Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7467155 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-28 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1796320 |
|
Stage: |
TS20 |
Assay Id: |
MGI:7467154 |
Age: |
embryonic day 12.5 |
Image: |
8B Foxl2 |
|
Specimen Label: |
8B Foxl2 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7467155 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-28 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796220 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:7467154 |
Age: |
embryonic day 12.5 |
Image: |
8B Foxl2 |
Note: |
Expression is not detected 1-2 cell layers below the epithelium. |
Specimen Label: |
8B Foxl2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5618299 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-04-26 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797221 |
Pattern: |
Single cells |
Stage: |
TS21 |
Assay Id: |
MGI:7466640 |
Age: |
embryonic day 13.5 |
Image: |
3A Wt FOXL2 |
|
Specimen Label: |
3A Wt FOXL2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6382565 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-06-13 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1797221 |
|
Stage: |
TS21 |
Assay Id: |
MGI:7489559 |
Age: |
embryonic day 13.5 |
Image: |
4B FOXL2 XY WT |
|
Specimen Label: |
4B FOXL2 XY WT |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5618299 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-04-26 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1738321 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:7466640 |
Age: |
embryonic day 13.5 |
Image: |
3A KO FOXL2 |
Note: |
The number of expressing cells is increased in the mutant relative to wild type. |
Specimen Label: |
3A KO FOXL2 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6382565 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-06-13 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796221 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:7489559 |
Age: |
embryonic day 13.5 |
Image: |
4B FOXL2 XX WT |
|
Specimen Label: |
4B FOXL2 XX WT |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7528855 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-09-19 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796225 |
Pattern: |
Regionally restricted |
Stage: |
TS25 |
Assay Id: |
MGI:7528869 |
Age: |
embryonic day 17.5 |
Image: |
S1A 17.5 dpc FOXL2 |
Note: |
Expression in nucleus of granulosa cells. |
Specimen Label: |
S1A 17.5 dpc FOXL2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7528855 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-09-19 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796227 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:7528869 |
Age: |
postnatal day 1 |
Image: |
S1A 1 dpp FOXL2 |
Note: |
Expression in nucleus of granulosa cells. |
Specimen Label: |
S1A 1 dpp FOXL2 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7528855 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-09-19 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796225 |
Pattern: |
Regionally restricted |
Stage: |
TS25 |
Assay Id: |
MGI:7528869 |
Age: |
embryonic day 17.5 |
Image: |
S1B 17.5 dpc FOXL2 |
Note: |
Expression in nucleus of granulosa cells. |
Specimen Label: |
S1B 17.5 dpc FOXL2 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7528855 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-09-19 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796227 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:7528869 |
Age: |
postnatal day 1 |
Image: |
S1B 1 dpp FOXL2 |
Note: |
Expression in nucleus of granulosa cells. |
Specimen Label: |
S1B 1 dpp FOXL2 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7528855 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-09-19 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3562727 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:7528869 |
Age: |
postnatal day 3 |
Image: |
S1A 3 dpp FOXL2 |
Note: |
Expression in nucleus of granulosa cells in growing follicles |
Specimen Label: |
S1A 3 dpp FOXL2 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7528855 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-09-19 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3562727 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:7528869 |
Age: |
postnatal day 3 |
Image: |
S1B 3 dpp FOXL2 |
Note: |
Expression in nucleus of granulosa cellsin growing follicles. |
Specimen Label: |
S1B 3 dpp FOXL2 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Publication |
First Author: |
Cocquet J |
Year: |
2005 |
Journal: |
Genomics |
Title: |
Sense and antisense Foxl2 transcripts in mouse. |
Volume: |
85 |
Issue: |
5 |
Pages: |
531-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tran S |
Year: |
2013 |
Journal: |
Mol Endocrinol |
