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Search results 1 to 100 out of 593 for Gclc

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0.079s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Publication
First Author: Feng W
Year: 2017
Journal: Hum Mol Genet
Title: Gclc deficiency in mouse CNS causes mitochondrial damage and neurodegeneration.
Volume: 26
Issue: 7
Pages: 1376-1390
Publication
First Author: Chen Y
Year: 2007
Journal: Hepatology
Title: Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure.
Volume: 45
Issue: 5
Pages: 1118-28
GXD Expression    
Probe: MGI:4416596
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3271122
Stage: TS22
Assay Id: MGI:4354889
Age: embryonic day 14.5
Note: There is no expression in either the upper or lower cortical plate.
Specimen Label: Table S5 - Gclc
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4416596
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354889
Age: embryonic day 14.5
Specimen Label: Table S5 - Gclc
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4416596
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3270422
Stage: TS22
Assay Id: MGI:4354889
Age: embryonic day 14.5
Specimen Label: Table S5 - Gclc
Detected: false
Specimen Num: 1
Publication
First Author: Mak TW
Year: 2017
Journal: Immunity
Title: Glutathione Primes T Cell Metabolism for Inflammation.
Volume: 46
Issue: 4
Pages: 675-689
Publication
First Author: Fan X
Year: 2012
Journal: PLoS One
Title: The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesis.
Volume: 7
Issue: 11
Pages: e50832
Publication
First Author: Krejsa CM
Year: 2010
Journal: J Biol Chem
Title: Rapid activation of glutamate cysteine ligase following oxidative stress.
Volume: 285
Issue: 21
Pages: 16116-24
Publication
First Author: Dalton TP
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous.
Volume: 279
Issue: 2
Pages: 324-9
Publication
First Author: Kurniawan H
Year: 2020
Journal: Cell Metab
Title: Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function.
Volume: 31
Issue: 5
Pages: 920-936.e7
Publication
First Author: Franchina DG
Year: 2022
Journal: Nat Commun
Title: Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cells.
Volume: 13
Issue: 1
Pages: 1789
Publication
First Author: Botta D
Year: 2004
Journal: Free Radic Biol Med
Title: Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis.
Volume: 37
Issue: 5
Pages: 632-42
Publication
First Author: Yang Y
Year: 2002
Journal: J Biol Chem
Title: Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response.
Volume: 277
Issue: 51
Pages: 49446-52
Publication
First Author: Chen Y
Year: 2005
Journal: J Biol Chem
Title: Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels.
Volume: 280
Issue: 40
Pages: 33766-74
Publication
First Author: Díaz D
Year: 2002
Journal: Mol Reprod Dev
Title: Expression of glutamate-cysteine ligase during mouse development.
Volume: 62
Issue: 1
Pages: 83-91
Publication
First Author: Díaz D
Year: 2004
Journal: Reprod Toxicol
Title: Effect of methylmercury on glutamate-cysteine ligase expression in the placenta and yolk sac during mouse development.
Volume: 19
Issue: 1
Pages: 117-29
Publication  
First Author: Sánchez-Vallejo V
Year: 2016
Journal: Free Radic Biol Med
Title: Alterations in glutamate cysteine ligase content in the retina of two retinitis pigmentosa animal models.
Volume: 96
Pages: 245-54
Publication
First Author: Hashimoto S
Year: 2023
Journal: Sci Rep
Title: Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation.
Volume: 13
Issue: 1
Pages: 1109
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Kang Y
Year: 1997
Journal: Neuroreport
Title: Cloning/brain localization of mouse glutamylcysteine synthetase heavy chain mRNA.
Volume: 8
Issue: 8
Pages: 2053-60
Publication
First Author: Reid LL
Year: 1997
Journal: Biochim Biophys Acta
Title: Molecular cloning and sequencing of the cDNA encoding the catalytic subunit of mouse glutamate-cysteine ligase.
Volume: 1352
Issue: 3
Pages: 233-7
Publication  
First Author: Whitson JA
Year: 2017
Journal: Free Radic Biol Med
Title: Proteomic analysis of the glutathione-deficient LEGSKO mouse lens reveals activation of EMT signaling, loss of lens specific markers, and changes in stress response proteins.
