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Search results 1 to 100 out of 631 for Gdf5

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0.053s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Kania K
Year: 2020
Journal: Sci Rep
Title: Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis.
Volume: 10
Issue: 1
Pages: 157
Publication
First Author: Hagiwara Y
Year: 2020
Journal: Ann N Y Acad Sci
Title: Cells from a GDF5 origin produce zonal tendon-to-bone attachments following anterior cruciate ligament reconstruction.
Volume: 1460
Issue: 1
Pages: 57-67
Publication
First Author: Dyment NA
Year: 2015
Journal: Dev Biol
Title: Gdf5 progenitors give rise to fibrocartilage cells that mineralize via hedgehog signaling to form the zonal enthesis.
Volume: 405
Issue: 1
Pages: 96-107
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Rountree RB
Year: 2004
Journal: PLoS Biol
Title: BMP receptor signaling is required for postnatal maintenance of articular cartilage.
Volume: 2
Issue: 11
Pages: e355
Publication
First Author: Shwartz Y
Year: 2016
Journal: Cell Rep
Title: Joint Development Involves a Continuous Influx of Gdf5-Positive Cells.
Volume: 15
Issue: 12
Pages: 2577-87
Publication
First Author: Gamer LW
Year: 2018
Journal: J Bone Miner Res
Title: The Role of Bmp2 in the Maturation and Maintenance of the Murine Knee Joint.
Volume: 33
Issue: 9
Pages: 1708-1717
Publication
First Author: Dy P
Year: 2010
Journal: Dev Biol
Title: Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage.
Volume: 341
Issue: 2
Pages: 346-59
Publication
First Author: Zhang Y
Year: 2020
Journal: Dev Dyn
Title: Cruciate ligament, patellar tendon, and patella formation involves differential cellular sources and dynamics as joint cavitation proceeds.
Volume: 249
Issue: 6
Pages: 711-722
Publication  
First Author: Koyama E
Year: 2007
Journal: Ann N Y Acad Sci
Title: Synovial joint formation during mouse limb skeletogenesis: roles of Indian hedgehog signaling.
Volume: 1116
Pages: 100-12
Publication
First Author: Ohta Y
Year: 2015
Journal: Arthritis Rheumatol
Title: Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg.
Volume: 67
Issue: 10
Pages: 2679-90
Publication
First Author: Mundy C
Year: 2011
Journal: Dev Biol
Title: Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine.
Volume: 351
Issue: 1
Pages: 70-81
Publication
First Author: Eyal S
Year: 2015
Journal: Development
Title: On the development of the patella.
Volume: 142
Issue: 10
Pages: 1831-9
Publication
First Author: Kahn J
Year: 2009
Journal: Dev Cell
Title: Muscle contraction is necessary to maintain joint progenitor cell fate.
Volume: 16
Issue: 5
Pages: 734-43
Publication  
First Author: Kan A
Year: 2013
Journal: BMC Dev Biol
Title: SOX11 contributes to the regulation of GDF5 in joint maintenance.
Volume: 13
Pages: 4
Publication
First Author: Storm EE
Year: 1999
Journal: Dev Biol
Title: GDF5 coordinates bone and joint formation during digit development.
Volume: 209
Issue: 1
Pages: 11-27
GXD Expression
Probe: MGI:5446225
Assay Type: RNA in situ
Annotation Date: 2012-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3264520
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5446474
Age: embryonic day 12.5
Image: 2 Gdf5 12.5 wt
Note: Expression in perichondrium of early digital anlage, with a striped pattern of expression in developing joints of digits.
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:5446225
Assay Type: RNA in situ
Annotation Date: 2012-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3264520
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5446474
Age: embryonic day 12.5
Image: 2 Gdf5 12.5 spdh/spdh
Note: No expression in phalangeal anlagen.
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:5446225
Assay Type: RNA in situ
Annotation Date: 2012-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3264522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5446491
Age: embryonic day 14.5
Image: 5 Gdf5 14.5 wt
Note: Subject: sclera & lacrimal glan
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:5446225
Assay Type: RNA in situ
Annotation Date: 2012-12-19
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3264522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5446491
Age: embryonic day 14.5
Image: 5 Gdf5 14.5 spdh/spdh
Note: Reduced expression in perichondrium. No expression in interzone.
