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Search results 1 to 100 out of 2879 for Fmr1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: pig, domestic
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Fragile X messenger ribonucleoprotein 1 (FMRP/FMR1), and its paralogues, FXR1 and FXR2 (RNA-binding protein FXR1 and 2, respectively), comprise a family of RNA-binding proteins [].FMR1 protein is a multifunctional polyribosome-associated protein that plays a central role in neuronal development and synaptic plasticity. It regulates alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs [, , ]. FMR1 is thought to bind target mRNA in the nucleus to form a ribonucleoprotein complex which is transported to dendrites and spines []. It is also required for ovary development and function []. FMR1 has also been shown to interact with components of the miRNA pathway []. A large expansion of the CGG trinucleotide repeat in the 5'-untranslated region of the FMR1 gene causes Fragile X syndrome (FXS), an inherited developmental disorder that causes a broad range of intellectual and physical challenges [].FXR1 and FXR2 interact with FMR1 and seem to have a related role; therefore they are likely to play important roles in the function of FMR1 and in the pathogenesis of the FXS syndrome [, ]. FXR1 is highly expressed in vertebrates muscle cells and is required for proper development of this tissue [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Kenny PJ
Year: 2014
Journal: Cell Rep
Title: MOV10 and FMRP regulate AGO2 association with microRNA recognition elements.
Volume: 9
Issue: 5
Pages: 1729-41
Gene
Type: gene
Organism: human
Protein
Organism: Mus musculus/domesticus
Length: 614  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 614  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 631  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
Publication
First Author: Mientjes EJ
Year: 2004
Journal: Hum Mol Genet
Title: Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo.
Volume: 13
Issue: 13
Pages: 1291-302
Publication
First Author: Zhang J
Year: 2009
Journal: J Neurophysiol
Title: Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models.
Volume: 101
Issue: 5
Pages: 2572-80
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Estañ MC
Year: 2019
Journal: Nat Commun
Title: Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy.
Volume: 10
Issue: 1
Pages: 797
Publication
First Author: Nimchinsky EA
Year: 2001
Journal: J Neurosci
Title: Abnormal development of dendritic spines in FMR1 knock-out mice.
Volume: 21
Issue: 14
Pages: 5139-46
GXD Expression    
Probe: MGI:7384503
Assay Type: Western blot
Annotation Date: 2022-11-15
Strength: Absent
Sex: Male
Emaps: EMAPS:3284223
Stage: TS23
Assay Id: MGI:7384547
Age: embryonic day 15.5
Image: 5
Specimen Label: Fmr1 KO
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:7464398
Assay Type: Western blot
Annotation Date: 2023-04-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7464706
Age: postnatal month 2
Image: 1
Specimen Label: fmr1 KO
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:7464398
Assay Type: Western blot
Annotation Date: 2023-04-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7464706
Age: postnatal month 2
Image: 1
Specimen Label: fmr1 KO
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:7464398
Assay Type: Western blot
Annotation Date: 2023-04-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7464706
Age: postnatal month 2
Image: 1
Specimen Label: fmr1 KO
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:7464400
Assay Type: Western blot
Annotation Date: 2023-04-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7464747
Age: postnatal month 2
Image: 2
Specimen Label: fmr1 KO
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:7464398
Assay Type: Western blot
Annotation Date: 2023-04-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7464706
Age: postnatal month 2
Image: 1
Specimen Label: fmr1 KO
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:7464400
Assay Type: Western blot
Annotation Date: 2023-04-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7464747
Age: postnatal month 2
Image: 2
Specimen Label: fmr1 KO
Detected: false
Specimen Num: 4
Publication
First Author: Zhang Y
Year: 1995
Journal: EMBO J
Title: The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.
Volume: 14
Issue: 21
Pages: 5358-66
Publication  
Year: 1994
Journal: Cell
Title: Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium.
Volume: 78
Issue: 1
Pages: 23-33
Publication
First Author: Miyashiro KY
Year: 2003
Journal: Neuron
Title: RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice.
Volume: 37
Issue: 3
Pages: 417-31
GXD Expression
Probe: MGI:7384504
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-15
Strength: Present
Sex: Male
Emaps: EMAPS:3284223
Pattern: Widespread
Stage: TS23
Assay Id: MGI:7384544
Age: embryonic day 15.5
Image: 5a Nf1 Fmr1 KO
Note: No difference compared with wild type.
