Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
pig, domestic |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee YM |
Year: |
2013 |
Journal: |
Mol Genet Metab |
Title: |
The upstream enhancer elements of the G6PC promoter are critical for optimal G6PC expression in murine glycogen storage disease type Ia. |
Volume: |
110 |
Issue: |
3 |
Pages: |
275-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roseman DS |
Year: |
2018 |
Journal: |
Mol Ther |
Title: |
G6PC mRNA Therapy Positively Regulates Fasting Blood Glucose and Decreases Liver Abnormalities in a Mouse Model of Glycogen Storage Disease 1a. |
Volume: |
26 |
Issue: |
3 |
Pages: |
814-821 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
357
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Allele |
Name: |
glucose-6-phosphatase catalytic subunit 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Allele |
Name: |
glucose-6-phosphatase catalytic subunit 1; endonuclease-mediated mutation 1, Janice Yang Chou |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
Allele |
Name: |
glucose-6-phosphatase catalytic subunit 1; targeted mutation 1.1, Mouse Clinical Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
glucose-6-phosphatase catalytic subunit 1; targeted mutation 1, Janice Yang Chou |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
glucose-6-phosphatase catalytic subunit 1; targeted mutation 2.2, Janice Yang Chou |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
solute carrier family 37 (glucose-6-phosphate transporter), member 4; targeted mutation 1, Janice Yang Chou |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Allele |
Name: |
glucose-6-phosphatase catalytic subunit 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Slc37a4/Slc37a4 |
Background: |
involves: 129S4/SvJae * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
G6pc1/G6pc1 |
Background: |
involves: 129S4/SvJae |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
G6pc1/G6pc1 |
Background: |
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
G6pc1/G6pc1 Alb/Alb<+> |
Background: |
involves: 129S2/SvPas * C57BL/6J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
G6pc1/G6pc1 Tg(Kap-icre)29066/2Sig/? |
Background: |
involves: 129S2/SvPas * C57BL/6J * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Genotype |
Symbol: |
G6pc1/G6pc1 |
Background: |
involves: 129S4/SvJae * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang P |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion. |
Volume: |
111 |
Issue: |
29 |
Pages: |
10684-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peng WT |
Year: |
2009 |
Journal: |
Genesis |
Title: |
Generation of mice with a conditional allele for G6pc. |
Volume: |
47 |
Issue: |
9 |
Pages: |
590-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Q |
Year: |
2021 |
Journal: |
Cell |
Title: |
Glycogen accumulation and phase separation drives liver tumor initiation. |
Volume: |
184 |
Issue: |
22 |
Pages: |
5559-5576.e19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee EY |
Year: |
2015 |
Journal: |
Sci Rep |
Title: |
Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet. |
Volume: |
5 |
|
Pages: |
17565 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fang Z |
Year: |
2023 |
Journal: |
Commun Biol |
Title: |
Downregulation of hepatic lncRNA Gm19619 improves gluconeogenesis and lipogenesis following vertical sleeve gastrectomy in mice. |
Volume: |
6 |
Issue: |
1 |
Pages: |
105 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fukushima A |
Year: |
2010 |
Journal: |
Diabetes |
Title: |
T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis. |
Volume: |
59 |
Issue: |
8 |
Pages: |
1906-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chung B |
Year: |
2015 |
Journal: |
Diabetologia |
Title: |
The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice. |
Volume: |
58 |
Issue: |
10 |
Pages: |
2403-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roepke TA |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Loss of ERα partially reverses the effects of maternal high-fat diet on energy homeostasis in female mice. |
Volume: |
7 |
Issue: |
1 |
Pages: |
6381 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morán-Salvador E |
Year: |
2011 |
Journal: |
FASEB J |
Title: |
Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts. |
Volume: |
25 |
Issue: |
8 |
Pages: |
2538-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2018 |
Journal: |
J Biol Chem |
Title: |
Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice. |
Volume: |
293 |
Issue: |
20 |
Pages: |
7894-7904 |
|
•
•
•
•
•
|
Publication |
First Author: |
Saeed A |
Year: |
2020 |
Journal: |
Hum Mol Genet |
Title: |
Glycogen storage disease type 1a is associated with disturbed vitamin A metabolism and elevated serum retinol levels. |
Volume: |
29 |
Issue: |
2 |
Pages: |
264-273 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gjorgjieva M |
Year: |
2016 |
Journal: |
Hum Mol Genet |
Title: |
Progressive development of renal cysts in glycogen storage disease type I. |
Volume: |
25 |
Issue: |
17 |
Pages: |
3784-3797 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mutel E |
Year: |
2011 |
Journal: |
J Hepatol |
Title: |
Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas. |
Volume: |
54 |
Issue: |
3 |
Pages: |
529-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Clar J |
Year: |
2014 |
Journal: |
Kidney Int |
Title: |
Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy. |
Volume: |
86 |
Issue: |
4 |
Pages: |
747-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Clar J |
Year: |
2015 |
Journal: |
Hum Mol Genet |
Title: |
Hepatic lentiviral gene transfer prevents the long-term onset of hepatic tumours of glycogen storage disease type 1a in mice. |
Volume: |
24 |
Issue: |
8 |
Pages: |
2287-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hedman AC |
Year: |
2021 |
Journal: |
J Biol Chem |
Title: |
IQGAP1 binds AMPK and is required for maximum AMPK activation. |
Volume: |
296 |
|
Pages: |
100075 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim GY |
Year: |
2015 |
Journal: |
Hum Mol Genet |
Title: |
Mice expressing reduced levels of hepatic glucose-6-phosphatase-α activity do not develop age-related insulin resistance or obesity. |
Volume: |
24 |
Issue: |
18 |
Pages: |
5115-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang L |
Year: |
2020 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Gene therapy using a novel G6PC-S298C variant enhances the long-term efficacy for treating glycogen storage disease type Ia. |
Volume: |
527 |
Issue: |
3 |
Pages: |
824-830 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang HJ |
Year: |
2015 |
Journal: |
Autophagy |
Title: |
Chronic HMGCR/HMG-CoA reductase inhibitor treatment contributes to dysglycemia by upregulating hepatic gluconeogenesis through autophagy induction. |
Volume: |
11 |
Issue: |
11 |
Pages: |
2089-2101 |
|
•
•
•
•
•
|
Publication |
First Author: |
Choi WI |
Year: |
2019 |
Journal: |
Biochim Biophys Acta Gene Regul Mech |
Title: |
Zbtb7c is a critical gluconeogenic transcription factor that induces glucose-6-phosphatase and phosphoenylpyruvate carboxykinase 1 genes expression during mice fasting. |
Volume: |
1862 |
Issue: |
6 |
Pages: |
643-656 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim MS |
Year: |
2016 |
Journal: |
J Clin Invest |
Title: |
ChREBP regulates fructose-induced glucose production independently of insulin signaling. |
Volume: |
126 |
Issue: |
11 |
Pages: |
4372-4386 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wei D |
Year: |
2011 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1. |
Volume: |
300 |
Issue: |
2 |
Pages: |
E312-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oh GS |
Year: |
2022 |
Journal: |
Mol Cells |
Title: |
Regulation of Hepatic Gluconeogenesis by Nuclear Receptor Coactivator 6. |
Volume: |
45 |
Issue: |
4 |
Pages: |
180-192 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kwon JH |
Year: |
2017 |
Journal: |
Hum Mol Genet |
Title: |
Liver-directed gene therapy for murine glycogen storage disease type Ib. |
Volume: |
26 |
Issue: |
22 |
Pages: |
4395-4405 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beaudry JB |
Year: |
2006 |
Journal: |
Mol Cell Biol |
Title: |
Threshold levels of hepatocyte nuclear factor 6 (HNF-6) acting in synergy with HNF-4 and PGC-1alpha are required for time-specific gene expression during liver development. |
Volume: |
26 |
Issue: |
16 |
Pages: |
6037-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh BK |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes. |
Volume: |
288 |
Issue: |
42 |
Pages: |
30365-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schilling MM |
Year: |
2008 |
Journal: |
Diabetologia |
Title: |
Sequence variation between the mouse and human glucose-6-phosphatase catalytic subunit gene promoters results in differential activation by peroxisome proliferator activated receptor gamma coactivator-1alpha. |
Volume: |
51 |
Issue: |
8 |
Pages: |
1505-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu X |
Year: |
2016 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Upregulation of lncRNA MEG3 promotes hepatic insulin resistance via increasing FoxO1 expression. |
Volume: |
469 |
Issue: |
2 |
Pages: |
319-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inaba Y |
Year: |
2019 |
Journal: |
Endocrinology |
Title: |
Hepatic Gluconeogenic Response to Single and Long-Term SGLT2 Inhibition in Lean/Obese Male Hepatic G6pc-Reporter Mice. |
Volume: |
160 |
Issue: |
12 |
Pages: |
2811-2824 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arora T |
Year: |
2016 |
Journal: |
Mol Metab |
Title: |
Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice. |
Volume: |
5 |
Issue: |
8 |
Pages: |
725-730 |
|
•
•
•
•
•
|
Publication |
First Author: |
Youn DY |
Year: |
2021 |
Journal: |
Mol Metab |
Title: |
The Mediator complex kinase module is necessary for fructose regulation of liver glycogen levels through induction of glucose-6-phosphatase catalytic subunit (G6pc). |
Volume: |
48 |
|
Pages: |
101227 |
|
•
•
•
•
•
|
Publication |
First Author: |
Charbonneau A |
Year: |
2010 |
Journal: |
Diabetes |
Title: |
Inducible nitric oxide synthase induction underlies lipid-induced hepatic insulin resistance in mice: potential role of tyrosine nitration of insulin signaling proteins. |
Volume: |
59 |
Issue: |
4 |
Pages: |
861-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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•
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