Title: |
Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice. |
Volume: |
27 |
Issue: |
3 |
Pages: |
407-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li R |
Year: |
2020 |
Journal: |
Biol Reprod |
Title: |
Increased FOXL2 expression alters uterine structures and functions†. |
Volume: |
103 |
Issue: |
5 |
Pages: |
951-965 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bellessort B |
Year: |
2015 |
Journal: |
Hum Mol Genet |
Title: |
Role of Foxl2 in uterine maturation and function. |
Volume: |
24 |
Issue: |
11 |
Pages: |
3092-103 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ongaro L |
Year: |
2020 |
Journal: |
Endocrinology |
Title: |
Human Follicle-Stimulating Hormone ß Subunit Expression Depends on FOXL2 and SMAD4. |
Volume: |
161 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ottolenghi C |
Year: |
2005 |
Journal: |
Hum Mol Genet |
Title: |
Foxl2 is required for commitment to ovary differentiation. |
Volume: |
14 |
Issue: |
14 |
Pages: |
2053-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee K |
Year: |
2005 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis. |
Volume: |
336 |
Issue: |
3 |
Pages: |
876-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cocquet J |
Year: |
2003 |
Journal: |
Cytogenet Genome Res |
Title: |
Structure, evolution and expression of the FOXL2 transcription unit. |
Volume: |
101 |
Issue: |
3-4 |
Pages: |
206-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Migale R |
Year: |
2024 |
Journal: |
Sci Adv |
Title: |
FOXL2 interaction with different binding partners regulates the dynamics of ovarian development. |
Volume: |
10 |
Issue: |
12 |
Pages: |
eadl0788 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marongiu M |
Year: |
2016 |
Journal: |
Dev Biol |
Title: |
Novel action of FOXL2 as mediator of Col1a2 gene autoregulation. |
Volume: |
416 |
Issue: |
1 |
Pages: |
200-211 |
|
•
•
•
•
•
|
Publication |
First Author: |
Herndon MK |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Maximal expression of Foxl2 in pituitary gonadotropes requires ovarian hormones. |
Volume: |
10 |
Issue: |
5 |
Pages: |
e0126527 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blount AL |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
FoxL2 and Smad3 coordinately regulate follistatin gene transcription. |
Volume: |
284 |
Issue: |
12 |
Pages: |
7631-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Y |
Year: |
2018 |
Journal: |
Endocrinology |
Title: |
Conditional Deletion of FOXL2 and SMAD4 in Gonadotropes of Adult Mice Causes Isolated FSH Deficiency. |
Volume: |
159 |
Issue: |
7 |
Pages: |
2641-2655 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ellsworth BS |
Year: |
2006 |
Journal: |
Mol Endocrinol |
Title: |
FOXL2 in the pituitary: molecular, genetic, and developmental analysis. |
Volume: |
20 |
Issue: |
11 |
Pages: |
2796-805 |
|
•
•
•
•
•
|
Publication |
First Author: |
Crisponi L |
Year: |
2001 |
Journal: |
Nat Genet |
Title: |
The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. |
Volume: |
27 |
Issue: |
2 |
Pages: |
159-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Uhlenhaut NH |
Year: |
2009 |
Journal: |
Cell |
Title: |
Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. |
Volume: |
139 |
Issue: |
6 |
Pages: |
1130-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marongiu M |
Year: |
2015 |
Journal: |
BMC Dev Biol |
Title: |
FOXL2 modulates cartilage, skeletal development and IGF1-dependent growth in mice. |
Volume: |
15 |
|
Pages: |
27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nicol B |
Year: |
2018 |
Journal: |
Hum Mol Genet |
Title: |
Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads. |
Volume: |
27 |
Issue: |
24 |
Pages: |
4273-4287 |
|
•
•
•
•
•
|
Publication |
First Author: |
Uda M |
Year: |
2004 |
Journal: |
Hum Mol Genet |
Title: |
Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development. |
Volume: |
13 |
Issue: |
11 |
Pages: |
1171-81 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6690812 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-04-26 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3600021 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:7466615 |
Age: |
embryonic day 13.5 |
Image: |
3A KO FOXL2 |
|
Specimen Label: |
3A KO FOXL2 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6690812 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-04-26 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797521 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:7466615 |
Age: |
embryonic day 13.5 |
Image: |
3A Wt FOXL2 |
|
Specimen Label: |
3A Wt FOXL2 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Auguste A |
Year: |
2011 |
Journal: |
Sex Dev |
Title: |
Loss of R-spondin1 and Foxl2 amplifies female-to-male sex reversal in XX mice. |
Volume: |
5 |
Issue: |
6 |
