Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This group represents glial cell line-derived neurotrophic factor (GDNF). This is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake [, ]. Defects in GDNF are a cause of congenital central hypoventilation syndrome (also known as Ondine's curse) and are also linked with Hirschsprung disease [, ]. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1201618 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-01-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3544421 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:6386327 |
Age: |
embryonic day 13.0 |
Image: |
5 GDNF |
Note: |
Expression is in the mucosal epithelium. |
Specimen Label: |
5 GDNF |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1201618 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-01-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684621 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6386327 |
Age: |
embryonic day 13.0 |
Image: |
5 GDNF |
|
Specimen Label: |
5 GDNF |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1201618 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-01-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3643721 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6386327 |
Age: |
embryonic day 13.0 |
Image: |
5 GDNF |
|
Specimen Label: |
5 GDNF |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1201618 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-01-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679727 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:6386327 |
Age: |
postnatal newborn |
Image: |
7 gdnf |
|
Specimen Label: |
7 gdnf |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2664233 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-07-14 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737519 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:2665169 |
Age: |
embryonic day 11.5 |
Image: |
Q Gdnf |
|
Specimen Label: |
Q Gdnf |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2664233 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-07-14 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737519 |
|
Stage: |
TS19 |
Assay Id: |
MGI:2665169 |
Age: |
embryonic day 11.5 |
Image: |
R Gdnf |
|
Specimen Label: |
R Gdnf |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1201618 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-01-27 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1702121 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6386327 |
Age: |
embryonic day 13.0 |
Image: |
5 GDNF |
|
Specimen Label: |
5 GDNF |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin LF |
Year: |
1993 |
Journal: |
Science |
Title: |
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. |
Volume: |
260 |
Issue: |
5111 |
Pages: |
1130-2 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
211
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Haniu M |
Year: |
1996 |
Journal: |
Biochemistry |
Title: |
Glial cell line-derived neurotrophic factor: selective reduction of the intermolecular disulfide linkage and characterization of its disulfide structure. |
Volume: |
35 |
Issue: |
51 |
Pages: |
16799-805 |
|
•
•
•
•
•
|
Publication |
First Author: |
Amiel J |
Year: |
1998 |
Journal: |
Am J Hum Genet |
Title: |
Mutations of the RET-GDNF signaling pathway in Ondine's curse. |
Volume: |
62 |
Issue: |
3 |
Pages: |
715-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hofstra RM |
Year: |
1997 |
Journal: |
Eur J Hum Genet |
Title: |
Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype. |
Volume: |
5 |
Issue: |
4 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Glerup S |
Year: |
2013 |
Journal: |
Cell Rep |
Title: |
SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET. |
Volume: |
3 |
Issue: |
1 |
Pages: |
186-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baloh RH |
Year: |
1997 |
Journal: |
Neuron |
Title: |
TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. |
Volume: |
18 |
Issue: |
5 |
Pages: |
793-802 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lemmetyinen TT |
Year: |
2024 |
Journal: |
iScience |
Title: |
Mesenchymal GDNF promotes intestinal enterochromaffin cell differentiation. |
Volume: |
27 |
Issue: |
12 |
Pages: |
111246 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pascual A |
Year: |
2008 |
Journal: |
Nat Neurosci |
Title: |
Absolute requirement of GDNF for adult catecholaminergic neuron survival. |
Volume: |
11 |
Issue: |
7 |
Pages: |
755-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muñoz-Bravo JL |
Year: |
2013 |
Journal: |
Development |
Title: |
GDNF is required for neural colonization of the pancreas. |
Volume: |
140 |
Issue: |
17 |
Pages: |
3669-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sharma M |
Year: |
2018 |
Journal: |
Development |
Title: |
Cyclical expression of GDNF is required for spermatogonial stem cell homeostasis. |
Volume: |
145 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gerlai R |
Year: |
2001 |
Journal: |
Eur J Neurosci |
Title: |
Impaired water maze learning performance without altered dopaminergic function in mice heterozygous for the GDNF mutation. |
Volume: |
14 |
Issue: |
7 |
Pages: |
1153-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
EnterrÃa-Morales D |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Striatal GDNF Production Is Independent to Circulating Estradiol Level Despite Pan-Neuronal Activation in the Female Mouse. |
