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Search results 1 to 100 out of 290 for Gip

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
2695 | GIP
Type: gene
Organism: human
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Gene
100036740 | gip
Type: gene
Organism: frog, western clawed
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Gene
25040 | Gip
Type: gene
Organism: rat
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Gene
749143 | GIP
Type: gene
Organism: chimpanzee
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Gene
511073 | GIP
Type: gene
Organism: cattle
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Gene
100856162 | GIP
Type: gene
Organism: dog, domestic
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Gene
419989 | GIP
Type: gene
Organism: chicken
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Gene
790901 | gip
Type: gene
Organism: zebrafish
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Gene
698335 | GIP
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR039078 | GIP
Type: Family
Description: Gastric inhibitory polypeptide or glucose-dependent insulinotropic polypeptide (GIP) is a hormone released from duodenal K cells in a glucose-dependent manner []. It is considered an incretin hormone as it stimulates the secretion of insulin in the presence of elevated glucose; the other incretin being glucagon-like peptide-1 (GLP-1). It acts through the GIP receptor (GIPR) expressed in pancreatic beta-cells []. GIP plays a role in glucose and lipid metabolism. It increases lipoprotein lipase (LPL) expression and activity, and promotes fatty acid incorporation and synthesis [, , ]. It is associated with obesity and insulin resistance [, ].
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Protein Coding Gene
MGI:107504 | Gip
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P48756
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: false
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Publication
20693566 | -
First Author: Kim SJ
Year: 2010
Journal: J Lipid Res
Title: GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene.
Volume: 51
Issue: 11
Pages: 3145-57
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Publication
31977316 | J:298236
First Author: Kanemaru Y
Year: 2020
Journal: J Endocrinol
Title: Absence of GIP secretion alleviates age-related obesity and insulin resistance.
Volume: 245
Issue: 1
Pages: 13-20
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Publication
21810601 | J:189273
First Author: Lyssenko V
Year: 2011
Journal: Diabetes
Title: Pleiotropic effects of GIP on islet function involve osteopontin.
Volume: 60
Issue: 9
Pages: 2424-33
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Publication
31003779 | J:291658
First Author: Hoizumi M
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Inhibition of GIP signaling extends lifespan without caloric restriction.
Volume: 513
Issue: 4
Pages: 974-982
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Publication
34466786 | J:338670
First Author: Murata Y
Year: 2021
Journal: iScience
Title: Medium-chain triglycerides inhibit long-chain triglyceride-induced GIP secretion through GPR120-dependent inhibition of CCK.
Volume: 24
Issue: 9
Pages: 102963
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Publication
17971513 | J:131258
First Author: Harada N
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Title: A novel GIP receptor splice variant influences GIP sensitivity of pancreatic beta-cells in obese mice.
Volume: 294
Issue: 1
Pages: E61-8
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Publication
35909510 | J:327154
 
First Author: Kiyobayashi S
Year: 2022
Journal: Front Endocrinol (Lausanne)
Title: Noninvasive Evaluation of GIP Effects on β-Cell Mass Under High-Fat Diet.
Volume: 13
Pages: 921125
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Publication
24584548 | J:229498
First Author: Nasteska D
Year: 2014
Journal: Diabetes
Title: Chronic reduction of GIP secretion alleviates obesity and insulin resistance under high-fat diet conditions.
Volume: 63
Issue: 7
Pages: 2332-43
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Publication
17937928 | J:128450
First Author: Yamada C
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes.
Volume: 364
Issue: 1
Pages: 175-80
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Publication
18723001 | J:141062
First Author: Naitoh R
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice.
Volume: 376
Issue: 1
Pages: 21-5
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Publication
4749457 | -
First Author: Dupre J
Year: 1973
Journal: J Clin Endocrinol Metab
Title: Stimulation of insulin secretion by gastric inhibitory polypeptide in man.
Volume: 37
Issue: 5
Pages: 826-8
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Publication
627329 | -
First Author: Creutzfeldt W
Year: 1978
Journal: Diabetologia
Title: Gastric inhibitory polypeptide (GIP) and insulin in obesity: increased response to stimulation and defective feedback control of serum levels.
Volume: 14
Issue: 1
Pages: 15-24
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Publication
7045154 | -
First Author: Salera M
Year: 1982
Journal: J Clin Endocrinol Metab
Title: Gastric inhibitory polypeptide release after oral glucose: relationship to glucose intolerance, diabetes mellitus, and obesity.
