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Search results 1 to 100 out of 379 for Gclm

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Hits by Category

Type Details Score
Gene
2730 | GCLM
Type: gene
Organism: human
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Gene
525659 | GCLM
Type: gene
Organism: cattle
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Gene
424492 | GCLM
Type: gene
Organism: chicken
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Gene
333974 | gclm
Type: gene
Organism: zebrafish
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Gene
713888 | GCLM
Type: gene
Organism: macaque, rhesus
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Gene
549290 | gclm
Type: gene
Organism: frog, western clawed
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Gene
29739 | Gclm
Type: gene
Organism: rat
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Gene
612283 | GCLM
Type: gene
Organism: dog, domestic
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Gene
457034 | GCLM
Type: gene
Organism: chimpanzee
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Protein Domain
IPR032963 | Gclm
Type: Family
Description: Glutamate--cysteine ligase or gamma-glutamylcysteine synthetase (gamma-GCS) catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine to form L-gamma-glutamyl-L-cysteine, the first and rate-limiting step in glutathione (GSH) biosynthesis []. The enzyme is a heterodimer composed of a catalytic subunit and a regulatory subunit. The catalytic subunit exhibits all of the catalytic activity, but its association with the regulator subunit alters its kinetic properties to enhance activity []. In addition to some conditions which specifically upregulate the catalytic subunit gene, expression of both genes is increased in response to oxidants, heavy metals, phenolic antioxidants, GSH-conjugating agents []and lack of amino acids [].
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Protein Coding Gene
MGI:104995 | Gclm
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23724032 | J:200712
First Author: McConnachie LA
Year: 2013
Journal: PLoS One
Title: The glutathione synthesis gene Gclm modulates amphiphilic polymer-coated CdSe/ZnS quantum dot-induced lung inflammation in mice.
Volume: 8
Issue: 5
Pages: e64165
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Publication
34953454 | J:321660
 
