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Search results 1 to 100 out of 2994 for Fmr1

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Categories

Hits by Pathway

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Hits by Strain

Type Details Score
Gene
2332 | FMR1
Type: gene
Organism: human
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Gene
448049 | fmr1
Type: gene
Organism: frog, western clawed
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Gene
key_80311 | FMR1
Type: gene
Organism: pig, domestic
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Gene
24948 | Fmr1
Type: gene
Organism: rat
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Gene
465894 | FMR1
Type: gene
Organism: chimpanzee
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Gene
481070 | FMR1
Type: gene
Organism: dog, domestic
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Gene
507482 | FMR1
Type: gene
Organism: cattle
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Gene
422395 | FMR1
Type: gene
Organism: chicken
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Gene
259191 | fmr1
Type: gene
Organism: zebrafish
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Gene
700138 | FMR1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR040148 | FMR1
Type: Family
Description: Fragile X messenger ribonucleoprotein 1 (FMRP/FMR1), and its paralogues, FXR1 and FXR2 (RNA-binding protein FXR1 and 2, respectively), comprise a family of RNA-binding proteins [].FMR1 protein is a multifunctional polyribosome-associated protein that plays a central role in neuronal development and synaptic plasticity. It regulates alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs [, , ]. FMR1 is thought to bind target mRNA in the nucleus to form a ribonucleoprotein complex which is transported to dendrites and spines []. It is also required for ovary development and function []. FMR1 has also been shown to interact with components of the miRNA pathway []. A large expansion of the CGG trinucleotide repeat in the 5'-untranslated region of the FMR1 gene causes Fragile X syndrome (FXS), an inherited developmental disorder that causes a broad range of intellectual and physical challenges [].FXR1 and FXR2 interact with FMR1 and seem to have a related role; therefore they are likely to play important roles in the function of FMR1 and in the pathogenesis of the FXS syndrome [, ]. FXR1 is highly expressed in vertebrates muscle cells and is required for proper development of this tissue [, ].
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Protein Coding Gene
MGI:95564 | Fmr1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
25464849 | J:232981
First Author: Kenny PJ
Year: 2014
Journal: Cell Rep
Title: MOV10 and FMRP regulate AGO2 association with microRNA recognition elements.
Volume: 9
Issue: 5
Pages: 1729-41
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Gene
158521 | FMR1NB
Type: gene
Organism: human
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Protein
P35922
Organism: Mus musculus/domesticus
Length: 614  
Fragment?: false
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Protein
Q6AXB7
Organism: Mus musculus/domesticus
Length: 614  
Fragment?: false
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Protein
E9QAS8
Organism: Mus musculus/domesticus
Length: 631  
Fragment?: false
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Protein
E9QAT0
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Protein
E9QAS9
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
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Protein
E9QNF5
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: false
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Protein
D3Z6U8
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
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Protein
Q547R0
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Publication
15128702 | J:91191
First Author: Mientjes EJ
Year: 2004
Journal: Hum Mol Genet
Title: Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo.
Volume: 13
Issue: 13
Pages: 1291-302
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Publication
19244359 | J:164979
First Author: Zhang J
Year: 2009
Journal: J Neurophysiol
Title: Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models.
Volume: 101
Issue: 5
Pages: 2572-80
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Gene
8087 | FXR1
Type: gene
Organism: human
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Gene
9513 | FXR2
Type: gene
Organism: human
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Gene
100126270 | FMR1-AS1
Type: gene
Organism: human
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Gene
106478973 | FMR1-IT1
Type: gene
Organism: human
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Publication
30770808 | J:276784
First Author: Estañ MC
Year: 2019
Journal: Nat Commun
Title: Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy.
Volume: 10
Issue: 1
Pages: 797
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Publication
11438589 | J:70178
First Author: Nimchinsky EA
Year: 2001
Journal: J Neurosci
Title: Abnormal development of dendritic spines in FMR1 knock-out mice.
Volume: 21
Issue: 14
Pages: 5139-46
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Publication
7489725 | J:59611
First Author: Zhang Y
Year: 1995
Journal: EMBO J
Title: The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.
Volume: 14
Issue: 21
Pages: 5358-66
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GXD Expression
GXD Expression
   
