Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
cat, domestic |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Momenilandi M |
Year: |
2024 |
Journal: |
Cell |
Title: |
FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice. |
Volume: |
187 |
Issue: |
11 |
Pages: |
2817-2837.e31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guermonprez P |
Year: |
2013 |
Journal: |
Nat Med |
Title: |
Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection. |
Volume: |
19 |
Issue: |
6 |
Pages: |
730-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mollah SA |
Year: |
2014 |
Journal: |
J Invest Dermatol |
Title: |
Flt3L dependence helps define an uncharacterized subset of murine cutaneous dendritic cells. |
Volume: |
134 |
Issue: |
5 |
Pages: |
1265-1275 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fujita K |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen. |
Volume: |
116 |
Issue: |
29 |
Pages: |
14714-14723 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anandasabapathy N |
Year: |
2011 |
Journal: |
J Exp Med |
Title: |
Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain. |
Volume: |
208 |
Issue: |
8 |
Pages: |
1695-705 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
169
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Rosborough BR |
Year: |
2014 |
Journal: |
J Immunol |
Title: |
Cutting edge: Flt3 ligand mediates STAT3-independent expansion but STAT3-dependent activation of myeloid-derived suppressor cells. |
Volume: |
192 |
Issue: |
8 |
Pages: |
3470-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Durai V |
Year: |
2018 |
Journal: |
J Exp Med |
Title: |
Altered compensatory cytokine signaling underlies the discrepancy between Flt3-/- and Flt3l-/- mice. |
Volume: |
215 |
Issue: |
5 |
Pages: |
1417-1435 |
|
•
•
•
•
•
|
Publication |
First Author: |
Anandasabapathy N |
Year: |
2014 |
Journal: |
J Exp Med |
Title: |
Classical Flt3L-dependent dendritic cells control immunity to protein vaccine. |
Volume: |
211 |
Issue: |
9 |
Pages: |
1875-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sathaliyawala T |
Year: |
2010 |
Journal: |
Immunity |
Title: |
Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling. |
Volume: |
33 |
Issue: |
4 |
Pages: |
597-606 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barry KC |
Year: |
2018 |
Journal: |
Nat Med |
Title: |
A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments. |
Volume: |
24 |
Issue: |
8 |
Pages: |
1178-1191 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mott KR |
Year: |
2008 |
Journal: |
J Virol |
Title: |
Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latency. |
Volume: |
82 |
Issue: |
20 |
Pages: |
9870-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brumshagen C |
Year: |
2012 |
Journal: |
Infect Immun |
Title: |
FMS-like tyrosine kinase 3 ligand treatment of mice aggravates acute lung injury in response to Streptococcus pneumoniae: role of pneumolysin. |
Volume: |
80 |
Issue: |
12 |
Pages: |
4281-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng M |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Distinct and overlapping patterns of cytokine regulation of thymic and bone marrow-derived NK cell development. |
Volume: |
182 |
Issue: |
3 |
Pages: |
1460-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Swee LK |
Year: |
2009 |
Journal: |
Blood |
Title: |
Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment. |
Volume: |
113 |
Issue: |
25 |
Pages: |
6277-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
McKenna HJ |
Year: |
2000 |
Journal: |
Blood |
Title: |
Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. |
Volume: |
95 |
Issue: |
11 |
Pages: |
3489-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Williams KM |
Year: |
2017 |
Journal: |
Exp Hematol |
Title: |
FLT3 ligand regulates thymic precursor cells and hematopoietic stem cells through interactions with CXCR4 and the marrow niche. |
Volume: |
52 |
|
Pages: |
40-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tussiwand R |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
Inhibition of natural type I IFN-producing and dendritic cell development by a small molecule receptor tyrosine kinase inhibitor with Flt3 affinity. |
Volume: |
175 |
Issue: |
6 |
Pages: |
3674-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Evers BD |
Year: |
2016 |
Journal: |
J Am Soc Nephrol |
Title: |
CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells. |
Volume: |
27 |
Issue: |
11 |
Pages: |
3368-3382 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Z |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Heart, but not skin, allografts from donors lacking Flt3 ligand exhibit markedly prolonged survival time. |
Volume: |
172 |
Issue: |
10 |
Pages: |
5924-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dupont CD |
Year: |
2015 |
Journal: |
J Immunol |
Title: |
Flt3 Ligand Is Essential for Survival and Protective Immune Responses during Toxoplasmosis. |
Volume: |
195 |
Issue: |
9 |
Pages: |
4369-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Horiuchi K |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Ectodomain shedding of FLT3 ligand is mediated by TNF-alpha converting enzyme. |
