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Search results 1 to 100 out of 652 for Fus

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
2521 | FUS
Type: gene
Organism: human
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Gene
100038234 | fus
Type: gene
Organism: frog, western clawed
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Gene
280796 | FUS
Type: gene
Organism: cattle
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Gene
104002580 | FUS
Type: gene
Organism: chimpanzee
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Gene
317385 | Fus
Type: gene
Organism: rat
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Gene
100856381 | FUS
Type: gene
Organism: dog, domestic
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Gene
414144 | FUS
Type: gene
Organism: chicken
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Gene
394058 | fus
Type: gene
Organism: zebrafish
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Gene
713433 | FUS
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR034459 | FUS
Type: Family
Description: FUS (FUsed in Sarcoma, also known as TLS, Translocated in LipoSarcoma) is a RNA binding protein participating in nucleo-cytoplasmic RNA shuttling. It has functions in multiple cellular pathways. Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS), a progressive and ultimately fatal neurodegenerative disease of the upper and lower motor neurons of the brain and spinal cord []. TLS contains the unstructured N-terminal half followed by the RRM and zinc finger-like domains, which are connected to each other by a flexible linker. Interestingly, whether its RRM domain functions in the binding with RNAs is controversial. Moreover, its C-terminal RGG2-zinc finger-RGG3 domains have been found to function in the interaction with RNA [].TAF15/EWS/TLS family members include human FUS (Fused in liposarcoma), EWS (Ewing Sarcoma) and TAF15 (TATA binding associated factor 15), and the Drosophila orthologue Cabeza. They are RNA binding proteins that contain a transcriptional-activation domain (EAD), 3 glycine-arginine(RGG) rich regions, an RNA-binding domain (RBD), and a zinc finger domain [, ]. They are involved in transcription and alternative splicing. They are subjected to different environmental signals that induce post-translational modifications in their RBD and in the RGG domains, thus modulating their activity []. TAF15/EWS/TLS play important roles in oncogenesis and neuronal disease [].
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Protein Coding Gene
MGI:1353633 | Fus
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
27460707 | -
First Author: Kamelgarn M
Year: 2016
Journal: Biochim Biophys Acta
Title: Proteomic analysis of FUS interacting proteins provides insights into FUS function and its role in ALS.
Volume: 1862
Issue: 10
Pages: 2004-14
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Protein
G3UZD2
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: true
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Protein
Q91VQ2
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
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Protein
P56959
Organism: Mus musculus/domesticus
Length: 518  
Fragment?: false
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Protein
G3UXT7
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: true
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Protein
Q8CFQ9
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: false
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Publication
25968143 | J:224878
 
First Author: Udagawa T
Year: 2015
Journal: Nat Commun
Title: FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization.
Volume: 6
Pages: 7098
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Publication
27159574 | -
First Author: Chau BL
Year: 2016
Journal: Transcription
Title: RGG boxes within the TET/FET family of RNA-binding proteins are functionally distinct.
Volume: 7
Issue: 4
Pages: 141-51
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Publication
27415968 | -
First Author: Svetoni F
Year: 2016
Journal: RNA Biol
Title: Role of FET proteins in neurodegenerative disorders.
Volume: 13
Issue: 11
Pages: 1089-1102
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Publication
22081015 | -
First Author: Hoell JI
Year: 2011
Journal: Nat Struct Mol Biol
Title: RNA targets of wild-type and mutant FET family proteins.
Volume: 18
Issue: 12
Pages: 1428-31
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Protein
Q3UK30
Organism: Mus musculus/domesticus
Length: 518  
Fragment?: false
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Protein
Q3USY4
Organism: Mus musculus/domesticus
Length: 518  
Fragment?: false
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Protein
Q564D0
Organism: Mus musculus/domesticus
Length: 518  
Fragment?: false
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Publication
25324524 | J:216672
First Author: Sephton CF
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Activity-dependent FUS dysregulation disrupts synaptic homeostasis.
Volume: 111
Issue: 44
Pages: E4769-78
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Publication
29499134 | J:260809
First Author: Zhang T
Year: 2018
Journal: Mol Cell
Title: FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.
Volume: 69
Issue: 5
Pages: 787-801.e8
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Publication
31383794 | J:279283
 