Volume: 55
Issue: 2
Pages: 329-36
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Publication
24843641 | -
First Author: Seino Y
Year: 2013
Journal: J Diabetes Investig
Title: Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: Incretin actions beyond the pancreas.
Volume: 4
Issue: 2
Pages: 108-30
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Publication
17244606 | -
First Author: Kim SJ
Year: 2007
Journal: J Biol Chem
Title: Activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes. A role for a protein kinase B, LKB1, and AMP-activated protein kinase cascade.
Volume: 282
Issue: 12
Pages: 8557-67
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Publication
6359287 | -
First Author: Beck B
Year: 1983
Journal: Regul Pept
Title: Gastric inhibitory polypeptide enhancement of the insulin effect on fatty acid incorporation into adipose tissue in the rat.
Volume: 7
Issue: 1
Pages: 3-8
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Publication
25268051 | J:214658
First Author: Sommer CA
Year: 2014
Journal: Mol Endocrinol
Title: RNA-Seq analysis of enteroendocrine cells reveals a role for FABP5 in the control of GIP secretion.
Volume: 28
Issue: 11
Pages: 1855-65
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Publication
31509948 | J:292761
 
First Author: Lee E
Year: 2019
Journal: Int J Mol Sci
Title: Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms.
Volume: 20
Issue: 18
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Publication
28324023 | J:247106
First Author: Sankoda A
Year: 2017
Journal: Endocrinology
Title: Long-Chain Free Fatty Acid Receptor GPR120 Mediates Oil-Induced GIP Secretion Through CCK in Male Mice.
Volume: 158
Issue: 5
Pages: 1172-1180
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Publication
29723041 | J:272409
First Author: Ikeguchi E
Year: 2018
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Transcriptional factor Pdx1 is involved in age-related GIP hypersecretion in mice.
Volume: 315
Issue: 2
Pages: G272-G282
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Publication
26661062 | J:339901
First Author: Psichas A
Year: 2016
Journal: Br J Pharmacol
Title: Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells.
Volume: 173
Issue: 5
Pages: 888-98
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Publication
25537494 | J:219759
First Author: Chen S
Year: 2015
Journal: Am J Physiol Endocrinol Metab
Title: Increased GIP signaling induces adipose inflammation via a HIF-1α-dependent pathway and impairs insulin sensitivity in mice.
Volume: 308
Issue: 5
Pages: E414-25
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Publication
24927416 | J:218559
First Author: Moffett RC
Year: 2014
Journal: PLoS One
Title: Incretin receptor null mice reveal key role of GLP-1 but not GIP in pancreatic beta cell adaptation to pregnancy.
Volume: 9
Issue: 6
Pages: e96863
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Publication
30990747 | J:278442
First Author: Murata Y
Year: 2019
Journal: Am J Physiol Endocrinol Metab
Title: Medium-chain triglyceride diet stimulates less GIP secretion and suppresses body weight and fat mass gain compared with long-chain triglyceride diet.
Volume: 317
Issue: 1
Pages: E53-E64
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Publication
23099862 | J:208608
First Author: Fukami A
Year: 2013
Journal: Diabetes
Title: Ectopic expression of GIP in pancreatic β-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides.
Volume: 62
Issue: 2
Pages: 510-8
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Publication
8764827 | J:34800
First Author: Schieldrop PJ
Year: 1996
Journal: Biochim Biophys Acta
Title: Isolation of a murine glucose-dependent insulinotropic polypeptide (GIP) cDNA from a tumor cell line (STC6-14) and quantification of glucose-induced increases in GIP mRNA.
Volume: 1308
Issue: 2
Pages: 111-3
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Protein
Q3SXG6
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: false
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Protein
Q9CVF1
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: true
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Publication
22892131 | J:188136
First Author: Omar B
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes--a role for the transcription factor NFAT and phosphodiesterase 3B.
Volume: 425
Issue: 4
Pages: 812-7
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Publication
25535828 | J:221505
First Author: Iwasaki K
Year: 2015
Journal: Endocrinology
Title: Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion.
Volume: 156
Issue: 3
Pages: 837-46
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Publication
23192339 | J:193877
First Author: Suzuki K
Year: 2013
Journal: J Biol Chem
Title: Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity.
Volume: 288
Issue: 3
Pages: 1929-38
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GO Term
GO:0005095 | GTPase inhibitor activity
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Publication
16822587 | J:129288
First Author: Ding KH
Year: 2006
Journal: Peptides
Title: Effects of glucose-dependent insulinotropic peptide on behavior.
