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Search results 1 to 100 out of 129 for Fuz

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
80199 | FUZ
Type: gene
Organism: human
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Gene
468957 | FUZ
Type: gene
Organism: chimpanzee
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Gene
476409 | FUZ
Type: gene
Organism: dog, domestic
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Gene
528818 | FUZ
Type: gene
Organism: cattle
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Gene
797090 | fuz
Type: gene
Organism: zebrafish
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Gene
719442 | FUZ
Type: gene
Organism: macaque, rhesus
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Gene
677733 | fuz
Type: gene
Organism: frog, western clawed
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Gene
121108678 | FUZ
Type: gene
Organism: chicken
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Gene
308577 | Fuz
Type: gene
Organism: rat
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Protein Coding Gene
MGI:1917550 | Fuz
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23806618 | J:198631
First Author: Tabler JM
Year: 2013
Journal: Dev Cell
Title: Fuz mutant mice reveal shared mechanisms between ciliopathies and FGF-related syndromes.
Volume: 25
Issue: 6
Pages: 623-35
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Publication
19767740 | J:158243
First Author: Gray RS
Year: 2009
Journal: Nat Cell Biol
Title: The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development.
Volume: 11
Issue: 10
Pages: 1225-32
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Publication
21935430 | J:177881
First Author: Zhang Z
Year: 2011
Journal: PLoS One
Title: Fuz regulates craniofacial development through tissue specific responses to signaling factors.
Volume: 6
Issue: 9
Pages: e24608
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Publication
20962855 | J:173143
First Author: Dai D
Year: 2011
Journal: J Invest Dermatol
Title: Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary cilia.
Volume: 131
Issue: 2
Pages: 302-10
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Publication
30026307 | J:265188
 
First Author: Chen ZS
Year: 2018
Journal: EMBO Rep
Title: Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models.
Volume: 19
Issue: 9
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Publication
21761479 | J:174196
First Author: Heydeck W
Year: 2011
Journal: Dev Dyn
Title: PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube.
Volume: 240
Issue: 8
Pages: 1938-48
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Publication
19877275 | J:154370
First Author: Heydeck W
Year: 2009
Journal: Dev Dyn
Title: Planar cell polarity effector gene Fuzzy regulates cilia formation and Hedgehog signal transduction in mouse.
Volume: 238
Issue: 12
Pages: 3035-42
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Publication
27158779 | J:243791
First Author: Toriyama M
Year: 2016
Journal: Nat Genet
Title: The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery.
Volume: 48
Issue: 6
Pages: 648-56
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Publication
27395007 | J:235627
First Author: Tabler JM
Year: 2016
Journal: Dev Biol
Title: A novel ciliopathic skull defect arising from excess neural crest.
Volume: 417
Issue: 1
Pages: 4-10
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Publication
37794731 | J:343069
     
First Author: Lodge EJ
Year: 2023
Journal: J Anat
Title: The Fuzzy planar cell polarity protein (FUZ), necessary for primary cilium formation, is essential for pituitary development.
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Protein Coding Gene
MGP_CAROLIEiJ_G0029682 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032185 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032164 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032100 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032176 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0031892 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1917550 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032668 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031220 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031856 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032014 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0031965 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032092 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032002 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032684 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0030943 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031337 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0012907 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030781 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
21840926 | J:177787
First Author: Seo JH
Year: 2011
Journal: Hum Mol Genet
Title: Mutations in the planar cell polarity gene, Fuzzy, are associated with neural tube defects in humans.
Volume: 20
Issue: 22
Pages: 4324-33
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GXD Expression
GXD Expression
   
Probe: MGI:5301560
Assay Type: RNA in situ
Annotation Date: 2012-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3559313
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5301561
Age: embryonic day 8.5
Specimen Label: 1B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5301560
Assay Type: RNA in situ
Annotation Date: 2012-01-16
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1614015
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5301561
Age: embryonic day 9.5
Specimen Label: 1D
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5301560
Assay Type: RNA in situ
Annotation Date: 2012-01-16
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1647015
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5301561
Age: embryonic day 9.5
Note: There is a low level of expression throughout the neural tube.
Specimen Label: 1C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5301560
Assay Type: RNA in situ
Annotation Date: 2012-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185815
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:5301561
Age: embryonic day 9.5
Note: Expression is present in facial structures.
Specimen Label: 1D
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5301560
Assay Type: RNA in situ
Annotation Date: 2012-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607313
Pattern: Non-Uniform
Stage: TS13
Assay Id: MGI:5301561
Age: embryonic day 8.5
Note: Expression is detected along the entire anterior-posterior axis of the emerging neural tube. The highest levels of expression are in the rostral part and cervical area.
Specimen Label: 1B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5301560
Assay Type: RNA in situ
Annotation Date: 2012-01-16
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1664015
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5301561
Age: embryonic day 9.5
Specimen Label: 1D
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5301560
Assay Type: RNA in situ
Annotation Date: 2012-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616415
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:5301561
Age: embryonic day 9.5
Note: Expression is detectable in midline structures.
Specimen Label: 1C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5301560
Assay Type: RNA in situ
Annotation Date: 2012-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619113
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:5301561
Age: embryonic day 8.5
Specimen Label: 1B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5301560
Assay Type: RNA in situ
Annotation Date: 2012-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619115
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5301561
Age: embryonic day 9.5
Specimen Label: 1C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5301560
Assay Type: RNA in situ
Annotation Date: 2012-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3268415
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:5301561
Age: embryonic day 9.5
Specimen Label: 1C
Detected: true
Specimen Num: 2
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Publication
21041309 | J:173142
First Author: Du H
Year: 2011
Journal: J Biol Chem
Title: BH3 domains other than Bim and Bid can directly activate Bax/Bak.
Volume: 286
Issue: 1
Pages: 491-501
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Publication
28177282 | J:241145
   
First Author: Tabler JM
Year: 2017
Journal: Elife
Title: Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx.
Volume: 6
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Publication
25807483 | J:222159
First Author: Li Y
Year: 2015
Journal: Nature
Title: Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Volume: 521
Issue: 7553
Pages: 520-4
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Publication
- | J:175213
     
First Author: Lo C
Year: 2011
Journal: MGI Direct Data Submission (B2B/CvDC)
Title: Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC)
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q6PGA8
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: false
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GXD Expression
GXD Expression
   
Probe: MGI:2684476
Assay Type: Western blot
Annotation Date: 2011-09-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640517
Stage: TS17
Assay Id: MGI:5286701
Age: embryonic day 10.5
Image: 5
Specimen Label: limb Fuz
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:2684476
Assay Type: Western blot
Annotation Date: 2011-09-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:5286701
Age: embryonic day 10.5
Image: 5
Specimen Label: embryo Fuz
Detected: true
Specimen Num: 4
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Protein Domain
IPR043989 | CCZ1/INTU/HSP4_longin_3
Type: Domain
Description: Longin domains are evolutionarily conserved regions widely distributed among eukaryotes, involved in membrane dynamic regulation and exhibit similarities in primary sequence and secondary structure. Longin-like domains are found in FUZ and related proteins, such as the MON1 and HPS1 proteins [, , ]. The MON1/CCZ1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking []. The HPS1/HPS4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules []. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia [, ]. Structurally, these domains are composed of an alpha/beta fold which contains five anti-parallel β-strands organised as a central β-sheet and around it, two α-helices [].This entry represents the third Longin domain found in CCZ1, INTU and HPS4 proteins.
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Protein Domain
IPR043987 | CCZ1/INTU/HSP4_longin_1
Type: Domain
Description: Longin domains are evolutionarily conserved regions widely distributed among eukaryotes, involved in membrane dynamic regulation and exhibit similarities in primary sequence and secondary structure. Longin-like domains are found in FUZ and related proteins, such as the MON1 and HPS1 proteins [, , ]. The MON1/CCZ1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking []. The HPS1/HPS4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules []. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia [, ]. Structurally, these domains are composed of an alpha/beta fold which contains five anti-parallel β-strands organised as a central β-sheet and around it, two α-helices [].This entry represents the first Longin domain found in INTU, CCZ1 and HPS4.
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Protein Domain
IPR043988 | CCZ1/INTU_longin_2
Type: Domain
Description: Longin domains are evolutionarily conserved regions widely distributed among eukaryotes, involved in membrane dynamic regulation and exhibit similarities in primary sequence and secondary structure. Longin-like domains are found in FUZ and related proteins, such as the MON1 and HPS1 proteins [, , ]. The MON1/CCZ1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking []. The HPS1/HPS4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules []. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia [, ]. Structurally, these domains are composed of an alpha/beta fold which contains five anti-parallel β-strands organised as a central β-sheet and around it, two α-helices [].This entry represents the second Longin domain found in INTU and CCZ1 proteins.
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Protein Domain
IPR043972 | FUZ/MON1/HPS1_longin_1
Type: Domain
Description: Longin domains are evolutionarily conserved regions widely distributed among eukaryotes, involved in membrane dynamic regulation and exhibit similarities in primary sequence and secondary structure. Longin-like domains are found in FUZ and related proteins, such as the MON1 and HPS1 proteins [, , ]. The MON1/CCZ1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking []. The HPS1/HPS4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules []. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia [, ]. Structurally, these domains are composed of an alpha/beta fold which contains five anti-parallel β-strands organised as a central β-sheet and around it, two α-helices [].This entry represents the first Longin domain found in FUZ, MON1 and HPS1 proteins.
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Protein Domain
IPR043970 | FUZ/MON1/HPS1_longin_3
Type: Domain
Description: Longin domains are evolutionarily conserved regions widely distributed among eukaryotes, involved in membrane dynamic regulation and exhibit similarities in primary sequence and secondary structure. Longin-like domains are found in FUZ and related proteins, such as the MON1 and HPS1 proteins [, , ]. The MON1/CCZ1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking []. The HPS1/HPS4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules []. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia [, ]. Structurally, these domains are composed of an alpha/beta fold which contains five anti-parallel β-strands organised as a central β-sheet and around it, two α-helices [].This entry represents the third Longin domain of FUZ, MON1 and HPS1 proteins.
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Protein Domain
IPR043971 | FUZ/MON1/HPS1_longin_2
Type: Domain
Description: Longin domains are evolutionarily conserved regions widely distributed among eukaryotes, involved in membrane dynamic regulation and exhibit similarities in primary sequence and secondary structure. Longin-like domains are found in FUZ and related proteins, such as the MON1 and HPS1 proteins [, , ]. The MON1/CCZ1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking []. The HPS1/HPS4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules []. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia [, ]. Structurally, these domains are composed of an alpha/beta fold which contains five anti-parallel β-strands organised as a central β-sheet and around it, two α-helices [].This entry represents the second Longin domain found in FUZ, MON1 and HPS1 proteins.
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Publication
17075139 | -
First Author: Kinch LN
Year: 2006
Journal: Protein Sci
Title: Longin-like folds identified in CHiPS and DUF254 proteins: vesicle trafficking complexes conserved in eukaryotic evolution.
Volume: 15
Issue: 11
Pages: 2669-74
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Publication
28051187 | -
 
First Author: Kiontke S
Year: 2017
Journal: Nat Commun
Title: Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1-Ccz1.
Volume: 8
Pages: 14034
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Publication
31562761 | -
First Author: Sanchez-Pulido L
Year: 2020
Journal: Bioinformatics
Title: Hexa-Longin domain scaffolds for inter-Rab signalling.
Volume: 36
Issue: 4
Pages: 990-993
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Protein
Q8C1Y8
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein
Q6PDG8
Organism: Mus musculus/domesticus
Length: 556  
Fragment?: false
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