Specimen Label: 5a Nf1 Fmr1 KO
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:2449010
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-15
Strength: Present
Sex: Male
Emaps: EMAPS:3284223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7384545
Age: embryonic day 15.5
Image: 5a Ctnnb1 Fmr1 KO
Note: No difference compared with wild type.
Specimen Label: 5a Ctnnb1 Fmr1 KO
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:5796583
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-15
Strength: Present
Sex: Male
Emaps: EMAPS:3284223
Pattern: Widespread
Stage: TS23
Assay Id: MGI:7384546
Age: embryonic day 15.5
Image: 5a mTOR Fmr1 KO
Note: No difference compared with wild type.
Specimen Label: 5a mTOR Fmr1 KO
Detected: true
Specimen Num: 2
Protein
Organism: Mus musculus/domesticus
Length: 54  
Fragment?: false
Publication
First Author: Greenblatt EJ
Year: 2018
Journal: Science
Title: Fragile X mental retardation 1 gene enhances the translation of large autism-related proteins.
Volume: 361
Issue: 6403
Pages: 709-712
Publication
First Author: Verkerk AJ
Year: 1991
Journal: Cell
Title: Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome.
Volume: 65
Issue: 5
Pages: 905-14
Publication
First Author: Siomi MC
Year: 1995
Journal: EMBO J
Title: FXR1, an autosomal homolog of the fragile X mental retardation gene.
Volume: 14
Issue: 11
Pages: 2401-8
Publication
First Author: Li X
Year: 2009
Journal: Neuromolecular Med
Title: Macro role(s) of microRNAs in fragile X syndrome?
Volume: 11
Issue: 3
Pages: 200-7
Publication
First Author: Bassell GJ
Year: 2008
Journal: Neuron
Title: Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function.
Volume: 60
Issue: 2
Pages: 201-14
Publication
First Author: Bengani H
Year: 2021
Journal: PLoS One
Title: Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability.
Volume: 16
Issue: 8
Pages: e0256181
Publication
First Author: Mineur YS
Year: 2002
Journal: Hippocampus
Title: Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse.
Volume: 12
Issue: 1
Pages: 39-46
Publication
First Author: Didiot MC
Year: 2008
Journal: Nucleic Acids Res
Title: The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer.
Volume: 36
Issue: 15
Pages: 4902-12
Publication
First Author: Reyniers E
Year: 1996
Journal: Hum Genet
Title: Mean corpuscular hemoglobin is not increased in Fmr1 knockout mice.
Volume: 97
Issue: 1
Pages: 49-50
Publication
First Author: Lee FHF
Year: 2019
Journal: Mol Brain
Title: Altered cortical Cytoarchitecture in the Fmr1 knockout mouse.
Volume: 12
Issue: 1
Pages: 56
Publication
First Author: Dobkin C
Year: 2000
Journal: Neuroscience
Title: Fmr1 knockout mouse has a distinctive strain-specific learning impairment.
Volume: 100
Issue: 2
Pages: 423-9
Protein
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 35  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: true
Publication
First Author: Adams-Cioaba MA
Year: 2010
Journal: PLoS One
Title: Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.
Volume: 5
Issue: 11
Pages: e13559
Publication
First Author: Bontekoe CJ
Year: 2001
Journal: Hum Mol Genet
Title: Instability of a (CGG)98 repeat in the Fmr1 promoter.
Volume: 10
Issue: 16
Pages: 1693-9
Publication
First Author: Mineur YS
Year: 2006
Journal: Behav Brain Res
Title: Social behavior deficits in the Fmr1 mutant mouse.
Volume: 168
Issue: 1
Pages: 172-5
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Garcia-Arocena D
Year: 2010
Journal: Hum Mol Genet
Title: Fibroblast phenotype in male carriers of FMR1 premutation alleles.
Volume: 19
Issue: 2
Pages: 299-312
Publication
First Author: Heitzer AM
Year: 2013
Journal: J Autism Dev Disord
Title: Brief report: altered social behavior in isolation-reared Fmr1 knockout mice.
Volume: 43
Issue: 6
Pages: 1452-8
Publication
First Author: Desai NS
Year: 2006
Journal: J Neurophysiol
Title: Early postnatal plasticity in neocortex of Fmr1 knockout mice.
Volume: 96
Issue: 4
Pages: 1734-45
Publication
First Author: Brennan FX
Year: 2006
Journal: Genes Brain Behav
Title: Fmr1 knockout mice are impaired in a leverpress escape/avoidance task.
