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Search results 1 to 95 out of 95 for Get4

0.036s

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
51608 | GET4
Type: gene
Organism: human
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Gene
549462 | get4
Type: gene
Organism: frog, western clawed
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Gene
288518 | Get4
Type: gene
Organism: rat
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Gene
491599 | GET4
Type: gene
Organism: dog, domestic
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Gene
463209 | GET4
Type: gene
Organism: chimpanzee
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Gene
618954 | GET4
Type: gene
Organism: cattle
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Gene
416450 | GET4
Type: gene
Organism: chicken
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Gene
796309 | get4
Type: gene
Organism: zebrafish
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Gene
696126 | GET4
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1914854 | Get4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR007317 | GET4
Type: Family
Description: In budding yeast, Get4 is part of the GET complex that inserts the tail-anchored (TA) proteins into the endoplasmic reticulum membrane [, ]. In humans, Get4 is part the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and facilitates their proper delivery to the endoplasmic reticulum, or alternatively promotes their sorting to the proteasome where they undergo degradation [, , , ]. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane [, , ].
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Publication
25535373 | J:320131
First Author: Mock JY
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.
Volume: 112
Issue: 1
Pages: 106-11
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Publication
20676083 | -
First Author: Mariappan M
Year: 2010
Journal: Nature
Title: A ribosome-associating factor chaperones tail-anchored membrane proteins.
Volume: 466
Issue: 7310
Pages: 1120-4
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Publication
22190685 | -
First Author: Chang YW
Year: 2012
Journal: J Biol Chem
Title: Interaction surface and topology of Get3-Get4-Get5 protein complex, involved in targeting tail-anchored proteins to endoplasmic reticulum.
Volume: 287
Issue: 7
Pages: 4783-9
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Publication
24727835 | -
First Author: Gristick HB
Year: 2014
Journal: Nat Struct Mol Biol
Title: Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4.
Volume: 21
Issue: 5
Pages: 437-42
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Publication
21636303 | -
First Author: Wang Q
Year: 2011
Journal: Mol Cell
Title: A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation.
Volume: 42
Issue: 6
Pages: 758-70
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Publication
21743475 | -
First Author: Hessa T
Year: 2011
Journal: Nature
Title: Protein targeting and degradation are coupled for elimination of mislocalized proteins.
Volume: 475
Issue: 7356
Pages: 394-7
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Publication
28104892 | -
First Author: Shao S
Year: 2017
Journal: Science
Title: Mechanistic basis for a molecular triage reaction.
Volume: 355
Issue: 6322
Pages: 298-302
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Protein
Q9D1H7
Organism: Mus musculus/domesticus
Length: 327  
Fragment?: false
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Protein
D3Z4J5
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: true
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Protein
D3Z7S0
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: true
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Protein Coding Gene
MGP_CAROLIEiJ_G0027927 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030278 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030247 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030179 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030264 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1914854 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030709 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029380 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029945 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030095 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030050 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030181 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030081 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030749 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029095 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029454 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024499 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028931 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:3584546
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Absent
Sex: Male
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:3586293
Age: postnatal adult
Specimen Label: Adult
Detected: false
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:3584546
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586293
Age: postnatal day 6-7
Specimen Label: P6/7
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:3584546
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586293
Age: postnatal day 8-10
Specimen Label: P8/10
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:3584546
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:3586293
Age: embryonic day 18.0
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: E18
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3584546
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3586293
Age: postnatal day 0-1
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P0/1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:3584546
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3586293
Age: postnatal day 2-3
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:3584546
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586293
Age: postnatal day 4-5
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P4/5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:3584546
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586293
Age: postnatal day 6-7
Specimen Label: P6/7
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:3584546
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586293
Age: postnatal day 8-10
Specimen Label: P8/10
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:3584546
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859224
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:3586293
Age: embryonic day 16.0
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: E16
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3584546
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:3586293
Age: embryonic day 14.0
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: E14
Detected: true
Specimen Num: 1
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
20106980 | -
First Author: Chang YW
Year: 2010
Journal: J Biol Chem
Title: Crystal structure of Get4-Get5 complex and its interactions with Sgt2, Get3, and Ydj1.
Volume: 285
Issue: 13
Pages: 9962-70
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Protein Domain
IPR031765 | Mdy2_get4-bd
Type: Domain
Description: This entry represents the binding domain at the N terminus of Mdy2 (also known as Get5) that binds to Get4. Together with Get3, this tripartite complex is involved in the insertion of tail-anchored proteins in the ER membrane [].
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GO Term
GO:0071818 | BAT3 complex
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Publication
23142665 | -
First Author: Chartron JW
Year: 2012
Journal: Cell Rep
Title: Structures of the Sgt2/SGTA dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface.
Volume: 2
Issue: 6
Pages: 1620-32
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Publication
22262836 | -
First Author: Chartron JW
Year: 2012
Journal: J Biol Chem
Title: Get5 carboxyl-terminal domain is a novel dimerization motif that tethers an extended Get4/Get5 complex.
Volume: 287
Issue: 11
Pages: 8310-7
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Protein Domain
IPR032374 | SGTA_dimer
Type: Domain
Description: This entry represents a short N-terminal domain at the start of small glutamine-rich tetratricopeptide repeat-containing protein (SGTA), a heat-shock protein (HSP) co-chaperone involvedin the targeting of tail-anchor membrane proteins to the endoplasmic reticulum. This is the homodimerisation domain that mediates the association with a single copy of Get4 or Get5 proteins, providing a link to the rest of the GET pathway [].
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Protein Domain
IPR040474 | Get5_C
Type: Domain
Description: Tail-anchored trans-membrane proteins are targeted to membranes post-translationally. The proteins Get4 and Get5 form an obligate complex that catalyzes the transfer of tail-anchored proteins destined to the endoplasmic reticulum from Sgt2 to the cytosolic targeting factor Get3. This is the carboxyl domain of Get5 (also known as Mdy2), a homodimerization domain, resulting in a heterotetrameric Get4/Get5 complex [].
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Protein Coding Gene
MGI:95049 | Ubl4a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:5621304 | Gm44504
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
E0CZ99
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: true
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Protein
Q8VD33
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: false
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Protein
Q8BJU0
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Protein
Q3TN35
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
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Protein
A0A1W2P7I5
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: true
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Protein
A0A1W2P6P1
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: true
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Protein Coding Gene
MGI:1919439 | Bag6
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom