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Search results 1 to 97 out of 97 for Fmo1

0.049s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Saccharomyces cerevisiae
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
GXD Expression
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2013-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1897623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5448197
Age: embryonic day 15.5
Image: 3B Fmo1
Note: Expression was detected in the proximal convoluted tubules.
Detected: true
Specimen Num: 1
Publication
First Author: Veeravalli S
Year: 2014
Journal: Biochem Pharmacol
Title: The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance.
Volume: 90
Issue: 1
Pages: 88-95
Publication
First Author: Hernandez D
Year: 2009
Journal: Pharmacogenet Genomics
Title: Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine.
Volume: 19
Issue: 4
Pages: 289-99
Publication
First Author: Itoh K
Year: 1997
Journal: J Toxicol Sci
Title: Molecular cloning of mouse liver flavin containing monooxygenase (FMO1) cDNA and characterization of the expression product: metabolism of the neurotoxin, 1,2,3,4-tetrahydroisoquinoline (TIQ).
Volume: 22
Issue: 1
Pages: 45-56
Publication
First Author: Cherrington NJ
Year: 1998
Journal: J Biochem Mol Toxicol
Title: Molecular cloning, sequence, and expression of mouse flavin-containing monooxygenases 1 and 5 (FMO1 and FMO5).
Volume: 12
Issue: 4
Pages: 205-12
Publication
First Author: Falls JG
Year: 1995
Journal: J Biochem Toxicol
Title: Gender differences in hepatic expression of flavin-containing monooxygenase isoforms (FMO1, FMO3, and FMO5) in mice.
Volume: 10
Issue: 3
Pages: 171-7
Publication
First Author: Falls JG
Year: 1997
Journal: Arch Biochem Biophys
Title: Regulation of mouse liver flavin-containing monooxygenases 1 and 3 by sex steroids.
Volume: 342
Issue: 2
Pages: 212-23
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression  
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2762123
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1797223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2845723
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1869223
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2853323
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5000848
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5541407
Age: embryonic day 15.5
Image: GUDMAP:9620
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:6172991
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190291
Age: postnatal day 28
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6172991
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190291
Age: postnatal day 14
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6172991
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190291
Age: postnatal day 4
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6172991
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190291
Age: embryonic day 18.5
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6172991
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190291
Age: embryonic day 15.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6172991
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190291
Age: embryonic day 13.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6172991
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190291
Age: embryonic day 11.5
Detected: true
Specimen Num: 1
Publication    
First Author: Huang X
Year: 2017
Journal: Elife
Title: Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling.
Volume: 6
Publication
First Author: Valerius MT
Year: 2008
Journal: Gene Expr Patterns
Title: Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation.
Volume: 8
Issue: 5
Pages: 297-306
Publication  
First Author: Brown AC
Year: 2005
Journal: BMC Genet
Title: Searching QTL by gene expression: analysis of diabesity.
Volume: 6
Pages: 12
Publication
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Allele
Name: deletion, Chr 1, Elizabeth A Shephard 1
Allele Type: Targeted
Attribute String: Null/knockout
Publication categories: ProxyCollection
Strain
Attribute String: congenic, mutant strain, deletion
Genotype
Symbol: Del(1Fmo4-Fmo2)1Eshe/Del(1Fmo4-Fmo2)1Eshe
Background: B6.129P2-Del(1Fmo4-Fmo2)1Eshe
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Del(1Fmo4-Fmo2)1Eshe/+
Background: B6.129P2-Del(1Fmo4-Fmo2)1Eshe
Zygosity: ht
Has Mutant Allele: true
GO Term
Publication
First Author: Lawton MP
Year: 1994
Journal: Arch Biochem Biophys
Title: A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities.
Volume: 308
Issue: 1
Pages: 254-7
Publication
First Author: Bennett BJ
Year: 2013
Journal: Cell Metab
Title: Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.
Volume: 17
Issue: 1
Pages: 49-60
Protein Domain
Type: Family
Description: Flavin-containing monooxygenases (FMOs) constitute a family of xenobiotic-metabolising enzymes [[cite:PUB00000158]]. Using an NADPH cofactor and FAD prosthetic group, these microsomal proteins catalyse the oxygenation of nucleophilic nitrogen, sulphur, phosphorous and selenium atoms in a range of structurally diverse compounds. FMOs have been implicated in the metabolism of a number of pharmaceuticals, pesticides and toxicants. In man, lack of hepatic FMO-catalysed trimethylamine metabolism results in trimethylaminuria (fish odour syndrome). Five mammalian forms of FMO are now known and have been designated FMO1-FMO5 [[cite:PUB00002642], [cite:PUB00002611], [cite:PUB00004772], [cite:PUB00000516], [cite:PUB00002834]].Human FMO1 mRNA is more abundant in foetal than in adult liver, indicating that the enzyme is subject to developmental regulation in man [[cite:PUB00002642]]. The deduced amino sequence contains putative FAD- (GxGxxG) and NADP+-binding (GxGxxA) sites, a 'FATGY' motif that has also been observed in a range of siderphore biosynthetic enzymes [[cite:PUB00005489]], and a C-terminal hydrophobic segment that is believed to anchor the monooxygenase to the microsomal membrane [[cite:PUB00002549]]. The human sequence shares 88 and 86% identity, respectively, with pig and rabbit 'hepatic' forms of FMO, but is only 58% similar to the abbit 'pulmonary' FMO [[cite:PUB00002642]].
Protein
Organism: Mus musculus
Length: 532  
Fragment?: false
Protein
Organism: Mus musculus
Length: 303  
Fragment?: true
Protein
Organism: Mus musculus
Length: 537  
Fragment?: false
Protein
Organism: Mus musculus
Length: 229  
Fragment?: true
Protein
Organism: Mus musculus
Length: 537  
Fragment?: false
Protein
Organism: Mus musculus
Length: 221  
Fragment?: true
Publication
First Author: Ozols J
Year: 1990
Journal: J Biol Chem
Title: Covalent structure of liver microsomal flavin-containing monooxygenase form 1.
Volume: 265
Issue: 18
Pages: 10289-99
Publication
First Author: Stehr M
Year: 1998
Journal: Trends Biochem Sci
Title: A hydrophobic sequence motif common to N-hydroxylating enzymes.
Volume: 23
Issue: 2
Pages: 56-7
Publication  
First Author: Dolphin CT
Year: 1992
Journal: Biochem J
Title: Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family.
Volume: 287 ( Pt 1)
Pages: 261-7
Publication
First Author: Lawton MP
Year: 1990
Journal: J Biol Chem
Title: The flavin-containing monooxygenase enzymes expressed in rabbit liver and lung are products of related but distinctly different genes.
Volume: 265
Issue: 10
Pages: 5855-61
Publication
First Author: Dolphin C
Year: 1991
Journal: J Biol Chem
Title: Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1).
Volume: 266
Issue: 19
Pages: 12379-85
Publication
First Author: Atta-Asafo-Adjei E
Year: 1993
Journal: J Biol Chem
Title: Cloning, sequencing, distribution, and expression in Escherichia coli of flavin-containing monooxygenase 1C1. Evidence for a third gene subfamily in rabbits.
Volume: 268
Issue: 13
Pages: 9681-9
Publication
First Author: Lomri N
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver.
Volume: 89
Issue: 5
Pages: 1685-9