Volume: |
11 |
Issue: |
10 |
Pages: |
e0164391 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shakya R |
Year: |
2005 |
Journal: |
Dev Biol |
Title: |
The role of GDNF in patterning the excretory system. |
Volume: |
283 |
Issue: |
1 |
Pages: |
70-84 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
260
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
397
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gianino S |
Year: |
2003 |
Journal: |
Development |
Title: |
GDNF availability determines enteric neuron number by controlling precursor proliferation. |
Volume: |
130 |
Issue: |
10 |
Pages: |
2187-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Young HM |
Year: |
2001 |
Journal: |
Dev Biol |
Title: |
GDNF is a chemoattractant for enteric neural cells. |
Volume: |
229 |
Issue: |
2 |
Pages: |
503-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Naveilhan P |
Year: |
1998 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor. |
Volume: |
95 |
Issue: |
3 |
Pages: |
1295-300 |
|
•
•
•
•
•
|
Publication |
First Author: |
Milbrandt J |
Year: |
1998 |
Journal: |
Neuron |
Title: |
Persephin, a novel neurotrophic factor related to GDNF and neurturin. |
Volume: |
20 |
Issue: |
2 |
Pages: |
245-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Enomoto H |
Year: |
2000 |
Journal: |
Development |
Title: |
Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin. |
Volume: |
127 |
Issue: |
22 |
Pages: |
4877-89 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiao N |
Year: |
2014 |
Journal: |
J Clin Invest |
Title: |
Neurotrophic factor GDNF promotes survival of salivary stem cells. |
Volume: |
124 |
Issue: |
8 |
Pages: |
3364-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Littrell OM |
Year: |
2012 |
Journal: |
Neurobiol Aging |
Title: |
Enhanced dopamine transporter activity in middle-aged Gdnf heterozygous mice. |
Volume: |
33 |
Issue: |
2 |
Pages: |
427.e1-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ola R |
Year: |
2011 |
Journal: |
J Am Soc Nephrol |
Title: |
The GDNF target Vsnl1 marks the ureteric tip. |
Volume: |
22 |
Issue: |
2 |
Pages: |
274-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haase G |
Year: |
2002 |
Journal: |
Neuron |
Title: |
GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools. |
Volume: |
35 |
Issue: |
5 |
Pages: |
893-905 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hidalgo-Figueroa M |
Year: |
2012 |
Journal: |
J Neurosci |
Title: |
GDNF is predominantly expressed in the PV+ neostriatal interneuronal ensemble in normal mouse and after injury of the nigrostriatal pathway. |
Volume: |
32 |
Issue: |
3 |
Pages: |
864-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baloh RH |
Year: |
2000 |
Journal: |
Curr Opin Neurobiol |
Title: |
The GDNF family ligands and receptors - implications for neural development. |
Volume: |
10 |
Issue: |
1 |
Pages: |
103-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Montaño-Rodriguez AR |
Year: |
2024 |
Journal: |
Cells |
Title: |
Striatal GDNF Neurons Chemoattract RET-Positive Dopamine Axons at Seven Times Farther Distance Than Medium Spiny Neurons. |
Volume: |
13 |
Issue: |
12 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Uesaka T |
Year: |
2013 |
Journal: |
J Neurosci |
Title: |
GDNF signaling levels control migration and neuronal differentiation of enteric ganglion precursors. |
Volume: |
33 |
Issue: |
41 |
Pages: |
16372-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kopra J |
Year: |
2015 |
Journal: |
Nat Neurosci |
Title: |
GDNF is not required for catecholaminergic neuron survival in vivo. |
Volume: |
18 |
Issue: |
3 |
Pages: |
319-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Airaksinen MS |
Year: |
2002 |
Journal: |
Nat Rev Neurosci |
Title: |
The GDNF family: signalling, biological functions and therapeutic value. |
Volume: |
3 |
Issue: |
5 |
Pages: |
383-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Linton JM |
Year: |
2007 |
Journal: |
Development |
Title: |
The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression. |
Volume: |
134 |
Issue: |
13 |
Pages: |
2501-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cullen-McEwen LA |
Year: |
2003 |
Journal: |
Hypertension |
Title: |
Nephron number, renal function, and arterial pressure in aged GDNF heterozygous mice. |
Volume: |
41 |
Issue: |
2 |
Pages: |
335-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harasztosi C |
Year: |
2019 |
Journal: |
J Neurosci Res |
Title: |
Differential deletion of GDNF in the auditory system leads to altered sound responsiveness. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bonafina A |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
GDNF and GFRα1 Are Required for Proper Integration of Adult-Born Hippocampal Neurons. |
Volume: |
29 |
Issue: |
13 |
Pages: |
4308-4319.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ortega-de San Luis C |
Year: |
2016 |
Journal: |
Front Neuroanat |
Title: |
Simultaneous Detection of Both GDNF and GFRα1 Expression Patterns in the Mouse Central Nervous System. |
Volume: |
10 |
|
Pages: |