First Author: Schaupp CM
Year: 2022
Journal: Redox Biol
Title: Persistence of improved glucose homeostasis in Gclm null mice with age and cadmium treatment.
Volume: 49
Pages: 102213
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Publication
22824862 | J:189597
First Author: Weldy CS
Year: 2012
Journal: Free Radic Biol Med
Title: Glutathione (GSH) and the GSH synthesis gene Gclm modulate vascular reactivity in mice.
Volume: 53
Issue: 6
Pages: 1264-78
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Publication
23704229 | J:207589
First Author: Liang LP
Year: 2013
Journal: Toxicol Sci
Title: Glutathione deficiency in Gclm null mice results in complex I inhibition and dopamine depletion following paraquat administration.
Volume: 134
Issue: 2
Pages: 366-73
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Protein
O09172
Organism: Mus musculus/domesticus
Length: 274  
Fragment?: false
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Protein
F6VNW5
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: true
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Protein
Q4FJZ6
Organism: Mus musculus/domesticus
Length: 274  
Fragment?: false
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Protein
Q3T9P2
Organism: Mus musculus/domesticus
Length: 274  
Fragment?: false
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Protein
A0A0G2JDI4
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
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Protein
H3BJA3
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: true
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Publication
9675072 | -
First Author: Misra I
Year: 1998
Journal: Protein Expr Purif
Title: Expression and purification of human gamma-glutamylcysteine synthetase.
Volume: 13
Issue: 2
Pages: 268-76
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Publication
10741850 | -
First Author: Wild AC
Year: 2000
Journal: Free Radic Res
Title: Regulation of gamma-glutamylcysteine synthetase subunit gene expression: insights into transcriptional control of antioxidant defenses.
Volume: 32
Issue: 4
Pages: 281-301
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Publication
8104188 | -
First Author: Huang CS
Year: 1993
Journal: J Biol Chem
Title: Amino acid sequence and function of the light subunit of rat kidney gamma-glutamylcysteine synthetase.
Volume: 268
Issue: 27
Pages: 20578-83
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Publication
24557597 | -
First Author: Sikalidis AK
Year: 2014
Journal: Amino Acids
Title: Upregulation of capacity for glutathione synthesis in response to amino acid deprivation: regulation of glutamate-cysteine ligase subunits.
Volume: 46
Issue: 5
Pages: 1285-96
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Publication
23135907 | J:194115
First Author: Lim J
Year: 2013
Journal: Cancer Res
Title: Glutathione-deficient mice have increased sensitivity to transplacental benzo[a]pyrene-induced premature ovarian failure and ovarian tumorigenesis.
Volume: 73
Issue: 2
Pages: 908-17
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Publication
22033334 | J:180686
First Author: Kulak A
Year: 2012
Journal: Behav Brain Res
Title: Behavioral phenotyping of glutathione-deficient mice: relevance to schizophrenia and bipolar disorder.
Volume: 226
Issue: 2
Pages: 563-70
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Publication
23129588 | J:210286
First Author: Watanabe Y
Year: 2013
Journal: Cardiovasc Res
Title: Chronic depletion of glutathione exacerbates ventricular remodelling and dysfunction in the pressure-overloaded heart.
Volume: 97
Issue: 2
Pages: 282-92
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Publication
17804861 | J:129045
First Author: Giordano G
Year: 2007
Journal: Toxicol Sci
Title: Glutathione levels modulate domoic acid induced apoptosis in mouse cerebellar granule cells.
Volume: 100
Issue: 2
Pages: 433-44
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Publication
22253057 | J:183704
First Author: Nakamura BN
Year: 2012
Journal: Toxicol Sci
Title: Increased sensitivity to testicular toxicity of transplacental benzo[a]pyrene exposure in male glutamate cysteine ligase modifier subunit knockout (Gclm-/-) mice.
Volume: 126
Issue: 1
Pages: 227-41
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Publication
17584759 | J:125009
First Author: McConnachie LA
Year: 2007
Journal: Toxicol Sci
Title: Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice.
Volume: 99
Issue: 2
Pages: 628-36
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Publication
23315585 | J:206905
First Author: Giordano G
Year: 2013
Journal: Toxicol Sci
Title: Low-level domoic acid protects mouse cerebellar granule neurons from acute neurotoxicity: role of glutathione.
Volume: 132
Issue: 2
Pages: 399-408
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Publication
21829542 | J:176255
First Author: Lavoie S
Year: 2011
Journal: PLoS One
Title: Altered glycogen metabolism in cultured astrocytes from mice with chronic glutathione deficit; relevance for neuroenergetics in schizophrenia.
Volume: 6
Issue: 7
Pages: e22875
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Publication
19427898 | J:151175
First Author: Chen Y
Year: 2009
Journal: Free Radic Biol Med
Title: Early onset senescence occurs when fibroblasts lack the glutamate-cysteine ligase modifier subunit.
Volume: 47
Issue: 4
Pages: 410-8
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Publication
19837697 | J:172549
First Author: Kobayashi T
Year: 2010
Journal: Cardiovasc Res
Title: Mice lacking the glutamate-cysteine ligase modifier subunit are susceptible to myocardial ischaemia-reperfusion injury.
Volume: 85
Issue: 4
Pages: 785-95
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Publication
21967773 | J:178537
First Author: Kendig EL
Year: 2011
Journal: Toxicol Appl Pharmacol
Title: Lipid metabolism and body composition in Gclm(-/-) mice.
Volume: 257
Issue: 3
Pages: 338-48
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Publication
20548286 | J:166276
First Author: Haque JA
Year: 2010
Journal: Lab Invest
Title: Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice.
Volume: 90
Issue: 12
Pages: 1704-17
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Publication
19200344 | J:149266
First Author: Giordano G
Year: 2009
Journal: J Neurochem
Title: Muscarinic receptors prevent oxidative stress-mediated apoptosis induced by domoic acid in mouse cerebellar granule cells.
Volume: 109
Issue: 2
Pages: 525-38
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Publication
23787995 | J:228617
First Author: Föller M
Year: 2013
Journal: Cell Death Differ
Title: Functional significance of glutamate-cysteine ligase modifier for erythrocyte survival in vitro and in vivo.
Volume: 20
Issue: 10
Pages: 1350-8
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Publication
21558310 | J:174892
First Author: Nakamura BN
Year: 2011
Journal: Endocrinology
Title: Lack of maternal glutamate cysteine ligase modifier subunit (Gclm) decreases oocyte glutathione concentrations and disrupts preimplantation development in mice.
Volume: 152
Issue: 7
Pages: 2806-15
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Publication
23685287 | J:205173
 
First Author: Bir SC
Year: 2013
Journal: Free Radic Biol Med
Title: Control of angiogenesis dictated by picomolar superoxide levels.
Volume: 63
Pages: 135-42
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Publication
17000861 | J:129361
First Author: Giordano G
Year: 2006
Journal: Mol Pharmacol
Title: Neurotoxicity of domoic Acid in cerebellar granule neurons in a genetic model of glutathione deficiency.
Volume: 70
Issue: 6
Pages: 2116-26
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Publication
24563856 | J:295002
 
