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Search results 1 to 100 out of 597 for Gck

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0.065s
Type Details Score
Protein Domain
Type: Domain
Description: This domain is found in proteins carrying other domains known to be involved in intracellular signalling pathways (such as ) indicating that it might also be involved in these pathways. It has 4 highly conserved cysteine residues, suggesting that it can bind zinc ions. Moreover, it is found repeated in some members of this family (such as ); this may indicate that these domains are able to interact with one another, raising the possibility that this domain mediates heterodimerisation.
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Allele
Name: transgene insertion #, Jeffrey M Friedman
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
GXD Expression  
Probe: MGI:3724958
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3565022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3826194
Age: embryonic day 14.5
Image: Additional file 4 Gck
Detected: true
Specimen Num: 1
Publication
First Author: Stanley S
Year: 2013
Journal: Cell Metab
Title: Profiling of Glucose-Sensing Neurons Reveals that GHRH Neurons Are Activated by Hypoglycemia.
Volume: 18
Issue: 4
Pages: 596-607
Allele
Name: transgene insertion TG7, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
Strain
Attribute String: transgenic, mutant stock
Genotype
Symbol: Eef1a1/Eef1a1<+> Tg(Gck-cre)#Rck/?
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Magnuson MA
Year: 2013
Journal: Cell Metab
Title: Pancreas-specific Cre driver lines and considerations for their prudent use.
Volume: 18
Issue: 1
Pages: 9-20
Publication      
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
Publication
First Author: Inoue M
Year: 2004
Journal: Hum Mol Genet
Title: A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program.
Volume: 13
Issue: 11
Pages: 1147-57
Publication      
First Author: Turer E
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for tootsie.
Publication
First Author: van Buerck L
Year: 2012
Journal: Mol Cell Endocrinol
Title: Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich Gck(D217V) mutants.
Volume: 362
Issue: 1-2
Pages: 139-48
Publication
First Author: Aigner B
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Title: Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects.
Volume: 294
Issue: 2
Pages: E232-40
Publication
First Author: Basco D
Year: 2018
Journal: Nat Commun
Title: α-cell glucokinase suppresses glucose-regulated glucagon secretion.
Volume: 9
Issue: 1
Pages: 546
Publication
First Author: Kishore M
Year: 2017
Journal: Immunity
Title: Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.
Volume: 47
Issue: 5
Pages: 875-889.e10
Publication
First Author: Xu W
Year: 2013
Journal: Int J Mol Sci
Title: Differential expression of genes associated with the progression of renal disease in the kidneys of liver-specific glucokinase gene knockout mice.
Volume: 14
Issue: 3
Pages: 6467-86
Publication
First Author: Guo T
Year: 2012
Journal: Biomed Pharmacother
Title: Characterization of the gene expression profile of heterozygous liver-specific glucokinase knockout mice at a young age.
Volume: 66
Issue: 8
Pages: 587-96
Publication
First Author: Steinbusch LK
Year: 2016
Journal: Diabetes
Title: Sex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase.
Volume: 65
Issue: 10
Pages: 2920-31
Publication
First Author: Fenner D
Year: 2011
Journal: J Biol Chem
Title: Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.
Volume: 286
Issue: 45
Pages: 39560-72
Publication
First Author: Wang R
Year: 2013
Journal: Gene
Title: Differential expression of genes and changes in glucose metabolism in the liver of liver-specific glucokinase gene knockout mice.
Volume: 516
Issue: 2
Pages: 248-54
Publication  
First Author: Li H
Year: 2014
Journal: Cardiovasc Diabetol
Title: Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK.
Volume: 13
Pages: 24
Publication
First Author: Pérez-García A
Year: 2018
Journal: Sci Rep
Title: PAS Kinase deficiency alters the glucokinase function and hepatic metabolism.
Volume: 8
Issue: 1
Pages: 11091
Publication
First Author: Baldini SF
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Glucokinase expression is regulated by glucose through O-GlcNAc glycosylation.
Volume: 478
Issue: 2
Pages: 942-8
Publication
First Author: Terauchi Y
Year: 2000
Journal: Diabetes
Title: Insulin effect during embryogenesis determines fetal growth: a possible molecular link between birth weight and susceptibility to type 2 diabetes.
Volume: 49
Issue: 1
Pages: 82-6
Publication
First Author: Terauchi Y
Year: 2007
Journal: J Clin Invest
Title: Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.
Volume: 117
Issue: 1
Pages: 246-57
Publication
First Author: Ait-Lounis A
Year: 2010
Journal: Diabetes
Title: The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression.
Volume: 59
Issue: 7
Pages: 1674-85
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Ishimura-Oka K
Year: 1995
Journal: Genomics
Title: Partial structure of the mouse glucokinase gene.
Volume: 29
Issue: 3
Pages: 751-4
Publication
First Author: Postic C
Year: 1995
Journal: Genomics
Title: Cloning and characterization of the mouse glucokinase gene locus and identification of distal liver-specific DNase I hypersensitive sites.
Volume: 29
Issue: 3
Pages: 740-50
Publication
First Author: Hughes SD
Year: 1991
Journal: J Biol Chem
Title: Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells.
Volume: 266
Issue: 7
Pages: 4521-30
Publication
First Author: Terauchi Y
Year: 1995
Journal: J Biol Chem
Title: Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose.
Volume: 270
Issue: 51
Pages: 30253-6
Publication
First Author: Postic C
Year: 1999
Journal: J Biol Chem
Title: Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.
Volume: 274
Issue: 1
Pages: 305-15
Publication
First Author: Babaya N
Year: 2010
Journal: Diabetologia
Title: Direct evidence for susceptibility genes for type 2 diabetes on mouse chromosomes 11 and 14.
