Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
Homo sapiens |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
Rattus norvegicus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
Danio rerio |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
GLI3 is a member of the GLI family of transcription factors, which also includes GLI1 and GLI2. They are central effectors of the Hedgehog (Hh) pathway in vertebrates [, ]. GLI1 is an obligatory activator, whereas GLI2 and GLI3 carry activator and repressor functions []. The full-length GLI3 form, after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while its C-terminally truncated form acts as a repressor (GLI3R). GLI3 participates in the patterning and growth of many organs, including the central nervous system (CNS) and limbs [, , , , ]. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang B |
Year: |
2000 |
Journal: |
Cell |
Title: |
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. |
Volume: |
100 |
Issue: |
4 |
Pages: |
423-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang C |
Year: |
2007 |
Journal: |
Dev Biol |
Title: |
The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. |
Volume: |
305 |
Issue: |
2 |
Pages: |
460-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aoto K |
Year: |
2002 |
Journal: |
Dev Biol |
Title: |
Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud. |
Volume: |
251 |
Issue: |
2 |
Pages: |
320-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Persson M |
Year: |
2002 |
Journal: |
Genes Dev |
Title: |
Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. |
Volume: |
16 |
Issue: |
22 |
Pages: |
2865-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Humke EW |
Year: |
2010 |
Journal: |
Genes Dev |
Title: |
The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. |
Volume: |
24 |
Issue: |
7 |
Pages: |
670-82 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
1583
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
596
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
1583
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
1583
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Anwar S |
Year: |
2015 |
Journal: |
Dev Growth Differ |
Title: |
Identification and functional characterization of novel transcriptional enhancers involved in regulating human GLI3 expression during early development. |
Volume: |
57 |
Issue: |
8 |
Pages: |
570-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thien H |
Year: |
1996 |
Journal: |
Biochim Biophys Acta |
Title: |
Cloning and sequence analysis of the murine Gli3 cDNA. |
Volume: |
1307 |
Issue: |
3 |
Pages: |
267-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thien H |
Year: |
1999 |
Journal: |
Mamm Genome |
Title: |
The mouse mutation Pdn (Polydactyly Nagoya) is caused by the integration of a retrotransposon into the Gli3 gene. |
Volume: |
10 |
Issue: |
3 |
Pages: |
205-9 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
535
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Hui CC |
Year: |
2011 |
Journal: |
Annu Rev Cell Dev Biol |
Title: |
Gli proteins in development and disease. |
Volume: |
27 |
|
Pages: |
513-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen V |
Year: |
2005 |
Journal: |
Development |
Title: |
Cooperative requirement of the Gli proteins in neurogenesis. |
Volume: |
132 |
Issue: |
14 |
Pages: |
3267-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pohl TM |
Year: |
1990 |
Journal: |
Development |
Title: |
Evidence for allelism of the recessive insertional mutation add and the dominant mouse mutation extra-toes (Xt). |
Volume: |
110 |
Issue: |
4 |
Pages: |
1153-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Renault MA |
Year: |
2009 |
Journal: |
Circ Res |
Title: |
The Hedgehog transcription factor Gli3 modulates angiogenesis. |
Volume: |
105 |
Issue: |
8 |
Pages: |
818-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Büscher D |
Year: |
1998 |
Journal: |
Mamm Genome |
Title: |
The XtJ allele generates a Gli3 fusion transcript. |
Volume: |
9 |
Issue: |
8 |
Pages: |
676-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Genestine M |
Year: |
2007 |
Journal: |
Genesis |
Title: |
High-resolution mapping of the Gli3 deletion in the mouse extra-toesH mutant. |
Volume: |
45 |
Issue: |
3 |
Pages: |
107-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schimmang T |
Year: |
1993 |
Journal: |
Prog Clin Biol Res |
Title: |
Gli3 expression is affected in the morphogenetic mouse mutants add and Xt. |
Volume: |
383A |
|
Pages: |
153-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hager-Theodorides AL |
Year: |
2005 |
Journal: |
Blood |
Title: |
The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes. |
Volume: |
106 |
Issue: |
4 |
Pages: |
1296-304 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zaki PA |
Year: |
2005 |
Journal: |
Eur J Neurosci |
Title: |
Loss of Gli3 enhances the viability of embryonic telencephalic cells in vitro. |
Volume: |
22 |
Issue: |
6 |
Pages: |
1547-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schimmang T |
Year: |
1992 |
Journal: |
Development |
Title: |
Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt). |
Volume: |
116 |
Issue: |
3 |
Pages: |
799-804 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martin B |
Year: |
2007 |
Journal: |
ScientificWorldJournal |
Title: |
Involvement of the Gli3 (extra-toes) gene region in body weight in mice. |
Volume: |
7 |
|
Pages: |
83-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ulloa F |
Year: |
2007 |
Journal: |
Curr Biol |
Title: |
Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling. |