First Author: Mohar I
Year: 2014
Journal: Redox Biol
Title: Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6.
Volume: 2
Pages: 377-87
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Publication
21868708 | J:191462
First Author: Callegari A
Year: 2011
Journal: Arterioscler Thromb Vasc Biol
Title: Gain and loss of function for glutathione synthesis: impact on advanced atherosclerosis in apolipoprotein E-deficient mice.
Volume: 31
Issue: 11
Pages: 2473-82
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Publication
12384496 | J:80927
First Author: Yang Y
Year: 2002
Journal: J Biol Chem
Title: Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response.
Volume: 277
Issue: 51
Pages: 49446-52
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Publication
16081425 | J:102460
First Author: Chen Y
Year: 2005
Journal: J Biol Chem
Title: Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels.
Volume: 280
Issue: 40
Pages: 33766-74
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Publication
11933164 | J:75783
First Author: Díaz D
Year: 2002
Journal: Mol Reprod Dev
Title: Expression of glutamate-cysteine ligase during mouse development.
Volume: 62
Issue: 1
Pages: 83-91
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Publication
25620030 | J:219963
First Author: Harris IS
Year: 2015
Journal: Cancer Cell
Title: Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.
Volume: 27
Issue: 2
Pages: 211-22
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Publication
22855800 | J:186628
First Author: LaPash Daniels CM
Year: 2012
Journal: J Neurosci
Title: Beneficial effects of Nrf2 overexpression in a mouse model of Alexander disease.
Volume: 32
Issue: 31
Pages: 10507-15
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Protein Coding Gene
MGP_CAROLIEiJ_G0025592 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027837 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027795 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027761 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027807 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0027538 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_104995 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028253 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026994 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0027513 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027654 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027622 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027764 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027652 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028309 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026720 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0027074 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027038 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026543 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9294003 | J:42362
First Author: Reid LL
Year: 1997
Journal: Biochim Biophys Acta
Title: Molecular cloning and sequencing of the cDNA encoding mouse glutamate-cysteine ligase regulatory subunit.
Volume: 1353
Issue: 2
Pages: 107-10
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Publication
18262489 | J:135305
First Author: Castro C
Year: 2008
Journal: Arch Biochem Biophys
Title: Liver betaine-homocysteine S-methyltransferase activity undergoes a redox switch at the active site zinc.
Volume: 472
Issue: 1
Pages: 26-33
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Publication
37248279 | J:341012
First Author: Lim J
Year: 2023
Journal: Sci Rep
Title: Prenatal exposure to benzo[a]pyrene depletes ovarian reserve and masculinizes embryonic ovarian germ cell transcriptome transgenerationally.
Volume: 13
Issue: 1
Pages: 8671
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Publication
26083875 | J:226942
First Author: Lim J
Year: 2015
Journal: Endocrinology
Title: Glutamate Cysteine Ligase Modifier Subunit (Gclm) Null Mice Have Increased Ovarian Oxidative Stress and Accelerated Age-Related Ovarian Failure.
Volume: 156
Issue: 9
Pages: 3329-43
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Publication
35238901 | J:340710
First Author: Malott KF
Year: 2022
Journal: Biol Reprod
Title: Glutathione deficiency decreases lipid droplet stores and increases reactive oxygen species in mouse oocytes†.
Volume: 106
Issue: 6
Pages: 1218-1231
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Publication
31950131 | J:295353
First Author: Lim J
Year: 2020
Journal: Biol Reprod
Title: Antioxidant supplementation partially rescues accelerated ovarian follicle loss, but not oocyte quality, of glutathione-deficient mice†.
Volume: 102
Issue: 5
Pages: 1065-1079
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Publication
24107266 | J:325914
First Author: Ortiz L
Year: 2013
Journal: Toxicol Lett
Title: In utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protective.
Volume: 223
Issue: 2
Pages: 260-7
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Publication
37543592 | J:339716
First Author: Skupienski R
Year: 2023
Journal: Transl Psychiatry
Title: Developmental changes in cerebral NAD and neuroenergetics of an antioxidant compromised mouse model of schizophrenia.
Volume: 13
Issue: 1
Pages: 275
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Publication
20417186 | J:162518
First Author: Johansson E
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Glutathione deficient C57BL/6J mice are not sensitized to ozone-induced lung injury.
Volume: 396
Issue: 2
Pages: 407-12
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Publication
29307609 | J:262110
 
