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Search results 1 to 100 out of 147 for Fyb1

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
2533 | FYB1
Type: gene
Organism: human
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Gene
100485737 | fyb1
Type: gene
Organism: frog, western clawed
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Gene
499537 | Fyb1
Type: gene
Organism: rat
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Gene
479355 | FYB1
Type: gene
Organism: dog, domestic
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Gene
461906 | FYB1
Type: gene
Organism: chimpanzee
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Gene
535347 | FYB1
Type: gene
Organism: cattle
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Gene
427448 | FYB1
Type: gene
Organism: chicken
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Gene
693951 | FYB1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR030635 | FYB1
Type: Family
Description: FYN-binding protein 1 (FYB1), also known as ADAP or SLAP, is an adapter protein in beta 1 integrin signalling and T lymphocyte migration []. It has been found to co-localise with F-actin in membrane ruffles, adhesion plaques/podosomes and phagocytic cups [, ]. In activated T cells, Fyb/SLAP associates with Ena/VASP family proteins and may link T cell signalling to the actin cytoskeleton remodelling []. FYB1 also interacts with mammalian actin binding protein 1 (mAbp1) that affects F-actin dynamics [].
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Protein Coding Gene
MGI:1346327 | Fyb1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15848169 | J:98236
First Author: Yuan M
Year: 2005
Journal: FEBS Lett
Title: Fyn binding protein, Fyb, interacts with mammalian actin binding protein, mAbp1.
Volume: 579
Issue: 11
Pages: 2339-47
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Publication
10747096 | J:156075
First Author: Krause M
Year: 2000
Journal: J Cell Biol
Title: Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton.
Volume: 149
Issue: 1
Pages: 181-94
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Protein
A0A2I3BRH1
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: true
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Protein
A0A2I3BPY6
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: true
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Protein
Q8CAX4
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Publication
10640723 | -
First Author: Hunter AJ
Year: 2000
Journal: J Immunol
Title: Cutting edge: a novel function for the SLAP-130/FYB adapter protein in beta 1 integrin signaling and T lymphocyte migration.
Volume: 164
Issue: 3
Pages: 1143-7
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Publication
11553777 | -
First Author: Geng L
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Adaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: differential involvement of the FYB SH3 domain.
Volume: 98
Issue: 20
Pages: 11527-32
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Publication
11739662 | -
First Author: Coppolino MG
Year: 2001
Journal: J Cell Sci
Title: Evidence for a molecular complex consisting of Fyb/SLAP, SLP-76, Nck, VASP and WASP that links the actin cytoskeleton to Fcgamma receptor signalling during phagocytosis.
Volume: 114
Issue: Pt 23
Pages: 4307-18
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Protein
O35601
Organism: Mus musculus/domesticus
Length: 819  
Fragment?: false
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Protein
Q3TA12
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: true
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Protein
B2RUR0
Organism: Mus musculus/domesticus
Length: 819  
Fragment?: false
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Protein Coding Gene
MGP_CAROLIEiJ_G0019641 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0021697 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0021658 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0021636 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0021665 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0021441 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1346327 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0022104 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020957 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0021410 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0021534 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0021512 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0021602 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0021537 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0022127 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0020700 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0021013 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016022 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0020538 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9207119 | J:41750
First Author: da Silva AJ
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production.
Volume: 94
Issue: 14
Pages: 7493-8
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Publication
10497204 | J:57919
First Author: Veale M
Year: 1999
Journal: J Biol Chem
Title: Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production.
Volume: 274
Issue: 40
Pages: 28427-35
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Publication
18383041 | J:133782
First Author: Zou L
Year: 2008
Journal: Eur J Immunol
Title: Defective positive selection results in T cell lymphopenia and increased autoimmune diabetes in ADAP-deficient BDC2.5-C57BL/6 mice.
Volume: 38
Issue: 4
Pages: 986-94
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Publication
17785790 | J:142998
First Author: Mueller KL
Year: 2007
Journal: J Immunol
Title: Adhesion and degranulation-promoting adapter protein (ADAP) positively regulates T cell sensitivity to antigen and T cell survival.
