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Search results 1 to 100 out of 337 for Fto

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
key_1584430 | Fto
Type: gene
Organism: Not Specified
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Gene
79068 | FTO
Type: gene
Organism: human
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Gene
550027 | fto
Type: gene
Organism: frog, western clawed
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Gene
478125 | FTO
Type: gene
Organism: dog, domestic
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Gene
454090 | FTO
Type: gene
Organism: chimpanzee
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Gene
618622 | FTO
Type: gene
Organism: cattle
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Gene
553363 | fto
Type: gene
Organism: zebrafish
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Gene
703724 | FTO
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR032868 | FTO
Type: Family
Description: Nine mammalian AlkB homologues exist, ALKBH1-8 and FTO [, ]. FTO, also known as Fat mass and obesity-associated protein, is an alpha-ketoglutarate-dependent dioxygenase involved in alkylated DNA and RNA repair []. FTO activity is highest towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine []. It has no detectable activity towards double-stranded DNA. FTO requires molecular oxygen, alpha-ketoglutarate and iron. FTO contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis, as well as the regulation of body size and body fat accumulation [].
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Gene
291905 | Fto
Type: gene
Organism: rat
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Gene
415718 | FTO
Type: gene
Organism: chicken
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Protein Coding Gene
MGI:1347093 | Fto
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
19234441 | J:147471
First Author: Fischer J
Year: 2009
Journal: Nature
Title: Inactivation of the Fto gene protects from obesity.
Volume: 458
Issue: 7240
Pages: 894-8
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Publication
17991826 | J:157439
First Author: Gerken T
Year: 2007
Journal: Science
Title: The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.
Volume: 318
Issue: 5855
Pages: 1469-72
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Publication
18775698 | J:141150
First Author: Jia G
Year: 2008
Journal: FEBS Lett
Title: Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.
Volume: 582
Issue: 23-24
Pages: 3313-9
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GXD Expression
GXD Expression
   
Probe: MGI:4938178
Assay Type: RT-PCR
Annotation Date: 2011-02-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796221
Stage: TS21
Assay Id: MGI:4938998
Age: embryonic day 13.5
Image: 6
Specimen Label: Fto
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:4938178
Assay Type: RT-PCR
Annotation Date: 2011-02-28
Strength: Present
Sex: Male
Emaps: EMAPS:1797221
Stage: TS21
Assay Id: MGI:4939003
Age: embryonic day 13.5
Image: 6
Specimen Label: Fto
Detected: true
Specimen Num: 10
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Protein
Q8BGW1
Organism: Mus musculus/domesticus
Length: 502  
Fragment?: false
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Protein
E9Q1E4
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: true
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Protein
D3Z127
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
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Publication
19680540 | J:152163
First Author: Church C
Year: 2009
Journal: PLoS Genet
Title: A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.
Volume: 5
Issue: 8
Pages: e1000599
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Publication
21076408 | J:166829
First Author: Church C
Year: 2010
Journal: Nat Genet
Title: Overexpression of Fto leads to increased food intake and results in obesity.
Volume: 42
Issue: 12
Pages: 1086-92
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Publication
26727661 | J:236760
 
First Author: Wang CY
Year: 2016
Journal: Sci Rep
Title: FTO modulates fibrogenic responses in obstructive nephropathy.
Volume: 6
Pages: 18874
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Publication
24743632 | J:215191
First Author: Carnevali L
Year: 2014
Journal: PLoS One
Title: Signs of cardiac autonomic imbalance and proarrhythmic remodeling in FTO deficient mice.
Volume: 9
Issue: 4
Pages: e95499
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Publication
19559399 | J:154241
First Author: Boissel S
Year: 2009
Journal: Am J Hum Genet
Title: Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations.
Volume: 85
Issue: 1
Pages: 106-11
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Publication
23359686 | J:194327
First Author: Gulati P
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Role for the obesity-related FTO gene in the cellular sensing of amino acids.
Volume: 110
Issue: 7
Pages: 2557-62
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Publication
25830092 | J:220973
First Author: Tung YC
Year: 2015
Journal: Mol Metab
Title: FTO is necessary for the induction of leptin resistance by high-fat feeding.
Volume: 4
Issue: 4
Pages: 287-98
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Publication
30197295 | J:265876
First Author: Wei J
Year: 2018
Journal: Mol Cell
Title: Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.
Volume: 71
Issue: 6
Pages: 973-985.e5
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Publication
33846348 | J:306306
First Author: Cui YH
Year: 2021
Journal: Nat Commun
Title: Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Volume: 12
Issue: 1
Pages: 2183
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Publication
34290091 | J:349711
 
First Author: Laber S
Year: 2021
Journal: Sci Adv
Title: Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo.
Volume: 7
Issue: 30
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Publication
23300482 | J:194922
First Author: McMurray F
Year: 2013
Journal: PLoS Genet
Title: Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.
Volume: 9
Issue: 1
Pages: e1003166
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Publication
25782772 | J:232912
 
