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Search results 1 to 100 out of 167 for Gja8

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Xia CH
Year: 2012
Journal: PLoS One
Title: Cataracts and microphthalmia caused by a Gja8 mutation in extracellular loop 2.
Volume: 7
Issue: 12
Pages: e52894
Publication
First Author: Rong P
Year: 2002
Journal: Development
Title: Disruption of Gja8 (alpha8 connexin) in mice leads to microphthalmia associated with retardation of lens growth and lens fiber maturation.
Volume: 129
Issue: 1
Pages: 167-74
Publication
First Author: Chang B
Year: 2002
Journal: Hum Mol Genet
Title: A Gja8 (Cx50) point mutation causes an alteration of alpha 3 connexin (Cx46) in semi-dominant cataracts of Lop10 mice.
Volume: 11
Issue: 5
Pages: 507-13
Publication
First Author: Bakthavachalu B
Year: 2010
Journal: J Genet
Title: Dense cataract and microphthalmia (dcm) in BALB/c mice is caused by mutations in the GJA8 locus.
Volume: 89
Issue: 2
Pages: 147-54
Publication
First Author: Kerscher S
Year: 1995
Journal: Genomics
Title: Mapping of four mouse genes encoding eye lens-specific structural, gap junction, and integral membrane proteins: Cryba1 (crystallin beta A3/A1), Crybb2 (crystallin beta B2), Gja8 (MP70), and Lim2 (MP19).
Volume: 29
Issue: 2
Pages: 445-50
Publication
First Author: Zhou Y
Year: 2023
Journal: FASEB J
Title: Charged multivesicular body protein 4b forms complexes with gap junction proteins during lens fiber cell differentiation.
Volume: 37
Issue: 4
Pages: e22801
Publication
First Author: Tjahjono N
Year: 2020
Journal: Invest Ophthalmol Vis Sci
Title: Connexin 50-R205G Mutation Perturbs Lens Epithelial Cell Proliferation and Differentiation.
Volume: 61
Issue: 3
Pages: 25
Publication
First Author: Pelletier RM
Year: 2015
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Complementary expression and phosphorylation of Cx46 and Cx50 during development and following gene deletion in mouse and in normal and orchitic mink testes.
Volume: 309
Issue: 3
Pages: R255-76
Publication
First Author: Xia CH
Year: 2006
Journal: Exp Eye Res
Title: Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cells.
Volume: 83
Issue: 3
Pages: 688-96
Publication
First Author: Graw J
Year: 2001
Journal: Exp Eye Res
Title: Characterization of a mutation in the lens-specific MP70 encoding gene of the mouse leading to a dominant cataract.
Volume: 73
Issue: 6
Pages: 867-76
Publication
First Author: Cheng C
Year: 2008
Journal: Exp Eye Res
Title: Gap junction communication influences intercellular protein distribution in the lens.
Volume: 86
Issue: 6
Pages: 966-74
Publication
First Author: Steele EC Jr
Year: 1998
Journal: Curr Eye Res
Title: A mutation in the connexin 50 (Cx50) gene is a candidate for the No2 mouse cataract.
Volume: 17
Issue: 9
Pages: 883-9
Publication
First Author: Xia CH
Year: 2006
Journal: Development
Title: Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis.
Volume: 133
Issue: 10
Pages: 2033-40
Publication      
First Author: Vetrivel S
Year: 2019
Journal: Exp Eye Res
Title: Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: White TW
Year: 1992
Journal: Mol Biol Cell
Title: Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70.
Volume: 3
Issue: 7
Pages: 711-20
Publication
First Author: Baldo GJ
Year: 2001
Journal: J Gen Physiol
Title: Gap junctional coupling in lenses from alpha(8) connexin knockout mice.
Volume: 118
Issue: 5
Pages: 447-56
Publication
First Author: White TW
Year: 1998
Journal: J Cell Biol
Title: Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts.
Volume: 143
Issue: 3
Pages: 815-25
Publication
First Author: Sellitto C
Year: 2004
Journal: Invest Ophthalmol Vis Sci
Title: Connexin50 is essential for normal postnatal lens cell proliferation.