Volume: 179
Issue: 6
Pages: 3559-69
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Publication
16709827 | J:131800
First Author: Wu JN
Year: 2006
Journal: J Immunol
Title: Adhesion- and degranulation-promoting adapter protein is required for efficient thymocyte development and selection.
Volume: 176
Issue: 11
Pages: 6681-9
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Publication
27354546 | J:236480
First Author: Hashimoto-Tane A
Year: 2016
Journal: J Exp Med
Title: Micro-adhesion rings surrounding TCR microclusters are essential for T cell activation.
Volume: 213
Issue: 8
Pages: 1609-25
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Publication
25909459 | J:246039
First Author: Li C
Year: 2015
Journal: PLoS Pathog
Title: The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection.
Volume: 11
Issue: 4
Pages: e1004824
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Publication
27605210 | J:243515
First Author: Parzmair GP
Year: 2017
Journal: J Leukoc Biol
Title: ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens.
Volume: 101
Issue: 2
Pages: 407-419
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Publication
11567141 | J:111368
First Author: Peterson EJ
Year: 2001
Journal: Science
Title: Coupling of the TCR to integrin activation by Slap-130/Fyb.
Volume: 293
Issue: 5538
Pages: 2263-5
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Publication
16973965 | J:142177
First Author: Suzuki J
Year: 2007
Journal: Blood
Title: The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation.
Volume: 109
Issue: 1
Pages: 168-75
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Publication
16775024 | J:112087
First Author: Fostel LV
Year: 2006
Journal: Int Immunol
Title: ADAP is dispensable for NK cell development and function.
Volume: 18
Issue: 8
Pages: 1305-14
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Publication
33431658 | J:303921
First Author: Yang N
Year: 2021
Journal: J Immunol
Title: ADAP Y571 Phosphorylation Is Required to Prime STAT3 for Activation in TLR4-Stimulated Macrophages.
Volume: 206
Issue: 4
Pages: 814-826
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Publication
18802088 | J:142742
First Author: Burbach BJ
Year: 2008
Journal: J Immunol
Title: Distinct regulation of integrin-dependent T cell conjugate formation and NF-kappa B activation by the adapter protein ADAP.
Volume: 181
Issue: 7
Pages: 4840-51
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Publication
29950291 | J:265984
First Author: Spindler M
Year: 2018
Journal: Blood
Title: ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia.
Volume: 132
Issue: 6
Pages: 635-646
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Publication
30833485 | J:280246
 
First Author: Rudolph JM
Year: 2019
Journal: Mol Cell Biol
Title: Characterization of Mice with a Platelet-Specific Deletion of the Adapter Molecule ADAP.
Volume: 39
Issue: 9
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Publication
11567140 | J:146727
First Author: Griffiths EK
Year: 2001
Journal: Science
Title: Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap.
Volume: 293
Issue: 5538
Pages: 2260-3
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Publication
16990435 | J:114698
First Author: Combs J
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Recruitment of dynein to the Jurkat immunological synapse.
Volume: 103
Issue: 40
Pages: 14883-8
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GXD Expression
GXD Expression
 
Probe: MGI:4425787
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824951
Age: embryonic day 14.5
Image: euxassay_013177_11
Specimen Label: euxassay_013177_11
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4425787
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824951
Age: embryonic day 14.5
Image: euxassay_013177_12
Specimen Label: euxassay_013177_12
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4425787
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824951
Age: embryonic day 14.5
Image: euxassay_013177_13
Specimen Label: euxassay_013177_13
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4425787
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824951
Age: embryonic day 14.5
Image: euxassay_013177_14
Specimen Label: euxassay_013177_14
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4425787
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824951
Age: embryonic day 14.5
Image: euxassay_013177_15
Specimen Label: euxassay_013177_15
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:4425787
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824951
Age: embryonic day 14.5
Image: euxassay_013177_16
Specimen Label: euxassay_013177_16
Detected: true
Specimen Num: 6
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Publication
32038647 | J:286099
 
First Author: Böning MAL
Year: 2019
Journal: Front Immunol
Title: ADAP Promotes Degranulation and Migration of NK Cells Primed During in vivo Listeria monocytogenes Infection in Mice.