Volume: 5
Issue: 6
Pages: 467-71
Publication
First Author: Verheij C
Year: 1995
Journal: Hum Mol Genet
Title: Characterization of FMR1 proteins isolated from different tissues.
Volume: 4
Issue: 5
Pages: 895-901
Publication
First Author: Fisch GS
Year: 1999
Journal: Am J Med Genet
Title: Learning and memory in the FMR1 knockout mouse.
Volume: 84
Issue: 3
Pages: 277-82
Publication  
First Author: Hagerman RJ
Year: 2017
Journal: Nat Rev Dis Primers
Title: Fragile X syndrome.
Volume: 3
Pages: 17065
Publication  
First Author: Drozd M
Year: 2018
Journal: Front Mol Neurosci
Title: Modeling Fragile X Syndrome in Drosophila.
Volume: 11
Pages: 124
Publication
First Author: Zhao S
Year: 2023
Journal: Mol Autism
Title: Tau reduction attenuates autism-like features in Fmr1 knockout mice.
Volume: 14
Issue: 1
Pages: 42
Publication
First Author: D'Hooge R
Year: 1997
Journal: Neuroscience
Title: Mildly impaired water maze performance in male Fmr1 knockout mice.
Volume: 76
Issue: 2
Pages: 367-76
Publication
First Author: Ivanco TL
Year: 2002
Journal: Hippocampus
Title: Altered mossy fiber distributions in adult Fmr1 (FVB) knockout mice.
Volume: 12
Issue: 1
Pages: 47-54
Protein
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 357  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: true
Publication
First Author: Myrick LK
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures.
Volume: 112
Issue: 4
Pages: 949-56
Protein
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 673  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 568  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 674  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 655  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 454  
Fragment?: false
Publication
First Author: Levenga J
Year: 2011
Journal: Neurobiol Learn Mem
Title: Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice.
Volume: 95
Issue: 4
Pages: 467-72
Publication
First Author: Tang B
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Fmr1 deficiency promotes age-dependent alterations in the cortical synaptic proteome.
Volume: 112
Issue: 34
Pages: E4697-706
Publication
First Author: Talvio K
Year: 2021
Journal: Biometals
Title: Increased iron content in the heart of the Fmr1 knockout mouse.
Volume: 34
Issue: 4
Pages: 947-954
Publication
First Author: Bülow P
Year: 2019
Journal: Cell Rep
Title: Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons.
Volume: 26
Issue: 6
Pages: 1378-1388.e3
Publication  
First Author: Wrenn CC
Year: 2015
Journal: Neurosci Lett
Title: Effects of clonidine and methylphenidate on motor activity in Fmr1 knockout mice.
Volume: 585
Pages: 109-13
Publication
First Author: Harlow EG
Year: 2010
Journal: Neuron
Title: Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice.
Volume: 65
Issue: 3
Pages: 385-98
Publication
First Author: Bostrom CA
Year: 2015
Journal: Cereb Cortex
Title: Rescue of NMDAR-dependent synaptic plasticity in Fmr1 knock-out mice.
Volume: 25
Issue: 1
Pages: 271-9
Publication  
First Author: Holley AJ
Year: 2022
Journal: Neurobiol Dis
Title: A sound-driven cortical phase-locking change in the Fmr1 KO mouse requires Fmr1 deletion in a subpopulation of brainstem neurons.
Volume: 170
Pages: 105767
Publication
First Author: Tervonen T
Year: 2005
Journal: Brain Res Mol Brain Res
Title: Rgs4 mRNA expression is decreased in the brain of Fmr1 knockout mouse.
Volume: 133
Issue: 1
Pages: 162-5
Publication  
First Author: Chatterjee M
Year: 2018
Journal: Neuropharmacology
Title: STEP inhibition reverses behavioral, electrophysiologic, and synaptic abnormalities in Fmr1 KO mice.
Volume: 128
Pages: 43-53
Publication
First Author: Cheng Y
Year: 2013
Journal: Dev Neurosci
Title: Programmed cell death is impaired in the developing brain of FMR1 mutants.
Volume: 35
Issue: 4
Pages: 347-58
Publication
First Author: Kaplan ES
Year: 2012
Journal: J Neurochem
Title: Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 pre-mutation mouse model.
Volume: 123
Issue: 4
Pages: 613-21
Publication
First Author: Cao Z
Year: 2012
Journal: Hum Mol Genet
Title: Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone.
Volume: 21
Issue: 13
Pages: 2923-35