First Author: Crivello M
Year: 2019
Journal: Dis Model Mech
Title: Vascular regression precedes motor neuron loss in the FUS (1-359) ALS mouse model.
Volume: 12
Issue: 8
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Publication
32479602 | J:291035
First Author: Humphrey J
Year: 2020
Journal: Nucleic Acids Res
Title: FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention.
Volume: 48
Issue: 12
Pages: 6889-6905
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Publication
12950080 | J:85485
First Author: Alappat SR
Year: 2003
Journal: Dev Dyn
Title: Mouse pigpen encodes a nuclear protein whose expression is developmentally regulated during craniofacial morphogenesis.
Volume: 228
Issue: 1
Pages: 59-71
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Publication
33311468 | J:301415
First Author: Jutzi D
Year: 2020
Journal: Nat Commun
Title: Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.
Volume: 11
Issue: 1
Pages: 6341
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Publication
38461154 | J:351972
First Author: Kodavati M
Year: 2024
Journal: Nat Commun
Title: FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease.
Volume: 15
Issue: 1
Pages: 2156
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Publication
28358055 | J:244840
 
First Author: Errichelli L
Year: 2017
Journal: Nat Commun
Title: FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons.
Volume: 8
Pages: 14741
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Publication
20412831 | J:164085
First Author: Sugawara T
Year: 2010
Journal: Exp Hematol
Title: FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells.
Volume: 38
Issue: 8
Pages: 696-706
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Publication
27418313 | J:236016
First Author: Stoica R
Year: 2016
Journal: EMBO Rep
Title: ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations.
Volume: 17
Issue: 9
Pages: 1326-42
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Publication
30747709 | J:275195
   
First Author: Ling SC
Year: 2019
Journal: Elife
Title: Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis.
Volume: 8
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Publication
30344044 | J:268412
First Author: López-Erauskin J
Year: 2018
Journal: Neuron
Title: ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS.
Volume: 100
Issue: 4
Pages: 816-830.e7
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Publication
23062703 | J:203384
First Author: Fratta P
Year: 2013
Journal: Neurobiol Aging
Title: FUS is not dysregulated by the spinal bulbar muscular atrophy androgen receptor polyglutamine repeat expansion.
Volume: 34
Issue: 5
Pages: 1516.e17-9
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Publication
34021139 | J:306467
First Author: Sahadevan S
Year: 2021
Journal: Nat Commun
Title: Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS.
Volume: 12
Issue: 1
Pages: 3027
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Publication
22934129 | J:206113
 
First Author: Rogelj B
Year: 2012
Journal: Sci Rep
Title: Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain.
Volume: 2
Pages: 603
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Publication
24297750 | J:208285
First Author: Yasuda K
Year: 2013
Journal: J Cell Biol
Title: The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules.
Volume: 203
Issue: 5
Pages: 737-46
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Publication
24036913 | J:204012
First Author: Wang WY
Year: 2013
Journal: Nat Neurosci
Title: Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons.
Volume: 16
Issue: 10
Pages: 1383-91
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Publication
34471224 | J:337701
First Author: Garone MG
Year: 2021
Journal: Commun Biol
Title: ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity.
Volume: 4
Issue: 1
Pages: 1025
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Publication
29053787 | J:249965
First Author: Devoy A
Year: 2017
Journal: Brain
Title: Humanized mutant FUS drives progressive motor neuron degeneration without aggregation in 'FUSDelta14' knockin mice.
Volume: 140
Issue: 11
Pages: 2797-2805
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Publication
37772684 | J:342847
 