Volume: 53
Issue: 7
Pages: 1362-71
Publication  
First Author: Chakera AJ
Year: 2018
Journal: Mol Metab
Title: Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes.
Volume: 17
Pages: 17-27
Publication
First Author: Porat S
Year: 2011
Journal: Cell Metab
Title: Control of pancreatic β cell regeneration by glucose metabolism.
Volume: 13
Issue: 4
Pages: 440-449
Publication
First Author: Zhang YL
Year: 2004
Journal: Acta Pharmacol Sin
Title: Establishment of liver specific glucokinase gene knockout mice: a new animal model for screening anti-diabetic drugs.
Volume: 25
Issue: 12
Pages: 1659-65
Publication
First Author: Juriloff DM
Year: 2000
Journal: Mamm Genome
Title: Gaping lids, gp, a mutation on centromeric chromosome 11 that causes defective eyelid development in mice.
Volume: 11
Issue: 6
Pages: 440-7
Publication
First Author: Grupe A
Year: 1995
Journal: Cell
Title: Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis.
Volume: 83
Issue: 1
Pages: 69-78
Publication
First Author: Yang XJ
Year: 2007
Journal: Endocrinology
Title: Glucokinase regulates reproductive function, glucocorticoid secretion, food intake, and hypothalamic gene expression.
Volume: 148
Issue: 4
Pages: 1928-32
Publication
First Author: Rossetti L
Year: 1997
Journal: Am J Physiol
Title: Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele.
Volume: 273
Issue: 4 Pt 1
Pages: E743-50
Publication
First Author: Pino MF
Year: 2007
Journal: J Biol Chem
Title: Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.
Volume: 282
Issue: 18
Pages: 13906-16
Publication
First Author: Toye AA
Year: 2004
Journal: Diabetes
Title: A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene.
Volume: 53
Issue: 6
Pages: 1577-83
Publication
First Author: van Bürck L
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2).
Volume: 298
Issue: 3
Pages: E512-23
Publication      
First Author: Chen Z
Year: 2015
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Grahamcracker
Publication
First Author: Shirakawa J
Year: 2011
Journal: J Biol Chem
Title: Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes.
Volume: 286
Issue: 29
Pages: 25467-76
Publication
First Author: Nakamura A
Year: 2009
Journal: Endocrinology
Title: Impact of small-molecule glucokinase activator on glucose metabolism and beta-cell mass.
Volume: 150
Issue: 3
Pages: 1147-54
Publication
First Author: Shirakawa J
Year: 2012
Journal: Endocrinology
Title: Effects of liraglutide on β-cell-specific glucokinase-deficient neonatal mice.
Volume: 153
Issue: 7
Pages: 3066-75
Publication
First Author: Aizawa T
Year: 1996
Journal: Biochem Biophys Res Commun
Title: Analysis of the pancreatic beta cell in the mouse with targeted disruption of the pancreatic beta cell-specific glucokinase gene.
Volume: 229
Issue: 2
Pages: 460-5
Publication
First Author: Shirakawa J
Year: 2011
Journal: Diabetes
Title: Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice.
Volume: 60
Issue: 4
Pages: 1246-57
Publication
First Author: Sakura H
Year: 1998
Journal: Diabetologia
Title: Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice.
Volume: 41
Issue: 6
Pages: 654-9
Publication
First Author: Piston DW
Year: 1999
Journal: J Biol Chem
Title: Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion.
Volume: 274
Issue: 2
Pages: 1000-4
Publication
First Author: Ciciotte SL
Year: 2014
Journal: Mamm Genome
Title: 3-Dimensional histological reconstruction and imaging of the murine pancreas.
Volume: 25
Issue: 9-10
Pages: 539-48
Publication
First Author: Ishihara H
Year: 1995
Journal: FEBS Lett
Title: Inhibition of pancreatic beta-cell glucokinase by antisense RNA expression in transgenic mice: mouse strain-dependent alteration of glucose tolerance.
Volume: 371
Issue: 3
Pages: 329-32
Publication
First Author: James PA
Year: 1985
Journal: Biochem Genet
Title: Comparison of glucokinase in C3H/He and C58 mice that differ in their hepatic activity.
Volume: 23
Issue: 7-8
Pages: 525-38
Publication
First Author: Coleman DL
Year: 1977
Journal: Biochem Genet
Title: Genetic control of glucokinase activity in mice.
Volume: 15
Issue: 3-4
Pages: 297-305
Publication
First Author: Efrat S
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion.
Volume: 91
Issue: 6
Pages: 2051-5
Publication
First Author: Shiota M
Year: 2001
Journal: Diabetes
Title: Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes.
Volume: 50
Issue: 3
Pages: 622-9
Publication
First Author: Lavender FL
Year: 1983
Journal: Diabetologia
Title: Hepatic glucokinase activity and circulating insulin concentrations in two inbred mouse strains.
Volume: 25
Issue: 2
Pages: 114-9
Publication
First Author: Moates JM
Year: 1997
Journal: Genomics
Title: Variable expression of hepatic glucokinase in mice is due to a regulational locus that cosegregates with the glucokinase gene.
Volume: 45
Issue: 1
Pages: 185-93
Publication
First Author: Muñoz S
Year: 2010
Journal: Diabetologia
Title: Chronically increased glucose uptake by adipose tissue leads to lactate production and improved insulin sensitivity rather than obesity in the mouse.
Volume: 53
Issue: 11
Pages: 2417-30
Publication  
First Author: Johansson BB
Year: 2017
Journal: Mol Cell Endocrinol
Title: Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation.
Volume: 454
Pages: 146-157
GXD Expression    
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1697428
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3599828
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Detected: false
Specimen Num: 14
GXD Expression    
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1720228
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Detected: true
Specimen Num: 17