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Search results 1 to 100 out of 124 for Fut8

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Type Details Score
Gene
2530 | FUT8
Type: gene
Organism: human
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Gene
423178 | FUT8
Type: gene
Organism: chicken
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Gene
708839 | FUT8
Type: gene
Organism: macaque, rhesus
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Gene
407913 | fut8
Type: gene
Organism: frog, western clawed
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Gene
281177 | FUT8
Type: gene
Organism: cattle
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Gene
432392 | Fut8
Type: gene
Organism: rat
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Gene
448804 | FUT8
Type: gene
Organism: dog, domestic
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Gene
449506 | FUT8
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1858901 | Fut8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR015827 | Fut8
Type: Family
Description: Alpha-(1,6)-fucosyltransferase Fut8 catalyses the alpha1,6-linkage of a fucose residue from a donor substrate to N-linked oligosaccharides on glycoproteins in a process called core fucosylation, which is crucial for growth factor receptor-mediated biological functions. Fut8-deficient mice show severe growth retardation, early death, and a pulmonary emphysema-like phenotype []. Fut8 is also implicated to play roles in ageing []and cancer metastasis []. It contains an N-terminal coiled-coil domain, a catalytic domain, and a C-terminal SH3 domain. The SH3 domain of Fut8 is located in the lumen and its role in glycosyl transfer is unclear [].
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Publication
21951615 | J:216117
First Author: Vanhooren V
Year: 2011
Journal: Aging Cell
Title: Alteration in N-glycomics during mouse aging: a role for FUT8.
Volume: 10
Issue: 6
Pages: 1056-66
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Gene
645431 | FUT8-AS1
Type: gene
Organism: human
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Publication
17132494 | -
 
First Author: Wang X
Year: 2006
Journal: Methods Enzymol
Title: Phenotype changes of Fut8 knockout mouse: core fucosylation is crucial for the function of growth factor receptor(s).
Volume: 417
Pages: 11-22
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Publication
36252012 | J:335482
First Author: Cantero-Recasens G
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: The ulcerative colitis-associated gene FUT8 regulates the quantity and quality of secreted mucins.
Volume: 119
Issue: 43
Pages: e2205277119
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Publication
19179362 | J:150157
First Author: Wang X
Year: 2009
Journal: J Biochem
Title: Requirement of Fut8 for the expression of vascular endothelial growth factor receptor-2: a new mechanism for the emphysema-like changes observed in Fut8-deficient mice.
Volume: 145
Issue: 5
Pages: 643-51
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Publication
17174880 | J:118263
First Author: Kondo A
Year: 2006
Journal: Biochim Biophys Acta
Title: From glycomics to functional glycomics of sugar chains: Identification of target proteins with functional changes using gene targeting mice and knock down cells of FUT8 as examples.
Volume: 1764
Issue: 12
Pages: 1881-9
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Publication
14568171 | -
First Author: Ito Y
Year: 2003
Journal: Cancer Lett
Title: Expression of alpha1,6-fucosyltransferase (FUT8) in papillary carcinoma of the thyroid: its linkage to biological aggressiveness and anaplastic transformation.
Volume: 200
Issue: 2
Pages: 167-72
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Publication
17172260 | -
First Author: Ihara H
Year: 2007
Journal: Glycobiology
Title: Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8.
Volume: 17
Issue: 5
Pages: 455-66
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Protein
Q9WTS2
Organism: Mus musculus/domesticus
Length: 575  
Fragment?: false
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Protein
Q3UYN7
Organism: Mus musculus/domesticus
Length: 575  
Fragment?: false
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Publication
22433854 | J:185455
First Author: Gao C
Year: 2012
Journal: J Biol Chem
Title: Sensitivity of heterozygous α1,6-fucosyltransferase knock-out mice to cigarette smoke-induced emphysema: implication of aberrant transforming growth factor-β signaling and matrix metalloproteinase gene expression.
Volume: 287
Issue: 20
Pages: 16699-708
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Publication
21471224 | J:173781
First Author: Fukuda T
Year: 2011
Journal: J Biol Chem
Title: Alpha1,6-fucosyltransferase-deficient mice exhibit multiple behavioral abnormalities associated with a schizophrenia-like phenotype: importance of the balance between the dopamine and serotonin systems.
Volume: 286
Issue: 21
Pages: 18434-43
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Publication
25873065 | J:225459
First Author: Wang Y
Year: 2015
Journal: FASEB J
Title: Loss of α1,6-fucosyltransferase inhibits chemical-induced hepatocellular carcinoma and tumorigenesis by down-regulating several cell signaling pathways.
Volume: 29
Issue: 8
Pages: 3217-27
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Publication
30572004 | J:270664
First Author: Lu X
Year: 2019
Journal: Biochim Biophys Acta Gen Subj
Title: Deficiency of α1,6-fucosyltransferase promotes neuroinflammation by increasing the sensitivity of glial cells to inflammatory mediators.
Volume: 1863
Issue: 3
Pages: 598-608
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Publication
25652335 | J:322677
 