Volume: |
182 |
Issue: |
12 |
Pages: |
7408-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lau-Kilby AW |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells. |
Volume: |
108 |
Issue: |
6 |
Pages: |
2408-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Quintana E |
Year: |
2015 |
Journal: |
Glia |
Title: |
DNGR-1(+) dendritic cells are located in meningeal membrane and choroid plexus of the noninjured brain. |
Volume: |
63 |
Issue: |
12 |
Pages: |
2231-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Parigi SM |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo. |
Volume: |
8 |
Issue: |
1 |
Pages: |
154 |
|
•
•
•
•
•
|
Publication |
First Author: |
Masten BJ |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
Flt3 ligand preferentially increases the number of functionally active myeloid dendritic cells in the lungs of mice. |
Volume: |
172 |
Issue: |
7 |
Pages: |
4077-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fry TJ |
Year: |
2004 |
Journal: |
Blood |
Title: |
Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution. |
Volume: |
104 |
Issue: |
9 |
Pages: |
2794-800 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bozzacco L |
Year: |
2010 |
Journal: |
Eur J Immunol |
Title: |
HIV gag protein is efficiently cross-presented when targeted with an antibody towards the DEC-205 receptor in Flt3 ligand-mobilized murine DC. |
Volume: |
40 |
Issue: |
1 |
Pages: |
36-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Larocque D |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology. |
Volume: |
107 |
Issue: |
32 |
Pages: |
14443-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Saito Y |
Year: |
2013 |
Journal: |
Eur J Immunol |
Title: |
Dendritic cell homeostasis is maintained by nonhematopoietic and T-cell-produced Flt3-ligand in steady state and during immune responses. |
Volume: |
43 |
Issue: |
6 |
Pages: |
1651-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Svensson MN |
Year: |
2016 |
Journal: |
J Leukoc Biol |
Title: |
Impaired signaling through the Fms-like tyrosine kinase 3 receptor increases osteoclast formation and bone damage in arthritis. |
Volume: |
99 |
Issue: |
3 |
Pages: |
413-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Walzer T |
Year: |
2005 |
Journal: |
J Allergy Clin Immunol |
Title: |
No defect in T-cell priming, secondary response, or tolerance induction in response to inhaled antigens in Fms-like tyrosine kinase 3 ligand-deficient mice. |
Volume: |
115 |
Issue: |
1 |
Pages: |
192-9 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zheng R |
Year: |
2011 |
Journal: |
Oncogene |
Title: |
Further activation of FLT3 mutants by FLT3 ligand. |
Volume: |
30 |
Issue: |
38 |
Pages: |
4004-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hannum C |
Year: |
1994 |
Journal: |
Nature |
Title: |
Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. |
Volume: |
368 |
Issue: |
6472 |
Pages: |
643-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lyman SD |
Year: |
1993 |
Journal: |
Cell |
Title: |
Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells. |
Volume: |
75 |
Issue: |
6 |
Pages: |
1157-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lyman SD |
Year: |
1995 |
Journal: |
Oncogene |
Title: |
Structural analysis of human and murine flt3 ligand genomic loci. |
Volume: |
11 |
Issue: |
6 |
Pages: |
1165-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lyman SD |
Year: |
1995 |
Journal: |
Oncogene |
Title: |
Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs. |
Volume: |
10 |
Issue: |
1 |
Pages: |
149-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Drissen R |
Year: |
2016 |
Journal: |
Nat Immunol |
Title: |
Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing. |
Volume: |
17 |
Issue: |
6 |
Pages: |
666-676 |
|
•
•
•
•
•
|
Publication |
First Author: |
Heuser M |
Year: |
2010 |
Journal: |
Exp Hematol |
Title: |
Extrinsic signals determine myeloid-erythroid lineage switch in MN1 leukemia. |
Volume: |
38 |
Issue: |
3 |
Pages: |
174-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Williams JW |
Year: |
2020 |
Journal: |
Nat Immunol |
Title: |
Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression. |
Volume: |
21 |
Issue: |
10 |
Pages: |
1194-1204 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wiesner DL |
Year: |
2017 |
Journal: |
J Immunol |
Title: |
Different Lymphocyte Populations Direct Dichotomous Eosinophil or Neutrophil Responses to Pulmonary Cryptococcus Infection. |
Volume: |
198 |
Issue: |
4 |
Pages: |
1627-1637 |
|
•
•
•
•
•
|
Publication |
First Author: |
Busch M |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Dendritic cell subset distributions in the aorta in healthy and atherosclerotic mice. |
Volume: |
9 |
Issue: |
2 |
Pages: |
e88452 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blaisdell A |
Year: |
2015 |
Journal: |
Cancer Cell |
Title: |
Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells. |
Volume: |
28 |
Issue: |
6 |
Pages: |
785-799 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bosteels C |
Year: |
2020 |
Journal: |
Immunity |
