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Search results 1 to 100 out of 1283 for Gcg

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0.056s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Shiota C
Year: 2017
Journal: Diabetologia
Title: Gcg CreERT2 knockin mice as a tool for genetic manipulation in pancreatic alpha cells.
Volume: 60
Issue: 12
Pages: 2399-2408
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Gaykema RP
Year: 2017
Journal: J Clin Invest
Title: Activation of murine pre-proglucagon-producing neurons reduces food intake and body weight.
Volume: 127
Issue: 3
Pages: 1031-1045
Publication
First Author: Chang YH
Year: 2020
Journal: Exp Anim
Title: Uncovering the role of MAFB in glucagon production and secretion in pancreatic α-cells using a new α-cell-specific Mafb conditional knockout mouse model.
Volume: 69
Issue: 2
Pages: 178-188
Publication    
First Author: Essawy A
Year: 2021
Journal: J Biol Chem
Title: O-linked N-Acetylglucosamine Transferase (OGT) regulates pancreatic α-cell function in mice.
Pages: 100297
Publication
First Author: Thiebaud N
Year: 2019
Journal: Sci Rep
Title: A unique olfactory bulb microcircuit driven by neurons expressing the precursor to glucagon-like peptide 1.
Volume: 9
Issue: 1
Pages: 15542
Publication
First Author: Shiota C
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: α-Cells are dispensable in postnatal morphogenesis and maturation of mouse pancreatic islets.
Volume: 305
Issue: 8
Pages: E1030-40
Publication  
First Author: Cheng W
Year: 2020
Journal: JCI Insight
Title: Leptin receptor-expressing nucleus tractus solitarius neurons suppress food intake independently of GLP1 in mice.
Volume: 5
Issue: 7
Publication
First Author: Sayers SR
Year: 2016
Journal: PLoS One
Title: Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.
Volume: 11
Issue: 3
Pages: e0149549
Publication    
First Author: Biddinger JE
Year: 2020
Journal: Elife
Title: Leptin suppresses development of GLP-1 inputs to the paraventricular nucleus of the hypothalamus.
Volume: 9
Publication
First Author: van der Meulen T
Year: 2017
Journal: Cell Metab
Title: Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets.
Volume: 25
Issue: 4
Pages: 911-926.e6
Publication
First Author: Ackermann AM
Year: 2017
Journal: Mol Metab
Title: High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting.
Volume: 6
Issue: 3
Pages: 236-244
Publication    
First Author: Zhu L
Year: 2019
Journal: JCI Insight
Title: Intra-islet glucagon signaling is critical for maintaining glucose homeostasis.
Volume: 5
Publication
First Author: Ackermann AM
Year: 2018
Journal: Cell Metab
Title: GABA and Artesunate Do Not Induce Pancreatic α-to-β Cell Transdifferentiation In Vivo.
Volume: 28
Issue: 5
Pages: 787-792.e3
Publication
First Author: Shi X
Year: 2017
Journal: Mol Metab
Title: Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity.
Volume: 6
Issue: 11
Pages: 1350-1359
Publication
First Author: Allister EM
Year: 2013
Journal: Diabetes
Title: UCP2 regulates the glucagon response to fasting and starvation.
Volume: 62
Issue: 5
Pages: 1623-33
Publication  
First Author: Campbell JR
Year: 2020
Journal: Endocrinology
Title: Essential Role of Syntaxin-Binding Protein-1 in the Regulation of Glucagon-Like Peptide-1 Secretion.
Volume: 161
Issue: 5
Publication
First Author: Basco D
Year: 2018
Journal: Nat Commun
Title: α-cell glucokinase suppresses glucose-regulated glucagon secretion.
Volume: 9
Issue: 1
Pages: 546
Publication    
First Author: Bahl V
Year: 2021
Journal: Mol Metab
Title: Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states.
Pages: 101193
Publication  
First Author: Croze ML
Year: 2021
Journal: Mol Metab
Title: Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice.
Volume: 45
Pages: 101166
GXD Expression  
Probe: MGI:4415918
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750322
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825956
Age: embryonic day 14.5
Image: 2 Gcg
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4415918
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3565022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825956
Age: embryonic day 14.5
Image: 5 Gcg
Detected: true
Specimen Num: 2
Publication
First Author: Schaffer AE
Year: 2013
Journal: PLoS Genet
Title: Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.