Pages: |
304-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kashimada K |
Year: |
2011 |
Journal: |
Endocrinology |
Title: |
FOXL2 and BMP2 act cooperatively to regulate follistatin gene expression during ovarian development. |
Volume: |
152 |
Issue: |
1 |
Pages: |
272-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang WH |
Year: |
2010 |
Journal: |
Biol Reprod |
Title: |
Synergistic activation of the Mc2r promoter by FOXL2 and NR5A1 in mice. |
Volume: |
83 |
Issue: |
5 |
Pages: |
842-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Llano E |
Year: |
2023 |
Journal: |
Cancer Res |
Title: |
The Oncogenic FOXL2 C134W Mutation Is a Key Driver of Granulosa Cell Tumors. |
Volume: |
83 |
Issue: |
2 |
Pages: |
239-250 |
|
•
•
•
•
•
|
Publication |
First Author: |
Migale R |
Year: |
2023 |
Journal: |
bioRxiv |
Title: |
FOXL2 interaction with different binding partners regulates the dynamics of granulosa cell differentiation across ovarian development. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Garcia-Ortiz JE |
Year: |
2009 |
Journal: |
BMC Dev Biol |
Title: |
Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. |
Volume: |
9 |
|
Pages: |
36 |
|
•
•
•
•
•
|
Publication |
First Author: |
L'Hôte D |
Year: |
2012 |
Journal: |
Hum Mol Genet |
Title: |
Discovery of novel protein partners of the transcription factor FOXL2 provides insights into its physiopathological roles. |
Volume: |
21 |
Issue: |
14 |
Pages: |
3264-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nicol B |
Year: |
2020 |
Journal: |
Biol Reprod |
Title: |
Aberrant and constitutive expression of FOXL2 impairs ovarian development and functions in mice. |
Volume: |
103 |
Issue: |
5 |
Pages: |
966-977 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ottolenghi C |
Year: |
2007 |
Journal: |
Hum Mol Genet |
Title: |
Loss of Wnt4 and Foxl2 leads to female-to-male sex reversal extending to germ cells. |
Volume: |
16 |
Issue: |
23 |
Pages: |
2795-804 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takasawa K |
Year: |
2014 |
Journal: |
FASEB J |
Title: |
FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice. |
Volume: |
28 |
Issue: |
5 |
Pages: |
2020-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kashimada K |
Year: |
2011 |
Journal: |
FASEB J |
Title: |
Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice. |
Volume: |
25 |
Issue: |
10 |
Pages: |
3561-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roybal LL |
Year: |
2014 |
Journal: |
Mol Endocrinol |
Title: |
Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ. |
Volume: |
28 |
Issue: |
10 |
Pages: |
1640-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi F |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
A piggyBac insertion disrupts Foxl2 expression that mimics BPES syndrome in mice. |
Volume: |
23 |
Issue: |
14 |
Pages: |
3792-800 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schmidt D |
Year: |
2004 |
Journal: |
Development |
Title: |
The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. |
Volume: |
131 |
Issue: |
4 |
Pages: |
933-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Crisponi L |
Year: |
2004 |
Journal: |
Genomics |
Title: |
FOXL2 inactivation by a translocation 171 kb away: analysis of 500 kb of chromosome 3 for candidate long-range regulatory sequences. |
Volume: |
83 |
Issue: |
5 |
Pages: |
757-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marongiu M |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity. |
Volume: |
5 |
Issue: |
3 |
Pages: |
e9477 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Y |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
β-Catenin directs the transformation of testis Sertoli cells to ovarian granulosa-like cells by inducing Foxl2 expression. |
Volume: |
292 |
Issue: |
43 |
Pages: |
17577-17586 |
|
•
•
•
•
•
|
Publication |
First Author: |
Loffler KA |
Year: |
2003 |
Journal: |
Endocrinology |
Title: |
Etiology of ovarian failure in blepharophimosis ptosis epicanthus inversus syndrome: FOXL2 is a conserved, early-acting gene in vertebrate ovarian development. |
Volume: |
144 |
Issue: |
7 |
Pages: |
3237-43 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6382565 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-05-09 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796222 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:7628312 |
Age: |
embryonic day 14.5 |
Image: |
3B E14.5 XX (lower) |
Note: |
Expression colocalizes with that of Foxl2 reporter. |
Specimen Label: |
3B E14.5 XX (lower) |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6382565 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-05-09 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796228 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7628312 |
Age: |
postnatal week 1 |
Image: |
3B 1W XX (lower) |
