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Search results 1 to 100 out of 711 for Furin

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
54281 | Furin
Type: gene
Organism: rat
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Gene
5045 | FURIN
Type: gene
Organism: human
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Gene
100327238 | furin
Type: gene
Organism: frog, western clawed
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Gene
453652 | FURIN
Type: gene
Organism: chimpanzee
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Gene
488746 | FURIN
Type: gene
Organism: dog, domestic
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Gene
281374 | FURIN
Type: gene
Organism: cattle
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Gene
395457 | FURIN
Type: gene
Organism: chicken
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Gene
715813 | FURIN
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:97513 | Furin
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P23188
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
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Protein
Q8CIY1
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: true
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Protein
D3YTP7
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
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Protein
D3Z401
Organism: Mus musculus/domesticus
Length: 59  
Fragment?: true
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Protein
A0A0U1RQ98
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: true
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Publication
2266110 | J:23406
First Author: Hatsuzawa K
Year: 1990
Journal: J Biol Chem
Title: Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells.
Volume: 265
Issue: 36
Pages: 22075-8
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Publication
9412467 | J:51716
First Author: Liu G
Year: 1997
Journal: J Cell Biol
Title: Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway.
Volume: 139
Issue: 7
Pages: 1719-33
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Publication
18713856 | J:138967
First Author: Louagie E
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate.
Volume: 105
Issue: 34
Pages: 12319-24
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Publication
38292192 | J:355548
First Author: Xie S
Year: 2024
Journal: Genes Dis
Title: Cerebral furin deficiency causes hydrocephalus in mice.
Volume: 11
Issue: 3
Pages: 101009
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Publication
12794637 | -
First Author: Henrich S
Year: 2003
Journal: Nat Struct Biol
Title: The crystal structure of the proprotein processing proteinase furin explains its stringent specificity.
Volume: 10
Issue: 7
Pages: 520-6
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Publication
9231654 | J:41797
First Author: Kayo T
Year: 1997
Journal: Diabetes
Title: Proprotein-processing endoprotease furin controls growth of pancreatic beta-cells.
Volume: 46
Issue: 8
Pages: 1296-304
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Publication
15471862 | J:118515
First Author: Roebroek AJ
Year: 2004
Journal: J Biol Chem
Title: Limited redundancy of the proprotein convertase furin in mouse liver.
Volume: 279
Issue: 51
Pages: 53442-50
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Publication
25926688 | J:242670
First Author: Ortutay Z
Year: 2015
Journal: J Leukoc Biol
Title: Proprotein convertase FURIN regulates T cell receptor-induced transactivation.
Volume: 98
Issue: 1
Pages: 73-83
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Publication
21147780 | J:169483
First Author: Essalmani R
Year: 2011
Journal: J Biol Chem
Title: In vivo evidence that furin from hepatocytes inactivates PCSK9.
Volume: 286
Issue: 6
Pages: 4257-63
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Publication
28972540 | J:252592
First Author: Al Rifai O
Year: 2017
Journal: J Clin Invest
Title: Proprotein convertase furin regulates osteocalcin and bone endocrine function.
Volume: 127
Issue: 11
Pages: 4104-4117
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Publication
12360192 | J:79598
First Author: Thomas G
Year: 2002
Journal: Nat Rev Mol Cell Biol
Title: Furin at the cutting edge: from protein traffic to embryogenesis and disease.
Volume: 3
Issue: 10
Pages: 753-66
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Publication
18701887 | J:138986
First Author: Pesu M
Year: 2008
Journal: Nature
Title: T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
Volume: 455
Issue: 7210
Pages: 246-50
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Publication
18772886 | J:141156
First Author: Blanchet MH
Year: 2008
Journal: EMBO J
Title: Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation.
Volume: 27
Issue: 19
Pages: 2580-91
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Publication
8422932 | J:3714
First Author: Torii S
Year: 1993
Journal: FEBS Lett
Title: Localization of Kex2-like processing endoproteases, furin and PC4, within mouse testis by in situ hybridization.
Volume: 316
Issue: 1
Pages: 12-6
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Publication
36274943 | J:330951
First Author: Liang Z
Year: 2022
Journal: iScience
Title: The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance.
Volume: 25
Issue: 10
Pages: 105233
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Publication
1354647 | J:1676
First Author: Copeland NG
Year: 1992
Journal: Genomics
Title: Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes.
Volume: 13
Issue: 4
Pages: 1356-8
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Publication
26167473 | J:317010
 
First Author: Declercq J
Year: 2015
Journal: Biomed Res Int
Title: Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth.
Volume: 2015
Pages: 148651
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Publication
22733989 | J:196532
First Author: Kim W
Year: 2012
Journal: Mol Cell Biol
Title: Loss of endothelial furin leads to cardiac malformation and early postnatal death.
Volume: 32
Issue: 17
Pages: 3382-91
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Publication
8631882 | J:32910
First Author: Kayo T
Year: 1996
Journal: J Biol Chem
Title: Proprotein-processing endoprotease furin decreases regulated secretory pathway-specific proteins in the pancreatic beta cell line MIN6.
Volume: 271
Issue: 18
Pages: 10731-7
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Publication
9199665 | J:40644
First Author: Farhadi H
Year: 1997
Journal: J Histochem Cytochem
Title: Prohormone convertases in mouse submandibular gland: co-localization of furin and nerve growth factor.
Volume: 45
Issue: 6
Pages: 795-804
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Publication
28569793 | J:272231
First Author: Meng TG
Year: 2017
Journal: Cell Death Dis
Title: Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice.
Volume: 8
Issue: 6
Pages: e2846
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Publication
17283058 | J:121404
First Author: Tellier E
Year: 2007
Journal: Mol Cell Biol
Title: Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.
Volume: 27
Issue: 8
Pages: 2997-3007
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Publication
8891276 | J:35361
First Author: Meyer A
Year: 1996
Journal: Brain Res
Title: Kainic acid increases the expression of the prohormone convertases furin and PC1 in the mouse hippocampus.
Volume: 732
Issue: 1-2
Pages: 121-32
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Publication
14684599 | J:88698
First Author: Dey A
Year: 2004
Journal: Endocrinology
Title: Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone.
Volume: 145
Issue: 4
Pages: 1961-71
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Publication
26416966 | J:227651
First Author: Bessonnard S
Year: 2015
Journal: J Cell Biol
Title: PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.
Volume: 210
Issue: 7
Pages: 1185-97
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Publication
21896659 | J:176435
First Author: Mesnard D
Year: 2011
Journal: Genes Dev
Title: The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities.
Volume: 25
Issue: 17
Pages: 1871-80
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Publication
36374777 | J:331452
 
First Author: Coppola I
Year: 2022
Journal: Mol Metab
Title: Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice.
Volume: 66
Pages: 101627
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Publication
32389711 | J:289151
 
First Author: He Z
Year: 2020
Journal: Cancer Lett
Title: Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer.
Volume: 484
Pages: 40-49
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Publication
23918928 | J:203527
First Author: Essalmani R
Year: 2013
Journal: J Biol Chem
Title: Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes.
Volume: 288
Issue: 37
Pages: 26410-8
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Publication
30651003 | J:291374
First Author: Yakala GK
Year: 2019
Journal: Arterioscler Thromb Vasc Biol
Title: FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice.
Volume: 39
Issue: 3
Pages: 387-401
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Publication
30266770 | J:267979
First Author: Li Y
Year: 2018
Journal: J Immunol
Title: STAT6 and Furin Are Successive Triggers for the Production of TGF-β by T Cells.
Volume: 201
Issue: 9
Pages: 2612-2623
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Publication
7499343 | J:354363
First Author: Takahashi S
Year: 1995
Journal: J Biol Chem
Title: Localization of furin to the trans-Golgi network and recycling from the cell surface involves Ser and Tyr residues within the cytoplasmic domain.
Volume: 270
Issue: 47
Pages: 28397-401
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Publication
1765368 | J:419
First Author: Seidah NG
Year: 1991
Journal: Genomics
Title: Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region).
Volume: 11
Issue: 1
Pages: 103-7
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UniProt Feature
UniProt Feature
Begin: 108
Description: Furin
Type: chain
End: 793
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Publication
10701998 | J:59052
First Author: Seidah NG
Year: 1999
Journal: Brain Res
Title: Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides.
Volume: 848
Issue: 1-2
Pages: 45-62
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Publication
8003017 | J:18659
First Author: Goodman LJ
Year: 1994
Journal: Biochem Biophys Res Commun
Title: Autoproteolytic activation of the mouse prohormone convertase mPC1.
Volume: 201
Issue: 2
Pages: 795-804
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Publication
8226974 | J:15843
First Author: Robertson BJ
Year: 1993
Journal: J Biol Chem
Title: Defective processing of the insulin receptor in an endoprotease-deficient Chinese hamster cell strain is corrected by expression of mouse furin.
Volume: 268
Issue: 32
Pages: 24274-7
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Publication
15606899 | J:95653
First Author: Wickham L
Year: 2005
Journal: J Neurochem
Title: Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin.
Volume: 92
Issue: 1
Pages: 93-102
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Publication
18425334 | J:142978
First Author: De Vos L
Year: 2008
Journal: Int J Oncol
Title: MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice.
Volume: 32
Issue: 5
Pages: 1073-83
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Publication
29723063 | J:282780
First Author: Shi LY
Year: 2018
Journal: FASEB J
Title: Placenta-specific 1 regulates oocyte meiosis and fertilization through furin.
Volume: 32
Issue: 10
Pages: 5483-5494
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Publication
34149625 | J:308473
 