Probe: MGI:7384503
Assay Type: Western blot
Annotation Date: 2022-11-15
Strength: Absent
Sex: Male
Emaps: EMAPS:3284223
Stage: TS23
Assay Id: MGI:7384547
Age: embryonic day 15.5
Image: 5
Specimen Label: Fmr1 KO
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7464398
Assay Type: Western blot
Annotation Date: 2023-04-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7464706
Age: postnatal month 2
Image: 1
Specimen Label: fmr1 KO
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7464398
Assay Type: Western blot
Annotation Date: 2023-04-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7464706
Age: postnatal month 2
Image: 1
Specimen Label: fmr1 KO
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:7464398
Assay Type: Western blot
Annotation Date: 2023-04-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7464706
Age: postnatal month 2
Image: 1
Specimen Label: fmr1 KO
Detected: false
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:7464398
Assay Type: Western blot
Annotation Date: 2023-04-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7464706
Age: postnatal month 2
Image: 1
Specimen Label: fmr1 KO
Detected: false
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:7464400
Assay Type: Western blot
Annotation Date: 2023-04-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7464747
Age: postnatal month 2
Image: 2
Specimen Label: fmr1 KO
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7464400
Assay Type: Western blot
Annotation Date: 2023-04-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7464747
Age: postnatal month 2
Image: 2
Specimen Label: fmr1 KO
Detected: false
Specimen Num: 4
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Publication
39848954 | J:361522
First Author: Tuma J
Year: 2025
Journal: Sci Rep
Title: Altered olfactory responses in Fmr1 KO mice.
Volume: 15
Issue: 1
Pages: 2952
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GXD Expression
GXD Expression
Probe: MGI:7384504
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-15
Strength: Present
Sex: Male
Emaps: EMAPS:3284223
Pattern: Widespread
Stage: TS23
Assay Id: MGI:7384544
Age: embryonic day 15.5
Image: 5a Nf1 Fmr1 KO
Note: No difference compared with wild type.
Specimen Label: 5a Nf1 Fmr1 KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:2449010
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-15
Strength: Present
Sex: Male
Emaps: EMAPS:3284223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7384545
Age: embryonic day 15.5
Image: 5a Ctnnb1 Fmr1 KO
Note: No difference compared with wild type.
Specimen Label: 5a Ctnnb1 Fmr1 KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5796583
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-15
Strength: Present
Sex: Male
Emaps: EMAPS:3284223
Pattern: Widespread
Stage: TS23
Assay Id: MGI:7384546
Age: embryonic day 15.5
Image: 5a mTOR Fmr1 KO
Note: No difference compared with wild type.
Specimen Label: 5a mTOR Fmr1 KO
Detected: true
Specimen Num: 2
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Protein
A0A0G2JGH0
Organism: Mus musculus/domesticus
Length: 54  
Fragment?: false
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Publication
30115809 | -
First Author: Greenblatt EJ
Year: 2018
Journal: Science
Title: Fragile X mental retardation 1 gene enhances the translation of large autism-related proteins.
Volume: 361
Issue: 6403
Pages: 709-712
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Publication
1710175 | -
First Author: Verkerk AJ
Year: 1991
Journal: Cell
Title: Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome.
Volume: 65
Issue: 5
Pages: 905-14
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Publication
7781595 | -
First Author: Siomi MC
Year: 1995
Journal: EMBO J
Title: FXR1, an autosomal homolog of the fragile X mental retardation gene.
Volume: 14
Issue: 11
Pages: 2401-8
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Publication
19669947 | -
First Author: Li X
Year: 2009
Journal: Neuromolecular Med
Title: Macro role(s) of microRNAs in fragile X syndrome?
Volume: 11
Issue: 3
Pages: 200-7
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Publication
18957214 | -
First Author: Bassell GJ
Year: 2008
Journal: Neuron
Title: Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function.
Volume: 60
Issue: 2
Pages: 201-14
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Publication
12575950 | J:107689
First Author: Miyashiro KY
Year: 2003
Journal: Neuron
Title: RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice.
Volume: 37
Issue: 3
Pages: 417-31
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Publication
8033209 | J:19220
 
