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Search results 1 to 100 out of 1150 for Flt3

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Hits by Pathway

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Type Details Score
Gene
key_979921 | Flt3
Type: gene
Organism: Not Specified
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Gene
2322 | FLT3
Type: gene
Organism: human
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Gene
512700 | FLT3
Type: gene
Organism: cattle
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Gene
100858422 | FLT3
Type: gene
Organism: chicken
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Gene
566708 | flt3
Type: gene
Organism: zebrafish
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Gene
721712 | FLT3
Type: gene
Organism: macaque, rhesus
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Gene
101733150 | flt3
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR030118 | FLT3
Type: Family
Description: FLT3 is a class III receptor tyrosine kinase that plays an important role in hematopoietic differentiation. Mutations in FLT3 that lead to constitutive activation are among the most common molecular lesions found in acute myeloid leukemia (AML) [, ]. FLT3 can be regulated by protein-tyrosine phosphatase DEP-1 []. An adaptor protein, Grb10, has been shown to bind both normal and oncogenic FLT3 and induces PI3K-Akt and STAT5 signalling pathways resulting in an enhanced proliferation, survival and colony formation of hematopoietic cells [].
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Gene
140635 | Flt3
Type: gene
Organism: rat
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Gene
486025 | FLT3
Type: gene
Organism: dog, domestic
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Gene
452508 | FLT3
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:95559 | Flt3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17124058 | -
   
First Author: Small D
Year: 2006
Journal: Hematology Am Soc Hematol Educ Program
Title: FLT3 mutations: biology and treatment.
Pages: 178-84
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Publication
21262971 | -
First Author: Arora D
Year: 2011
Journal: J Biol Chem
Title: Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
Volume: 286
Issue: 13
Pages: 10918-29
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Publication
23246379 | -
First Author: Kazi JU
Year: 2013
Journal: Mol Oncol
Title: FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia.
Volume: 7
Issue: 3
Pages: 402-18
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Protein
Q00342
Organism: Mus musculus/domesticus
Length: 1000  
Fragment?: false
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Publication
21516120 | J:177101
First Author: Zheng R
Year: 2011
Journal: Oncogene
Title: Further activation of FLT3 mutants by FLT3 ligand.
Volume: 30
Issue: 38
Pages: 4004-14
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Publication
18469816 | J:136209
First Author: Waskow C
Year: 2008
Journal: Nat Immunol
Title: The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Volume: 9
Issue: 6
Pages: 676-83
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Publication
20457904 | J:159599
First Author: Eidenschenk C
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells.
Volume: 107
Issue: 21
Pages: 9759-64
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Protein
Q3TQF1
Organism: Mus musculus/domesticus
Length: 488  
Fragment?: true
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Protein
Q8BR20
Organism: Mus musculus/domesticus
Length: 406  
Fragment?: false
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Protein
Q60515
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
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Gene
84922 | FIZ1
Type: gene
Organism: human
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Protein
Q3UEW6
Organism: Mus musculus/domesticus
Length: 1000  
Fragment?: false
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Publication
10409713 | J:56367
First Author: Wolf I
Year: 1999
Journal: J Biol Chem
Title: Fiz1, a novel zinc finger protein interacting with the receptor tyrosine kinase Flt3.
Volume: 274
Issue: 30
Pages: 21478-84
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Publication
21628405 | J:176945
First Author: Buza-Vidas N
Year: 2011
Journal: Blood
Title: FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells.
Volume: 118
Issue: 6
Pages: 1544-8
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Publication
1656368 | J:1614
First Author: Rosnet O
Year: 1991
Journal: Oncogene
Title: Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family.
Volume: 6
Issue: 9
Pages: 1641-50
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Publication
27458164 | J:268117
First Author: Moharram SA
Year: 2016
Journal: Oncotarget
Title: Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling.
Volume: 7
Issue: 36
Pages: 57770-57782
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Publication
8384358 | J:140548
First Author: Maroc N
Year: 1993
Journal: Oncogene
Title: Biochemical characterization and analysis of the transforming potential of the FLT3/FLK2 receptor tyrosine kinase.
Volume: 8
Issue: 4
Pages: 909-18
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Publication
1648448 | J:11299
First Author: Matthews W
Year: 1991
Journal: Cell
Title: A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations.
Volume: 65
Issue: 7
Pages: 1143-52
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Publication
7621074 | J:27238
First Author: Mackarehtschian K
Year: 1995
Journal: Immunity
Title: Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors.
Volume: 3
Issue: 1
Pages: 147-61
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Publication
7917833 | J:19248
First Author: Ito A
Year: 1993
Journal: J Mol Neurosci
Title: Developmental expression of flt3 mRNA in the mouse brain.
