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Search results 1 to 100 out of 648 for Gck

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Type Details Score
Gene
2645 | GCK
Type: gene
Organism: human
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Gene
606490 | GCK
Type: gene
Organism: dog, domestic
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Gene
616576 | GCK
Type: gene
Organism: cattle
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Gene
430370 | GCK
Type: gene
Organism: chicken
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Gene
751668 | gck
Type: gene
Organism: zebrafish
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Gene
699728 | GCK
Type: gene
Organism: macaque, rhesus
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Gene
100124905 | gck
Type: gene
Organism: frog, western clawed
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Gene
24385 | Gck
Type: gene
Organism: rat
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Gene
737923 | GCK
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:1270854 | Gck
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
 
Probe: MGI:3724958
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3565022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3826194
Age: embryonic day 14.5
Image: Additional file 4 Gck
Specimen Label: Additional file 4 Gck
Detected: true
Specimen Num: 1
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Publication
34325016 | J:321688
 
First Author: Rohrbach A
Year: 2021
Journal: Mol Metab
Title: Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice.
Volume: 53
Pages: 101311
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Publication
19011240 | -
First Author: Terziyska N
Year: 2009
Journal: J Biol Chem
Title: Structural and functional roles of the conserved cysteine residues of the redox-regulated import receptor Mia40 in the intermembrane space of mitochondria.
Volume: 284
Issue: 3
Pages: 1353-63
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Protein Domain
IPR012891 | GCK_dom
Type: Domain
Description: This domain is found in proteins carrying other domains known to be involved in intracellular signalling pathways indicating that it might also be involved in these pathways. It has 4 highly conserved cysteine residues, suggesting that it can bind zinc ions. Moreover, it is found repeated in some members of this entry (such as ), which may indicate that these domains are able to interact with one another, raising the possibility that it mediates heterodimerisation. Mitochondrial intermembrane space import and assembly protein 40 (MIA40) from the yeast Ashbya gossypii also belongs to this entry. Experimental data showed that its cysteine residues have an structural role while the disulfide bond formed by the third and sixth cysteine residues seem to support a conformation essencial for the function of this protein [].
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Publication
34622169 | J:313162
First Author: Kessler S
Year: 2021
Journal: iScience
Title: Glucokinase neurons of the paraventricular nucleus of the thalamus sense glucose and decrease food consumption.
Volume: 24
Issue: 10
Pages: 103122
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Publication
35303367 | J:328300
First Author: Gaspari S
Year: 2022
Journal: J Comp Neurol
Title: Structural and molecular characterization of paraventricular thalamic glucokinase-expressing neuronal circuits in the mouse.
Volume: 530
Issue: 11
Pages: 1773-1949
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Publication
33558985 | J:302600
     
First Author: Tornovsky-Babeay S
Year: 2021
Journal: Diabetologia
Title: Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes.
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Publication
- | J:264650
     
First Author: Turer E
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for tootsie.
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Publication
33610858 | J:302479
   
First Author: Bahl V
Year: 2021
Journal: Mol Metab
Title: Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states.
Pages: 101193
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Publication
22698525 | J:189544
First Author: van Buerck L
Year: 2012
Journal: Mol Cell Endocrinol
Title: Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich Gck(D217V) mutants.
Volume: 362
Issue: 1-2
Pages: 139-48
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Publication
29416045 | J:257792
First Author: Basco D
Year: 2018
Journal: Nat Commun
Title: α-cell glucokinase suppresses glucose-regulated glucagon secretion.
Volume: 9
Issue: 1
Pages: 546
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Publication
29166588 | J:260564
First Author: Kishore M
Year: 2017
Journal: Immunity
Title: Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.
Volume: 47
Issue: 5
Pages: 875-889.e10
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Publication
21921030 | J:196563
First Author: Fenner D
Year: 2011
Journal: J Biol Chem
Title: Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.
Volume: 286
Issue: 45
Pages: 39560-72
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Publication
27422385 | J:247100
First Author: Steinbusch LK
Year: 2016
Journal: Diabetes
Title: Sex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase.
Volume: 65
Issue: 10
Pages: 2920-31
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Publication
23519111 | J:251749
First Author: Xu W
Year: 2013
Journal: Int J Mol Sci
Title: Differential expression of genes associated with the progression of renal disease in the kidneys of liver-specific glucokinase gene knockout mice.
Volume: 14
Issue: 3
Pages: 6467-86
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Publication
23085254 | J:219178
First Author: Guo T
Year: 2012
Journal: Biomed Pharmacother
Title: Characterization of the gene expression profile of heterozygous liver-specific glucokinase knockout mice at a young age.
Volume: 66
Issue: 8
Pages: 587-96
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Publication
24447392 | J:250069
 
