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Search results 1 to 90 out of 90 for Gen1

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Hits by Category

Type Details Score
Gene
348654 | GEN1
Type: gene
Organism: human
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Gene
785690 | GEN1
Type: gene
Organism: cattle
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Gene
699692 | GEN1
Type: gene
Organism: macaque, rhesus
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Gene
470313 | GEN1
Type: gene
Organism: chimpanzee
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Gene
298884 | Gen1
Type: gene
Organism: rat
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Gene
482980 | GEN1
Type: gene
Organism: dog, domestic
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Gene
421951 | GEN1
Type: gene
Organism: chicken
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Gene
101884233 | gen1
Type: gene
Organism: zebrafish
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Gene
100145302 | gen1
Type: gene
Organism: frog, western clawed
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Protein Coding Gene
MGI:2443149 | Gen1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
30632787 | J:274873
First Author: Zhang Y
Year: 2019
Journal: DNA Cell Biol
Title: Gen1 Modulates Metanephric Morphology Through Retinoic Acid Signaling.
Volume: 38
Issue: 3
Pages: 263-271
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Publication
27383418 | J:330453
First Author: Wang X
Year: 2016
Journal: DNA Cell Biol
Title: Gen1 and Eme1 Play Redundant Roles in DNA Repair and Meiotic Recombination in Mice.
Volume: 35
Issue: 10
Pages: 585-590
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Publication
34922199 | J:319638
 
First Author: Li Y
Year: 2022
Journal: Biochem Biophys Res Commun
Title: Disruption of Gen1 causes ectopic budding and kidney hypoplasia in mice.
Volume: 589
Pages: 173-179
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Publication
36190107 | J:330401
   
First Author: Fernandez KC
Year: 2022
Journal: Elife
Title: The structure-selective endonucleases GEN1 and MUS81 mediate complementary functions in safeguarding the genome of proliferating B lymphocytes.
Volume: 11
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Publication
29483821 | J:272082
First Author: Wang H
Year: 2018
Journal: Int J Biol Sci
Title: Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice.
Volume: 14
Issue: 1
Pages: 10-20
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Publication
32226308 | J:309152
First Author: Wang X
Year: 2020
Journal: Int J Biol Sci
Title: Gen1 mutation caused kidney hypoplasia and defective ureter-bladder connections in mice.
Volume: 16
Issue: 9
Pages: 1640-1647
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Protein Coding Gene
MGP_CAROLIEiJ_G0017616 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019598 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019565 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019535 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019540 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019346 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2443149 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0019989 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018902 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019317 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019430 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019421 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019501 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019454 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020028 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018668 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0018953 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029372 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018458 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:6302778
Assay Type: RT-PCR
Annotation Date: 2019-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:6302790
Age: embryonic day 12.5
Image: 1
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6302778
Assay Type: RT-PCR
Annotation Date: 2019-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:6302790
Age: embryonic day 12.5
Image: 1
Specimen Label: PB/+
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6302778
Assay Type: RT-PCR
Annotation Date: 2019-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:6302790
Age: embryonic day 12.5
Image: 1
Specimen Label: PB/PB
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6877081
Assay Type: RT-PCR
Annotation Date: 2022-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737319
Stage: TS19
Assay Id: MGI:6877086
Age: embryonic day 11.5
Image: 1
Specimen Label: E11.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6877081
Assay Type: RT-PCR
Annotation Date: 2022-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737320
Stage: TS20
Assay Id: MGI:6877086
Age: embryonic day 12.5
Image: 1
Specimen Label: E12.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6877081
Assay Type: RT-PCR
Annotation Date: 2022-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:6877086
Age: embryonic day 14.5
Image: 1
Specimen Label: E14.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6877081
Assay Type: RT-PCR
Annotation Date: 2022-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737324
Stage: TS24
Assay Id: MGI:6877086
Age: embryonic day 16.5
Image: 1
Specimen Label: E16.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6877081
Assay Type: RT-PCR
Annotation Date: 2022-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737326
Stage: TS26
Assay Id: MGI:6877086
Age: embryonic day 18.5
Image: 1
Specimen Label: E18.5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6877081
Assay Type: RT-PCR
Annotation Date: 2022-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737327
Stage: TS27
Assay Id: MGI:6877086
Age: postnatal day 0
Image: 1
Specimen Label: P0
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6877081
Assay Type: RT-PCR
Annotation Date: 2022-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6877086
Age: postnatal week 4
Image: 1
Specimen Label: P4W
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:6877081
Assay Type: RT-PCR
Annotation Date: 2022-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737320
Stage: TS20
Assay Id: MGI:6877088
Age: embryonic day 12.5
Image: 1
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6877081
Assay Type: RT-PCR
Annotation Date: 2022-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737320
Stage: TS20
Assay Id: MGI:6877088
Age: embryonic day 12.5
Image: 1
Specimen Label: PB/+
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6877081
Assay Type: RT-PCR
Annotation Date: 2022-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737320
Stage: TS20
Assay Id: MGI:6877088
Age: embryonic day 12.5
Image: 1
Specimen Label: PB/PB
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:6302827
Assay Type: RNA in situ
Annotation Date: 2019-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6302828
Age: embryonic day 10.5
Image: S4a
Specimen Label: S4a
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6302827
Assay Type: RNA in situ
Annotation Date: 2019-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6302828
Age: embryonic day 10.5
Image: S4b
Note: Weaker expression in the homozygotes.
Specimen Label: S4b
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6302827
Assay Type: RNA in situ
Annotation Date: 2019-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1657717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6302828
Age: embryonic day 10.5
Image: S4a
Specimen Label: S4a
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6302827
Assay Type: RNA in situ
Annotation Date: 2019-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1657717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6302828
Age: embryonic day 10.5
Image: S4b
Note: Weaker expression in the homozygotes.
Specimen Label: S4b
Detected: true
Specimen Num: 2
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Publication
16096065 | J:123680
First Author: Ding S
Year: 2005
Journal: Cell
Title: Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice.
Volume: 122
Issue: 3
Pages: 473-83
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Publication
27694478 | J:268403
First Author: Zhou L
Year: 2017
Journal: FASEB J
Title: Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.
Volume: 31
Issue: 1
Pages: 132-147
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
26682650 | -
   