First Author: Al Rifai O
Year: 2021
Journal: Front Endocrinol (Lausanne)
Title: In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23.
Volume: 12
Pages: 690681
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Publication
23441131 | J:316434
First Author: Fu J
Year: 2013
Journal: Neoplasia
Title: Enhanced UV-induced skin carcinogenesis in transgenic mice overexpressing proprotein convertases.
Volume: 15
Issue: 2
Pages: 169-79
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Publication
15505202 | J:93446
First Author: Guzman-Ayala M
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment.
Volume: 101
Issue: 44
Pages: 15656-60
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Publication
24101515 | J:201970
First Author: Wetsel WC
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.
Volume: 110
Issue: 43
Pages: 17362-7
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Publication
19056739 | J:147603
First Author: Ikonomov OC
Year: 2009
Journal: J Biol Chem
Title: Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin.
Volume: 284
Issue: 6
Pages: 3750-61
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Publication
28468828 | J:245609
First Author: Essalmani R
Year: 2017
Journal: J Biol Chem
Title: Thrombin activation of protein C requires prior processing by a liver proprotein convertase.
Volume: 292
Issue: 25
Pages: 10564-10573
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Publication
20876279 | J:165252
First Author: Mesnard D
Year: 2010
Journal: J Cell Biol
Title: Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.
Volume: 191
Issue: 1
Pages: 129-39
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Publication
16950123 | J:112799
First Author: Ben-Haim N
Year: 2006
Journal: Dev Cell
Title: The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4.
Volume: 11
Issue: 3
Pages: 313-23
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Publication
30840660 | J:273415
First Author: Dupays L
Year: 2019
Journal: PLoS One
Title: Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function.
Volume: 14
Issue: 3
Pages: e0212992
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Publication
10603343 | J:56972
First Author: Constam DB
Year: 2000
Journal: Development
Title: Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping.
Volume: 127
Issue: 2
Pages: 245-54
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Publication
18664504 | J:140467
First Author: Scamuffa N
Year: 2008
Journal: Gut
Title: Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.
Volume: 57
Issue: 11
Pages: 1573-82
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Publication
15082773 | J:90197
First Author: Marschang P
Year: 2004
Journal: Mol Cell Biol
Title: Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.
Volume: 24
Issue: 9
Pages: 3782-93
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Publication
9811571 | J:50582
First Author: Roebroek AJ
Year: 1998
Journal: Development
Title: Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin.
Volume: 125
Issue: 24
Pages: 4863-76
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Publication
7819324 | J:23191
First Author: Seidah NG
Year: 1994
Journal: Biochimie
Title: The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.
Volume: 76
Issue: 3-4
Pages: 197-209
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Publication
12447384 | J:81247
First Author: Beck S
Year: 2002
Journal: Nat Cell Biol
Title: Extraembryonic proteases regulate Nodal signalling during gastrulation.
Volume: 4
Issue: 12
Pages: 981-5
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Publication
16728477 | J:289378
First Author: Mesnard D
Year: 2006
Journal: Development
Title: Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning.
Volume: 133
Issue: 13
Pages: 2497-505
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Publication
17936261 | J:127541
First Author: Andersson O
Year: 2007
Journal: Dev Biol
Title: Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development.
Volume: 311
Issue: 2
Pages: 500-11
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Protein Coding Gene
MGP_CAROLIEiJ_G0029906 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032415 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032394 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032330 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032406 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032119 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_97513 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032898 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031447 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032085 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032240 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032195 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032321 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032232 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032916 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031167 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031565 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013128 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031008 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8473289 | J:354367
First Author: Wasley LC
Year: 1993
Journal: J Biol Chem
Title: PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway.
Volume: 268
Issue: 12
Pages: 8458-65
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GXD Expression
GXD Expression
   
Probe: MGI:1309864
Assay Type: Northern blot
Annotation Date: 1999-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1329898
Age: postnatal adult
Image: 2
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:1309864
Assay Type: Northern blot
Annotation Date: 1999-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1329898
Age: postnatal adult
Image: 2
Specimen Label: +/+
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:1309864
Assay Type: Northern blot
Annotation Date: 1999-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1329898
Age: postnatal adult
Image: 2
Specimen Label: +/-
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:1309864
Assay Type: Northern blot
Annotation Date: 1999-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1329898
Age: postnatal adult
Image: 2
Specimen Label: +/-
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:1309864
Assay Type: Northern blot
Annotation Date: 1999-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1329898
Age: postnatal adult
Image: 2
Specimen Label: +/-
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:1309864
Assay Type: Northern blot
Annotation Date: 1999-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1329898
Age: postnatal adult
Image: 2
Specimen Label: +/-
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:1309868
Assay Type: RT-PCR
Annotation Date: 1999-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:1329901
Age: embryonic day 9.5
Image: 2
Specimen Label: +/+
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1309868
Assay Type: RT-PCR
Annotation Date: 1999-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:1329901
Age: embryonic day 9.5
Image: 2
Specimen Label: +/+
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1309868
Assay Type: RT-PCR
Annotation Date: 1999-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:1329901
Age: embryonic day 9.5
Image: 2
Specimen Label: +/-
Detected: true
Specimen Num: 4
•
•
•
•
•




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