Volume: |
17 |
Issue: |
6 |
Pages: |
545-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maynard TM |
Year: |
2002 |
Journal: |
Mamm Genome |
Title: |
High-resolution mapping of the Gli3 mutation extra-toes reveals a 51.5-kb deletion. |
Volume: |
13 |
Issue: |
1 |
Pages: |
58-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang S |
Year: |
1997 |
Journal: |
Nat Genet |
Title: |
GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome. |
Volume: |
15 |
Issue: |
3 |
Pages: |
266-8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271120 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex. |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex. |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271124 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex. |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271220 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271222 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271224 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex. |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754320 |
Pattern: |
Scattered |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
There is moderate, scattered staining in the ventricular zone of the dorsal thalamus and prethalamus. |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754322 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
There is moderate staining in the ventricular zone of the prethalamus. Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus. |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754324 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
There is moderate staining in the ventricular zone of the prethalamus. Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus. |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753720 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs. |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs. |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753724 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, SCH, DMH, VMH and ARH nuclei, the AVH, the DAH and the PH. |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691319 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 11.5 |
Image: |
Gli3 - E11.5 |
Note: |
There is very strong staining in the ventricular zone of the cerebral cortex and the ganglionic eminences. |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271820 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the premam, mam and supramam zones and the TT. |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271822 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the premam, mam and supramam zones and the TT. |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271824 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the premam, mam and supramam zones. |
|
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1690819 |
Pattern: |
Non-Uniform |
Stage: |
TS19 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 11.5 |
Image: |
Gli3 - E11.5 |
Note: |
Staining is strong in the VZ of premam zone & TT, moderate in dorsal thalamus & prethalamus, weak & scattered in dorsal & ventral POAs & PVH nucleus & either absent or ubiquitous in AVH, anterior & posterior IDs, VMH & ARH nuclei & mam & supramam zones. |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753920 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
There is moderate, scattered staining in the VZ of the dorsal and ventral POAs and the PVH nucleus and weak staining in the AVH. Staining is either absent or ubiquitous in the VZ of the anterior and posterior IDs and the VMH and ARH nuclei. |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753922 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
There is weak staining in the ventricular zone of the dorsal POA. Staining is either absent or ubiquitous in the ventricular zone of the ventral POA, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs. |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753924 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
There is moderate staining in the VZ of the ARH nucleus and weak staining in the dorsal and ventral POAs, the PVH nucleus and the AVH. Staining is either absent or ubiquitous in the VZ of the DAH, the SCH, DMH and VMH nuclei and the PH. |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691119 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 11.5 |
Image: |
Gli3 - E11.5 |
Note: |
Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone and cortical plate of the cerebral cortex and in the mantle zone of the ganglionic eminences. |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754720 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
There is strong staining in the ventricular zone of the cerebral cortex. |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
There is very strong staining in the ventricular zone of the cerebral cortex. |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754724 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
There is very strong staining in the ventricular zone of the cerebral cortex. |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271020 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
There is strong staining in the ventricular zone of the premam zone. Staining is either absent or ubiquitous in the ventricular zone of the mam and supramam zones and the TT. |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271022 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