Note: |
Expression colocalizes with that of Foxl2 reporter. |
Specimen Label: |
3B 1W XX (lower) |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6382565 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-05-09 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796228 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7628312 |
Age: |
postnatal week 8 |
Image: |
3B 8W XX (lower) |
Note: |
Expression colocalizes with that of Foxl2 reporter. |
Specimen Label: |
3B 8W XX (lower) |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6382565 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-05-09 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796222 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:7628312 |
Age: |
embryonic day 14.5 |
Image: |
S8 E14.5 XX |
Note: |
Expression colocalizes with that of Foxl2 reporter. |
Specimen Label: |
S8 E14.5 XX |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6382565 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-05-09 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796228 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7628312 |
Age: |
postnatal week 1 |
Image: |
S8 1W XX |
Note: |
Expression colocalizes with that of Foxl2 reporter. |
Specimen Label: |
S8 1W XX |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6382565 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-05-09 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796228 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7628312 |
Age: |
postnatal week 8 |
Image: |
S8 8W XX EGFP/+ |
Note: |
Expression colocalizes with that of Foxl2 reporter. |
Specimen Label: |
S8 8W XX EGFP/+ |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6382565 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-05-09 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796228 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7628312 |
Age: |
postnatal week 8 |
Image: |
S8 8W XX +/+ |
Note: |
Expression colocalizes with that of Foxl2 reporter. |
Specimen Label: |
S8 8W XX +/+ |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cluzet V |
Year: |
2020 |
Journal: |
Oncogene |
Title: |
Aberrant granulosa cell-fate related to inactivated p53/Rb signaling contributes to granulosa cell tumors and to FOXL2 downregulation in the mouse ovary. |
Volume: |
39 |
Issue: |
9 |
Pages: |
1875-1890 |
|
•
•
•
•
•
|
Publication |
First Author: |
Georg I |
Year: |
2012 |
Journal: |
Biol Reprod |
Title: |
Sox9 and Sox8 are required for basal lamina integrity of testis cords and for suppression of FOXL2 during embryonic testis development in mice. |
Volume: |
87 |
Issue: |
4 |
Pages: |
99 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7782546 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-12-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1738324 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:7783742 |
Age: |
embryonic day 16.5 |
Image: |
10D XY FOG2cKO right |
Note: |
Partial sex reversal, with ectopic expression in the mutant. SOX9 and FOXL2 expression was not segregated spatially, the proteins were not expressed in the same cell. |
Specimen Label: |
10D XY FOG2cKO right |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Minkina A |
Year: |
2014 |
Journal: |
Dev Cell |
Title: |
DMRT1 protects male gonadal cells from retinoid-dependent sexual transdifferentiation. |
Volume: |
29 |
Issue: |
5 |
Pages: |
511-520 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fortin J |
Year: |
2014 |
Journal: |
FASEB J |
Title: |
Follicle-stimulating hormone synthesis and fertility depend on SMAD4 and FOXL2. |
Volume: |
28 |
Issue: |
8 |
Pages: |
3396-410 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fortin J |
Year: |
2015 |
Journal: |
Mol Endocrinol |
Title: |
Minireview: Activin Signaling in Gonadotropes: What Does the FOX say… to the SMAD? |
Volume: |
29 |
Issue: |
7 |
Pages: |
963-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang H |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
HDAC3 maintains oocyte meiosis arrest by repressing amphiregulin expression before the LH surge. |
Volume: |
10 |
Issue: |
1 |
Pages: |
5719 |
|
•
•
•
•
•
|
Publication |
First Author: |
Heude É |
Year: |
2015 |
Journal: |
Hum Mol Genet |
Title: |
Etiology of craniofacial malformations in mouse models of blepharophimosis, ptosis and epicanthus inversus syndrome. |
Volume: |
24 |
Issue: |
6 |
Pages: |
1670-81 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
375
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Pannetier M |
Year: |
2003 |
Journal: |
Cytogenet Genome Res |
Title: |
Expression studies of the PIS-regulated genes suggest different mechanisms of sex determination within mammals. |
Volume: |
101 |
Issue: |
3-4 |
Pages: |
199-205 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dai Y |
