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Search results 1 to 100 out of 859 for Fzd6

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0.057s
Type Details Score
Gene
Type: gene
Organism: Not Specified
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Frizzleds are seven transmembrane-spanning proteins that constitute an unconventional class of G protein-coupled receptors []. They have important regulatory roles during embryonic development [, ].Frizzleds expose their large N terminus on the extracellular side. The N-terminal, extracellular cysteine-rich domain (CRD) has been implicated as the Wnt binding domain and its structure has been solved []. The cysteine-rich domain of Frizzled (Fz) is shared with other receptor tyrosine kinases that have roles in development including the muscle-specific receptor tyrosine kinase (MuSK), the neuronal specific kinase (NSK2), and ROR1 and ROR2. The cytoplasmic side of many Fz proteins has been shown to interact with the PDZ domains of PSD-95 family members and is thought to have a role in the assembly of signalling complexes. The conserved cytoplasmic motif of Fz, Lys-Thr-X-X-X-Trp, is required for activation of the beta-catenin pathway, and for membrane localisation and phosphorylation of Dsh.In Drosophila melanogaster, the frizzled locus is involved in planar cell polarity, which is the coordination of the cytoskeleton of epidermal cells to produce a parallel array of cuticular hairs and bristles [, ]. In the wild-type wing, all hairs point towards the distal tip [], whereas in Fz mutants, the orientation of individual hairs with respect both to their neighbours and to the organism as a whole is altered. In the developing wing, Fz function is required for cells to respond to the extracellular polarity signal as well as the proximal-distal transmission of an intracellular polarity signal.In Caenorhabditis elegans, protein mom-5 is the equivalent of frizzled [].Three main signaling pathways are activated by agonist-activated Frizzled proteins: the Fz/beta-catenin pathway, the Fz/Ca2+ pathway and the Fz/PCP (planar cell polarity) pathway []. The Wnt/beta-catenin pathway is the best studied signalling pathway involving Fz receptors. In the Wnt/beta-catenin pathway the first downstream cytoplasmic components activated by Fz signalling include Dishevelled (Dsh) and/or its regulatory kinases.This entry represents Frizzled-6. Frizzled-6 deficiency results in a severe midbrain morphogenesis defect in mice []. In humans, mutations in Frizzled-6 have been described to cause nail dysplasia [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Stuebner S
Year: 2010
Journal: Dev Dyn
Title: Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect.
Volume: 239
Issue: 1
Pages: 246-60
Publication
First Author: Fröjmark AS
Year: 2011
Journal: Am J Hum Genet
Title: Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia.
Volume: 88
Issue: 6
Pages: 852-860
Publication      
First Author: Dong B
Year: 2022
Journal: J Invest Dermatol
Title: FZD6 Promotes Melanoma Cell Invasion but Not Proliferation by Regulating Canonical Wnt Signaling and Epithelial‒Mesenchymal Transition.
Publication
First Author: van Helden YG
Year: 2010
Journal: Carcinogenesis
Title: Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/- mice.
Volume: 31
Issue: 8
Pages: 1329-37
Protein
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
Publication
First Author: Dann CE
Year: 2001
Journal: Nature
Title: Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.
Volume: 412
Issue: 6842
Pages: 86-90
Protein
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 386  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
Publication
First Author: Adler PN
Year: 1990
Journal: Genetics
Title: Molecular structure of frizzled, a Drosophila tissue polarity gene.
Volume: 126
Issue: 2
Pages: 401-16
Publication
First Author: Vinson CR
Year: 1989
Journal: Nature
Title: A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains.
Volume: 338
Issue: 6212
Pages: 263-4
Publication
First Author: Schulte G
Year: 2007
Journal: Trends Pharmacol Sci
Title: The Frizzled family of unconventional G-protein-coupled receptors.
Volume: 28
Issue: 10
Pages: 518-25
Publication
First Author: Katanaev VL
Year: 2010
Journal: Biochemistry (Mosc)
Title: The Wnt/Frizzled GPCR signaling pathway.
Volume: 75
Issue: 12
Pages: 1428-34
Publication
First Author: Rocheleau CE
Year: 1997
Journal: Cell
Title: Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos.
Volume: 90
Issue: 4
Pages: 707-16
GXD Expression    
Probe: MGI:6173206
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190340
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Fzd6
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6173206
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190340
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Fzd6
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6173206
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190340
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Fzd6
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6173206
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190340
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Fzd6
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6173206
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190340
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Fzd6
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6173206
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190340
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Fzd6
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6173206
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190340
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Fzd6
Detected: false
Specimen Num: 5
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
Publication  
First Author: Cetera M
Year: 2023
Journal: Development
Title: Region-specific reversal of epidermal planar polarity in the rosette fancy mouse.
Volume: 150
Issue: 17
Publication
First Author: Nguyen TH
Year: 2022
Journal: Stem Cell Reports
Title: Frizzled-6 promotes hematopoietic stem/progenitor cell mobilization and survival during LPS-induced emergency myelopoiesis.
Volume: 17
Issue: 10
Pages: 2303-2317
Publication  
First Author: Dong B
Year: 2018
Journal: Development
Title: Functional redundancy of frizzled 3 and frizzled 6 in planar cell polarity control of mouse hair follicles.