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:5446225
Assay Type: RNA in situ
Annotation Date: 2012-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3264524
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:5446491
Age: embryonic day 16.5
Image: 5 Gdf5 16.5 wt
Note: Expression in perichondrium, joint interzone, and cartilage of joint.
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:5446225
Assay Type: RNA in situ
Annotation Date: 2012-12-19
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3264524
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:5446491
Age: embryonic day 16.5
Image: 5 Gdf5 16.5 spdh/spdh
Note: Reduced expression in perichondrium. No expression in interzone, with the exception of digit 1 and distal interphalangeal joints.
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:5446225
Assay Type: RNA in situ
Annotation Date: 2012-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1745721
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5446474
Age: embryonic day 13.5
Image: 2 Gdf5 13.5 wt
Note: Expression in developing joints of entire autopod.
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:5446225
Assay Type: RNA in situ
Annotation Date: 2012-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1745721
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5446474
Age: embryonic day 13.5
Image: 2 Gdf5 13.5 spdh/spdh
Note: Some expression in joints between distal and middle phalanges, and between carpal bones. No expression in the joint interzone of digits.
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:5446225
Assay Type: RNA in situ
Annotation Date: 2012-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1743121
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5446474
Age: embryonic day 13.5
Image: 2 Gdf5 13.5 spdh/spdh
Note: Some expression in metacarpophalangeal joint of digit 1,
Detected: true
Specimen Num: 4
Protein
Organism: Mus musculus
Length: 275  
Fragment?: true
Publication
First Author: Degenkolbe E
Year: 2013
Journal: PLoS Genet
Title: A GDF5 point mutation strikes twice--causing BDA1 and SYNS2.
Volume: 9
Issue: 10
Pages: e1003846
Publication  
First Author: Liu J
Year: 2016
Journal: Sci Rep
Title: Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2-induced Smad1/5/8 phosphorylation.
Volume: 6
Pages: 23670
Allele
Name: transgene insertion 1, David M Kingsley
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
Publication      
First Author: Karst SY
Year: 2013
Journal: MGI Direct Data Submission
Title: Brachypodism 5 Jackson, a mouse model of GDF5 genetic diseases
Publication
First Author: Kiapour AM
Year: 2018
Journal: PLoS One
Title: The role of Gdf5 regulatory regions in development of hip morphology.
Volume: 13
Issue: 11
Pages: e0202785
Publication
First Author: Coleman CM
Year: 2003
Journal: Anat Rec A Discov Mol Cell Evol Biol
Title: Correlation of GDF5 and connexin 43 mRNA expression during embryonic development.
Volume: 275
Issue: 2
Pages: 1117-21
Strain
Attribute String: coisogenic, mutant strain, transgenic
Publication
First Author: Chen H
Year: 2016
Journal: PLoS Genet
Title: Heads, Shoulders, Elbows, Knees, and Toes: Modular Gdf5 Enhancers Control Different Joints in the Vertebrate Skeleton.
Volume: 12
Issue: 11
Pages: e1006454
Publication
First Author: Daans M
Year: 2011
Journal: Ann Rheum Dis
Title: GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes.
Volume: 70
Issue: 1
Pages: 208-13
Publication  
First Author: Traoré M
Year: 2019
Journal: Sci Transl Med
Title: An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.
Volume: 11
Issue: 517
Publication
First Author: Hatazawa Y
Year: 2018
Journal: FASEB J
Title: Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration.
Volume: 32
Issue: 3
Pages: 1452-1467
Publication
First Author: Masuya H
Year: 2007
Journal: Hum Mol Genet
Title: A novel dominant-negative mutation in Gdf5 generated by ENU mutagenesis impairs joint formation and causes osteoarthritis in mice.
Volume: 16
Issue: 19
Pages: 2366-75
Publication
First Author: Pregizer SK
Year: 2018
Journal: Ann Rheum Dis
Title: Impact of broad regulatory regions on Gdf5 expression and function in knee development and susceptibility to osteoarthritis.
Volume: 77
Issue: 3
Pages: 450
Publication
First Author: Candela ME
Year: 2016
Journal: PLoS One
Title: Alpha 5 Integrin Mediates Osteoarthritic Changes in Mouse Knee Joints.