First Author: Killoy KM
Year: 2018
Journal: Exp Neurol
Title: Decreased glutathione levels cause overt motor neuron degeneration in hSOD1WT over-expressing mice.
Volume: 302
Pages: 129-135
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Publication
21945305 | J:251726
First Author: das Neves Duarte JM
Year: 2012
Journal: Biol Psychiatry
Title: N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development.
Volume: 71
Issue: 11
Pages: 1006-14
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Publication
20164340 | J:157995
First Author: Steullet P
Year: 2010
Journal: J Neurosci
Title: Redox dysregulation affects the ventral but not dorsal hippocampus: impairment of parvalbumin neurons, gamma oscillations, and related behaviors.
Volume: 30
Issue: 7
Pages: 2547-58
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Publication
26799654 | J:257394
First Author: Zhang Y
Year: 2016
Journal: PLoS One
Title: Decreased Brain Levels of Vitamin B12 in Aging, Autism and Schizophrenia.
Volume: 11
Issue: 1
Pages: e0146797
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Publication
27148080 | J:289514
 
First Author: Lavoie S
Year: 2016
Journal: Front Physiol
Title: Glutamate Cysteine Ligase-Modulatory Subunit Knockout Mouse Shows Normal Insulin Sensitivity but Reduced Liver Glycogen Storage.
Volume: 7
Pages: 142
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Publication
28664650 | J:248199
First Author: Corcoba A
Year: 2017
Journal: J Neurochem
Title: Social isolation stress and chronic glutathione deficiency have a common effect on the glutamine-to-glutamate ratio and myo-inositol concentration in the mouse frontal cortex.
Volume: 142
Issue: 5
Pages: 767-775
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Publication
10899580 | J:63622
First Author: Hudson FN
Year: 2000
Journal: Biochim Biophys Acta
Title: Cloning and characterization of the proximal promoter region of the mouse glutamate-L-cysteine ligase regulatory subunit gene.
Volume: 1492
Issue: 2-3
Pages: 447-51
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GXD Expression
GXD Expression
     
Probe: MGI:3050376
Assay Type: Western blot
Annotation Date: 2004-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608524
Stage: TS24
Assay Id: MGI:3050388
Age: embryonic day 16.5
Specimen Label: 0 ppm
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3050376
Assay Type: Western blot
Annotation Date: 2004-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:3050388
Age: embryonic day 16.5
Specimen Label: 0 ppm
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3844675
Assay Type: RT-PCR
Annotation Date: 2009-05-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3845121
Age: embryonic day 7.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3844675
Assay Type: RT-PCR
Annotation Date: 2009-05-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3845121
Age: embryonic day 7.5
Specimen Label: -/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3844675
Assay Type: RT-PCR
Annotation Date: 2009-05-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3845121
Age: embryonic day 7.5
Specimen Label: +/+
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3844675
Assay Type: RT-PCR
Annotation Date: 2009-05-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3845121
Age: embryonic day 7.5
Specimen Label: -/-
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3844675
Assay Type: RT-PCR
Annotation Date: 2009-05-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3845121
Age: embryonic day 7.5
Specimen Label: +/+
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:3844675
Assay Type: RT-PCR
Annotation Date: 2009-05-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3845121
Age: embryonic day 7.5
Specimen Label: -/-
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:3844675
Assay Type: RT-PCR
Annotation Date: 2009-05-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3845135
Age: embryonic day 7.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3844675
Assay Type: RT-PCR
Annotation Date: 2009-05-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3845135
Age: embryonic day 7.5
Specimen Label: -/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7491573
Assay Type: RT-PCR
Annotation Date: 2023-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759723
Stage: TS23
Assay Id: MGI:7491594
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7491573
Assay Type: RT-PCR
Annotation Date: 2023-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759726
Stage: TS26
Assay Id: MGI:7491594
Age: embryonic day 18.5
Specimen Label: E18.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7491573
Assay Type: RT-PCR
Annotation Date: 2023-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:7491594
Age: postnatal day 5
Specimen Label: P5d
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7491573
Assay Type: RT-PCR
Annotation Date: 2023-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:7491594
Age: postnatal day 15
Specimen Label: P15d
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7491573
Assay Type: RT-PCR
Annotation Date: 2023-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:7491594
Age: postnatal month 1-2
Specimen Label: P1-2M
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7491573
Assay Type: RT-PCR
Annotation Date: 2023-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759728
Stage: TS28
Assay Id: MGI:7491594
Age: postnatal month 5
Specimen Label: P5m
Detected: true
Specimen Num: 6
•
•
•
•
•




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