Volume: 45
Issue: 9
Pages: 3196-202
Publication
First Author: Gerido DA
Year: 2003
Journal: Invest Ophthalmol Vis Sci
Title: Genetic background influences cataractogenesis, but not lens growth deficiency, in Cx50-knockout mice.
Volume: 44
Issue: 6
Pages: 2669-74
Publication
First Author: Runge PE
Year: 1992
Journal: Invest Ophthalmol Vis Sci
Title: Autosomal dominant mouse cataract (Lop-10). Consistent differences of expression in heterozygotes.
Volume: 33
Issue: 11
Pages: 3202-8
Publication  
First Author: Alapure BV
Year: 2012
Journal: Exp Eye Res
Title: The unfolded protein response is activated in connexin 50 mutant mouse lenses.
Volume: 102
Pages: 28-37
Publication    
First Author: Steele EC
Year: 1998
Journal: Gap Junctions
Title: Identification of a mutation in the connexin 50 (Cx50) gene of the No2 cataractous mouse mutant.
Pages: 289-293
Publication
First Author: DeRosa AM
Year: 2007
Journal: J Cell Sci
Title: The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins.
Volume: 120
Issue: Pt 23
Pages: 4107-16
Publication      
First Author: Xia CH
Year: 2008
Journal: MGI Direct Data Submission
Title: Diverse gap junctions modulate distinct mechamisms for fiber cell formation during lens development and cataractogenesis
Publication
First Author: Kohale K
Year: 2004
Journal: Comp Med
Title: Dense cataract and microphthalmia--new spontaneous mutation in BALB/c mice.
Volume: 54
Issue: 3
Pages: 275-9
Publication
First Author: White TW
Year: 2007
Journal: Invest Ophthalmol Vis Sci
Title: Optimal lens epithelial cell proliferation is dependent on the connexin isoform providing gap junctional coupling.
Volume: 48
Issue: 12
Pages: 5630-7
Publication
First Author: Martinez-Wittinghan FJ
Year: 2004
Journal: Invest Ophthalmol Vis Sci
Title: Lens gap junctional coupling is modulated by connexin identity and the locus of gene expression.
Volume: 45
Issue: 10
Pages: 3629-37
Publication
First Author: Berthoud VM
Year: 2019
Journal: Invest Ophthalmol Vis Sci
Title: The Connexin50D47A Mutant Causes Cataracts by Calcium Precipitation.
Volume: 60
Issue: 6
Pages: 2336-2346
Publication
First Author: Berthoud VM
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: Connexin50D47A decreases levels of fiber cell connexins and impairs lens fiber cell differentiation.
Volume: 54
Issue: 12
Pages: 7614-22
Publication  
First Author: Jara O
Year: 2018
Journal: Exp Eye Res
Title: Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses.
Volume: 175
Pages: 192-198
Publication
First Author: Berthoud VM
Year: 2016
Journal: J Biol Chem
Title: The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses.
Volume: 291
Issue: 34
Pages: 17569-78
Publication
First Author: Evans CW
Year: 1993
Journal: Eur J Cell Biol
Title: Gap junction formation during development of the mouse lens.
Volume: 60
Issue: 2
Pages: 243-9
Publication
First Author: Xu X
Year: 1999
Journal: Invest Ophthalmol Vis Sci
Title: Characterization of a mouse Cx50 mutation associated with the No2 mouse cataract.
Volume: 40
Issue: 8
Pages: 1844-50
Publication
First Author: Yamashita S
Year: 2002
Journal: Invest Ophthalmol Vis Sci
Title: Mapping of A gene responsible for cataract formation and its modifier in the UPL rat.
Volume: 43
Issue: 10
Pages: 3153-9
Publication
First Author: DeRosa AM
Year: 2006
Journal: Invest Ophthalmol Vis Sci
Title: Functional characterization of a naturally occurring Cx50 truncation.
Volume: 47
Issue: 10
Pages: 4474-81
Publication
First Author: Chung J
Year: 2007
Journal: Exp Eye Res
Title: Transgenic overexpression of connexin50 induces cataracts.