First Author: Wang Y
Year: 2015
Journal: Sci Rep
Title: Loss of α1,6-fucosyltransferase suppressed liver regeneration: implication of core fucose in the regulation of growth factor receptor-mediated cellular signaling.
Volume: 5
Pages: 8264
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Publication
22084235 | J:181388
First Author: Li W
Year: 2012
Journal: J Biol Chem
Title: Core fucosylation of μ heavy chains regulates assembly and intracellular signaling of precursor B cell receptors.
Volume: 287
Issue: 4
Pages: 2500-8
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Publication
22732410 | J:185966
First Author: Kamio K
Year: 2012
Journal: Biochem Biophys Res Commun
Title: α1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonary disease (COPD).
Volume: 424
Issue: 1
Pages: 112-7
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Publication
11070054 | J:65428
First Author: Javaud C
Year: 2000
Journal: Mol Biol Evol
Title: Ancestral exonic organization of FUT8, the gene encoding the alpha6-fucosyltransferase, reveals successive peptide domains which suggest a particular three-dimensional core structure for the alpha6-fucosyltransferase family.
Volume: 17
Issue: 11
Pages: 1661-72
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Publication
23609441 | J:203497
First Author: Sasaki H
Year: 2013
Journal: J Biol Chem
Title: α-1,6-Fucosyltransferase (FUT8) inhibits hemoglobin production during differentiation of murine and K562 human erythroleukemia cells.
Volume: 288
Issue: 23
Pages: 16839-47
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Publication
31623829 | J:291416
First Author: Fang M
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Inhibition of core fucosylation limits progression of diabetic kidney disease.
Volume: 520
Issue: 3
Pages: 612-618
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Publication
35189379 | J:340139
 
First Author: Liu A
Year: 2022
Journal: Acta Biomater
Title: Core fucosylation involvement in the paracrine regulation of proteinuria-induced renal interstitial fibrosis evaluated with the use of a microfluidic chip.
Volume: 142
Pages: 99-112
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Publication
32141499 | J:289158
First Author: Huang G
Year: 2020
Journal: Biochem J
Title: Loss of core fucosylation in both ST6GAL1 and its substrate enhances glycoprotein sialylation in mice.
Volume: 477
Issue: 6
Pages: 1179-1201
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Publication
16861703 | J:330426
First Author: Li W
Year: 2006
Journal: Glycobiology
Title: Down-regulation of trypsinogen expression is associated with growth retardation in alpha1,6-fucosyltransferase-deficient mice: attenuation of proteinase-activated receptor 2 activity.
Volume: 16
Issue: 10
Pages: 1007-19
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Publication
32423823 | J:322678
First Author: Kamada Y
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Loss of core fucosylation reduces low-density lipoprotein receptor expression in hepatocytes by inducing PCSK9 production.
Volume: 527
Issue: 3
Pages: 682-688
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Publication
24619415 | J:217242
First Author: Kurimoto A
Year: 2014
Journal: J Biol Chem
Title: The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function.
Volume: 289
Issue: 17
Pages: 11704-14
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Publication
17043354 | J:117643
First Author: Zhao Y
Year: 2006
Journal: J Biol Chem
Title: Deletion of core fucosylation on alpha3beta1 integrin down-regulates its functions.
Volume: 281
Issue: 50
Pages: 38343-50
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Publication
16236725 | J:102932
First Author: Wang X
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.
Volume: 102
Issue: 44
Pages: 15791-6
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Protein Coding Gene
MGP_CAROLIEiJ_G0017875 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019868 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019826 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019801 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019805 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019611 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1858901 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020257 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019162 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019581 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019697 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019684 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019769 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019723 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020293 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018928 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019214 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029632 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018722 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10902914 | J:74082
First Author: Hayashi H
Year: 2000
Journal: DNA Seq
Title: Molecular cloning of mouse alpha-1,6-fucosyltransferase and expression of its mRNA in the developing cerebrum.
Volume: 11
Issue: 1-2
Pages: 91-6
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Publication
31229844 | J:340409
 
First Author: Liang W
Year: 2019
Journal: Mol Immunol
Title: Ablation of core fucosylation attenuates the signal transduction via T cell receptor to suppress the T cell development.
Volume: 112
Pages: 312-321
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Publication
32460355 | J:298129
First Author: Zhang N
Year: 2020
Journal: Eur J Immunol
Title: Loss of core fucosylation enhances the anticancer activity of cytotoxic T lymphocytes by increasing PD-1 degradation.
Volume: 50
Issue: 11
Pages: 1820-1833
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Publication
25979332 | J:223060
First Author: Gu W
Year: 2015
Journal: J Biol Chem
Title: Loss of α1,6-Fucosyltransferase Decreases Hippocampal Long Term Potentiation: IMPLICATIONS FOR CORE FUCOSYLATION IN THE REGULATION OF AMPA RECEPTOR HETEROMERIZATION AND CELLULAR SIGNALING.
Volume: 290
Issue: 28
Pages: 17566-75
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Publication
26965517 | J:335530
First Author: Fujii H
Year: 2016
Journal: Gastroenterology
Title: Core Fucosylation on T Cells, Required for Activation of T-Cell Receptor Signaling and Induction of Colitis in Mice, Is Increased in Patients With Inflammatory Bowel Disease.
Volume: 150
Issue: 7
Pages: 1620-1632
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Publication
25979322 | J:223304
 
