Variant Able to Heterodimerize with VEGF-A. |
Volume: |
23 |
Issue: |
12 |
Pages: |
3635-3646 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang F |
Year: |
2018 |
Journal: |
Science |
Title: |
Lacteal junction zippering protects against diet-induced obesity. |
Volume: |
361 |
Issue: |
6402 |
Pages: |
599-603 |
|
•
•
•
•
•
|
Publication |
First Author: |
Khankin EV |
Year: |
2012 |
Journal: |
Biol Reprod |
Title: |
Hemodynamic, vascular, and reproductive impact of FMS-like tyrosine kinase 1 (FLT1) blockade on the uteroplacental circulation during normal mouse pregnancy. |
Volume: |
86 |
Issue: |
2 |
Pages: |
57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Robciuc MR |
Year: |
2016 |
Journal: |
Cell Metab |
Title: |
VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications. |
Volume: |
23 |
Issue: |
4 |
Pages: |
712-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lichtenberger BM |
Year: |
2010 |
Journal: |
Cell |
Title: |
Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development. |
Volume: |
140 |
Issue: |
2 |
Pages: |
268-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stefater JA 3rd |
Year: |
2013 |
Journal: |
Blood |
Title: |
Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair. |
Volume: |
121 |
Issue: |
13 |
Pages: |
2574-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Benhadou F |
Year: |
2020 |
Journal: |
Sci Adv |
Title: |
Epidermal autonomous VEGFA/Flt1/Nrp1 functions mediate psoriasis-like disease. |
Volume: |
6 |
Issue: |
2 |
Pages: |
eaax5849 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muhl L |
Year: |
2016 |
Journal: |
Cell Tissue Res |
Title: |
Expression of vascular endothelial growth factor (VEGF)-B and its receptor (VEGFR1) in murine heart, lung and kidney. |
Volume: |
365 |
Issue: |
1 |
Pages: |
51-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koyano-Nakagawa N |
Year: |
2015 |
Journal: |
J Biol Chem |
Title: |
Feedback Mechanisms Regulate Ets Variant 2 (Etv2) Gene Expression and Hematoendothelial Lineages. |
Volume: |
290 |
Issue: |
47 |
Pages: |
28107-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fan X |
Year: |
2014 |
Journal: |
J Clin Invest |
Title: |
Endometrial VEGF induces placental sFLT1 and leads to pregnancy complications. |
Volume: |
124 |
Issue: |
11 |
Pages: |
4941-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hirashima M |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Trophoblast expression of fms-like tyrosine kinase 1 is not required for the establishment of the maternal-fetal interface in the mouse placenta. |
Volume: |
100 |
Issue: |
26 |
Pages: |
15637-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawahara M |
Year: |
2010 |
Journal: |
J Reprod Dev |
Title: |
Involvement of insulin-like growth factor 2 in angiogenic factor transcription in Bi-maternal mouse conceptuses. |
Volume: |
56 |
Issue: |
1 |
Pages: |
79-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Otowa Y |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Flt1/VEGFR1 heterozygosity causes transient embryonic edema. |
Volume: |
6 |
|
Pages: |
27186 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ogura S |
Year: |
2017 |
Journal: |
JCI Insight |
Title: |
Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown. |
Volume: |
2 |
Issue: |
3 |
Pages: |
e90905 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okabe K |
Year: |
2020 |
Journal: |
Dev Biol |
Title: |
Neuron-derived VEGF contributes to cortical and hippocampal development independently of VEGFR1/2-mediated neurotrophism. |
Volume: |
459 |
Issue: |
2 |
Pages: |
65-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsubara T |
Year: |
2022 |
Journal: |
J Exp Med |
Title: |
Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice. |
Volume: |
219 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Muthig V |
Year: |
2007 |
Journal: |
Circ Res |
Title: |
Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice. |
Volume: |
101 |
Issue: |
7 |
Pages: |
682-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Komabayashi-Suzuki M |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Spatiotemporally Dependent Vascularization Is Differently Utilized among Neural Progenitor Subtypes during Neocortical Development. |
Volume: |
29 |
Issue: |
5 |
Pages: |
1113-1129.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ren X |
Year: |
2014 |
Journal: |
Circ Res |
Title: |
FOXF1 transcription factor is required for formation of embryonic vasculature by regulating VEGF signaling in endothelial cells. |
Volume: |
115 |
Issue: |
8 |
Pages: |
709-20 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Choi K |
Year: |
1994 |
Journal: |
Oncogene |
Title: |
Isolation of a gene encoding a novel receptor tyrosine kinase from differentiated embryonic stem cells. |
Volume: |
9 |
Issue: |
4 |
Pages: |
1261-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kondo K |
Year: |
1998 |
Journal: |
Gene |
Title: |
Genomic organization of the flt-1 gene encoding for vascular endothelial growth factor (VEGF) receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors. |
Volume: |
208 |
Issue: |
2 |
Pages: |
297-305 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hiratsuka S |
Year: |
2001 |
Journal: |
Cancer Res |
Title: |
Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis. |
Volume: |
61 |
Issue: |
3 |
Pages: |
1207-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muramatsu M |
Year: |
2010 |
Journal: |
Cancer Res |
Title: |
Vascular endothelial growth factor receptor-1 signaling promotes mobilization of macrophage lineage cells from bone marrow and stimulates solid tumor growth. |
Volume: |
70 |
Issue: |
20 |
Pages: |
8211-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
He Y |
Year: |
1999 |
Journal: |
Mol Endocrinol |
Title: |
Alternative splicing of vascular endothelial growth factor (VEGF)-R1 (FLT-1) pre-mRNA is important for the regulation of VEGF activity. |
Volume: |
13 |
Issue: |
4 |
Pages: |
537-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vaquié A |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Injured Axons Instruct Schwann Cells to Build Constricting Actin Spheres to Accelerate Axonal Disintegration. |
Volume: |
27 |
Issue: |
11 |
Pages: |
3152-3166.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Licht T |
Year: |
2015 |
Journal: |
J Clin Invest |
Title: |
Vessel maturation schedule determines vulnerability to neuronal injuries of prematurity. |
Volume: |
125 |
Issue: |
3 |
Pages: |
1319-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Selvaraj D |
Year: |
2015 |
Journal: |
Cancer Cell |
Title: |
A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain. |
Volume: |
27 |
Issue: |
6 |
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