Volume: 11
Issue: 6
Pages: e0156783
Genotype
Symbol: Ank/Ank<+> Tg(Gdf5-cre-ALPP)1Kng/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Erg/Erg Tg(Gdf5-cre-ALPP)1Kng/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Koyama E
Year: 2008
Journal: Dev Biol
Title: A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis.
Volume: 316
Issue: 1
Pages: 62-73
Publication
First Author: Dyment NA
Year: 2014
Journal: PLoS One
Title: Lineage tracing of resident tendon progenitor cells during growth and natural healing.
Volume: 9
Issue: 4
Pages: e96113
Publication
First Author: Itoh S
Year: 2008
Journal: Genes Cells
Title: Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells.
Volume: 13
Issue: 4
Pages: 355-63
Publication
First Author: Seemann P
Year: 2005
Journal: J Clin Invest
Title: Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2.
Volume: 115
Issue: 9
Pages: 2373-81
Publication
First Author: Huegel J
Year: 2013
Journal: Dev Biol
Title: Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses.
Volume: 377
Issue: 1
Pages: 100-12
Publication
First Author: Gurley KA
Year: 2006
Journal: J Bone Miner Res
Title: Mineral formation in joints caused by complete or joint-specific loss of ANK function.
Volume: 21
Issue: 8
Pages: 1238-47
Genotype
Symbol: Gt(ROSA)26Sor/? Tg(Gdf5-cre-ALPP)1Kng/?
Background: involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Settle SH Jr
Year: 2003
Journal: Dev Biol
Title: Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes.
Volume: 254
Issue: 1
Pages: 116-30
Allele
Name: growth differentiation factor 5; targeted mutation 1.1, Elazar Zelzer
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Publication categories: ProxyCollection
Strain
Attribute String: mutant strain, targeted mutation
Publication
First Author: Macica C
Year: 2011
Journal: Arthritis Rheum
Title: Genetic evidence of the regulatory role of parathyroid hormone-related protein in articular chondrocyte maintenance in an experimental mouse model.
Volume: 63
Issue: 11
Pages: 3333-43
Publication
First Author: Huang BL
Year: 2015
Journal: PLoS One
Title: Tamoxifen-dependent, inducible Bmp2CreER drives selective recombinase activity in early interdigital mesenchyme and digit collateral ligaments.
Volume: 10
Issue: 4
Pages: e0123325
Genotype
Symbol: Bmpr1a/Bmpr1a Tg(Gdf5-cre-ALPP)1Kng/?
Background: involves: 129 * C57BL/6 * FVB/N-Tg(Gdf5-cre-ALPP)1Kng
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Schwaerzer GK
Year: 2012
Journal: J Bone Miner Res
Title: New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance.
Volume: 27
Issue: 2
Pages: 429-42
Publication  
First Author: Roelofs AJ
Year: 2017
Journal: Nat Commun
Title: Joint morphogenetic cells in the adult mammalian synovium.
Volume: 8
Pages: 15040
Publication  
First Author: Kobayashi T
Year: 2018
Journal: Development
Title: Lin28a overexpression reveals the role of Erk signaling in articular cartilage development.
Volume: 145
Issue: 15
Publication
First Author: Yasuhara R
Year: 2011
Journal: Lab Invest
Title: Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells.
Volume: 91
Issue: 12
Pages: 1739-52
Publication
First Author: Rockel JS
Year: 2016
Journal: J Clin Invest
Title: Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis.
Volume: 126
Issue: 5
Pages: 1649-63
GXD Expression
Probe: MGI:5806588
Assay Type: RNA in situ
Annotation Date: 2016-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640521
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5806796
Age: embryonic day 13.5
Image: 5d,f
Note: Gdf5 and Bmpr1b are expressed in nonoverlapping, but adjacent regions of the limb.
Detected: true
Specimen Num: 11
GXD Expression
Probe: MGI:5806588
Assay Type: RNA in situ
Annotation Date: 2016-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640520
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5806796
Age: embryonic day 12.5
Image: 5a,c
Note: Gdf5 and Bmpr1b are expressed in nonoverlapping, but adjacent regions of the limb.
Detected: true
Specimen Num: 10
Publication
First Author: Suto J
Year: 2006
Journal: J Vet Med Sci
Title: Identification of mutation in the growth differentiation factor 5 (Gdf5) gene in NC-brp/brp mice.