Volume: 10
Pages: 3144
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Publication
24101551 | J:206334
First Author: Engelmann S
Year: 2013
Journal: J Immunol
Title: T cell-independent modulation of experimental autoimmune encephalomyelitis in ADAP-deficient mice.
Volume: 191
Issue: 10
Pages: 4950-9
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Publication
17948263 | J:126331
First Author: Dluzniewska J
Year: 2007
Journal: Eur J Immunol
Title: Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostatsis.
Volume: 37
Issue: 11
Pages: 3208-19
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Publication
34659211 | J:312698
 
First Author: Böning MAL
Year: 2021
Journal: Front Immunol
Title: Enhanced Susceptibility of ADAP-Deficient Mice to Listeria monocytogenes Infection Is Associated With an Altered Phagocyte Phenotype and Function.
Volume: 12
Pages: 724855
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Publication
31632410 | J:280747
 
First Author: Rudolph J
Year: 2019
Journal: Front Immunol
Title: Immune Cell-Type Specific Ablation of Adapter Protein ADAP Differentially Modulates EAE.
Volume: 10
Pages: 2343
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Publication
15153494 | J:90531
First Author: Wu JN
Year: 2004
Journal: J Immunol
Title: Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell function.
Volume: 172
Issue: 11
Pages: 6768-74
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Publication
21949020 | J:179442
First Author: Burns JC
Year: 2011
Journal: J Immunol
Title: The SLP-76 Src homology 2 domain is required for T cell development and activation.
Volume: 187
Issue: 9
Pages: 4459-66
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Publication
22117043 | J:181785
First Author: Kliche S
Year: 2012
Journal: Blood
Title: CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules.
Volume: 119
Issue: 3
Pages: 777-85
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Publication
15477347 | J:94914
First Author: Wang H
Year: 2004
Journal: J Exp Med
Title: ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation.
Volume: 200
Issue: 8
Pages: 1063-74
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Publication
16020549 | J:101167
First Author: Koga S
Year: 2005
Journal: J Biol Chem
Title: Physical and functional association of c-Src and adhesion and degranulation promoting adaptor protein (ADAP) in osteoclastogenesis in vitro.
Volume: 280
Issue: 36
Pages: 31564-71
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Publication
21525391 | J:173181
First Author: Burbach BJ
Year: 2011
Journal: J Immunol
Title: The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation.
Volume: 186
Issue: 11
Pages: 6227-37
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Publication
21881001 | J:178334
First Author: Azhibekov TA
Year: 2011
Journal: Am J Physiol Cell Physiol
Title: TM4SF10 and ADAP interaction in podocytes: role in Fyn activity and nephrin phosphorylation.
Volume: 301
Issue: 6
Pages: C1351-9
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Publication
19996090 | J:158859
First Author: Kasirer-Friede A
Year: 2010
Journal: Blood
Title: Role for ADAP in shear flow-induced platelet mechanotransduction.
Volume: 115
Issue: 11
Pages: 2274-82
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Publication
27349342 | J:246640
First Author: Danzer C
Year: 2016
Journal: Eur J Immunol
Title: A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.
Volume: 46
Issue: 9
Pages: 2121-36
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Publication
23918975 | J:205802
First Author: Mitchell JS
Year: 2013
Journal: J Immunol
Title: Multistage T cell-dendritic cell interactions control optimal CD4 T cell activation through the ADAP-SKAP55-signaling module.
Volume: 191
Issue: 5
Pages: 2372-83
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Publication
17646386 | J:126545
First Author: Wang H
Year: 2007
Journal: Mol Cell Biol
Title: Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion.
Volume: 27
Issue: 19
Pages: 6863-75
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Publication
25821220 | J:236699
First Author: Schmidt AM
Year: 2015
Journal: J Immunol
Title: Regulatory T cells require TCR signaling for their suppressive function.
