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Search results 1 to 48 out of 48 for Gars

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Hits by Pathway

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Type Details Score
Gene
428403 | GARS
Type: gene
Organism: chicken
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Publication
22144914 | J:179811
First Author: Motley WW
Year: 2011
Journal: PLoS Genet
Title: Charcot-Marie-Tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels.
Volume: 7
Issue: 12
Pages: e1002399
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Author
Gars E
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Author
Le Gars M
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Protein
Q9CZD3
Organism: Mus musculus/domesticus
Length: 729  
Fragment?: false
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Publication
28351971 | J:242146
First Author: Sleigh JN
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations.
Volume: 114
Issue: 16
Pages: E3324-E3333
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Protein Coding Gene
MGI:2449057 | Gars1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
2617 | GARS1
Type: gene
Organism: human
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Publication
22307620 | J:182039
First Author: Descamps D
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Toll-like receptor 5 (TLR5), IL-1β secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing.
Volume: 109
Issue: 5
Pages: 1619-24
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Allele
Tg(CAG-GARS)DRwb | MGI:5308112
Name: transgene insertion D, Robert W Burgess
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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GO Term
GO:0004637 | phosphoribosylamine-glycine ligase activity
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Protein Domain
IPR000115 | PRibGlycinamide_synth
Type: Family
Description: Phosphoribosylglycinamide synthetase () (GARS) (phosphoribosylamine glycine ligase) []catalyses the second step in the de novobiosynthesis of purine. The reaction catalysed by phosphoribosylglycinamide synthetase is the ATP-dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide:ATP + 5-phosphoribosylamine + glycine = ADP + Pi+ 5'-phosphoribosylglycinamideIn bacteria, GARS is a monofunctional enzyme (encoded by the purD gene). Inyeast, GARS is part of a bifunctional enzyme (encoded by the ADE5,7 gene) in conjunction with phosphoribosylformylglycinamidine cyclo-ligase (AIRS) []. In higher eukaryotes, GARS is part of a trifunctional enzyme in conjunction with AIRS and with phosphoribosylglycinamide formyltransferase (GART), forming GARS-AIRS-GART [].
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Protein Domain
IPR020560 | PRibGlycinamide_synth_C-dom
Type: Domain
Description: Phosphoribosylglycinamide synthetase () (GARS) (phosphoribosylamine glycine ligase) []catalyses the second step in the de novobiosynthesis of purine. The reaction catalysed by phosphoribosylglycinamide synthetase is the ATP-dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide:ATP + 5-phosphoribosylamine + glycine = ADP + Pi+ 5'-phosphoribosylglycinamideIn bacteria, GARS is a monofunctional enzyme (encoded by the purD gene). Inyeast, GARS is part of a bifunctional enzyme (encoded by the ADE5,7 gene) in conjunction with phosphoribosylformylglycinamidine cyclo-ligase (AIRS) []. In higher eukaryotes, GARS is part of a trifunctional enzyme in conjunction with AIRS and with phosphoribosylglycinamide formyltransferase (GART), forming GARS-AIRS-GART [].This entry represents the C-domain, which is related to the C-terminal domain of biotin carboxylase/carbamoyl phosphate synthetase ().
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Protein Domain
IPR020562 | PRibGlycinamide_synth_N
Type: Domain
Description: Phosphoribosylglycinamide synthetase () (GARS) (phosphoribosylamine glycine ligase) []catalyses the second step in the de novobiosynthesis of purine. The reaction catalysed by phosphoribosylglycinamide synthetase is the ATP-dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide:ATP + 5-phosphoribosylamine + glycine = ADP + Pi+ 5'-phosphoribosylglycinamideIn bacteria, GARS is a monofunctional enzyme (encoded by the purD gene). Inyeast, GARS is part of a bifunctional enzyme (encoded by the ADE5,7 gene) in conjunction with phosphoribosylformylglycinamidine cyclo-ligase (AIRS) []. In higher eukaryotes, GARS is part of a trifunctional enzyme in conjunction with AIRS and with phosphoribosylglycinamide formyltransferase (GART), forming GARS-AIRS-GART [].This entry represents the N-domain, which is related to the N-terminal domain of biotin carboxylase/carbamoyl phosphate synthetase ().