Volume: 27
Issue: 11
Pages: 2750-5
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Publication
9211887 | J:41729
First Author: Boylan MO
Year: 1997
Journal: J Biol Chem
Title: Cell-specific expression of the glucose-dependent insulinotropic polypeptide gene in a mouse neuroendocrine tumor cell line.
Volume: 272
Issue: 28
Pages: 17438-43
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Publication
10509810 | J:57512
First Author: Yeung CM
Year: 1999
Journal: Mol Cell Endocrinol
Title: Glucose-dependent insulinotropic polypeptide gene expression in the stomach: revealed by a transgenic mouse study, in situ hybridization and immunohistochemical staining.
Volume: 154
Issue: 1-2
Pages: 161-70
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Publication
17321229 | J:141669
First Author: Xie D
Year: 2007
Journal: Bone
Title: Glucose-dependent insulinotropic peptide-overexpressing transgenic mice have increased bone mass.
Volume: 40
Issue: 5
Pages: 1352-60
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CL Term
CL:0002278 | GIP cell
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Publication
12068290 | J:77483
First Author: Miyawaki K
Year: 2002
Journal: Nat Med
Title: Inhibition of gastric inhibitory polypeptide signaling prevents obesity.
Volume: 8
Issue: 7
Pages: 738-42
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Publication
20138041 | J:329319
First Author: Fujita Y
Year: 2010
Journal: Gastroenterology
Title: Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion.
Volume: 138
Issue: 5
Pages: 1966-75
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Publication
16105663 | J:100642
First Author: Zhou H
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action.
Volume: 335
Issue: 3
Pages: 937-42
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Publication
28250160 | J:247805
First Author: Mantelmacher FD
Year: 2017
Journal: J Immunol
Title: Glucose-Dependent Insulinotropic Polypeptide Receptor Deficiency Leads to Impaired Bone Marrow Hematopoiesis.
Volume: 198
Issue: 8
Pages: 3089-3098
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Publication
29406782 | J:262188
First Author: Maekawa R
Year: 2018
Journal: Am J Physiol Endocrinol Metab
Title: Glucose-dependent insulinotropic polypeptide is required for moderate high-fat diet- but not high-carbohydrate diet-induced weight gain.
Volume: 314
Issue: 6
Pages: E572-E583
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Publication
24072682 | J:210562
First Author: Coon SD
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Glucose-dependent insulinotropic polypeptide regulates dipeptide absorption in mouse jejunum.
Volume: 305
Issue: 10
Pages: G678-84
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Publication
15486225 | J:105459
First Author: Jepeal LI
Year: 2005
Journal: Endocrinology
Title: Cell-specific expression of glucose-dependent-insulinotropic polypeptide is regulated by the transcription factor PDX-1.
Volume: 146
Issue: 1
Pages: 383-91
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Publication
17681422 | J:145256
First Author: Cani PD
Year: 2007
Journal: Mol Cell Endocrinol
Title: GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion.
Volume: 276
Issue: 1-2
Pages: 18-23
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Publication
30862908 | J:275866
First Author: Girard R
Year: 2019
Journal: Sci Rep
Title: HNF4α is a novel regulator of intestinal glucose-dependent insulinotropic polypeptide.
Volume: 9
Issue: 1
Pages: 4200
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Publication
18420580 | J:138081
First Author: Althage MC
Year: 2008
Journal: J Biol Chem
Title: Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet.
Volume: 283
Issue: 26
Pages: 18365-76
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Publication
25930999 | J:228360
First Author: Ramesh N
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Nesfatin-1 stimulates glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide secretion from STC-1 cells in vitro.
Volume: 462
Issue: 2
Pages: 124-30
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Publication
16469773 | J:110067
First Author: Tsukiyama K
Year: 2006
Journal: Mol Endocrinol
Title: Gastric inhibitory polypeptide as an endogenous factor promoting new bone formation after food ingestion.
Volume: 20
Issue: 7
Pages: 1644-51
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Publication
16476726 | J:112681
First Author: Ugleholdt R
Year: 2006
Journal: J Biol Chem
Title: Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor.
Volume: 281
Issue: 16
Pages: 11050-7
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Publication
25979074 | J:247237
First Author: Brial F
Year: 2015
Journal: Diabetes
Title: Ghrelin Inhibition Restores Glucose Homeostasis in Hepatocyte Nuclear Factor-1α (MODY3)-Deficient Mice.