First Author: Ali Z
Year: 2023
Journal: Dis Model Mech
Title: Mutation in the FUS nuclear localisation signal domain causes neurodevelopmental and systemic metabolic alterations.
Volume: 16
Issue: 10
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Publication
34233002 | J:326347
First Author: Reber S
Year: 2021
Journal: Nucleic Acids Res
Title: The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation.
Volume: 49
Issue: 13
Pages: 7713-7731
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Publication
20674093 | J:188233
First Author: Gal J
Year: 2011
Journal: Neurobiol Aging
Title: Nuclear localization sequence of FUS and induction of stress granules by ALS mutants.
Volume: 32
Issue: 12
Pages: 2323.e27-40
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Publication
28453628 | J:243043
First Author: Svetoni F
Year: 2017
Journal: Hum Mol Genet
Title: Post-transcriptional regulation of FUS and EWS protein expression by miR-141 during neural differentiation.
Volume: 26
Issue: 14
Pages: 2732-2746
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Publication
35075293 | J:326930
First Author: Korobeynikov VA
Year: 2022
Journal: Nat Med
Title: Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis.
Volume: 28
Issue: 1
Pages: 104-116
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Publication
26842965 | J:232167
 
First Author: Sharma A
Year: 2016
Journal: Nat Commun
Title: ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function.
Volume: 7
Pages: 10465
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Publication
34988393 | J:342505
First Author: Devoy A
Year: 2021
Journal: iScience
Title: Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models.
Volume: 24
Issue: 12
Pages: 103463
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Publication
27378374 | J:240782
 
First Author: Kapeli K
Year: 2016
Journal: Nat Commun
Title: Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.
Volume: 7
Pages: 12143
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Publication
23681068 | J:199583
First Author: Groen EJ
Year: 2013
Journal: Hum Mol Genet
Title: ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN.
Volume: 22
Issue: 18
Pages: 3690-704
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Publication
23172908 | J:191202
First Author: Tauffenberger A
Year: 2013
Journal: Hum Mol Genet
Title: Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models.
Volume: 22
Issue: 4
Pages: 782-94
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Publication
10655065 | J:60213
First Author: Hicks GG
Year: 2000
Journal: Nat Genet
Title: Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death.
Volume: 24
Issue: 2
Pages: 175-9
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Publication
28954225 | J:255261
First Author: Yokoi S
Year: 2017
Journal: Cell Rep
Title: 3'UTR Length-Dependent Control of SynGAP Isoform α2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function.
Volume: 20
Issue: 13
Pages: 3071-3084
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Publication
32187401 | J:297575
First Author: Guzman KM
Year: 2020
Journal: Glia
Title: Conditional depletion of Fus in oligodendrocytes leads to motor hyperactivity and increased myelin deposition associated with Akt and cholesterol activation.
Volume: 68
Issue: 10
Pages: 2040-2056
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Publication
22240165 | J:182315
First Author: Thomsen C
Year: 2012
Journal: Exp Cell Res
Title: Fused in sarcoma (FUS) interacts with the cytolinker protein plectin: implications for FUS subcellular localization and function.
Volume: 318
Issue: 5
Pages: 653-61
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Publication
33329699 | J:299765
 
First Author: Jarvis S
Year: 2020
Journal: Front Genet
Title: A Comparison of Low Read Depth QuantSeq 3' Sequencing to Total RNA-Seq in FUS Mutant Mice.
Volume: 11
Pages: 562445
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Publication
26951610 | J:233532
First Author: Scekic-Zahirovic J
Year: 2016
Journal: EMBO J
Title: Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.
Volume: 35
Issue: 10
Pages: 1077-97
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Publication
16317045 | J:105609
First Author: Fujii R
Year: 2005
Journal: J Cell Sci
Title: TLS facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spines.
Volume: 118
Issue: Pt 24
Pages: 5755-65
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Publication
29982879 | J:315888
First Author: Funikov SY
Year: 2018
Journal: Neurogenetics
Title: FUS(1-359) transgenic mice as a model of ALS: pathophysiological and molecular aspects of the proteinopathy.
Volume: 19
Issue: 3
Pages: 189-204
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Allele
Fus<tm1.1Emcf> | MGI:6100933
Name: fused in sarcoma; targeted mutation 1.1, Elizabeth MC Fisher
Allele Type: Targeted
Attribute String: Humanized sequence
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Publication
10654943 | J:60224
First Author: Kuroda M
Year: 2000
Journal: EMBO J
Title: Male sterility and enhanced radiation sensitivity in TLS(-/-) mice.
Volume: 19
Issue: 3
Pages: 453-62
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Publication
31694512 | J:291455
First Author: Gutner UA
Year: 2019
Journal: Biochemistry (Mosc)
Title: Changes in the Metabolism of Sphingoid Bases in the Brain and Spinal Cord of Transgenic FUS(1-359) Mice, a Model of Amyotrophic Lateral Sclerosis.
Volume: 84
Issue: 10
Pages: 1166-1176
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Publication
25274782 | J:218094
First Author: Tibshirani M
Year: 2015
Journal: Hum Mol Genet
Title: Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1.
Volume: 24
Issue: 3
Pages: 773-86
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Publication
10220412 | J:75732
First Author: Kuroda M
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Induction of a secreted protein by the myxoid liposarcoma oncogene.
Volume: 96
Issue: 9
Pages: 5025-30
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Publication
24509083 | J:209419
First Author: Qiu H
Year: 2014
Journal: J Clin Invest
Title: ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
Volume: 124
Issue: 3
Pages: 981-99
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Publication
21109527 | J:173804
First Author: Kino Y
Year: 2011
Journal: Nucleic Acids Res
Title: Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations.
Volume: 39
Issue: 7
Pages: 2781-98
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Publication
24049082 | J:211427
First Author: Rulten SL
Year: 2014
Journal: Nucleic Acids Res
Title: PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.
Volume: 42
Issue: 1
Pages: 307-14
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Publication
31591561 | J:281481
First Author: Picchiarelli G
Year: 2019
Journal: Nat Neurosci
Title: FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis.
Volume: 22
Issue: 11
Pages: 1793-1805
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Publication
34290090 | J:310837
 