73 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6173457 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190395 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Gdnf |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6173457 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190395 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Gdnf |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6173457 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190395 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Gdnf |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6173457 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190395 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Gdnf |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6173457 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190395 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Gdnf |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6173457 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190395 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Gdnf |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6173457 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190395 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Gdnf |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pozas E |
Year: |
2005 |
Journal: |
Neuron |
Title: |
GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons. |
Volume: |
45 |
Issue: |
5 |
Pages: |
701-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Charoy C |
Year: |
2012 |
Journal: |
Neuron |
Title: |
gdnf activates midline repulsion by Semaphorin3B via NCAM during commissural axon guidance. |
Volume: |
75 |
Issue: |
6 |
Pages: |
1051-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boger HA |
Year: |
2009 |
Journal: |
Neurobiol Dis |
Title: |
Minocycline restores striatal tyrosine hydroxylase in GDNF heterozygous mice but not in methamphetamine-treated mice. |
Volume: |
33 |
Issue: |
3 |
Pages: |
459-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pepicelli CV |
Year: |
1997 |
Journal: |
Dev Biol |
Title: |
GDNF induces branching and increased cell proliferation in the ureter of the mouse. |
Volume: |
192 |
Issue: |
1 |
Pages: |
193-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
468
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Sergaki MC |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
Compromised Survival of Cerebellar Molecular Layer Interneurons Lacking GDNF Receptors GFRα1 or RET Impairs Normal Cerebellar Motor Learning. |
Volume: |
19 |
Issue: |
10 |
Pages: |
1977-1986 |
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Publication |
First Author: |
Ai X |
Year: |
2007 |
Journal: |
Development |
Title: |
SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. |
Volume: |
134 |
Issue: |
18 |
Pages: |
3327-38 |
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Publication |
First Author: |
Angka HE |
Year: |
2008 |
Journal: |
Dev Dyn |
Title: |
Differential survival response of neurons to exogenous GDNF depends on the presence of skeletal muscle. |
Volume: |
237 |
Issue: |
11 |
Pages: |
3169-78 |
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Publication |
First Author: |
Michos O |
Year: |
2010 |
Journal: |
PLoS Genet |
Title: |
Kidney development in the absence of Gdnf and Spry1 requires Fgf10. |
Volume: |
6 |
Issue: |
1 |
Pages: |
e1000809 |
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Publication |
First Author: |
Farrand AQ |
Year: |
2015 |
Journal: |
Neurobiol Aging |
Title: |
Effects of aging on glutamate neurotransmission in the substantia nigra of Gdnf heterozygous mice. |
Volume: |
36 |
Issue: |
3 |
Pages: |
1569-76 |
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Publication |
First Author: |
Airavaara M |
Year: |
2004 |
Journal: |
Eur J Neurosci |
Title: |
Increased extracellular dopamine concentrations and FosB/DeltaFosB expression in striatal brain areas of heterozygous GDNF knockout mice. |
Volume: |
20 |
Issue: |
9 |
Pages: |
2336-44 |
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Publication |
First Author: |
Chen LY |
Year: |
2016 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Targeting the Gdnf Gene in peritubular myoid cells disrupts undifferentiated spermatogonial cell development. |
Volume: |
113 |
Issue: |
7 |
Pages: |
1829-34 |
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Publication |
First Author: |
Hadaczek P |
Year: |
2015 |
Journal: |
Exp Neurol |
Title: |
GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model. |
Volume: |
263 |
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Pages: |
177-89 |
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Publication |
First Author: |
Mätlik K |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Two-fold elevation of endogenous GDNF levels in mice improves motor coordination without causing side-effects. |
Volume: |
8 |
Issue: |
1 |
Pages: |
11861 |
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Publication |
First Author: |
Jin L |
Year: |
2022 |
Journal: |
Cell Death Dis |
Title: |
Astrocytic SARM1 promotes neuroinflammation and axonal demyelination in experimental autoimmune encephalomyelitis through inhibiting GDNF signaling. |
Volume: |
13 |
Issue: |
9 |
Pages: |
759 |
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Publication |
First Author: |
Uchida A |
Year: |
2016 |
Journal: |
Biochem Biophys Res Commun |
Title: |
In vivo dynamics of GFRα1-positive spermatogonia stimulated by GDNF signals using a bead transplantation assay. |
Volume: |
476 |
Issue: |
4 |
Pages: |
546-552 |