Volume: 4
Issue: 4
Pages: 235-43
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Publication
19286519 | J:147362
First Author: Liu K
Year: 2009
Journal: Science
Title: In vivo analysis of dendritic cell development and homeostasis.
Volume: 324
Issue: 5925
Pages: 392-7
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Publication
30596405 | J:295115
First Author: Zriwil A
Year: 2018
Journal: Br J Haematol
Title: Direct role of FLT3 in regulation of early lymphoid progenitors.
Volume: 183
Issue: 4
Pages: 588-600
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Publication
22078798 | J:178831
First Author: Choi JH
Year: 2011
Journal: Immunity
Title: Flt3 signaling-dependent dendritic cells protect against atherosclerosis.
Volume: 35
Issue: 5
Pages: 819-31
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Publication
25234168 | J:219685
First Author: Kato T
Year: 2015
Journal: Leukemia
Title: Hes1 suppresses acute myeloid leukemia development through FLT3 repression.
Volume: 29
Issue: 3
Pages: 576-85
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Publication
26062848 | J:234072
First Author: Lim Y
Year: 2015
Journal: Sci Transl Med
Title: Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia.
Volume: 7
Issue: 291
Pages: 291ra96
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Publication
18299401 | J:133083
First Author: Kenins L
Year: 2008
Journal: J Exp Med
Title: Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation.
Volume: 205
Issue: 3
Pages: 523-31
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GXD Expression
GXD Expression
     
Probe: MGI:6172979
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190289
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Flt3
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6172979
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190289
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Flt3
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6172979
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190289
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Flt3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6172979
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190289
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Flt3
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6172979
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190289
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Flt3
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6172979
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190289
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Flt3
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6172979
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190289
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Flt3
Detected: true
Specimen Num: 7
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Publication
7622010 | J:26783
First Author: deLapeyrière O
Year: 1995
Journal: Differentiation
Title: Expression of Flt3 tyrosine kinase receptor gene in mouse hematopoietic and nervous tissues.
Volume: 58
Issue: 5
Pages: 351-9
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Publication
20393130 | J:161537
First Author: Böiers C
Year: 2010
Journal: Blood
Title: Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.
Volume: 115
Issue: 24
Pages: 5061-8
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Publication
16618805 | J:108330
First Author: Holmes ML
Year: 2006
Journal: Genes Dev
Title: Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment.
Volume: 20
Issue: 8
Pages: 933-8
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Publication
26411368 | J:234309
First Author: Chen Y
Year: 2016
Journal: Oncogene
Title: Identification of an orally available compound with potent and broad FLT3 inhibition activity.
Volume: 35
Issue: 23
Pages: 2971-8
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Publication
23759524 | J:238831
First Author: Bailey EJ
Year: 2013
Journal: Comp Med
Title: Effect of FLT3 ligand on survival and disease phenotype in murine models harboring a FLT3 internal tandem duplication mutation.
Volume: 63
Issue: 3
Pages: 218-26
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Publication
29531216 | J:259705
First Author: Rivat C
Year: 2018
Journal: Nat Commun
Title: Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice.
Volume: 9
Issue: 1
Pages: 1042
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Publication
23772038 | J:204950
First Author: Gwin KA
Year: 2013
Journal: J Immunol
Title: Hoxa9 and Flt3 signaling synergistically regulate an early checkpoint in lymphopoiesis.
Volume: 191
Issue: 2
Pages: 745-54
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Publication
7630197 | J:27743
First Author: Brasel K
Year: 1995
Journal: Leukemia
Title: Expression of the flt3 receptor and its ligand on hematopoietic cells.
Volume: 9
Issue: 7
Pages: 1212-8
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Publication
24269847 | J:215723
First Author: Kamezaki K
Year: 2014
Journal: Exp Hematol
Title: Differential requirement for wild-type Flt3 in leukemia initiation among mouse models of human leukemia.
Volume: 42
Issue: 3
Pages: 192-203.e1
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Publication
23977266 | J:204431
First Author: Albouhair S
Year: 2013
Journal: PLoS One
Title: Flt3 does not play a critical role in murine myeloid leukemias induced by MLL fusion genes.
Volume: 8
Issue: 8
Pages: e72261
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Publication
16116483 | J:103427
First Author: Lee BH
Year: 2005
Journal: Oncogene
Title: FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model.
Volume: 24
Issue: 53
Pages: 7882-92
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Publication
20951944 | J:165552
First Author: Rathinam C
Year: 2010
Journal: Cancer Cell
Title: Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling.