Volume: 9
Issue: 1
Pages: e1003274
Publication
First Author: Mastracci TL
Year: 2013
Journal: PLoS Genet
Title: Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas.
Volume: 9
Issue: 2
Pages: e1003278
Publication
First Author: Lu J
Year: 2010
Journal: Gastroenterology
Title: Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.
Volume: 138
Issue: 5
Pages: 1954-65
Publication
First Author: Bonnavion R
Year: 2015
Journal: Mol Cell Biol
Title: Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors.
Volume: 35
Issue: 19
Pages: 3274-83
Publication
First Author: Kodani N
Year: 2020
Journal: iScience
Title: FCoR-Foxo1 Axis Regulates α-Cell Mass through Repression of Arx Expression.
Volume: 23
Issue: 1
Pages: 100798
Publication
First Author: Yang YP
Year: 2011
Journal: Genes Dev
Title: Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.
Volume: 25
Issue: 16
Pages: 1680-5
Publication      
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
Publication      
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
Publication  
First Author: Panaro BL
Year: 2020
Journal: Mol Metab
Title: Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion.
Volume: 37
Pages: 100990
GXD Expression  
Probe: MGI:6695358
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1725617
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6695729
Age: embryonic day 10.5
Image: 5A Gcg (lower)
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6695358
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6695729
Age: embryonic day 10.5
Image: 5A Gcg (upper)
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4415918
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3565022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825956
Age: embryonic day 14.5
Image: Additional file 4 Gcg
Detected: true
Specimen Num: 3
Allele
Name: transgene insertion, Michael M Scott
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
GO Term
Allele
Name: glucagon; targeted mutation 1.1, Richard D Palmiter
Allele Type: Targeted
Attribute String: Recombinase, Reporter
Publication categories: ProxyCollection
Allele  
Name: Mutant line 1297; Bench to Bassinet Program (B2B/CVDC), mutation 1297 Cecilia Lo
Allele Type: Chemically induced (ENU)
Publication categories: ProxyCollection
Strain
Attribute String: congenic, mutant strain, targeted mutation
Publication
First Author: Vastagh C
Year: 2021
Journal: Brain Struct Funct
Title: Networking of glucagon-like peptide-1 axons with GnRH neurons in the basal forebrain of male mice revealed by 3DISCO-based immunocytochemistry and optogenetics.
Volume: 226
Issue: 1
Pages: 105-120
Allele
Name: transgene insertion 12, Fiona M Gribble
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
Allele
Name: transgene insertion 23, Chiyo Shiota
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
Allele
Name: glucagon; targeted mutation 1.1, George K Gittes
Allele Type: Targeted
Attribute String: Recombinase
Publication categories: ProxyCollection
Publication
First Author: Briant LJB
Year: 2018
Journal: Cell Rep
Title: CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets.
Volume: 23
Issue: 11
Pages: 3300-3311
Strain
Attribute String: targeted mutation, mutant stock
Genotype
Symbol: Tg(Gcg-icre)23Cshi/?
Background: involves: C57BL/6
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Bozadjieva Kramer N
Year: 2021
Journal: Diabetes
Title: Glucagon Resistance and Decreased Susceptibility to Diabetes in a Model of Chronic Hyperglucagonemia.
Volume: 70
Issue: 2
Pages: 477-491
Publication
First Author: Zhang Q
Year: 2013
Journal: Cell Metab
Title: Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.
Volume: 18
Issue: 6
Pages: 871-82
Publication
First Author: Dickerson MT
Year: 2019
Journal: Am J Physiol Endocrinol Metab
Title: Glucose-mediated inhibition of calcium-activated potassium channels limits α-cell calcium influx and glucagon secretion.
Volume: 316
Issue: 4
Pages: E646-E659
Publication
First Author: Parker HE
Year: 2012
Journal: Diabetologia
Title: Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion.
Volume: 55
Issue: 9
Pages: 2445-55
Publication
First Author: Knudsen JG
Year: 2019
Journal: Cell Metab
Title: Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.