First Author: Sakai-Kato K
Year: 2015
Journal: J Control Release
Title: General considerations regarding the in vitro and in vivo properties of block copolymer micelle products and their evaluation.
Volume: 210
Pages: 76-83
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Publication
17383961 | J:122676
First Author: Matsumura K
Year: 2007
Journal: J Biol Chem
Title: Carbohydrate binding specificity of a fucose-specific lectin from Aspergillus oryzae: a novel probe for core fucose.
Volume: 282
Issue: 21
Pages: 15700-8
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GXD Expression
GXD Expression
     
Probe: MGI:2654765
Assay Type: RT-PCR
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691021
Stage: TS21
Assay Id: MGI:2654775
Age: embryonic day 13.0
Specimen Label: E13
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:2654765
Assay Type: RT-PCR
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691025
Stage: TS25
Assay Id: MGI:2654775
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:2654765
Assay Type: RT-PCR
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691027
Stage: TS27
Assay Id: MGI:2654775
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:2654765
Assay Type: RT-PCR
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691027
Stage: TS27
Assay Id: MGI:2654775
Age: postnatal day 3
Specimen Label: P3
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
     
Probe: MGI:2654765
Assay Type: RT-PCR
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:2654775
Age: postnatal day 5
Specimen Label: P5
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
     
Probe: MGI:2654765
Assay Type: RT-PCR
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:2654775
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
     
Probe: MGI:2654765
Assay Type: RT-PCR
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:2654775
Age: postnatal day 14
Specimen Label: P14
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
     
Probe: MGI:2654765
Assay Type: RT-PCR
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:2654775
Age: postnatal day 21
Specimen Label: P21
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
     
Probe: MGI:2654765
Assay Type: RT-PCR
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:2654775
Age: postnatal day 28
Specimen Label: P28
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
     
Probe: MGI:2654765
Assay Type: RT-PCR
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:2654775
Age: postnatal day 35
Specimen Label: P35
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
     
Probe: MGI:2654765
Assay Type: RT-PCR
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:2654775
Age: postnatal day 98
Specimen Label: P98
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
     
Probe: MGI:2654765
Assay Type: RT-PCR
Annotation Date: 2003-04-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:2654775
Age: postnatal day 252
Specimen Label: P252
Detected: true
Specimen Num: 17
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Publication
- | J:62335
   
First Author: Hayashi H
Year: 1999
Journal: GenBank Submission
Title: Mus musculus mRNA for alpha-1, 6-fucosyltransferase, complete cds
Pages: AB025198
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Publication
27773703 | J:251304
First Author: Hirano M
Year: 2017
Journal: Biochim Biophys Acta
Title: N-Glycoform-dependent interactions of megalin with its ligands.
Volume: 1861
Issue: 1 Pt A
Pages: 3106-3118
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Publication
28768188 | J:254942
First Author: Okada M
Year: 2017
Journal: Cell Rep
Title: Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells.
Volume: 20
Issue: 5
Pages: 1017-1028
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Publication
11698403 | J:74415
First Author: Roos C
Year: 2002
Journal: J Biol Chem
Title: Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism.
Volume: 277
Issue: 5
Pages: 3168-75
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Publication
18381897 | J:137278
First Author: Akagi K
Year: 2008
Journal: Genome Res
Title: Extensive variation between inbred mouse strains due to endogenous L1 retrotransposition.
Volume: 18
Issue: 6
Pages: 869-80
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Publication
29539633 | J:261316
First Author: Perez-Garcia V
Year: 2018
Journal: Nature
Title: Placentation defects are highly prevalent in embryonic lethal mouse mutants.
Volume: 555
Issue: 7697
Pages: 463-468
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Publication
- | J:239583
     
First Author: Mouse Genome Informatics and the Consortium: Deciphering the Mechanisms of Developmental Disorders (DMDD)
Year: 2017
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Deciphering the Mechanisms of Developmental Disorders (DMDD)
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Publication
23375831 | J:237827
First Author: Gineste C
Year: 2013
Journal: Neuromuscul Disord
Title: In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype.
Volume: 23
Issue: 4
Pages: 357-69
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Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
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Publication
15840001 | J:110088
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
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First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
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First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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