Volume: 113
Pages: 84-96
Publication
First Author: Whitson JA
Year: 2017
Journal: Invest Ophthalmol Vis Sci
Title: Transcriptome of the GSH-Depleted Lens Reveals Changes in Detoxification and EMT Signaling Genes, Transport Systems, and Lipid Homeostasis.
Volume: 58
Issue: 5
Pages: 2666-2684
Publication
First Author: Wang B
Year: 2017
Journal: Aging Cell
Title: The oxidized thiol proteome in aging and cataractous mouse and human lens revealed by ICAT labeling.
Volume: 16
Issue: 2
Pages: 244-261
Publication
First Author: Wei Z
Year: 2017
Journal: Am J Pathol
Title: Reduced Glutathione Level Promotes Epithelial-Mesenchymal Transition in Lens Epithelial Cells via a Wnt/β-Catenin-Mediated Pathway: Relevance for Cataract Therapy.
Volume: 187
Issue: 11
Pages: 2399-2412
Publication
First Author: Whitson JA
Year: 2016
Journal: Invest Ophthalmol Vis Sci
Title: Evidence of Dual Mechanisms of Glutathione Uptake in the Rodent Lens: A Novel Role for Vitreous Humor in Lens Glutathione Homeostasis.
Volume: 57
Issue: 8
Pages: 3914-25
Publication
First Author: Botta D
Year: 2006
Journal: J Biol Chem
Title: Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice.
Volume: 281
Issue: 39
Pages: 28865-75
Publication
First Author: Stover SK
Year: 2000
Journal: Toxicol Appl Pharmacol
Title: Regulation of gamma-glutamate-cysteine ligase expression by oxidative stress in the mouse preimplantation embryo.
Volume: 168
Issue: 2
Pages: 153-9
Publication
First Author: Chinta SJ
Year: 2007
Journal: J Neurosci
Title: Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration.
Volume: 27
Issue: 51
Pages: 13997-4006
GXD Expression      
Probe: MGI:1331992
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1331993
Age: embryonic day 7.5
Specimen Label: 1x
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:1331992
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1331993
Age: embryonic day 7.5
Specimen Label: 10x
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:1331992
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1331993
Age: embryonic day 7.5
Specimen Label: 100x
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:1331992
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1331993
Age: embryonic day 7.5
Specimen Label: 1x
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1331992
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1331993
Age: embryonic day 7.5
Specimen Label: 10x
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:1331992
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1331993
Age: embryonic day 7.5
Specimen Label: 100x
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:1346170
Assay Type: RT-PCR
Annotation Date: 1999-11-01
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:1346547
Age: postnatal adult
Specimen Label: 1
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1346170
Assay Type: RT-PCR
Annotation Date: 1999-11-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1346547
Age: postnatal adult
Specimen Label: 2
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:1346170
Assay Type: RT-PCR
Annotation Date: 1999-11-01
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:1346552
Age: postnatal adult
Specimen Label: 1
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1346170
Assay Type: RT-PCR
Annotation Date: 1999-11-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1346552
Age: postnatal adult
Specimen Label: 2
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:1346170
Assay Type: RT-PCR
Annotation Date: 1999-11-01
Strength: Present
Sex: Female
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:1346557
Age: embryonic day 3.5
Specimen Label: 1
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1346170
Assay Type: RT-PCR
Annotation Date: 1999-11-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1346557
Age: postnatal adult
Specimen Label: 2
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:1346170
Assay Type: RT-PCR
Annotation Date: 1999-11-01
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:1346568
Age: postnatal adult
Specimen Label: 4
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2656933
Assay Type: RT-PCR
Annotation Date: 2003-05-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:2656958
Age: embryonic day 13.5
Specimen Label: 25 ng
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2656933
Assay Type: RT-PCR
Annotation Date: 2003-05-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:2656958
Age: embryonic day 13.5
Specimen Label: 25 ng +/-
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2656933
Assay Type: RT-PCR
Annotation Date: 2003-05-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:2656958
Age: embryonic day 13.5
Specimen Label: 25 ng -/-
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:2656933
Assay Type: RT-PCR
Annotation Date: 2003-05-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:2656958
Age: embryonic day 13.5
Specimen Label: 100 ng +/+
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:2656933
Assay Type: RT-PCR
Annotation Date: 2003-05-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:2656958
Age: embryonic day 13.5
Specimen Label: 100 ng +/-
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:2656933
Assay Type: RT-PCR