Volume: 68
Issue: 10
Pages: 1121-4
Publication      
First Author: Harris BS
Year: 2015
Journal: MGI Direct Data Submission
Title: brachypodism 6 Jackson
Publication
First Author: Takahara M
Year: 2004
Journal: Bone
Title: Developmental failure of phalanges in the absence of growth/differentiation factor 5.
Volume: 35
Issue: 5
Pages: 1069-76
Publication  
First Author: O'Keeffe GW
Year: 2016
Journal: Neural Dev
Title: Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation.
Volume: 11
Pages: 4
Publication
First Author: Zaidi SH
Year: 2010
Journal: J Am Coll Cardiol
Title: Growth differentiation factor 5 regulates cardiac repair after myocardial infarction.
Volume: 55
Issue: 2
Pages: 135-43
Publication
First Author: Osório C
Year: 2013
Journal: Development
Title: Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development.
Volume: 140
Issue: 23
Pages: 4751-62
Publication
First Author: Hinoi E
Year: 2014
Journal: Diabetes
Title: Growth differentiation factor-5 promotes brown adipogenesis in systemic energy expenditure.
Volume: 63
Issue: 1
Pages: 162-75
Publication
First Author: Storm EE
Year: 1996
Journal: Development
Title: Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family.
Volume: 122
Issue: 12
Pages: 3969-79
Publication
First Author: Storm EE
Year: 1994
Journal: Nature
Title: Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily.
Volume: 368
Issue: 6472
Pages: 639-43
Publication
First Author: Perez WD
Year: 2010
Journal: Dev Dyn
Title: Survival of Hoxa13 homozygous mutants reveals a novel role in digit patterning and appendicular skeletal development.
Volume: 239
Issue: 2
Pages: 446-57
Publication
First Author: Macpherson PC
Year: 2015
Journal: Development
Title: Dach2-Hdac9 signaling regulates reinnervation of muscle endplates.
Volume: 142
Issue: 23
Pages: 4038-48
Publication
First Author: Hinoi E
Year: 2014
Journal: Biochem Biophys Res Commun
Title: PI3K/Akt is involved in brown adipogenesis mediated by growth differentiation factor-5 in association with activation of the Smad pathway.
Volume: 450
Issue: 1
Pages: 255-60
Publication
First Author: Hinoi E
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Nuclear factor-κB is a common upstream signal for growth differentiation factor-5 expression in brown adipocytes exposed to pro-inflammatory cytokines and palmitate.
Volume: 452
Issue: 4
Pages: 974-9
Publication
First Author: Meech R
Year: 2005
Journal: Development
Title: The homeobox transcription factor Barx2 regulates chondrogenesis during limb development.
Volume: 132
Issue: 9
Pages: 2135-46
Publication
First Author: Choe Y
Year: 2012
Journal: Neuron
Title: A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation.
Volume: 73
Issue: 4
Pages: 698-712
Publication
First Author: Tavella S
Year: 2006
Journal: Matrix Biol
Title: Forced chondrocyte expression of sonic hedgehog impairs joint formation affecting proliferation and apoptosis.
Volume: 25
Issue: 7
Pages: 389-97
Publication
First Author: Yi SE
Year: 2000
Journal: Development
Title: The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb.
Volume: 127
Issue: 3
Pages: 621-30
Publication
First Author: Raz R
Year: 2008
Journal: Development
Title: The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome.
Volume: 135
Issue: 9
Pages: 1713-23
Publication
First Author: Tang L
Year: 2017
Journal: Hum Mol Genet
Title: A point mutation in Fgf9 impedes joint interzone formation leading to multiple synostoses syndrome.
Volume: 26
Issue: 7
Pages: 1280-1293
Publication
First Author: Baur ST
Year: 2000
Journal: Development
Title: Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity.
Volume: 127
Issue: 3
Pages: 605-19
Publication
First Author: Tucker AS
Year: 2004
Journal: Development
Title: Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution.
Volume: 131
Issue: 6
Pages: 1235-45
Publication
First Author: Chiang C
Year: 2001
Journal: Dev Biol
Title: Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function.
Volume: 236
Issue: 2
Pages: 421-35
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus