|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 102 for Gp2

<< First    < Previous  |  Next >    Last >>
0.02s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Iwasaki M
Year: 2016
Journal: J Virol
Title: Residues K465 and G467 within the Cytoplasmic Domain of GP2 Play a Critical Role in the Persistence of Lymphocytic Choriomeningitis Virus in Mice.
Volume: 90
Issue: 22
Pages: 10102-10112
Publication
First Author: Yu S
Year: 2004
Journal: J Biol Chem
Title: Absence of the major zymogen granule membrane protein, GP2, does not affect pancreatic morphology or secretion.
Volume: 279
Issue: 48
Pages: 50274-9
Publication
First Author: Hase K
Year: 2009
Journal: Nature
Title: Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.
Volume: 462
Issue: 7270
Pages: 226-30
Publication
First Author: Kobayashi K
Year: 2004
Journal: Biochem Biophys Res Commun
Title: GP2/THP gene family of self-binding, GPI-anchored proteins forms a cluster at chromosome 7F1 region in mouse genome.
Volume: 322
Issue: 2
Pages: 659-64
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: de Lau W
Year: 2012
Journal: Mol Cell Biol
Title: Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts".
Volume: 32
Issue: 18
Pages: 3639-47
Publication
First Author: Kanaya T
Year: 2012
Journal: Nat Immunol
Title: The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells.
Volume: 13
Issue: 8
Pages: 729-36
Publication      
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
UniProt Feature  
Begin: 22
Description: Pancreatic secretory granule membrane major glycoprotein GP2
Type: chain
Publication
First Author: Learmonth GS
Year: 2002
Journal: Arch Virol
Title: The C-terminal regions of the envelope glycoprotein gp2 of equine herpesviruses 1 and 4 are antigenically distinct.
Volume: 147
Issue: 3
Pages: 607-15
Protein
Organism: Mus musculus
Length: 531  
Fragment?: false
Protein
Organism: Mus musculus
Length: 534  
Fragment?: false
Protein
Organism: Mus musculus
Length: 556  
Fragment?: false
Publication
First Author: Bae B
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of σ70 domain 1.1.
Volume: 110
Issue: 49
Pages: 19772-7
Publication
First Author: Cámara B
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: T7 phage protein Gp2 inhibits the Escherichia coli RNA polymerase by antagonizing stable DNA strand separation near the transcription start site.
Volume: 107
Issue: 5
Pages: 2247-52
Protein Domain
Type: Family
Description: This entry consists of a number of glycoprotein Gp2 sequences mainly found from equine herpesviruses [].
Publication
First Author: Roy A
Year: 2012
Journal: Structure
Title: Small terminase couples viral DNA binding to genome-packaging ATPase activity.
Volume: 20
Issue: 8
Pages: 1403-13
Protein Domain
Type: Domain
Description: This entry represents a protein region that is cleaved from a bunyavirus polyprotein to become the nonstructural protein NSm (encoded by the M segment). This region is flanked by glycoprotein GP2 and glycoprotein GP1.
Protein Domain
Type: Family
Description: DNA-packaging protein gp3 (terminase small subunit) is involved in DNA packing in bacteriophage. It contains a channel where DNA is bound and passed to DNA-packaging protein gp2 (terminase large subunit) [].
Protein Domain
Type: Domain
Description: Initiation of packaging of double-stranded viral DNA involves the specific interaction of the prohead with viral DNA in a process mediated by a phage-encoded terminase protein. The terminase enzymes are usually hetero-oligomers composed of a small and a large subunit [, ]. This entry represents the C-terminal domain of the large subunit.Proteins containing this domain include gp2 from Bacillus phage SPP1 [, ].
Publication
First Author: Gual A
Year: 2000
Journal: J Biol Chem
Title: Functional analysis of the terminase large subunit, G2P, of Bacillus subtilis bacteriophage SPP1.