Volume: 18
Issue: 4
Pages: 341-52
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Publication
21813452 | J:177063
First Author: Kharazi S
Year: 2011
Journal: Blood
Title: Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.
Volume: 118
Issue: 13
Pages: 3613-21
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Publication
7531700 | J:23709
First Author: Lavagna C
Year: 1995
Journal: J Biol Chem
Title: Identification and characterization of a functional murine FLT3 isoform produced by exon skipping.
Volume: 270
Issue: 7
Pages: 3165-71
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Publication
26382271 | J:243178
First Author: Volpe G
Year: 2015
Journal: PLoS One
Title: Regulation of the Flt3 Gene in Haematopoietic Stem and Early Progenitor Cells.
Volume: 10
Issue: 9
Pages: e0138257
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Publication
8896402 | J:36245
First Author: McClanahan T
Year: 1996
Journal: Blood
Title: Biochemical and genetic characterization of multiple splice variants of the Flt3 ligand.
Volume: 88
Issue: 9
Pages: 3371-82
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Publication
17936561 | J:126003
First Author: Lee BH
Year: 2007
Journal: Cancer Cell
Title: FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia.
Volume: 12
Issue: 4
Pages: 367-80
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Publication
19830725 | J:155707
First Author: Kenins L
Year: 2010
Journal: Eur J Immunol
Title: Flt3 ligand-receptor interaction is important for maintenance of early thymic progenitor numbers in steady-state thymopoiesis.
Volume: 40
Issue: 1
Pages: 81-90
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Publication
19188666 | J:148292
First Author: Buza-Vidas N
Year: 2009
Journal: Blood
Title: FLT3 receptor and ligand are dispensable for maintenance and posttransplantation expansion of mouse hematopoietic stem cells.
Volume: 113
Issue: 15
Pages: 3453-60
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Publication
23741395 | J:200827
First Author: Wu X
Year: 2013
Journal: PLoS One
Title: Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo.
Volume: 8
Issue: 5
Pages: e64800
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Publication
8765501 | J:34954
First Author: Begley CG
Year: 1996
Journal: Exp Hematol
Title: Murine flt3 ligand protects M1 leukemic cells from LIF-induced differentiation and suppression of self-renewal.
Volume: 24
Issue: 10
Pages: 1247-57
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Protein
Q61104
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Publication
27617578 | J:236455
First Author: Staffas A
Year: 2017
Journal: Oncogene
Title: Upregulation of Flt3 is a passive event in Hoxa9/Meis1-induced acute myeloid leukemia in mice.
Volume: 36
Issue: 11
Pages: 1516-1524
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Publication
16418395 | J:118807
First Author: Onai N
Year: 2006
Journal: J Exp Med
Title: Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development.
Volume: 203
Issue: 1
Pages: 227-38
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Publication
20510871 | J:160816
First Author: Carotta S
Year: 2010
Journal: Immunity
Title: The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner.
Volume: 32
Issue: 5
Pages: 628-41
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Publication
24888589 | J:211638
First Author: Johnson RM
Year: 2014
Journal: Genes Dev
Title: MuLV-related endogenous retroviral elements and Flt3 participate in aberrant end-joining events that promote B-cell leukemogenesis.
Volume: 28
Issue: 11
Pages: 1179-90
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Publication
26903243 | J:232928
First Author: Lau CM
Year: 2016
Journal: J Exp Med
Title: Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses.
Volume: 213
Issue: 3
Pages: 415-31
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Publication
17540845 | J:148909
First Author: Sitnicka E
Year: 2007
Journal: Blood
Title: Critical role of FLT3 ligand in IL-7 receptor independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors.
Volume: 110
Issue: 8
Pages: 2955-64
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Publication
36739348 | J:335077
First Author: Straube J
Year: 2023
Journal: Leukemia
Title: Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia.
Volume: 37
Issue: 4
Pages: 741-750
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Publication
36073548 | J:329450
 
First Author: Ramdas B
Year: 2022
Journal: JCI Insight
Title: Combined heterozygosity of FLT3 ITD, TET2, and DNMT3A results in aggressive leukemia.
Volume: 7
Issue: 17
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Publication
24444745 | J:215709
First Author: Dolence JJ
Year: 2014
Journal: Exp Hematol
Title: Flt3 signaling regulates the proliferation, survival, and maintenance of multipotent hematopoietic progenitors that generate B cell precursors.
Volume: 42
Issue: 5
Pages: 380-393.e3
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Publication
27099147 | J:234793
First Author: Uras IZ
Year: 2016
Journal: Blood
Title: Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6.
Volume: 127
Issue: 23
Pages: 2890-902
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Publication
36206490 | J:333323
First Author: Chen H
Year: 2023
Journal: Blood
Title: PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371.