Volume: 84
Issue: 3
Pages: 513-28
Publication
First Author: Tong X
Year: 2014
Journal: J Physiol
Title: Charge at the 46th residue of connexin 50 is crucial for the gap-junctional unitary conductance and transjunctional voltage-dependent gating.
Volume: 592
Issue: 23
Pages: 5187-202
GXD Expression      
Probe: MGI:3656071
Assay Type: RT-PCR
Annotation Date: 2006-09-29
Strength: Absent
Sex: Male
Emaps: EMAPS:1797225
Stage: TS25
Assay Id: MGI:3656212
Age: embryonic day 17.5
Specimen Label: -/-
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:3656071
Assay Type: RT-PCR
Annotation Date: 2006-09-29
Strength: Absent
Sex: Male
Emaps: EMAPS:1797225
Stage: TS25
Assay Id: MGI:3656212
Age: embryonic day 17.5
Specimen Label: +/-
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3656071
Assay Type: RT-PCR
Annotation Date: 2006-09-29
Strength: Absent
Sex: Male
Emaps: EMAPS:1797225
Stage: TS25
Assay Id: MGI:3656212
Age: embryonic day 17.5
Specimen Label: +/+
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:3656071
Assay Type: RT-PCR
Annotation Date: 2006-09-29
Strength: Absent
Sex: Female
Emaps: EMAPS:1796225
Stage: TS25
Assay Id: MGI:3656231
Age: embryonic day 17.5
Specimen Label: -/-
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:3656071
Assay Type: RT-PCR
Annotation Date: 2006-09-29
Strength: Absent
Sex: Female
Emaps: EMAPS:1796225
Stage: TS25
Assay Id: MGI:3656231
Age: embryonic day 17.5
Specimen Label: +/-
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3656071
Assay Type: RT-PCR
Annotation Date: 2006-09-29
Strength: Absent
Sex: Female
Emaps: EMAPS:1796225
Stage: TS25
Assay Id: MGI:3656231
Age: embryonic day 17.5
Specimen Label: +/+
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:3656071
Assay Type: RT-PCR
Annotation Date: 2015-05-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1770127
Stage: TS27
Assay Id: MGI:5635146
Age: postnatal day 0
Specimen Label: Cx50
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3656071
Assay Type: RT-PCR
Annotation Date: 2015-05-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:5635590
Age: embryonic day 3.5
Specimen Label: not shown
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6360891
Assay Type: RT-PCR
Annotation Date: 2019-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:6360894
Age: postnatal adult
Specimen Label: 3
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6360891
Assay Type: RT-PCR
Annotation Date: 2019-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:6360894
Age: embryonic day 9.0
Specimen Label: 4
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6360891
Assay Type: RT-PCR
Annotation Date: 2019-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603916
Stage: TS16
Assay Id: MGI:6360894
Age: embryonic day 10.0
Specimen Label: 5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6360891
Assay Type: RT-PCR
Annotation Date: 2019-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185818
Stage: TS18
Assay Id: MGI:6360894
Age: embryonic day 11.0
Specimen Label: 6
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6360891
Assay Type: RT-PCR
Annotation Date: 2019-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185820
Stage: TS20
Assay Id: MGI:6360894
Age: embryonic day 12.0
Specimen Label: 7
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:6360891
Assay Type: RT-PCR
Annotation Date: 2019-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:6360894
Age: embryonic day 13.0
Specimen Label: 8
Detected: true
Specimen Num: 8
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1619828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6693280
Age: postnatal adult
Image: MRC Harwell_219183
Specimen Label: MRC Harwell_219183
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4422391
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1783823
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4825058
Age: embryonic day 14.5
Image: euxassay_008373_01
Specimen Label: euxassay_008373_01
Detected: true
Specimen Num: 1
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:1706828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6693280
Age: postnatal adult
Image: MRC Harwell_219185
Specimen Label: MRC Harwell_219185
Specimen Num: 2
GXD Expression
Probe: MGI:7461839
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716319
Pattern: Widespread
Stage: TS19
Assay Id: MGI:7461916
Age: embryonic day 11.5
Image: 7 E11.5 C3H wild type
Note: Expressing covering entire lens vesicle.