First Author: Birsa N
Year: 2021
Journal: Sci Adv
Title: FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.
Volume: 7
Issue: 30
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Publication
25192599 | J:218440
First Author: Wang T
Year: 2015
Journal: Neurobiol Aging
Title: Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways.
Volume: 36
Issue: 1
Pages: 527-35
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Publication
28941811 | J:261236
First Author: Wiesner D
Year: 2018
Journal: Exp Neurol
Title: Reversible induction of TDP-43 granules in cortical neurons after traumatic injury.
Volume: 299
Issue: Pt A
Pages: 15-25
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Publication
21965298 | J:178865
First Author: Tradewell ML
Year: 2012
Journal: Hum Mol Genet
Title: Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations.
Volume: 21
Issue: 1
Pages: 136-49
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Publication
34112844 | J:323697
First Author: Mejia Maza A
Year: 2021
Journal: Sci Rep
Title: NMJ-Analyser identifies subtle early changes in mouse models of neuromuscular disease.
Volume: 11
Issue: 1
Pages: 12251
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Publication
32900826 | J:305018
 
First Author: Ouali Alami N
Year: 2020
Journal: Life Sci Alliance
Title: Multiplexed chemogenetics in astrocytes and motoneurons restore blood-spinal cord barrier in ALS.
Volume: 3
Issue: 11
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Publication
25216585 | J:218433
First Author: Ryu HH
Year: 2014
Journal: Neurobiol Aging
Title: Autophagy regulates amyotrophic lateral sclerosis-linked fused in sarcoma-positive stress granules in neurons.
Volume: 35
Issue: 12
Pages: 2822-2831
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Publication
30354839 | J:284994
   
First Author: Gasperini L
Year: 2018
Journal: Mol Biol Cell
Title: The hnRNP raly regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization.
Pages: mbcE18020108
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Publication
24257758 | J:209309
First Author: Bronisz A
Year: 2014
Journal: J Biol Chem
Title: The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF).
Volume: 289
Issue: 1
Pages: 326-34
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UniProt Feature
UniProt Feature
Begin: 1
Description: RNA-binding protein FUS
Type: chain
End: 518
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Protein Coding Gene
MGP_CAROLIEiJ_G0030533 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033067 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033050 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032982 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033051 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032765 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1353633 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033560 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032094 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032738 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032890 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032843 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032984 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032875 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033580 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031801 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032206 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013740 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031647 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
26896672 | J:252337
First Author: Sugiura T
Year: 2016
Journal: FEBS J
Title: Translocated in liposarcoma regulates the distribution and function of mammalian enabled, a modulator of actin dynamics.
Volume: 283
Issue: 8
Pages: 1475-87
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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