Year: 1994
Journal: Cell
Title: Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium.
Volume: 78
Issue: 1
Pages: 23-33
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Publication
34388204 | J:308813
First Author: Bengani H
Year: 2021
Journal: PLoS One
Title: Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability.
Volume: 16
Issue: 8
Pages: e0256181
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Publication
18653529 | J:173059
First Author: Didiot MC
Year: 2008
Journal: Nucleic Acids Res
Title: The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer.
Volume: 36
Issue: 15
Pages: 4902-12
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Publication
11918286 | J:113306
First Author: Mineur YS
Year: 2002
Journal: Hippocampus
Title: Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse.
Volume: 12
Issue: 1
Pages: 39-46
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Publication
8557260 | J:31093
First Author: Reyniers E
Year: 1996
Journal: Hum Genet
Title: Mean corpuscular hemoglobin is not increased in Fmr1 knockout mice.
Volume: 97
Issue: 1
Pages: 49-50
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Protein
Q925S6
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
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Protein
Q925S7
Organism: Mus musculus/domesticus
Length: 35  
Fragment?: true
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Protein
A0A0G2JGL6
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: true
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Publication
21072162 | -
First Author: Adams-Cioaba MA
Year: 2010
Journal: PLoS One
Title: Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.
Volume: 5
Issue: 11
Pages: e13559
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Publication
31200759 | J:289433
First Author: Lee FHF
Year: 2019
Journal: Mol Brain
Title: Altered cortical Cytoarchitecture in the Fmr1 knockout mouse.
Volume: 12
Issue: 1
Pages: 56
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Publication
35290907 | J:355173
 
First Author: Armstrong JL
Year: 2022
Journal: Epilepsy Res
Title: Spontaneous seizures in adult Fmr1 knockout mice: FVB.129P2-Pde6b(+)Tyr(c-ch)Fmr1(tm1Cgr)/J.
Volume: 182
Pages: 106891
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Gene
23191 | CYFIP1
Type: gene
Organism: human
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Gene
26999 | CYFIP2
Type: gene
Organism: human
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Gene
26747 | NUFIP1
Type: gene
Organism: human
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Gene
57532 | NUFIP2
Type: gene
Organism: human
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Gene
100132797 | LOC100132797
Type: gene
Organism: human
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Publication
28960184 | -
 
First Author: Hagerman RJ
Year: 2017
Journal: Nat Rev Dis Primers
Title: Fragile X syndrome.
Volume: 3
Pages: 17065
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Publication
29713264 | -
 