First Author: Li H
Year: 2014
Journal: Cardiovasc Diabetol
Title: Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK.
Volume: 13
Pages: 24
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Publication
23291412 | J:194286
First Author: Wang R
Year: 2013
Journal: Gene
Title: Differential expression of genes and changes in glucose metabolism in the liver of liver-specific glucokinase gene knockout mice.
Volume: 516
Issue: 2
Pages: 248-54
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Publication
30038292 | J:268114
First Author: Pérez-García A
Year: 2018
Journal: Sci Rep
Title: PAS Kinase deficiency alters the glucokinase function and hepatic metabolism.
Volume: 8
Issue: 1
Pages: 11091
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Publication
10615953 | J:107128
First Author: Terauchi Y
Year: 2000
Journal: Diabetes
Title: Insulin effect during embryogenesis determines fetal growth: a possible molecular link between birth weight and susceptibility to type 2 diabetes.
Volume: 49
Issue: 1
Pages: 82-6
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Publication
27520373 | J:238957
First Author: Baldini SF
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Glucokinase expression is regulated by glucose through O-GlcNAc glycosylation.
Volume: 478
Issue: 2
Pages: 942-8
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Publication
15102714 | J:88919
First Author: Inoue M
Year: 2004
Journal: Hum Mol Genet
Title: A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program.
Volume: 13
Issue: 11
Pages: 1147-57
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Publication
26752353 | J:325920
First Author: Lu G
Year: 2016
Journal: Gene Ther
Title: Overexpression of a glucokinase point mutant in the treatment of diabetes mellitus.
Volume: 23
Issue: 4
Pages: 323-9
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Publication
17200721 | J:117446
First Author: Terauchi Y
Year: 2007
Journal: J Clin Invest
Title: Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.
Volume: 117
Issue: 1
Pages: 246-57
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Publication
20413507 | J:169647
First Author: Ait-Lounis A
Year: 2010
Journal: Diabetes
Title: The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression.
Volume: 59
Issue: 7
Pages: 1674-85
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Publication
18056790 | J:137483
First Author: Aigner B
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Title: Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects.
Volume: 294
Issue: 2
Pages: E232-40
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Protein
Q8K4S8
Organism: Mus musculus/domesticus
Length: 19  
Fragment?: true
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Protein Coding Gene
MGP_CAROLIEiJ_G0016063 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018012 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017985 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017949 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017953 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017766 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1270854 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018405 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017328 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017741 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017851 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017843 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017922 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017869 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018445 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0017108 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0017382 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016828 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016905 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8575769 | J:29368
First Author: Ishimura-Oka K
Year: 1995
Journal: Genomics
Title: Partial structure of the mouse glucokinase gene.
Volume: 29
Issue: 3
Pages: 751-4
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Publication
8575768 | J:29367
First Author: Postic C
Year: 1995
Journal: Genomics
Title: Cloning and characterization of the mouse glucokinase gene locus and identification of distal liver-specific DNase I hypersensitive sites.
Volume: 29
Issue: 3
Pages: 740-50
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Publication
1999433 | J:75735
First Author: Hughes SD
Year: 1991
Journal: J Biol Chem
Title: Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells.
Volume: 266
Issue: 7
Pages: 4521-30
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Publication
8530440 | J:30334
First Author: Terauchi Y
Year: 1995
Journal: J Biol Chem
Title: Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose.
Volume: 270
Issue: 51
Pages: 30253-6
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Publication
9867845 | J:51826
First Author: Postic C
Year: 1999
Journal: J Biol Chem
Title: Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.
Volume: 274
Issue: 1
Pages: 305-15
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Publication
20390404 | J:162171
First Author: Babaya N
Year: 2010
Journal: Diabetologia
Title: Direct evidence for susceptibility genes for type 2 diabetes on mouse chromosomes 11 and 14.
Volume: 53
Issue: 7
Pages: 1362-71
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Publication
30146176 | J:281200
 