First Author: Ronkainen J
Year: 2015
Journal: Sci Rep
Title: Fat mass- and obesity-associated gene Fto affects the dietary response in mouse white adipose tissue.
Volume: 5
Pages: 9233
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Publication
32956847 | J:298981
 
First Author: Mittenbühler MJ
Year: 2020
Journal: Mol Metab
Title: Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo.
Volume: 42
Pages: 101085
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Publication
29203346 | J:262081
First Author: Sachse G
Year: 2018
Journal: Biochim Biophys Acta
Title: FTO demethylase activity is essential for normal bone growth and bone mineralization in mice.
Volume: 1864
Issue: 3
Pages: 843-850
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Publication
30730976 | J:271883
First Author: Spychala A
Year: 2019
Journal: PLoS One
Title: FTO affects hippocampal function by regulation of BDNF processing.
Volume: 14
Issue: 2
Pages: e0211937
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Publication
23751871 | J:202153
First Author: Tews D
Year: 2013
Journal: Endocrinology
Title: FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes.
Volume: 154
Issue: 9
Pages: 3141-51
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Publication
31751468 | J:286650
First Author: Cao Y
Year: 2020
Journal: Hum Mol Genet
Title: Dynamic effects of Fto in regulating the proliferation and differentiation of adult neural stem cells of mice.
Volume: 29
Issue: 5
Pages: 727-735
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Publication
24646999 | J:208887
First Author: Smemo S
Year: 2014
Journal: Nature
Title: Obesity-associated variants within FTO form long-range functional connections with IRX3.
Volume: 507
Issue: 7492
Pages: 371-5
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Publication
24503721 | J:212970
First Author: Osborn DP
Year: 2014
Journal: PLoS One
Title: Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies.
Volume: 9
Issue: 2
Pages: e87662
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Publication
20360686 | J:158958
First Author: Speakman JR
Year: 2010
Journal: Nature
Title: FTO effect on energy demand versus food intake.
Volume: 464
Issue: 7289
Pages: E1; discussion E2
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Publication
25144618 | J:219118
First Author: Ikels K
Year: 2014
Journal: PLoS One
Title: FTO is a relevant factor for the development of the metabolic syndrome in mice.
Volume: 9
Issue: 8
Pages: e105349
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Publication
20858458 | J:166165
First Author: Wu Q
Year: 2010
Journal: Biochem Biophys Res Commun
Title: The obesity-associated Fto gene is a transcriptional coactivator.
Volume: 401
Issue: 3
Pages: 390-5
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Publication
31801409 | J:303479
First Author: Krüger N
Year: 2020
Journal: Circ Res
Title: Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction.
Volume: 126
Issue: 2
Pages: 232-242
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Publication
22872099 | J:321470
First Author: Berulava T
Year: 2013
Journal: Eur J Hum Genet
Title: FTO levels affect RNA modification and the transcriptome.
Volume: 21
Issue: 3
Pages: 317-23
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Gene
100874223 | FTOP1
Type: gene
Organism: human
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Publication
31434789 | J:278823
First Author: Zhang Q
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage.
Volume: 116
Issue: 36
Pages: 17980-17989
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Publication
29501742 | J:273677
First Author: Li H
Year: 2018
Journal: Biochem Biophys Res Commun
Title: FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling.
Volume: 498
Issue: 1
Pages: 234-239
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Publication
35085712 | J:321614
 
First Author: Zeng B
Year: 2022
Journal: Gene
Title: FTO knockout in adipose tissue effectively alleviates hepatic steatosis partially via increasing the secretion of adipocyte-derived IL-6.
Volume: 818
Pages: 146224
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Publication
28017614 | J:238414
First Author: Li Z
Year: 2017
Journal: Cancer Cell
Title: FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase.
Volume: 31
Issue: 1
Pages: 127-141
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Publication
26671148 | J:259512
First Author: Wang CY
Year: 2015
Journal: Sci Signal
Title: Loss of FTO in adipose tissue decreases Angptl4 translation and alters triglyceride metabolism.
Volume: 8
Issue: 407
Pages: ra127
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Publication
26188089 | J:228836
First Author: Wang CY
Year: 2015
Journal: Biochem Biophys Res Commun
Title: FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1-induced transcription.
Volume: 464
Issue: 3
Pages: 826-32
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Publication
30996080 | J:273800
 