Specimen Label: 7 E11.5 C3H wild type
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7461839
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716319
Stage: TS19
Assay Id: MGI:7461916
Age: embryonic day 11.5
Image: 7 E11.5 Aey69 mutant
Specimen Label: 7 E11.5 Aey69 mutant
Detected: false
Specimen Num: 2
GXD Expression
Probe: MGI:7461839
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716319
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:7461916
Age: embryonic day 11.5
Image: 7 E11.5 aphakia mutant
Note: Highly irregular expression restrictred to one part of lens vesicle.
Specimen Label: 7 E11.5 aphakia mutant
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:7461839
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716320
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7461916
Age: embryonic day 12.5
Image: 7 E12.5 C3H wild type
Note: Expression more restricted to region beneath future lens epithelial layer.
Specimen Label: 7 E12.5 C3H wild type
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7461839
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716320
Stage: TS20
Assay Id: MGI:7461916
Age: embryonic day 12.5
Image: 7 E12.5 Aey69 mutant
Specimen Label: 7 E12.5 Aey69 mutant
Detected: false
Specimen Num: 5
GXD Expression
Probe: MGI:7461839
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716320
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7461916
Age: embryonic day 12.5
Image: 7 E12.5 aphakia mutant
Note: Continued one-sided expression in disorganlized lens structure.
Specimen Label: 7 E12.5 aphakia mutant
Detected: true
Specimen Num: 6
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6693280
Age: postnatal adult
Image: MRC Harwell_219181
Specimen Label: MRC Harwell_219181
Detected: true
Specimen Num: 3
Publication
First Author: Delamere NA
Year: 2020
Journal: Invest Ophthalmol Vis Sci
Title: Signaling Between TRPV1/TRPV4 and Intracellular Hydrostatic Pressure in the Mouse Lens.
Volume: 61
Issue: 6
Pages: 58
Publication
First Author: Tong JJ
Year: 2019
Journal: Invest Ophthalmol Vis Sci
Title: Calcium-Activated Chloride Channels in Newly Differentiating Mouse Lens Fiber Cells and Their Role in Volume Regulation.
Volume: 60
Issue: 5
Pages: 1621-1629
Publication
First Author: Ebihara L
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Properties of connexin 46 hemichannels in dissociated lens fiber cells.
Volume: 52
Issue: 2
Pages: 882-9
Publication
First Author: Martinez-Wittinghan FJ
Year: 2003
Journal: J Cell Biol
Title: Dominant cataracts result from incongruous mixing of wild-type lens connexins.
Volume: 161
Issue: 5
Pages: 969-78
Publication
First Author: Ebihara L
Year: 2014
Journal: Am J Physiol Cell Physiol
Title: Cx46 hemichannels contribute to the sodium leak conductance in lens fiber cells.
Volume: 306
Issue: 5
Pages: C506-13
Publication
First Author: Baruch A
Year: 2001
Journal: J Biol Chem
Title: Defining a link between gap junction communication, proteolysis, and cataract formation.
Volume: 276
Issue: 31
Pages: 28999-9006
Publication
First Author: Xia CH
Year: 2006
Journal: J Cell Sci
Title: Knock-in of alpha3 connexin prevents severe cataracts caused by an alpha8 point mutation.
Volume: 119
Issue: Pt 10
Pages: 2138-44
Publication
First Author: White TW
Year: 2002
Journal: Science
Title: Unique and redundant connexin contributions to lens development.
Volume: 295
Issue: 5553
Pages: 319-20
Publication
First Author: Gao J
Year: 2004
Journal: J Gen Physiol
Title: Connections between connexins, calcium, and cataracts in the lens.
Volume: 124
Issue: 4
Pages: 289-300
Publication  
First Author: Li L
Year: 2010
Journal: PLoS One
Title: Connexin mediated cataract prevention in mice.
Volume: 5
Issue: 9
Publication  
First Author: Minogue PJ
Year: 2019
Journal: Mol Vis
Title: CHOP is dispensable for lens transparency in wild-type and connexin50 mutant mice.
Volume: 25
Pages: 535-545