Volume: 141
Issue: 3
Pages: 244-259
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Publication
7824267 | J:22411
First Author: Lyman SD
Year: 1995
Journal: Oncogene
Title: Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs.
Volume: 10
Issue: 1
Pages: 149-57
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Publication
21967974 | J:179097
First Author: Avagyan S
Year: 2011
Journal: Blood
Title: Quantitative trait mapping reveals a regulatory axis involving peroxisome proliferator-activated receptors, PRDM16, transforming growth factor-β2 and FLT3 in hematopoiesis.
Volume: 118
Issue: 23
Pages: 6078-86
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Publication
18245664 | J:133528
First Author: Li L
Year: 2008
Journal: Blood
Title: Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model.
Volume: 111
Issue: 7
Pages: 3849-58
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Publication
8183574 | J:18780
First Author: Rottapel R
Year: 1994
Journal: Oncogene
Title: Substrate specificities and identification of a putative binding site for PI3K in the carboxy tail of the murine Flt3 receptor tyrosine kinase.
Volume: 9
Issue: 6
Pages: 1755-65
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Publication
12387740 | J:79569
First Author: Sitnicka E
Year: 2002
Journal: Immunity
Title: Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool.
Volume: 17
Issue: 4
Pages: 463-72
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Protein
P49772
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
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Publication
16863910 | J:111904
First Author: Fukuda S
Year: 2006
Journal: Exp Hematol
Title: Internal tandem duplication of Flt3 modulates chemotaxis and survival of hematopoietic cells by SDF1alpha but negatively regulates marrow homing in vivo.
Volume: 34
Issue: 8
Pages: 1041-51
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Publication
27387666 | J:248809
First Author: Abe M
Year: 2016
Journal: PLoS One
Title: Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21Cdkn1a and Pbx1 in Hematopoietic Cells.
Volume: 11
Issue: 7
Pages: e0158290
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Publication
8380915 | J:3709
First Author: Rosnet O
Year: 1993
Journal: Oncogene
Title: Close physical linkage of the FLT1 and FLT3 genes on chromosome 13 in man and chromosome 5 in mouse.
Volume: 8
Issue: 1
Pages: 173-9
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Publication
9345066 | J:43756
First Author: Brasel K
Year: 1997
Journal: Blood
Title: Flt3 ligand synergizes with granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor to mobilize hematopoietic progenitor cells into the peripheral blood of mice.
Volume: 90
Issue: 9
Pages: 3781-8
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Publication
19830741 | J:155704
First Author: Bozzacco L
Year: 2010
Journal: Eur J Immunol
Title: HIV gag protein is efficiently cross-presented when targeted with an antibody towards the DEC-205 receptor in Flt3 ligand-mobilized murine DC.
Volume: 40
Issue: 1
Pages: 36-46
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Publication
22674806 | J:189096
First Author: Zorko NA
Year: 2012
Journal: Blood
Title: Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias.
Volume: 120
Issue: 5
Pages: 1130-6
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Gene
114669851 | LOC114669851
Type: gene
Organism: macaque, rhesus
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Publication
23418353 | J:213100
First Author: Smith CJ
Year: 2013
Journal: J Cell Sci
Title: The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor.
Volume: 126
Issue: Pt 6
Pages: 1366-80
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Publication
20360400 | J:162445
First Author: Tsuruyama T
Year: 2010
Journal: J Leukoc Biol
Title: Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas.
Volume: 88
Issue: 1
Pages: 107-16
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Protein Domain
IPR004213 | Flt3_lig
Type: Family
Description: The flt3 (fms-related tyrosine kinase 3) ligand is a short chain cytokine with a 4 helical bundle fold. It is a type I membrane protein which stimulates the proliferation of of early hematopoeitic cells, and synergises well with other colony stimulating factors and interleukins.
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Publication
2004790 | J:11061
First Author: Rosnet O
Year: 1991
Journal: Genomics
Title: Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene.
Volume: 9
Issue: 2
Pages: 380-5
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Gene
456307 | FIZ1
Type: gene
Organism: chimpanzee
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Gene
789631 | FIZ1
Type: gene
Organism: cattle
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Gene
100856606 | FIZ1
Type: gene
Organism: dog, domestic
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Gene
701452 | FIZ1
Type: gene
Organism: macaque, rhesus
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Publication
22958930 | J:193429
First Author: Chu SH
Year: 2012
Journal: Cell Stem Cell
Title: FLT3-ITD knockin impairs hematopoietic stem cell quiescence/homeostasis, leading to myeloproliferative neoplasm.
Volume: 11
Issue: 3
Pages: 346-58
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