Title: |
Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection. |
Volume: |
52 |
Issue: |
6 |
Pages: |
1039-1056.e9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rizzuto G |
Year: |
2022 |
Journal: |
Nature |
Title: |
Establishment of fetomaternal tolerance through glycan-mediated BÂ cell suppression. |
Volume: |
603 |
Issue: |
7901 |
Pages: |
497-502 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tussiwand R |
Year: |
2015 |
Journal: |
Immunity |
Title: |
Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses. |
Volume: |
42 |
Issue: |
5 |
Pages: |
916-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
von Muenchow L |
Year: |
2016 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Permissive roles of cytokines interleukin-7 and Flt3 ligand in mouse B-cell lineage commitment. |
Volume: |
113 |
Issue: |
50 |
Pages: |
E8122-E8130 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jensen CT |
Year: |
2008 |
Journal: |
Blood |
Title: |
FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis. |
Volume: |
112 |
Issue: |
6 |
Pages: |
2297-304 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jensen CT |
Year: |
2008 |
Journal: |
Blood |
Title: |
Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T-cell development. |
Volume: |
111 |
Issue: |
4 |
Pages: |
2083-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Medina KL |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Separation of plasmacytoid dendritic cells from B-cell-biased lymphoid progenitor (BLP) and Pre-pro B cells using PDCA-1. |
Volume: |
8 |
Issue: |
10 |
Pages: |
e78408 |
|
•
•
•
•
•
|
Publication |
First Author: |
Böiers C |
Year: |
2013 |
Journal: |
Cell Stem Cell |
Title: |
Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells. |
Volume: |
13 |
Issue: |
5 |
Pages: |
535-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sitnicka E |
Year: |
2003 |
Journal: |
J Exp Med |
Title: |
Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis. |
Volume: |
198 |
Issue: |
10 |
Pages: |
1495-506 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schwarz BA |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
Selective thymus settling regulated by cytokine and chemokine receptors. |
Volume: |
178 |
Issue: |
4 |
Pages: |
2008-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sitnicka E |
Year: |
2007 |
Journal: |
Blood |
Title: |
Critical role of FLT3 ligand in IL-7 receptor independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors. |
Volume: |
110 |
Issue: |
8 |
Pages: |
2955-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu X |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo. |
Volume: |
8 |
Issue: |
5 |
Pages: |
e64800 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kinnebrew MA |
Year: |
2012 |
Journal: |
Immunity |
Title: |
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. |
Volume: |
36 |
Issue: |
2 |
Pages: |
276-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Teshima T |
Year: |
2002 |
Journal: |
Blood |
Title: |
Flt3 ligand therapy for recipients of allogeneic bone marrow transplants expands host CD8 alpha(+) dendritic cells and reduces experimental acute graft-versus-host disease. |
Volume: |
99 |
Issue: |
5 |
Pages: |
1825-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shalaby KH |
Year: |
2018 |
Journal: |
J Allergy Clin Immunol |
Title: |
Pathogenic TH17 inflammation is sustained in the lungs by conventional dendritic cells and Toll-like receptor 4 signaling. |
Volume: |
142 |
Issue: |
4 |
Pages: |
1229-1242.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
De Koker S |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12. |
Volume: |
7 |
Issue: |
1 |
Pages: |
5986 |
|
•
•
•
•
•
|
Publication |
First Author: |
Izumi G |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
CD11b+ lung dendritic cells at different stages of maturation induce Th17 or Th2 differentiation. |
Volume: |
12 |
Issue: |
1 |
Pages: |
5029 |
|
•
•
•
•
•
|
Publication |
First Author: |
Satpathy AT |
Year: |
2013 |
Journal: |
Nat Immunol |
Title: |
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. |
Volume: |
14 |
Issue: |
9 |
Pages: |
937-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baptista AP |
Year: |
2019 |
Journal: |
Immunity |
Title: |
The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity. |
Volume: |
50 |
Issue: |
5 |
Pages: |
1188-1201.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lauterbach H |
Year: |
2010 |
Journal: |
J Exp Med |
Title: |
Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC. |
Volume: |
207 |
Issue: |
12 |
Pages: |
2703-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sasaki T |
Year: |
2010 |
Journal: |
Development |
Title: |
Regulation of hematopoietic cell clusters in the placental niche through SCF/Kit signaling in embryonic mouse. |
Volume: |
137 |
Issue: |
23 |
Pages: |
3941-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pereira de Sousa A |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors. |
Volume: |
189 |
Issue: |
8 |
Pages: |
3822-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
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