First Author: Chakera AJ
Year: 2018
Journal: Mol Metab
Title: Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes.
Volume: 17
Pages: 17-27
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Publication
21459328 | J:172243
First Author: Porat S
Year: 2011
Journal: Cell Metab
Title: Control of pancreatic β cell regeneration by glucose metabolism.
Volume: 13
Issue: 4
Pages: 440-449
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Publication
17353190 | J:121910
First Author: Pino MF
Year: 2007
Journal: J Biol Chem
Title: Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.
Volume: 282
Issue: 18
Pages: 13906-16
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Publication
- | J:221479
     
First Author: Chen Z
Year: 2015
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Grahamcracker
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Publication
19952346 | J:162903
First Author: van Bürck L
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2).
Volume: 298
Issue: 3
Pages: E512-23
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Publication
15161764 | J:90389
First Author: Toye AA
Year: 2004
Journal: Diabetes
Title: A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene.
Volume: 53
Issue: 6
Pages: 1577-83
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Publication
7553875 | J:29255
First Author: Grupe A
Year: 1995
Journal: Cell
Title: Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis.
Volume: 83
Issue: 1
Pages: 69-78
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Publication
24838824 | J:214141
First Author: Ciciotte SL
Year: 2014
Journal: Mamm Genome
Title: 3-Dimensional histological reconstruction and imaging of the murine pancreas.
Volume: 25
Issue: 9-10
Pages: 539-48
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Publication
21613229 | J:175391
First Author: Shirakawa J
Year: 2011
Journal: J Biol Chem
Title: Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes.
Volume: 286
Issue: 29
Pages: 25467-76
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Publication
9662046 | J:48148
First Author: Sakura H
Year: 1998
Journal: Diabetologia
Title: Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice.
Volume: 41
Issue: 6
Pages: 654-9
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Publication
8954920 | J:38011
First Author: Aizawa T
Year: 1996
Journal: Biochem Biophys Res Commun
Title: Analysis of the pancreatic beta cell in the mouse with targeted disruption of the pancreatic beta cell-specific glucokinase gene.
Volume: 229
Issue: 2
Pages: 460-5
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Publication
19008318 | J:158088
First Author: Nakamura A
Year: 2009
Journal: Endocrinology
Title: Impact of small-molecule glucokinase activator on glucose metabolism and beta-cell mass.
Volume: 150
Issue: 3
Pages: 1147-54
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Publication
21330637 | J:171760
First Author: Shirakawa J
Year: 2011
Journal: Diabetes
Title: Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice.
Volume: 60
Issue: 4
Pages: 1246-57
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Publication
22569791 | J:189047
First Author: Shirakawa J
Year: 2012
Journal: Endocrinology
Title: Effects of liraglutide on β-cell-specific glucokinase-deficient neonatal mice.
Volume: 153
Issue: 7
Pages: 3066-75
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Publication
18034843 | J:291379
First Author: Gorman T
Year: 2008
Journal: Diabetes Obes Metab
Title: Effect of high-fat diet on glucose homeostasis and gene expression in glucokinase knockout mice.
Volume: 10
Issue: 10
Pages: 885-97
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Publication
17218412 | J:119521
First Author: Yang XJ
Year: 2007
Journal: Endocrinology
Title: Glucokinase regulates reproductive function, glucocorticoid secretion, food intake, and hypothalamic gene expression.
Volume: 148
Issue: 4
Pages: 1928-32
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Publication
9357804 | J:43906
First Author: Rossetti L
Year: 1997
Journal: Am J Physiol
Title: Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele.
Volume: 273
Issue: 4 Pt 1
Pages: E743-50
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Publication
15569412 | J:105247
First Author: Zhang YL
Year: 2004
Journal: Acta Pharmacol Sin
Title: Establishment of liver specific glucokinase gene knockout mice: a new animal model for screening anti-diabetic drugs.
Volume: 25
Issue: 12
Pages: 1659-65
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Publication
35046471 | J:321290
First Author: Rajab BS
Year: 2022
Journal: Sci Rep
Title: Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes.
Volume: 12
Issue: 1
Pages: 978
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Publication
9873043 | J:115233
First Author: Piston DW
Year: 1999
Journal: J Biol Chem
Title: Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion.
Volume: 274
Issue: 2
Pages: 1000-4
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Publication
10818208 | J:62514
First Author: Juriloff DM
Year: 2000
Journal: Mamm Genome
Title: Gaping lids, gp, a mutation on centromeric chromosome 11 that causes defective eyelid development in mice.
Volume: 11
Issue: 6
Pages: 440-7
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Publication
141272 | J:5824
First Author: Coleman DL
Year: 1977
Journal: Biochem Genet
Title: Genetic control of glucokinase activity in mice.
Volume: 15
Issue: 3-4
Pages: 297-305
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Publication
7556622 | J:29415
First Author: Ishihara H
Year: 1995
Journal: FEBS Lett
Title: Inhibition of pancreatic beta-cell glucokinase by antisense RNA expression in transgenic mice: mouse strain-dependent alteration of glucose tolerance.
Volume: 371
Issue: 3
Pages: 329-32
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Publication
3931624 | J:8051
First Author: James PA
Year: 1985
Journal: Biochem Genet
Title: Comparison of glucokinase in C3H/He and C58 mice that differ in their hepatic activity.
Volume: 23
Issue: 7-8
Pages: 525-38
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Publication
7510884 | J:109919
First Author: Efrat S
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion.
Volume: 91
Issue: 6
Pages: 2051-5
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Publication
11246883 | J:67749
First Author: Shiota M
Year: 2001
Journal: Diabetes
Title: Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes.
Volume: 50
Issue: 3
Pages: 622-9
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Publication
6354813 | J:7215
First Author: Lavender FL
Year: 1983
Journal: Diabetologia
Title: Hepatic glucokinase activity and circulating insulin concentrations in two inbred mouse strains.
Volume: 25
Issue: 2
Pages: 114-9
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Publication
9339375 | J:43494
First Author: Moates JM
Year: 1997
Journal: Genomics
Title: Variable expression of hepatic glucokinase in mice is due to a regulational locus that cosegregates with the glucokinase gene.
Volume: 45
Issue: 1
Pages: 185-93
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Publication
20623219 | J:162774
First Author: Muñoz S
Year: 2010
Journal: Diabetologia
Title: Chronically increased glucose uptake by adipose tissue leads to lactate production and improved insulin sensitivity rather than obesity in the mouse.
Volume: 53
Issue: 11
Pages: 2417-30
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Publication
28648619 | J:255281
 
First Author: Johansson BB
Year: 2017
Journal: Mol Cell Endocrinol
Title: Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation.
Volume: 454
Pages: 146-157
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GXD Expression
GXD Expression
   
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Specimen Label: None
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Specimen Label: None
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Specimen Label: None
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1697428
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Specimen Label: None
Detected: true
Specimen Num: 4
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•
•
GXD Expression
GXD Expression
   
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Specimen Label: None
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Specimen Label: None
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Specimen Label: None
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1205740
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:1205742
Age: postnatal week 6-8
Image: st97_657
Specimen Label: None
Detected: true
Specimen Num: 8
•
•
•
•
•




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