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Publication |
First Author: |
Brodbeck S |
Year: |
2004 |
Journal: |
Mech Dev |
Title: |
The transcription factor Six2 activates expression of the Gdnf gene as well as its own promoter. |
Volume: |
121 |
Issue: |
10 |
Pages: |
1211-22 |
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Publication |
First Author: |
Paratcha G |
Year: |
2006 |
Journal: |
Mol Cell Neurosci |
Title: |
GDNF is a chemoattractant factor for neuronal precursor cells in the rostral migratory stream. |
Volume: |
31 |
Issue: |
3 |
Pages: |
505-14 |
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Publication |
First Author: |
Shen L |
Year: |
2002 |
Journal: |
Am J Hum Genet |
Title: |
Gdnf haploinsufficiency causes Hirschsprung-like intestinal obstruction and early-onset lethality in mice. |
Volume: |
70 |
Issue: |
2 |
Pages: |
435-47 |
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Publication |
First Author: |
Anitha M |
Year: |
2006 |
Journal: |
J Clin Invest |
Title: |
GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathway. |
Volume: |
116 |
Issue: |
2 |
Pages: |
344-56 |
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Publication |
First Author: |
Shneider NA |
Year: |
2009 |
Journal: |
Neural Dev |
Title: |
Gamma motor neurons express distinct genetic markers at birth and require muscle spindle-derived GDNF for postnatal survival. |
Volume: |
4 |
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Pages: |
42 |
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Publication |
First Author: |
Flynn B |
Year: |
2007 |
Journal: |
Dev Dyn |
Title: |
Effect of Gdnf haploinsufficiency on rate of migration and number of enteric neural crest-derived cells. |
Volume: |
236 |
Issue: |
1 |
Pages: |
134-41 |
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Publication |
First Author: |
Arce V |
Year: |
1998 |
Journal: |
J Neurosci |
Title: |
Synergistic effects of schwann- and muscle-derived factors on motoneuron survival involve GDNF and cardiotrophin-1 (CT-1). |
Volume: |
18 |
Issue: |
4 |
Pages: |
1440-8 |
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Publication |
First Author: |
Gottschalk CG |
Year: |
2021 |
Journal: |
J Neurosci |
Title: |
Gemfibrozil Protects Dopaminergic Neurons in a Mouse Model of Parkinson's Disease via PPARα-Dependent Astrocytic GDNF Pathway. |
Volume: |
41 |
Issue: |
10 |
Pages: |
2287-2300 |
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Publication |
First Author: |
Basson MA |
Year: |
2006 |
Journal: |
Dev Biol |
Title: |
Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1. |
Volume: |
299 |
Issue: |
2 |
Pages: |
466-77 |
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Publication |
First Author: |
Hes C |
Year: |
2025 |
Journal: |
Mol Metab |
Title: |
GDNF family receptor alpha-like (GFRAL) expression is restricted to the caudal brainstem. |
Volume: |
91 |
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Pages: |
102070 |
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Publication |
First Author: |
Callahan T |
Year: |
2008 |
Journal: |
Glia |
Title: |
Development of satellite glia in mouse sympathetic ganglia: GDNF and GFR alpha 1 are not essential. |
Volume: |
56 |
Issue: |
13 |
Pages: |
1428-37 |
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Publication |
First Author: |
Golden JP |
Year: |
1999 |
Journal: |
Exp Neurol |
Title: |
Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse. |
Volume: |
158 |
Issue: |
2 |
Pages: |
504-28 |
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Publication |
First Author: |
Kumar A |
Year: |
2015 |
Journal: |
PLoS Genet |
Title: |
GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function. |
Volume: |
11 |
Issue: |
12 |
Pages: |
e1005710 |
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Publication |
First Author: |
Griffin WC 3rd |
Year: |
2006 |
Journal: |
Brain Res |
Title: |
Partial deletion of glial cell line-derived neurotrophic factor (GDNF) in mice: Effects on sucrose reward and striatal GDNF concentrations. |
Volume: |
1068 |
Issue: |
1 |
Pages: |
257-60 |
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Publication |
First Author: |
Zhang N |
Year: |
2020 |
Journal: |
Glia |
Title: |
GLAST-CreERT2 mediated deletion of GDNF increases brain damage and exacerbates long-term stroke outcomes after focal ischemic stroke in mouse model. |
Volume: |
68 |
Issue: |
11 |
Pages: |
2395-2414 |
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Publication |
First Author: |
Rosenthal A |
Year: |
1999 |
Journal: |
Neuron |
Title: |
The GDNF protein family: gene ablation studies reveal what they really do and how. |
Volume: |
22 |
Issue: |
2 |
Pages: |
201-3 |
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Publication |
First Author: |
Virtanen HT |
Year: |
2024 |
Journal: |
Cell Mol Gastroenterol Hepatol |
Title: |
Interindividual Variation in Gut Nitrergic Neuron Density Is Regulated By GDNF Levels and ETV1. |
Volume: |
18 |
Issue: |
6 |
Pages: |
101405 |
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Publication |
First Author: |
Boger HA |
Year: |
2006 |
Journal: |
Exp Neurol |
Title: |
A partial GDNF depletion leads to earlier age-related deterioration of motor function and tyrosine hydroxylase expression in the substantia nigra. |
Volume: |
202 |
Issue: |
2 |
Pages: |
336-47 |
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