Volume: 29
Issue: 2
Pages: 430-442.e4
Publication
First Author: Pais R
Year: 2016
Journal: Endocrinology
Title: Angiotensin II Type 1 Receptor-Dependent GLP-1 and PYY Secretion in Mice and Humans.
Volume: 157
Issue: 10
Pages: 3821-3831
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Gcg-icre)23Cshi/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Gcg-icre)23Cshi/?
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Liu J
Year: 2017
Journal: Neuron
Title: Enhanced AMPA Receptor Trafficking Mediates the Anorexigenic Effect of Endogenous Glucagon-like Peptide-1 in the Paraventricular Hypothalamus.
Volume: 96
Issue: 4
Pages: 897-909.e5
Publication
First Author: Anesten F
Year: 2016
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6.
Volume: 311
Issue: 1
Pages: R115-23
Publication    
First Author: Worth AA
Year: 2020
Journal: Elife
Title: The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling.
Volume: 9
Publication
First Author: Holt MK
Year: 2019
Journal: Diabetes
Title: Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food.
Volume: 68
Issue: 1
Pages: 21-33
Publication
First Author: Zac-Varghese S
Year: 2014
Journal: Dis Model Mech
Title: The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice.
Volume: 7
Issue: 11
Pages: 1275-86
Publication
First Author: Emery EC
Year: 2015
Journal: Diabetes
Title: Stimulation of GLP-1 secretion downstream of the ligand-gated ion channel TRPA1.
Volume: 64
Issue: 4
Pages: 1202-10
Publication
First Author: Bozadjieva N
Year: 2017
Journal: J Clin Invest
Title: Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.
Volume: 127
Issue: 12
Pages: 4379-4393
Publication
First Author: Lu VB
Year: 2019
Journal: Nat Commun
Title: Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.
Volume: 10
Issue: 1
Pages: 1029
Publication
First Author: Zhang Q
Year: 2014
Journal: J Physiol
Title: Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.
Volume: 592
Issue: 21
Pages: 4677-96
Publication
First Author: Nakamura Y
Year: 2014
Journal: PLoS One
Title: Targeting SUR1/Abcc8-type neuroendocrine KATP channels in pancreatic islet cells.
Volume: 9
Issue: 3
Pages: e91525
Publication
First Author: Piran R
Year: 2016
Journal: Cell Death Dis
Title: PAR2 regulates regeneration, transdifferentiation, and death.
Volume: 7
Issue: 11
Pages: e2452
Publication
First Author: Magnuson MA
Year: 2013
Journal: Cell Metab
Title: Pancreas-specific Cre driver lines and considerations for their prudent use.
Volume: 18
Issue: 1
Pages: 9-20
Publication
First Author: Le Marchand SJ
Year: 2010
Journal: J Biol Chem
Title: Glucose suppression of glucagon secretion: metabolic and calcium responses from alpha-cells in intact mouse pancreatic islets.
Volume: 285
Issue: 19
Pages: 14389-98
Publication
First Author: Herrera PL
Year: 2002
Journal: Endocrine
Title: Pancreatic cell lineage analyses in mice.
Volume: 19
Issue: 3
Pages: 267-78
Publication      
First Author: Pavlovic G
Year: 2013
Journal: MGI Direct Data Submission
Title: Data submissions from the Mouse Clinical Institute (ICS)
Publication
First Author: Semplici F
Year: 2016
Journal: Diabetologia
Title: Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production.
Volume: 59
Issue: 9
Pages: 1938-47
Publication  
First Author: Yu R
Year: 2016
Journal: Mol Cell Endocrinol
Title: Animal models of spontaneous pancreatic neuroendocrine tumors.
Volume: 421
Pages: 60-7
Publication
First Author: Schraenen A
Year: 2010
Journal: Diabetologia
Title: Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy.
Volume: 53
Issue: 12
Pages: 2589-99
Publication
First Author: Thorel F
Year: 2010
Journal: Nature
Title: Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss.
Volume: 464
Issue: 7292
Pages: 1149-54
Publication
First Author: Ahmad Z
Year: 2015
Journal: PLoS One
Title: Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation Marker.
Volume: 10
Issue: 12
Pages: e0144597
Publication
First Author: Ben-Othman N
Year: 2017
Journal: Cell
Title: Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis.