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Protein Domain
IPR020559 | PRibGlycinamide_synth_CS
Type: Conserved_site
Description: Phosphoribosylglycinamide synthetase () (GARS) (phosphoribosylamine glycine ligase) []catalyses the second step in the de novobiosynthesis of purine. The reaction catalysed by phosphoribosylglycinamide synthetase is the ATP-dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide:ATP + 5-phosphoribosylamine + glycine = ADP + Pi+ 5'-phosphoribosylglycinamideIn bacteria, GARS is a monofunctional enzyme (encoded by the purD gene). Inyeast, GARS is part of a bifunctional enzyme (encoded by the ADE5,7 gene) in conjunction with phosphoribosylformylglycinamidine cyclo-ligase (AIRS) []. In higher eukaryotes, GARS is part of a trifunctional enzyme in conjunction with AIRS and with phosphoribosylglycinamide formyltransferase (GART), forming GARS-AIRS-GART [].This signature pattern identifies a highly conserved octapeptide.
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DO Term
DOID:0111203 | autosomal dominant distal hereditary motor neuronopathy 5
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Protein Domain
IPR020561 | PRibGlycinamid_synth_ATP-grasp
Type: Domain
Description: Phosphoribosylglycinamide synthetase () (GARS) (phosphoribosylamine glycine ligase) []catalyses the second step in the de novobiosynthesis of purine. The reaction catalysed by phosphoribosylglycinamide synthetase is the ATP-dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide:ATP + 5-phosphoribosylamine + glycine = ADP + Pi+ 5'-phosphoribosylglycinamideIn bacteria, GARS is a monofunctional enzyme (encoded by the purD gene). Inyeast, GARS is part of a bifunctional enzyme (encoded by the ADE5,7 gene) in conjunction with phosphoribosylformylglycinamidine cyclo-ligase (AIRS) []. In higher eukaryotes, GARS is part of a trifunctional enzyme in conjunction with AIRS and with phosphoribosylglycinamide formyltransferase (GART), forming GARS-AIRS-GART [].This entry represents the A-domain of the enzyme, and is related to the ATP-grasp domain of biotin carboxylase/carbamoyl phosphate synthetase.
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Protein Domain
IPR037123 | PRibGlycinamide_synth_C_sf
Type: Homologous_superfamily
Description: Phosphoribosylglycinamide synthetase () (GARS) (phosphoribosylamine glycine ligase) []catalyses the second step in the de novobiosynthesis of purine. The reaction catalysed by phosphoribosylglycinamide synthetase is the ATP-dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide:ATP + 5-phosphoribosylamine + glycine = ADP + Pi+ 5'-phosphoribosylglycinamideIn bacteria, GARS is a monofunctional enzyme (encoded by the purD gene). Inyeast, GARS is part of a bifunctional enzyme (encoded by the ADE5,7 gene) in conjunction with phosphoribosylformylglycinamidine cyclo-ligase (AIRS) []. In higher eukaryotes, GARS is part of a trifunctional enzyme in conjunction with AIRS and with phosphoribosylglycinamide formyltransferase (GART), forming GARS-AIRS-GART [].This entry represents the C-domain superfamily of the phosphoribosylglycinamide synthetase, which is related to the C-terminal domain of biotin carboxylase/carbamoyl phosphate synthetase ().
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Publication
2687276 | -
First Author: Aiba A
Year: 1989
Journal: J Biol Chem
Title: Nucleotide sequence analysis of genes purH and purD involved in the de novo purine nucleotide biosynthesis of Escherichia coli.
Volume: 264
Issue: 35
Pages: 21239-46
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Publication
2147474 | -
First Author: Aimi J
Year: 1990
Journal: Nucleic Acids Res
Title: De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli.
Volume: 18
Issue: 22
Pages: 6665-72
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Publication
3097325 | -
First Author: Henikoff S
Year: 1986
Journal: J Mol Biol
Title: The Saccharomyces cerevisiae ADE5,7 protein is homologous to overlapping Drosophila melanogaster Gart polypeptides.
Volume: 190
Issue: 4
Pages: 519-28
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Publication
32576678 | J:291450
 
First Author: Tal MC
Year: 2020
Journal: mBio
Title: Upregulation of CD47 Is a Host Checkpoint Response to Pathogen Recognition.
Volume: 11
Issue: 3
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Genotype
Genotype
Symbol: Gars1/Gars1<+> Tg(CAG-GARS)DRwb/?
Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gars1/Gars1 Tg(CAG-GARS)DRwb/?
Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Protein
Q3TH49
Organism: Mus musculus/domesticus
Length: 433  
Fragment?: false
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Protein
D6RCG1
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
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Genotype
Genotype
Symbol: Gars1/Gars1 Tg(CAG-GARS)DRwb/?
Background: involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gars1/Gars1<+> Tg(CAG-GARS)DRwb/?
Background: involves: C57BL/6J * CAST/Ei * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gars1/Gars1 Tg(CAG-GARS)DRwb/?
Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Protein
Q64737
Organism: Mus musculus/domesticus
Length: 1010  
Fragment?: false
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Protein
Q3UJP8
Organism: Mus musculus/domesticus
Length: 1010  
Fragment?: false
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Protein
A0A338P676
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: true
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Publication
16982418 | J:112221
First Author: Seburn KL
Year: 2006
Journal: Neuron
Title: An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model.
Volume: 51
Issue: 6
Pages: 715-26
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Publication
30239612 | J:355103
First Author: Shorrock HK
Year: 2018
Journal: Brain
Title: UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy.
Volume: 141
Issue: 10
Pages: 2878-2894
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Protein
A0A338P6X4
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: true
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Publication
8299947 | J:16622
First Author: Kan JL
Year: 1993
Journal: Gene
Title: Mouse cDNAs encoding a trifunctional protein of de novo purine synthesis and a related single-domain glycinamide ribonucleotide synthetase.
Volume: 137
Issue: 2
Pages: 195-202
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Publication
19593442 | J:151592
First Author: Banks GT
Year: 2009
Journal: PLoS One
Title: Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1(G93A) motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice.
Volume: 4
Issue: 7
Pages: e6218
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Publication
19470612 | J:149830
First Author: Achilli F
Year: 2009
Journal: Dis Model Mech
Title: An ENU-induced mutation in mouse glycyl-tRNA synthetase (GARS) causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy.
Volume: 2
Issue: 7-8
Pages: 359-73
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Publication
24368416 | J:209061
First Author: Sleigh JN
Year: 2014
Journal: Hum Mol Genet
Title: Neuromuscular junction maturation defects precede impaired lower motor neuron connectivity in Charcot-Marie-Tooth type 2D mice.
Volume: 23
Issue: 10
Pages: 2639-50
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Publication
31557132 | J:284948
First Author: Morelli KH
Year: 2019
Journal: J Clin Invest
Title: Allele-specific RNA interference prevents neuropathy in Charcot-Marie-Tooth disease type 2D mouse models.
Volume: 129
Issue: 12
Pages: 5568-5583
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Publication
32703932 | J:332709
First Author: Sleigh JN
Year: 2020
Journal: Cell Death Dis
Title: Developmental demands contribute to early neuromuscular degeneration in CMT2D mice.
Volume: 11
Issue: 7
Pages: 564
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Publication
29415205 | J:285515
First Author: Benoy V
Year: 2018
Journal: Brain
Title: HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease.
Volume: 141
Issue: 3
Pages: 673-687
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Publication
29648643 | J:262480
First Author: Boczonadi V
Year: 2018
Journal: Hum Mol Genet
Title: Mutations in glycyl-tRNA synthetase impair mitochondrial metabolism in neurons.
Volume: 27
Issue: 12
Pages: 2187-2204
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Publication
17595294 | J:248269
First Author: Nangle LA
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect.
Volume: 104
Issue: 27
Pages: 11239-44
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Publication
7829519 | J:22527
First Author: Kan JL
Year: 1995
Journal: J Biol Chem
Title: Analysis of a mouse gene encoding three steps of purine synthesis reveals use of an intronic polyadenylation signal without alternative exon usage.
Volume: 270
Issue: 4
Pages: 1823-32
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Publication
21115117 | J:171297
First Author: Stum M
Year: 2011
Journal: Mol Cell Neurosci
Title: An assessment of mechanisms underlying peripheral axonal degeneration caused by aminoacyl-tRNA synthetase mutations.
Volume: 46
Issue: 2
Pages: 432-43
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Publication
32848623 | J:308233
 
First Author: Sleigh JN
Year: 2020
Journal: Front Cell Neurosci
Title: Altered Sensory Neuron Development in CMT2D Mice Is Site-Specific and Linked to Increased GlyRS Levels.
Volume: 14
Pages: 232
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Publication
27288508 | J:233821
First Author: Bais P
Year: 2016
Journal: Biol Open
Title: Metabolite profile of a mouse model of Charcot-Marie-Tooth type 2D neuropathy: implications for disease mechanisms and interventions.
Volume: 5
Issue: 7
Pages: 908-20
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