First Author: Drozd M
Year: 2018
Journal: Front Mol Neurosci
Title: Modeling Fragile X Syndrome in Drosophila.
Volume: 11
Pages: 124
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Publication
11008180 | J:119166
First Author: Dobkin C
Year: 2000
Journal: Neuroscience
Title: Fmr1 knockout mouse has a distinctive strain-specific learning impairment.
Volume: 100
Issue: 2
Pages: 423-9
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Publication
16343653 | J:105026
First Author: Mineur YS
Year: 2006
Journal: Behav Brain Res
Title: Social behavior deficits in the Fmr1 mutant mouse.
Volume: 168
Issue: 1
Pages: 172-5
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Publication
11487573 | J:71202
First Author: Bontekoe CJ
Year: 2001
Journal: Hum Mol Genet
Title: Instability of a (CGG)98 repeat in the Fmr1 promoter.
Volume: 10
Issue: 16
Pages: 1693-9
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Publication
10331607 | J:54509
First Author: Fisch GS
Year: 1999
Journal: Am J Med Genet
Title: Learning and memory in the FMR1 knockout mouse.
Volume: 84
Issue: 3
Pages: 277-82
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Publication
16923151 | J:123642
First Author: Brennan FX
Year: 2006
Journal: Genes Brain Behav
Title: Fmr1 knockout mice are impaired in a leverpress escape/avoidance task.
Volume: 5
Issue: 6
Pages: 467-71
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Publication
19864489 | J:155344
First Author: Garcia-Arocena D
Year: 2010
Journal: Hum Mol Genet
Title: Fibroblast phenotype in male carriers of FMR1 premutation alleles.
Volume: 19
Issue: 2
Pages: 299-312
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Publication
23015112 | J:323444
First Author: Heitzer AM
Year: 2013
Journal: J Autism Dev Disord
Title: Brief report: altered social behavior in isolation-reared Fmr1 knockout mice.
Volume: 43
Issue: 6
Pages: 1452-8
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Publication
16823030 | J:135706
First Author: Desai NS
Year: 2006
Journal: J Neurophysiol
Title: Early postnatal plasticity in neocortex of Fmr1 knockout mice.
Volume: 96
Issue: 4
Pages: 1734-45
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Publication
7633450 | J:25209
First Author: Verheij C
Year: 1995
Journal: Hum Mol Genet
Title: Characterization of FMR1 proteins isolated from different tissues.
Volume: 4
Issue: 5
Pages: 895-901
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Protein
Q8C7U4
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: true
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Protein
Q8BPK8
Organism: Mus musculus/domesticus
Length: 357  
Fragment?: true
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Protein
Q8BPN5
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: true
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Publication
9015322 | J:38436
First Author: D'Hooge R
Year: 1997
Journal: Neuroscience
Title: Mildly impaired water maze performance in male Fmr1 knockout mice.
Volume: 76
Issue: 2
Pages: 367-76
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Publication
11918288 | J:113177
First Author: Ivanco TL
Year: 2002
Journal: Hippocampus
Title: Altered mossy fiber distributions in adult Fmr1 (FVB) knockout mice.
Volume: 12
Issue: 1
Pages: 47-54
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Protein
Q61584
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: false
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Protein
Q9WVR4
Organism: Mus musculus/domesticus
Length: 673  
Fragment?: false
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Protein
A0A0G2JEP0
Organism: Mus musculus/domesticus
Length: 568  
Fragment?: false
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Protein
Q6P5B5
Organism: Mus musculus/domesticus
Length: 674  
Fragment?: false
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Protein
Q3TA75
Organism: Mus musculus/domesticus
Length: 655  
Fragment?: true
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Protein
A0A0H2UH27
Organism: Mus musculus/domesticus
Length: 454  
Fragment?: false
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Publication
37936174 | J:342427
First Author: Zhao S
Year: 2023
Journal: Mol Autism
Title: Tau reduction attenuates autism-like features in Fmr1 knockout mice.
Volume: 14
Issue: 1
Pages: 42
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Publication
25561520 | J:232980
First Author: Myrick LK
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures.
Volume: 112
Issue: 4
Pages: 949-56
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Publication
21371563 | J:323463
First Author: Levenga J
Year: 2011
Journal: Neurobiol Learn Mem
Title: Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice.
Volume: 95
Issue: 4
Pages: 467-72
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Publication
26307763 | J:226802
First Author: Tang B
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Fmr1 deficiency promotes age-dependent alterations in the cortical synaptic proteome.
Volume: 112
Issue: 34
Pages: E4697-706
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Publication
34089433 | J:323472
First Author: Talvio K
Year: 2021
Journal: Biometals
Title: Increased iron content in the heart of the Fmr1 knockout mouse.
Volume: 34
Issue: 4
Pages: 947-954
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Publication
30726724 | J:290874
First Author: Bülow P
Year: 2019
Journal: Cell Rep
Title: Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons.
Volume: 26
Issue: 6
Pages: 1378-1388.e3
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Publication
25433180 | J:218519
 
First Author: Wrenn CC
Year: 2015
Journal: Neurosci Lett
Title: Effects of clonidine and methylphenidate on motor activity in Fmr1 knockout mice.
Volume: 585
Pages: 109-13
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Publication
20159451 | J:167766
First Author: Harlow EG
Year: 2010
Journal: Neuron
Title: Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice.
Volume: 65
Issue: 3
Pages: 385-98
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Publication
23968838 | J:227614
First Author: Bostrom CA
Year: 2015
Journal: Cereb Cortex
Title: Rescue of NMDAR-dependent synaptic plasticity in Fmr1 knock-out mice.
Volume: 25
Issue: 1
Pages: 271-9
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Publication
35588990 | J:326382
 
First Author: Holley AJ
Year: 2022
Journal: Neurobiol Dis
Title: A sound-driven cortical phase-locking change in the Fmr1 KO mouse requires Fmr1 deletion in a subpopulation of brainstem neurons.
Volume: 170
Pages: 105767
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Publication
15661377 | J:95566
First Author: Tervonen T
Year: 2005
Journal: Brain Res Mol Brain Res
Title: Rgs4 mRNA expression is decreased in the brain of Fmr1 knockout mouse.
Volume: 133
Issue: 1
Pages: 162-5
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Publication
31587487 | J:355175
First Author: Nolan SO
Year: 2020
Journal: Genes Brain Behav
Title: High-throughput analysis of vocalizations reveals sex-specific changes in Fmr1 mutant pups.
Volume: 19
Issue: 2
Pages: e12611
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Publication
27824730 | J:323443
First Author: Reynolds CD
Year: 2016
Journal: Neuroreport
Title: Sex-specific and genotype-specific differences in vocalization development in FMR1 knockout mice.
Volume: 27
Issue: 18
Pages: 1331-1335
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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