Annotation Date: 2003-05-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:2656958
Age: embryonic day 13.5
Specimen Label: 100 ng -/-
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:2656936
Assay Type: Northern blot
Annotation Date: 2003-05-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:2656960
Age: embryonic day 13.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2656936
Assay Type: Northern blot
Annotation Date: 2003-05-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:2656960
Age: embryonic day 13.5
Specimen Label: +/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2656936
Assay Type: Northern blot
Annotation Date: 2003-05-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:2656960
Age: embryonic day 13.5
Specimen Label: -/-
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:1097643
Assay Type: Northern blot
Annotation Date: 2004-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3050384
Age: embryonic day 12.5
Specimen Label: GD12 0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:1097643
Assay Type: Northern blot
Annotation Date: 2004-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:3050384
Age: embryonic day 16.5
Specimen Label: GD16 0
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1097643
Assay Type: Northern blot
Annotation Date: 2004-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608520
Stage: TS20
Assay Id: MGI:3050384
Age: embryonic day 12.5
Specimen Label: GD12 0
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:1097643
Assay Type: Northern blot
Annotation Date: 2004-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608524
Stage: TS24
Assay Id: MGI:3050384
Age: embryonic day 16.5
Specimen Label: GD16 0
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3050373
Assay Type: Western blot
Annotation Date: 2004-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608524
Stage: TS24
Assay Id: MGI:3050387
Age: embryonic day 16.5
Specimen Label: 0 ppm
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3050373
Assay Type: Western blot
Annotation Date: 2004-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:3050387
Age: embryonic day 16.5
Specimen Label: 0 ppm
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6200406
Assay Type: RT-PCR
Annotation Date: 2018-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752524
Stage: TS24
Assay Id: MGI:6200428
Age: embryonic day 16.5
Specimen Label: wt
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6200406
Assay Type: RT-PCR
Annotation Date: 2018-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752524
Stage: TS24
Assay Id: MGI:6200428
Age: embryonic day 16.5
Specimen Label: LKO
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3050359
Assay Type: RT-PCR
Annotation Date: 2004-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3050364
Age: embryonic day 1.5
Specimen Label: d1
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3050359
Assay Type: RT-PCR
Annotation Date: 2004-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360633
Stage: TS03
Assay Id: MGI:3050364
Age: embryonic day 2.5
Specimen Label: d2
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3050359
Assay Type: RT-PCR
Annotation Date: 2004-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:3050364
Age: embryonic day 2.5
Specimen Label: d2
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3050359
Assay Type: RT-PCR
Annotation Date: 2004-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:364734
Stage: TS04
Assay Id: MGI:3050364
Age: embryonic day 3.5
Specimen Label: d3
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3050361
Assay Type: Western blot
Annotation Date: 2004-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3050365
Age: embryonic day 1.5
Specimen Label: d1
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3050361
Assay Type: Western blot
Annotation Date: 2004-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:364734
Stage: TS04
Assay Id: MGI:3050365
Age: embryonic day 3.5
Specimen Label: d3
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7491572
Assay Type: RT-PCR
Annotation Date: 2023-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759723
Stage: TS23
Assay Id: MGI:7491590
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7491572
Assay Type: RT-PCR
Annotation Date: 2023-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759726
Stage: TS26
Assay Id: MGI:7491590
Age: embryonic day 18.5
Specimen Label: E18.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7491572
Assay Type: RT-PCR
Annotation Date: 2023-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:7491590
Age: postnatal day 5
Specimen Label: P5d
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7491572
Assay Type: RT-PCR
Annotation Date: 2023-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:7491590
Age: postnatal day 15
Specimen Label: P15d
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7491572
Assay Type: RT-PCR
Annotation Date: 2023-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:7491590
Age: postnatal month 1-2
Specimen Label: P1-2M
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:7491572
Assay Type: RT-PCR
Annotation Date: 2023-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:7491590
Age: postnatal month 5
Specimen Label: P5m
Detected: true
Specimen Num: 6