Volume: 145
Issue: 19
Publication
First Author: Abidin BM
Year: 2015
Journal: J Immunol
Title: Frizzled-6 Regulates Hematopoietic Stem/Progenitor Cell Survival and Self-Renewal.
Volume: 195
Issue: 5
Pages: 2168-76
Publication  
First Author: Han H
Year: 2022
Journal: Front Mol Neurosci
Title: Identification of a Novel Functional Non-synonymous Single Nucleotide Polymorphism in Frizzled Class Receptor 6 Gene for Involvement in Depressive Symptoms.
Volume: 15
Pages: 882396
Publication
First Author: Wu QL
Year: 2009
Journal: Blood
Title: Dysregulation of Frizzled 6 is a critical component of B-cell leukemogenesis in a mouse model of chronic lymphocytic leukemia.
Volume: 113
Issue: 13
Pages: 3031-9
Publication
First Author: Wang Y
Year: 2006
Journal: J Neurosci
Title: The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells.
Volume: 26
Issue: 8
Pages: 2147-56
Publication  
First Author: Choi JH
Year: 2019
Journal: Science
Title: LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.
Volume: 364
Issue: 6440
Publication
First Author: Devenport D
Year: 2008
Journal: Nat Cell Biol
Title: Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles.
Volume: 10
Issue: 11
Pages: 1257-68
Publication
First Author: Cui CY
Year: 2013
Journal: J Invest Dermatol
Title: Frizzled6 deficiency disrupts the differentiation process of nail development.
Volume: 133
Issue: 8
Pages: 1990-7
Publication
First Author: Markovič R
Year: 2017
Journal: PLoS One
Title: Planar cell polarity genes frizzled4 and frizzled6 exert patterning influence on arterial vessel morphogenesis.
Volume: 12
Issue: 3
Pages: e0171033
Publication
First Author: Devenport D
Year: 2011
Journal: Nat Cell Biol
Title: Mitotic internalization of planar cell polarity proteins preserves tissue polarity.
Volume: 13
Issue: 8
Pages: 893-902
Publication  
First Author: Simonson L
Year: 2022
Journal: Development
Title: Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development.
Volume: 149
Issue: 22
Publication
First Author: Ghimire SR
Year: 2019
Journal: J Neurosci
Title: Frizzled3 and Frizzled6 Cooperate with Vangl2 to Direct Cochlear Innervation by Type II Spiral Ganglion Neurons.
Volume: 39
Issue: 41
Pages: 8013-8023
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Guo N
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Frizzled6 controls hair patterning in mice.
Volume: 101
Issue: 25
Pages: 9277-81
Publication  
First Author: Wallace ME
Year: 1971
Journal: Mouse News Lett
Title: Rosette (rst)
Volume: 44
Pages: 18
Publication  
First Author: Wallace ME
Year: 1968
Journal: Mouse News Lett
Title: Rosette hair pattern (later rst)
Volume: 39
Pages: 18
Publication
First Author: Wang Y
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Order from disorder: Self-organization in mammalian hair patterning.
Volume: 103
Issue: 52
Pages: 19800-5
GXD Expression    
Probe: MGI:2655089
Assay Type: RT-PCR
Annotation Date: 2003-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775122
Stage: TS22
Assay Id: MGI:2655118
Age: embryonic day 14.0
Image: 3
Specimen Label: E14
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:2655089
Assay Type: RT-PCR
Annotation Date: 2003-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775125
Stage: TS25
Assay Id: MGI:2655118
Age: embryonic day 17.0
Image: 3
Specimen Label: E17
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:2655089
Assay Type: RT-PCR
Annotation Date: 2003-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775127
Stage: TS27
Assay Id: MGI:2655118
Age: postnatal day 1
Image: 3
Specimen Label: D1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2655089
Assay Type: RT-PCR
Annotation Date: 2003-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775128
Stage: TS28
Assay Id: MGI:2655118
Age: postnatal day 5
Image: 3
Specimen Label: D5
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:2655089
Assay Type: RT-PCR
Annotation Date: 2003-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775128
Stage: TS28
Assay Id: MGI:2655118
Age: postnatal month 3
Image: 3
Specimen Label: Ad
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: whole brain
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: cortex
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: subcortical region
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: cerebellum
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: brainstem
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: olfactory bulb
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: spinal cord
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: eyes
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915328
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: harderian gland
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: heart
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: lung
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: liver
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: pancreas
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: kidney
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: spleen
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: thymus
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3552328
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: lymph nodes
Detected: true
Specimen Num: 17
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: bone marrow
Detected: true
Specimen Num: 18
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: skin
Detected: true
Specimen Num: 19
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1720228
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: gallbladder
Detected: true
Specimen Num: 20
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: urinary bladder
Detected: true
Specimen Num: 21
GXD Expression    
Probe: MGI:3625430
Assay Type: RT-PCR
Annotation Date: 2006-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3599828
Stage: TS28
Assay Id: MGI:3625431
Age: postnatal
Image: Gene 669 RT-PCR
Specimen Label: pituitary gland
Detected: true
Specimen Num: 22