Volume: 168
Issue: 1-2
Pages: 73-85.e11
Publication    
First Author: Takatani T
Year: 2021
Journal: J Biol Chem
Title: Insulin receptor substrate 1 (IRS1), but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice.
Pages: 100646
Publication
First Author: Shen HC
Year: 2009
Journal: PLoS One
Title: Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations.
Volume: 4
Issue: 4
Pages: e4897
Publication
First Author: Shen HC
Year: 2010
Journal: Endocrinology
Title: Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice.
Volume: 151
Issue: 8
Pages: 4024-30
Publication
First Author: van der Meulen T
Year: 2015
Journal: Nat Med
Title: Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion.
Volume: 21
Issue: 7
Pages: 769-76
Allele
Name: transgene insertion 9, Frank Reimann
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
Publication categories: ProxyCollection
Publication
First Author: Herrera PL
Year: 1998
Journal: Mol Cell Endocrinol
Title: Two transgenic approaches to define the cell lineages in endocrine pancreas development.
Volume: 140
Issue: 1-2
Pages: 45-50
Publication
First Author: Herrera PL
Year: 2000
Journal: Development
Title: Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages.
Volume: 127
Issue: 11
Pages: 2317-22
Publication
First Author: Collombat P
Year: 2009
Journal: Cell
Title: The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells.
Volume: 138
Issue: 3
Pages: 449-62
Publication
First Author: Wilcox CL
Year: 2013
Journal: PLoS One
Title: Pancreatic α-cell specific deletion of mouse Arx leads to α-cell identity loss.
Volume: 8
Issue: 6
Pages: e66214
Publication
First Author: Xiao X
Year: 2014
Journal: Diabetologia
Title: Pancreatic duct cells as a source of VEGF in mice.
Volume: 57
Issue: 5
Pages: 991-1000
Publication
First Author: Tudurí E
Year: 2014
Journal: Am J Physiol Endocrinol Metab
Title: Partial ablation of leptin signaling in mouse pancreatic α-cells does not alter either glucose or lipid homeostasis.
Volume: 306
Issue: 7
Pages: E748-55
Publication
First Author: Brown ML
Year: 2016
Journal: Endocrinology
Title: Activin Enhances α- to β-Cell Transdifferentiation as a Source For β-Cells In Male FSTL3 Knockout Mice.
Volume: 157
Issue: 3
Pages: 1043-54
Publication
First Author: Akiyama M
Year: 2013
Journal: Diabetes
Title: X-box binding protein 1 is essential for insulin regulation of pancreatic α-cell function.
Volume: 62
Issue: 7
Pages: 2439-49
Publication
First Author: Matsuoka TA
Year: 2017
Journal: Diabetes
Title: Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo.
Volume: 66
Issue: 5
Pages: 1293-1300
Publication
First Author: da Silva Xavier G
Year: 2017
Journal: Diabetologia
Title: Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice.
Volume: 60
Issue: 6
Pages: 1043-1050
Publication
First Author: Wang Y
Year: 2016
Journal: J Cell Sci
Title: An optical method to evaluate both mass and functional competence of pancreatic α- and β-cells.
Volume: 129
Issue: 12
Pages: 2462-71
Publication
First Author: Lemaire K
Year: 2017
Journal: PLoS One
Title: How stable is repression of disallowed genes in pancreatic islets in response to metabolic stress?
Volume: 12
Issue: 8
Pages: e0181651
Publication
First Author: Chow SZ
Year: 2014
Journal: Diabetes
Title: Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes.
Volume: 63
Issue: 9
Pages: 2984-95
Publication
First Author: Motterle A
Year: 2017
Journal: Mol Metab
Title: Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes.
Volume: 6
Issue: 11
Pages: 1407-1418
Publication
First Author: Sun G
Year: 2015
Journal: Mol Metab
Title: LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia.
Volume: 4
Issue: 4
Pages: 277-86
Publication
First Author: El-Gohary Y
Year: 2014
Journal: Diabetes
Title: A smad signaling network regulates islet cell proliferation.
Volume: 63
Issue: 1
Pages: 224-36
Publication
First Author: Hutchens T
Year: 2015
Journal: Diabetes
Title: EphA4 Receptor Forward Signaling Inhibits Glucagon Secretion From α-Cells.
Volume: 64
Issue: 11
Pages: 3839-51