There is strong staining in the ventricular zone of the premam zone. Staining is either absent or ubiquitous in the ventricular zone of the mam and supramam zones and the TT. |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271024 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
There is very strong staining in the ventricular zone of the premam zone. Staining is either absent or ubiquitous in the ventricular zone of the mam and supramam zones. |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266520 |
Pattern: |
Non-Uniform |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
There is strong staining in the ventricular zone of the ganglionic eminences. Staining is either absent or ubiquitous in the mantle zone of the ganglionic eminences. |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266522 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
Staining is either absent or ubiquitous in the ventricular and mantle zones of the ganglionic eminences. |
|
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Very strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3266524 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
There is very strong staining in the ventricular zone of the ganglionic eminences. Staining is either absent or ubiquitous in the mantle zone of the ganglionic eminences. |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1690619 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 11.5 |
Image: |
Gli3 - E11.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus, prethalamus, dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH, the anterior and posterior IDs, the premam, mam and supramam zones and the TT. |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754120 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 12.5 |
Image: |
Gli3 - E12.5 |
Note: |
Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus and prethalamus. |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754122 |
Pattern: |
Non-Uniform |
Stage: |
TS22 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 14.5 |
Image: |
Gli3 - E14.5 |
Note: |
There is strong staining in the mantle zone of the dorsal thalamus. Staining is either absent or ubiquitous in the mantle zone of the prethalamus. |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4442661 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-05-13 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754124 |
Pattern: |
Non-Uniform |
Stage: |
TS24 |
Assay Id: |
MGI:4450864 |
Age: |
embryonic day 16.5 |
Image: |
Gli3 - E16.5 |
Note: |
There is strong staining in the mantle zone of the dorsal thalamus. Staining is either absent or ubiquitous in the mantle zone of the prethalamus. |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vortkamp A |
Year: |
1992 |
Journal: |
Mamm Genome |
Title: |
Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra toes (Xt). |
Volume: |
3 |
Issue: |
8 |
Pages: |
461-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vortkamp A |
Year: |
1991 |
Journal: |
Nature |
Title: |
GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families. |
Volume: |
352 |
Issue: |
6335 |
Pages: |
539-40 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1320895 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-01-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1735519 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:1320904 |
Age: |
embryonic day 11.5 |
Image: |
1F |
Note: |
Expression of Gli3 was widespread. |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1320895 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-01-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1735919 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:1320904 |
Age: |
embryonic day 11.5 |
Image: |
1F |
Note: |
Expression of Gli3 was widespread. |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohba S |
Year: |
2008 |
Journal: |
Dev Cell |
Title: |
Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity. |
Volume: |
14 |
Issue: |
5 |
Pages: |
689-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hager-Theodorides AL |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms. |
Volume: |
183 |
Issue: |
5 |
Pages: |
3023-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ruppert JM |
Year: |
1990 |
Journal: |
Mol Cell Biol |
Title: |
GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. |
Volume: |
10 |
Issue: |
10 |
Pages: |
5408-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Panman L |
Year: |
2005 |
Journal: |
Int J Dev Biol |
Title: |
Genetic interaction of Gli3 and Alx4 during limb development. |
Volume: |
49 |
Issue: |
4 |
Pages: |
443-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hyun J |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression. |
Volume: |
7 |
|
Pages: |
10993 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ueta E |
Year: |
2002 |
Journal: |
Congenit Anom (Kyoto) |
Title: |
Integration of a transposon into the Gli3 gene in the Pdn mouse. |
Volume: |
42 |
Issue: |
4 |
Pages: |
318-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ueta E |
Year: |
2004 |
Journal: |
Congenit Anom (Kyoto) |
Title: |
Sonic hedgehog expression in Gli3 depressed mouse embryo, Pdn/Pdn. |
Volume: |
44 |
Issue: |
1 |
Pages: |
27-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abbasi AA |
Year: |
2010 |
Journal: |
BMC Dev Biol |
Title: |
Human intronic enhancers control distinct sub-domains of Gli3 expression during mouse CNS and limb development. |
Volume: |
10 |
|
Pages: |
44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamada Y |
Year: |
2020 |
Journal: |
Neuroscience |
Title: |