Volume: 64
Issue: 9
Pages: 3314-20
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Publication
33196462 | J:311843
First Author: Oduori OS
Year: 2020
Journal: J Clin Invest
Title: Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes.
Volume: 130
Issue: 12
Pages: 6639-6655
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Publication
9075801 | J:328576
First Author: Ding WG
Year: 1997
Journal: Diabetes
Title: Protein kinase A-dependent stimulation of exocytosis in mouse pancreatic beta-cells by glucose-dependent insulinotropic polypeptide.
Volume: 46
Issue: 4
Pages: 615-21
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Publication
25091498 | J:218472
First Author: García-Martínez JM
Year: 2014
Journal: Biochim Biophys Acta
Title: Insulin drives glucose-dependent insulinotropic peptide expression via glucose-dependent regulation of FoxO1 and LEF1/β-catenin.
Volume: 1839
Issue: 11
Pages: 1141-50
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Protein Coding Gene
MGP_CAROLIEiJ_G0017017 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018994 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018962 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018932 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018935 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018749 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_107504 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0019387 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018303 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0018720 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0018828 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0018817 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0018898 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0018844 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0019427 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018074 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0018352 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0018147 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0017863 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
26395740 | J:246932
First Author: Berglund LM
Year: 2016
Journal: Diabetes
Title: Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.
Volume: 65
Issue: 1
Pages: 239-54
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Publication
23027401 | J:191140
First Author: Grigoryan M
Year: 2012
Journal: Dev Dyn
Title: Phenotype of entero-endocrine L cells becomes restricted during development.
Volume: 241
Issue: 12
Pages: 1986-92
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Publication
21270265 | J:169398
First Author: Prasadan K
Year: 2011
Journal: Diabetes
Title: The expression and function of glucose-dependent insulinotropic polypeptide in the embryonic mouse pancreas.
Volume: 60
Issue: 2
Pages: 548-54
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GXD Expression
GXD Expression
     
Probe: MGI:5476542
Assay Type: RT-PCR
Annotation Date: 2013-04-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1636315
Stage: TS15
Assay Id: MGI:5476670
Age: embryonic day 9.5
Specimen Label: E9
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5476542
Assay Type: RT-PCR
Annotation Date: 2013-04-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1636316
Stage: TS16
Assay Id: MGI:5476670
Age: embryonic day 10.5
Specimen Label: 10
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5476542
Assay Type: RT-PCR
Annotation Date: 2013-04-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706619
Stage: TS19
Assay Id: MGI:5476670
Age: embryonic day 11.5
Specimen Label: 11
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5476542
Assay Type: RT-PCR
Annotation Date: 2013-04-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750320
Stage: TS20
Assay Id: MGI:5476670
Age: embryonic day 12.5
Specimen Label: 12
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:5476542
Assay Type: RT-PCR
Annotation Date: 2013-04-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750321
Stage: TS21
Assay Id: MGI:5476670
Age: embryonic day 13.5
Specimen Label: 13
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:5476542
Assay Type: RT-PCR
Annotation Date: 2013-04-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750323
Stage: TS23
Assay Id: MGI:5476670
Age: embryonic day 15.5
Specimen Label: 15
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:5476542
Assay Type: RT-PCR
Annotation Date: 2013-04-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750325
Stage: TS25
Assay Id: MGI:5476670
Age: embryonic day 17.5
Specimen Label: 17
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:5476542
Assay Type: RT-PCR
Annotation Date: 2013-04-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:5476670
Age: embryonic day 18.5
Specimen Label: 18
Detected: true
Specimen Num: 8
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•
•
GXD Expression
GXD Expression
     
Probe: MGI:5476542
Assay Type: RT-PCR
Annotation Date: 2013-04-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750327
Stage: TS27
Assay Id: MGI:5476670
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5476542
Assay Type: RT-PCR
Annotation Date: 2013-04-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1636315
Stage: TS15
Assay Id: MGI:5476671
Age: embryonic day 9.5
Specimen Label: E9
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5476542
Assay Type: RT-PCR
Annotation Date: 2013-04-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1706619
Stage: TS19
Assay Id: MGI:5476671
Age: embryonic day 11.5
Specimen Label: 11
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5476542
Assay Type: RT-PCR
Annotation Date: 2013-04-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750321
Stage: TS21
Assay Id: MGI:5476671
Age: embryonic day 13.5
Specimen Label: 13
Detected: true
Specimen Num: 3
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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