Volume: 194
Issue: 9
Pages: 4362-70
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Publication
23407547 | J:196459
First Author: May RM
Year: 2013
Journal: Blood
Title: Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
Volume: 121
Issue: 16
Pages: 3135-46
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Publication
20957749 | J:166154
First Author: Patzak IM
Year: 2010
Journal: Eur J Immunol
Title: HPK1 competes with ADAP for SLP-76 binding and via Rap1 negatively affects T-cell adhesion.
Volume: 40
Issue: 11
Pages: 3220-5
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Publication
17478723 | J:121348
First Author: Medeiros RB
Year: 2007
Journal: Science
Title: Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1.
Volume: 316
Issue: 5825
Pages: 754-8
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Publication
12681493 | J:82731
First Author: Fujii Y
Year: 2003
Journal: FEBS Lett
Title: Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells.
Volume: 540
Issue: 1-3
Pages: 111-6
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Publication
17003372 | J:144396
First Author: Kasirer-Friede A
Year: 2007
Journal: Blood
Title: ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.
Volume: 109
Issue: 3
Pages: 1018-25
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Publication
17403904 | J:122332
First Author: Ménasché G
Year: 2007
Journal: Mol Cell Biol
Title: RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation.
Volume: 27
Issue: 11
Pages: 4070-81
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Publication
27500644 | J:237248
First Author: Freund J
Year: 2016
Journal: PLoS Biol
Title: Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells.
Volume: 14
Issue: 8
Pages: e1002526
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Publication
24036998 | J:208208
First Author: Rajasekaran K
Year: 2013
Journal: Nat Immunol
Title: Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.
Volume: 14
Issue: 11
Pages: 1127-36
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Publication
26872694 | J:264694
First Author: Halle S
Year: 2016
Journal: Immunity
Title: In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity.
Volume: 44
Issue: 2
Pages: 233-45
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Publication
25851535 | J:233407
First Author: Li C
Year: 2015
Journal: EMBO Mol Med
Title: ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.
Volume: 7
Issue: 6
Pages: 754-69
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Publication
19617540 | J:150950
First Author: Wang H
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.
Volume: 106
Issue: 30
Pages: 12436-41
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Publication
24523237 | J:210761
First Author: Kasirer-Friede A
Year: 2014
Journal: Blood
Title: ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.
Volume: 123
Issue: 20
Pages: 3156-65
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Publication
25455592 | J:319083
First Author: Thaker YR
Year: 2015
Journal: Immunol Lett
Title: TCR and CD28 activate the transcription factor NF-κB in T-cells via distinct adaptor signaling complexes.
Volume: 163
Issue: 1
Pages: 113-9
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Publication
22291096 | J:181695
First Author: Block H
Year: 2012
Journal: J Exp Med
Title: Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.
Volume: 209
Issue: 2
Pages: 407-21
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Publication
20164171 | J:161173
First Author: Srivastava R
Year: 2010
Journal: J Biol Chem
Title: NF-kappaB activation in T cells requires discrete control of IkappaB kinase alpha/beta (IKKalpha/beta) phosphorylation and IKKgamma ubiquitination by the ADAP adapter protein.
Volume: 285
Issue: 15
Pages: 11100-5
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Publication
12176364 | J:230362
First Author: Berry DM
Year: 2002
Journal: Curr Biol
Title: A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling.
Volume: 12
Issue: 15
Pages: 1336-41
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Publication
24584089 | J:209882
First Author: Roncagalli R
Year: 2014
Journal: Nat Immunol
Title: Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.
Volume: 15
Issue: 4
Pages: 384-392
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Publication
22411628 | J:185746
First Author: Srivastava R
Year: 2012
Journal: Mol Cell Biol
Title: ADAP regulates cell cycle progression of T cells via control of cyclin E and Cdk2 expression through two distinct CARMA1-dependent signaling pathways.
Volume: 32
Issue: 10
Pages: 1908-17
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Publication
31591574 | J:282407
First Author: Voisinne G
Year: 2019
Journal: Nat Immunol
Title: Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.
Volume: 20
Issue: 11
Pages: 1530-1541
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Publication
17062627 | J:137511
First Author: Lin Q
Year: 2006
Journal: Nucleic Acids Res
Title: Mutagenesis of diploid mammalian genes by gene entrapment.
Volume: 34
Issue: 20
Pages: e139
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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