Year: |
2022 |
Journal: |
BMC Biol |
Title: |
Asynchronous embryonic germ cell development leads to a heterogeneity of postnatal ovarian follicle activation and may influence the timing of puberty onset in mice. |
Volume: |
20 |
Issue: |
1 |
Pages: |
109 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Oocyte-derived microvilli control female fertility by optimizing ovarian follicle selection in mice. |
Volume: |
12 |
Issue: |
1 |
Pages: |
2523 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim SY |
Year: |
2009 |
Journal: |
Endocrinology |
Title: |
Foxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-alpha. |
Volume: |
150 |
Issue: |
11 |
Pages: |
5085-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Terao M |
Year: |
2022 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Turnover of mammal sex chromosomes in the Sry-deficient Amami spiny rat is due to male-specific upregulation of Sox9. |
Volume: |
119 |
Issue: |
49 |
Pages: |
e2211574119 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zheng W |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
Two classes of ovarian primordial follicles exhibit distinct developmental dynamics and physiological functions. |
Volume: |
23 |
Issue: |
4 |
Pages: |
920-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang H |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Life-long in vivo cell-lineage tracing shows that no oogenesis originates from putative germline stem cells in adult mice. |
Volume: |
111 |
Issue: |
50 |
Pages: |
17983-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pisarska MD |
Year: |
2004 |
Journal: |
Endocrinology |
Title: |
Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene. |
Volume: |
145 |
Issue: |
7 |
Pages: |
3424-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lv X |
Year: |
2019 |
Journal: |
FASEB J |
Title: |
Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development. |
Volume: |
33 |
Issue: |
9 |
Pages: |
10049-10064 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang H |
Year: |
2014 |
Journal: |
Curr Biol |
Title: |
Somatic cells initiate primordial follicle activation and govern the development of dormant oocytes in mice. |
Volume: |
24 |
Issue: |
21 |
Pages: |
2501-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nicol B |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2. |
Volume: |
10 |
Issue: |
1 |
Pages: |
5116 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rossitto M |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway. |
Volume: |
13 |
Issue: |
1 |
Pages: |
4412 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schillebeeckx M |
Year: |
2015 |
Journal: |
Mol Cell Endocrinol |
Title: |
Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret. |
Volume: |
399 |
|
Pages: |
122-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsuji-Hosokawa A |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development. |
Volume: |
8 |
Issue: |
1 |
Pages: |
13263 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barrionuevo F |
Year: |
2006 |
Journal: |
Biol Reprod |
Title: |
Homozygous inactivation of Sox9 causes complete XY sex reversal in mice. |
Volume: |
74 |
Issue: |
1 |
Pages: |
195-201 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ikeda Y |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
The conditional deletion of steroidogenic factor 1 (Nr5a1) in Sox9-Cre mice compromises testis differentiation. |
Volume: |
11 |
Issue: |
1 |
Pages: |
4486 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gustin SE |
Year: |
2016 |
Journal: |
Dev Biol |
Title: |
WNT/β-catenin and p27/FOXL2 differentially regulate supporting cell proliferation in the developing ovary. |
Volume: |
412 |
Issue: |
2 |
Pages: |
250-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilhelm D |
Year: |
2009 |
Journal: |
Mech Dev |
Title: |
Antagonism of the testis- and ovary-determining pathways during ovotestis development in mice. |
Volume: |
126 |
Issue: |
5-6 |
Pages: |
324-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ellsworth BS |
Year: |
2003 |
Journal: |
Mol Cell Endocrinol |
Title: |
The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein. |
Volume: |
206 |
Issue: |
1-2 |
Pages: |
93-111 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rudigier LJ |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Ex vivo cultures combined with vivo-morpholino induced gene knockdown provide a system to assess the role of WT1 and GATA4 during gonad differentiation. |
Volume: |
12 |
Issue: |
4 |
Pages: |
e0176296 |
|
•
•
•
•
•
|
Publication |
First Author: |
Combes AN |
Year: |
2010 |
Journal: |
Int J Dev Biol |
Title: |
Gonadal defects in Cited2-mutant mice indicate a role for SF1 in both testis and ovary differentiation. |
Volume: |
54 |
Issue: |
4 |
Pages: |
683-9 |
|
•
•
•
•
•
|