First Author: Peng S
Year: 2019
Journal: Sci Transl Med
Title: Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.
Volume: 11
Issue: 488
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Publication
27064284 | J:234938
First Author: Stratigopoulos G
Year: 2016
Journal: J Clin Invest
Title: Hypomorphism of Fto and Rpgrip1l causes obesity in mice.
Volume: 126
Issue: 5
Pages: 1897-910
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Publication
21103374 | J:166984
First Author: Gao X
Year: 2010
Journal: PLoS One
Title: The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice.
Volume: 5
Issue: 11
Pages: e14005
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Publication
33761320 | J:305419
First Author: Kim H
Year: 2021
Journal: Dev Cell
Title: RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis.
Volume: 56
Issue: 8
Pages: 1118-1130.e6
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Gene
100505692 | FTO-IT1
Type: gene
Organism: human
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Publication
10501967 | J:57790
First Author: Peters T
Year: 1999
Journal: Mamm Genome
Title: Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation.
Volume: 10
Issue: 10
Pages: 983-6
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Publication
23867619 | J:201401
First Author: Karra E
Year: 2013
Journal: J Clin Invest
Title: A link between FTO, ghrelin, and impaired brain food-cue responsivity.
Volume: 123
Issue: 8
Pages: 3539-51
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Publication
37146971 | J:353888
First Author: Wu Y
Year: 2023
Journal: J Biol Chem
Title: Fat mass and obesity-associated factor (FTO)-mediated N6-methyladenosine regulates spermatogenesis in an age-dependent manner.
Volume: 299
Issue: 6
Pages: 104783
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Publication
26003568 | -
First Author: Ougland R
Year: 2015
Journal: J Mol Cell Biol
Title: Non-homologous functions of the AlkB homologs.
Volume: 7
Issue: 6
Pages: 494-504
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Publication
32766784 | J:296435
First Author: Gao H
Year: 2020
Journal: Hum Mol Genet
Title: Fto-modulated lipid niche regulates adult neurogenesis through modulating adenosine metabolism.
Volume: 29
Issue: 16
Pages: 2775-2787
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Publication
27827997 | J:240460
 
First Author: Ronkainen J
Year: 2016
Journal: Int J Mol Sci
Title: Fto-Deficiency Affects the Gene and MicroRNA Expression Involved in Brown Adipogenesis and Browning of White Adipose Tissue in Mice.
Volume: 17
Issue: 11
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Publication
34262022 | J:314515
First Author: Du K
Year: 2021
Journal: Cell Death Dis
Title: Distinct roles of Fto and Mettl3 in controlling development of the cerebral cortex through transcriptional and translational regulations.
Volume: 12
Issue: 7
Pages: 700
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Publication
30809304 | J:292168
First Author: Sun L
Year: 2019
Journal: Theranostics
Title: Fto Deficiency Reduces Anxiety- and Depression-Like Behaviors in Mice via Alterations in Gut Microbiota.
Volume: 9
Issue: 3
Pages: 721-733
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Publication
28398475 | J:242914
First Author: Li L
Year: 2017
Journal: Hum Mol Genet
Title: Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis.
Volume: 26
Issue: 13
Pages: 2398-2411
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Publication
26152727 | -
First Author: Fedeles BI
Year: 2015
Journal: J Biol Chem
Title: The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond.
Volume: 290
Issue: 34
Pages: 20734-42
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Publication
23817550 | J:203742
First Author: Hess ME
Year: 2013
Journal: Nat Neurosci
Title: The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.
Volume: 16
Issue: 8
Pages: 1042-8
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Publication
34836959 | J:331154
First Author: Liu S
Year: 2021
Journal: Nat Commun
Title: Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice.
Volume: 12
Issue: 1
Pages: 6937
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Publication
25448700 | J:218771
First Author: Tung YC
Year: 2014
Journal: Cell Metab
Title: Obesity and FTO: Changing Focus at a Complex Locus.
Volume: 20
Issue: 5
Pages: 710-8
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Publication
31451060 | J:310717
First Author: Wang X
Year: 2020
Journal: Autophagy
Title: m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7.
Volume: 16
Issue: 7
Pages: 1221-1235
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Publication
30728336 | J:309339
 
First Author: Wang L
Year: 2019
Journal: JCI Insight
Title: Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development.
Volume: 4
Issue: 3
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Publication
30279140 | J:270171
First Author: Shen GS
Year: 2018
Journal: Biochim Biophys Acta Mol Basis Dis
Title: The GDF11-FTO-PPARγ axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis.
Volume: 1864
Issue: 12
Pages: 3644-3654
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Publication
36465115 | J:344162
First Author: Zhang J
Year: 2022
Journal: iScience
Title: TWIK-related acid-sensitive K(+) channel 2 promotes renal fibrosis by inducing cell-cycle arrest.
Volume: 25
Issue: 12
Pages: 105620
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Protein Coding Gene
MGP_CAROLIEiJ_G0031369 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033932 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033915 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033841 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033907 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033617 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1347093 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034428 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032949 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033593 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033747 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033694 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033839 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033736 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034446 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032651 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033061 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0022968 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032488 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2656095
Age: postnatal adult
Specimen Label: 2
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2656095
Age: postnatal adult
Specimen Label: 3
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:2656095
Age: postnatal adult
Specimen Label: 4
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2656095
Age: postnatal adult
Specimen Label: 5
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2656095
Age: postnatal adult
Specimen Label: 6
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2656095
Age: postnatal adult
Specimen Label: 7
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2656095
Age: postnatal adult
Specimen Label: 8
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2656095
Age: postnatal adult
Specimen Label: 9
Detected: true
Specimen Num: 10
•
•
•
•
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