First Author: Lee SH
Year: 2015
Journal: Elife
Title: Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage.
Volume: 4
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Publication
26686639 | -
First Author: Liu Y
Year: 2015
Journal: Cell Rep
Title: Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA.
Volume: 13
Issue: 11
Pages: 2565-2575
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Protein Domain
IPR041012 | GEN_chromo
Type: Domain
Description: Chromodomains serve as chromatin-targeting modules, general protein interaction elements as well as dimerization sites. They are found in many chromatin-associated proteins that bind modified histone tails for chromatin targeting. Chromodomains often recognize modified lysines through their aromatic cage thus targeting proteins to chromatin. Family members such as GEN1 carry a chomodomain which directly contacts DNA and its truncation severely hampers GEN1's catalytic activity. The chromodomain allows GEN1 to correctly position itself against DNA molecules, and without the chromodomain, GEN1's ability to cut DNA was severely impaired. The GEN1 chromodomain was found to be distantly related to the CDY chromodomains and chromobox proteins, particularly to the chromo-shadow domains of CBX1, CBX3 and CBX5. Furthermore, it is conserved from yeast (Yen1) to humans with the only exception being the Caenorhabditis elegans GEN1, which has a much smaller protein size of 443 amino acids compared to yeast Yen1 (759 aa) or human GEN1 (908 aa) [].
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Publication
28049850 | -
First Author: Shah Punatar R
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Resolution of single and double Holliday junction recombination intermediates by GEN1.
Volume: 114
Issue: 3
Pages: 443-450
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Protein Domain
IPR041177 | GEN1_C
Type: Domain
Description: This is the C-terminal domain found in GEN1 resolvase. It is composed of three-strand antiparallel beta sheets and four alpha helices []. GEN1 protein, a member of the XPG/Rad2 family of structure-selective endonucleases, is specialized for the cleavage of Holliday junction recombination intermediates []. Structural comparison indicates that the C-terminal domain is similar to a series of chromobox homology proteins []. Functional analysis indicates that the chromodomain provides an additional DNA binding site necessary for efficient HJ cleavage, and its truncation severely hampers GEN1's catalytic activity [].
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Protein
A0A1W2P6M6
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: true
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Protein
Q8BMI4
Organism: Mus musculus/domesticus
Length: 908  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom