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Search results 1 to 100 out of 328 for Fto

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Type Details Score
Gene
Type: gene
Organism: Not Specified
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: chicken
Protein Domain
Type: Family
Description: Nine mammalian AlkB homologues exist, ALKBH1-8 and FTO [, ]. FTO, also known as Fat mass and obesity-associated protein, is an alpha-ketoglutarate-dependent dioxygenase involved in alkylated DNA and RNA repair []. FTO activity is highest towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine []. It has no detectable activity towards double-stranded DNA. FTO requires molecular oxygen, alpha-ketoglutarate and iron. FTO contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis, as well as the regulation of body size and body fat accumulation [].
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Fischer J
Year: 2009
Journal: Nature
Title: Inactivation of the Fto gene protects from obesity.
Volume: 458
Issue: 7240
Pages: 894-8
Publication
First Author: Gerken T
Year: 2007
Journal: Science
Title: The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.
Volume: 318
Issue: 5855
Pages: 1469-72
Publication
First Author: Jia G
Year: 2008
Journal: FEBS Lett
Title: Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.
Volume: 582
Issue: 23-24
Pages: 3313-9
GXD Expression    
Probe: MGI:4938178
Assay Type: RT-PCR
Annotation Date: 2011-02-28
Strength: Present
Sex: Male
Emaps: EMAPS:1797221
Stage: TS21
Assay Id: MGI:4939003
Age: embryonic day 13.5
Image: 6
Specimen Label: Fto
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:4938178
Assay Type: RT-PCR
Annotation Date: 2011-02-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796221
Stage: TS21
Assay Id: MGI:4938998
Age: embryonic day 13.5
Image: 6
Specimen Label: Fto
Detected: true
Specimen Num: 10
Protein
Organism: Mus musculus/domesticus
Length: 502  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
Publication
First Author: Church C
Year: 2009
Journal: PLoS Genet
Title: A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.
Volume: 5
Issue: 8
Pages: e1000599
Publication
First Author: Church C
Year: 2010
Journal: Nat Genet
Title: Overexpression of Fto leads to increased food intake and results in obesity.
Volume: 42
Issue: 12
Pages: 1086-92
Publication  
First Author: Wang CY
Year: 2016
Journal: Sci Rep
Title: FTO modulates fibrogenic responses in obstructive nephropathy.
Volume: 6
Pages: 18874
Publication
First Author: Carnevali L
Year: 2014
Journal: PLoS One
Title: Signs of cardiac autonomic imbalance and proarrhythmic remodeling in FTO deficient mice.
Volume: 9
Issue: 4
Pages: e95499
Publication
First Author: Boissel S
Year: 2009
Journal: Am J Hum Genet
Title: Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations.
Volume: 85
Issue: 1
Pages: 106-11
Publication
First Author: Gulati P
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Role for the obesity-related FTO gene in the cellular sensing of amino acids.
Volume: 110
Issue: 7
Pages: 2557-62
Publication
First Author: Tung YC
Year: 2015
Journal: Mol Metab
Title: FTO is necessary for the induction of leptin resistance by high-fat feeding.
Volume: 4
Issue: 4
Pages: 287-98
Publication
First Author: Wei J
Year: 2018
Journal: Mol Cell
Title: Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.
Volume: 71
Issue: 6
Pages: 973-985.e5
Publication
First Author: Cui YH
Year: 2021
Journal: Nat Commun
Title: Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Volume: 12
Issue: 1
Pages: 2183
Publication
First Author: McMurray F
Year: 2013
Journal: PLoS Genet
Title: Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.
Volume: 9
Issue: 1
Pages: e1003166
Publication  
First Author: Ronkainen J
Year: 2015
Journal: Sci Rep
Title: Fat mass- and obesity-associated gene Fto affects the dietary response in mouse white adipose tissue.
Volume: 5
Pages: 9233
Publication  
First Author: Mittenbühler MJ
Year: 2020
Journal: Mol Metab
Title: Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo.
Volume: 42
Pages: 101085
Publication
First Author: Sachse G
Year: 2018
Journal: Biochim Biophys Acta
Title: FTO demethylase activity is essential for normal bone growth and bone mineralization in mice.
Volume: 1864
Issue: 3
Pages: 843-850
Publication
First Author: Spychala A
Year: 2019
Journal: PLoS One
Title: FTO affects hippocampal function by regulation of BDNF processing.
Volume: 14
Issue: 2
Pages: e0211937
Publication
First Author: Tews D
Year: 2013
Journal: Endocrinology
Title: FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes.
Volume: 154
Issue: 9
Pages: 3141-51
Publication
First Author: Cao Y
Year: 2020
Journal: Hum Mol Genet
Title: Dynamic effects of Fto in regulating the proliferation and differentiation of adult neural stem cells of mice.
Volume: 29
Issue: 5
Pages: 727-735
Publication
First Author: Smemo S
Year: 2014
Journal: Nature
Title: Obesity-associated variants within FTO form long-range functional connections with IRX3.
Volume: 507
Issue: 7492
Pages: 371-5
Publication
First Author: Osborn DP
Year: 2014
Journal: PLoS One
Title: Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies.
Volume: 9
Issue: 2
Pages: e87662
Publication
First Author: Ikels K
Year: 2014
Journal: PLoS One
Title: FTO is a relevant factor for the development of the metabolic syndrome in mice.
Volume: 9
Issue: 8
Pages: e105349
Publication
First Author: Speakman JR
Year: 2010
Journal: Nature
Title: FTO effect on energy demand versus food intake.
Volume: 464
Issue: 7289
Pages: E1; discussion E2
Publication
First Author: Wu Q
Year: 2010
Journal: Biochem Biophys Res Commun
Title: The obesity-associated Fto gene is a transcriptional coactivator.
Volume: 401
Issue: 3
Pages: 390-5
Publication
First Author: Krüger N
Year: 2020
Journal: Circ Res
Title: Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction.
Volume: 126
Issue: 2
Pages: 232-242
Publication
First Author: Berulava T
Year: 2013
Journal: Eur J Hum Genet
Title: FTO levels affect RNA modification and the transcriptome.
Volume: 21
Issue: 3
Pages: 317-23
Gene
Type: gene
Organism: human
Publication
First Author: Zhang Q
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage.
Volume: 116
Issue: 36
Pages: 17980-17989
Publication
First Author: Li H
Year: 2018
Journal: Biochem Biophys Res Commun
Title: FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling.
Volume: 498
Issue: 1
Pages: 234-239
Publication  
First Author: Zeng B
Year: 2022
Journal: Gene
Title: FTO knockout in adipose tissue effectively alleviates hepatic steatosis partially via increasing the secretion of adipocyte-derived IL-6.
Volume: 818
Pages: 146224
Publication
First Author: Li Z
Year: 2017
Journal: Cancer Cell
Title: FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase.
Volume: 31
Issue: 1
Pages: 127-141
Publication
First Author: Wang CY
Year: 2015
Journal: Sci Signal
Title: Loss of FTO in adipose tissue decreases Angptl4 translation and alters triglyceride metabolism.
Volume: 8
Issue: 407
Pages: ra127
Publication
First Author: Wang CY
Year: 2015
Journal: Biochem Biophys Res Commun
Title: FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1-induced transcription.
Volume: 464
Issue: 3
Pages: 826-32
Publication  
First Author: Peng S
Year: 2019
Journal: Sci Transl Med
Title: Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.
Volume: 11
Issue: 488
Publication
First Author: Stratigopoulos G
Year: 2016
Journal: J Clin Invest
Title: Hypomorphism of Fto and Rpgrip1l causes obesity in mice.
Volume: 126
Issue: 5
Pages: 1897-910
Publication
First Author: Gao X
Year: 2010
Journal: PLoS One
Title: The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice.
Volume: 5
Issue: 11
Pages: e14005
Publication
First Author: Kim H
Year: 2021
Journal: Dev Cell
Title: RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis.
Volume: 56
Issue: 8
Pages: 1118-1130.e6
Gene
Type: gene
Organism: human
Publication
First Author: Peters T
Year: 1999
Journal: Mamm Genome
Title: Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation.
Volume: 10
Issue: 10
Pages: 983-6
Publication
First Author: Karra E
Year: 2013
Journal: J Clin Invest
Title: A link between FTO, ghrelin, and impaired brain food-cue responsivity.
Volume: 123
Issue: 8
Pages: 3539-51
Publication
First Author: Ougland R
Year: 2015
Journal: J Mol Cell Biol
Title: Non-homologous functions of the AlkB homologs.
Volume: 7
Issue: 6
Pages: 494-504
Publication
First Author: Gao H
Year: 2020
Journal: Hum Mol Genet
Title: Fto-modulated lipid niche regulates adult neurogenesis through modulating adenosine metabolism.
Volume: 29
Issue: 16
Pages: 2775-2787
Publication  
First Author: Ronkainen J
Year: 2016
Journal: Int J Mol Sci
Title: Fto-Deficiency Affects the Gene and MicroRNA Expression Involved in Brown Adipogenesis and Browning of White Adipose Tissue in Mice.
Volume: 17
Issue: 11
Publication
First Author: Du K
Year: 2021
Journal: Cell Death Dis
Title: Distinct roles of Fto and Mettl3 in controlling development of the cerebral cortex through transcriptional and translational regulations.
Volume: 12
Issue: 7
Pages: 700
Publication
First Author: Sun L
Year: 2019
Journal: Theranostics
Title: Fto Deficiency Reduces Anxiety- and Depression-Like Behaviors in Mice via Alterations in Gut Microbiota.
Volume: 9
Issue: 3
Pages: 721-733
Publication
First Author: Li L
Year: 2017
Journal: Hum Mol Genet
Title: Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis.
Volume: 26
Issue: 13
Pages: 2398-2411
Publication
First Author: Fedeles BI
Year: 2015
Journal: J Biol Chem
Title: The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond.
Volume: 290
Issue: 34
Pages: 20734-42
Publication
First Author: Hess ME
Year: 2013
Journal: Nat Neurosci
Title: The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.
Volume: 16
Issue: 8
Pages: 1042-8
Publication
First Author: Liu S
Year: 2021
Journal: Nat Commun
Title: Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice.
Volume: 12
Issue: 1
Pages: 6937
Publication
First Author: Tung YC
Year: 2014
Journal: Cell Metab
Title: Obesity and FTO: Changing Focus at a Complex Locus.
Volume: 20
Issue: 5
Pages: 710-8
Publication
First Author: Wang X
Year: 2020
Journal: Autophagy
Title: m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7.
Volume: 16
Issue: 7
Pages: 1221-1235
Publication  
First Author: Wang L
Year: 2019
Journal: JCI Insight
Title: Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development.
Volume: 4
Issue: 3
Publication
First Author: Shen GS
Year: 2018
Journal: Biochim Biophys Acta Mol Basis Dis
Title: The GDF11-FTO-PPARγ axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis.
Volume: 1864
Issue: 12
Pages: 3644-3654
Publication
First Author: Zhang J
Year: 2022
Journal: iScience
Title: TWIK-related acid-sensitive K(+) channel 2 promotes renal fibrosis by inducing cell-cycle arrest.
Volume: 25
Issue: 12
Pages: 105620
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
GXD Expression      
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2656095
Age: postnatal adult
Specimen Label: 2
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2656095
Age: postnatal adult
Specimen Label: 8
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2656095
Age: postnatal adult
Specimen Label: 5
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:2656104
Age: embryonic day 8.5
Specimen Label: 2
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:2656104
Age: embryonic day 10.5
Specimen Label: 4
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:2656104
Age: embryonic day 11.5
Specimen Label: 5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:2656104
Age: embryonic day 13.5
Specimen Label: 7
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2656095
Age: postnatal adult
Specimen Label: 3
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7433102
Assay Type: RT-PCR
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:7434282
Age: embryonic day 18.0
Image: S1
Specimen Label: SPF
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775128
Stage: TS28
Assay Id: MGI:2656095
Age: postnatal adult
Specimen Label: 12
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:4938178
Assay Type: RT-PCR
Annotation Date: 2011-02-25
Strength: Present
Sex: Male
Emaps: EMAPS:1797220
Stage: TS20
Assay Id: MGI:4938191
Age: embryonic day 12.0
Image: 1
Specimen Label: E12.0
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4938178
Assay Type: RT-PCR
Annotation Date: 2011-02-25
Strength: Present
Sex: Male
Emaps: EMAPS:1797221
Stage: TS21
Assay Id: MGI:4938191
Age: embryonic day 13.5
Image: 1
Specimen Label: E13.5
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7433102
Assay Type: RT-PCR
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:7434141
Age: embryonic day 18.0
Image: 1
Specimen Label: SPF
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7433123
Assay Type: Western blot
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:7434163
Age: embryonic day 18.0
Image: 1
Specimen Label: SPF
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7433102
Assay Type: RT-PCR
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:7434195
Age: embryonic day 18.0
Image: 5
Specimen Label: CONV
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7433123
Assay Type: Western blot
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:7434205
Age: embryonic day 18.0
Image: 5
Specimen Label: CONV
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2655233
Assay Type: RT-PCR
Annotation Date: 2003-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:2656095
Age: postnatal adult
Specimen Label: 4
Detected: true
Specimen Num: 5