Gli3 is a Key Factor in the Schwann Cells from Both Intact and Injured Peripheral Nerves. |
Volume: |
432 |
|
Pages: |
229-239 |
|
•
•
•
•
•
|
Publication |
First Author: |
Solanki A |
Year: |
2018 |
Journal: |
Development |
Title: |
Gli3 in fetal thymic epithelial cells promotes thymocyte positive selection and differentiation by repression of Shh. |
Volume: |
145 |
Issue: |
3 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hui CC |
Year: |
1993 |
Journal: |
Nat Genet |
Title: |
A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. |
Volume: |
3 |
Issue: |
3 |
Pages: |
241-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Veistinen L |
Year: |
2012 |
Journal: |
Front Physiol |
Title: |
Loss-of-Function of Gli3 in Mice Causes Abnormal Frontal Bone Morphology and Premature Synostosis of the Interfrontal Suture. |
Volume: |
3 |
|
Pages: |
121 |
|
•
•
•
•
•
|
Publication |
First Author: |
Renault MA |
Year: |
2013 |
Journal: |
Circ Res |
Title: |
Gli3 regulation of myogenesis is necessary for ischemia-induced angiogenesis. |
Volume: |
113 |
Issue: |
10 |
Pages: |
1148-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Balmer CW |
Year: |
2004 |
Journal: |
J Comp Neurol |
Title: |
Loss of Gli3 and Shh function disrupts olfactory axon trajectories. |
Volume: |
472 |
Issue: |
3 |
Pages: |
292-307 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim JH |
Year: |
2005 |
Journal: |
Dev Dyn |
Title: |
Gli3 null mice display glandular overgrowth of the developing stomach. |
Volume: |
234 |
Issue: |
4 |
Pages: |
984-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Quinn ME |
Year: |
2012 |
Journal: |
Hum Mol Genet |
Title: |
Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice. |
Volume: |
21 |
Issue: |
8 |
Pages: |
1888-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rachel RA |
Year: |
2002 |
Journal: |
Genesis |
Title: |
A new allele of Gli3 and a new mutation, circletail (Crc), resulting from a single transgenic experiment. |
Volume: |
33 |
Issue: |
2 |
Pages: |
55-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Büscher D |
Year: |
1997 |
Journal: |
Mech Dev |
Title: |
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. |
Volume: |
62 |
Issue: |
2 |
Pages: |
175-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Motoyama J |
Year: |
1998 |
Journal: |
Nat Genet |
Title: |
Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. |
Volume: |
20 |
Issue: |
1 |
Pages: |
54-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wuelling M |
Year: |
2020 |
Journal: |
Dev Biol |
Title: |
Wnt5a is a transcriptional target of Gli3 and Trps1 at the onset of chondrocyte hypertrophy. |
Volume: |
457 |
Issue: |
1 |
Pages: |
104-118 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deimling SJ |
Year: |
2018 |
Journal: |
Mech Dev |
Title: |
Genetic interaction between Gli3 and Ezh2 during limb pattern formation. |
Volume: |
151 |
|
Pages: |
30-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wiegering A |
Year: |
2019 |
Journal: |
Dev Biol |
Title: |
GLI3 repressor but not GLI3 activator is essential for mouse eye patterning and morphogenesis. |
Volume: |
450 |
Issue: |
2 |
Pages: |
141-154 |
|
•
•
•
•
•
|
Publication |
First Author: |
Buttitta L |
Year: |
2003 |
Journal: |
Development |
Title: |
Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. |
Volume: |
130 |
Issue: |
25 |
Pages: |
6233-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hardcastle Z |
Year: |
1998 |
Journal: |
Development |
Title: |
The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. |
Volume: |
125 |
Issue: |
15 |
Pages: |
2803-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tan M |
Year: |
2006 |
Journal: |
Brain Res |
Title: |
Gli3 mutation rescues the generation, but not the differentiation, of oligodendrocytes in Shh mutants. |
Volume: |
1067 |
Issue: |
1 |
Pages: |
158-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Naruse I |
Year: |
2001 |
Journal: |
Congenit Anom (Kyoto) |
Title: |
Phenotypic differences in the brains and limbs of mutant mice caused by differences of Gli3 gene expression levels |
Volume: |
41 |
|
Pages: |
89-94 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:12281 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-01-18 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1742820 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:1327347 |
Age: |
embryonic day 12.5 |
Image: |
12.5 p.c. embryo |
Note: |
Gli3 is expressed at a higher level in the autopods. |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:12281 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-01-18 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1745920 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:1327347 |
Age: |
embryonic day 12.5 |
Image: |
12.5 p.c. embryo |
Note: |
Gli3 is expressed at a higher level in the autopods. |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:12281 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-01-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1745920 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:1327347 |
Age: |
embryonic day 12.5 |
Image: |
12.5 p.c. fore limb |
Note: |
Gli3 is expressed at higher levels in the autopods. |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:12281 |
Assay Type: |
RNA in situ |
Annotation Date: |
1999-01-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1741220 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:1327347 |
Age: |
embryonic day 12.5 |
Image: |
12.5 p.c. fore limb |
Note: |
Gli3 is expressed in the mesenchyme surrounding the condensing mesenchyme. |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|