Volume: 275
Issue: 45
Pages: 35311-9
Publication
First Author: Chai S
Year: 1992
Journal: J Mol Biol
Title: Molecular analysis of the Bacillus subtilis bacteriophage SPP1 region encompassing genes 1 to 6. The products of gene 1 and gene 2 are required for pac cleavage.
Volume: 224
Issue: 1
Pages: 87-102
Publication
First Author: Camacho AG
Year: 2003
Journal: J Biol Chem
Title: Bacillus subtilis bacteriophage SPP1 DNA packaging motor requires terminase and portal proteins.
Volume: 278
Issue: 26
Pages: 23251-9
Protein Domain
Type: Family
Description: This entry represents RNA polymerase inhibitor, including Gp2 from T7-like viruses. Bacterial RNA polymerase inhibitor, which is expressed in the late stage of lytic development, is also essential for continuous synthesis of phage DNA and functions in the packaging of the viral genome into the mature phage particle []. It inhibits the bacterial host RNA polymerase by interacting with the RpoC subunit and inhibiting the formation of a promoter complex [, ].
Protein Domain
Type: Family
Description: The class F scavenger receptor 1 (SCARF1/SREC-I) contains epidermal growth factor (EGF)-like repeats in its extracellular domain, followed by a long C-terminal cytoplasmic tail composed of serine and proline-rich regions. SCARF1 is an endocytic receptor for acetylated low density lipoprotein, HSP70, HSP90, calreticulin, gp96, and GP2 [, , , , ]. Dendritic cells (DCs), macrophages and endothelial cells use SCARF1 to recognize and engulf apoptotic cells via the complement component C1q; this mediates apoptotic cells clearance, antigen clearance and prevents autoimmunity [].
Publication
First Author: Kimura S
Year: 2019
Journal: J Exp Med
Title: Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice.
Volume: 216
Issue: 4
Pages: 831-846
Protein Domain
Type: Domain
Description: This entry represents the N-terminal domain of the large subunit of the terminase protein.Initiation of packaging of double-stranded viral DNA involves the specific interaction of the prohead with viral DNA in a process mediated by a phage-encoded terminase protein. The terminase enzymes are usually hetero-oligomers composed of a small and a large subunit. This region possess an endonuclease and ATPase activity that require Mg2+ and a neutral or slightly basic reaction. This region is also found in bacterial sequences [, ].Proteins containing this domain include gp2 from Bacillus phage SPP1 [, ].
Publication
First Author: Hesselbach BA
Year: 1977
Journal: J Virol
Title: I protein: bacteriophage T7-coded inhibitor of Escherichia coli RNA polymerase.
Volume: 24
Issue: 3
Pages: 746-60
Publication
First Author: Tamura Y
Year: 2004
Journal: J Biol Chem
Title: Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide.
Volume: 279
Issue: 30
Pages: 30938-44
Publication
First Author: Murshid A
Year: 2010
Journal: J Immunol
Title: Heat shock protein 90 mediates efficient antigen cross presentation through the scavenger receptor expressed by endothelial cells-I.
Volume: 185
Issue: 5
Pages: 2903-17
Publication
First Author: Hölzl MA
Year: 2011
Journal: Cell Immunol
Title: The zymogen granule protein 2 (GP2) binds to scavenger receptor expressed on endothelial cells I (SREC-I).
Volume: 267
Issue: 2
Pages: 88-93
Publication
First Author: Berwin B
Year: 2004
Journal: J Biol Chem
Title: SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin.
Volume: 279
Issue: 49
Pages: 51250-7
Publication
First Author: Ramirez-Ortiz ZG
Year: 2013
Journal: Nat Immunol
Title: The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity.
Volume: 14
Issue: 9
Pages: 917-26
Publication
First Author: Murshid A
Year: 2014
Journal: Immunobiology
Title: Hsp90-peptide complexes stimulate antigen presentation through the class II pathway after binding scavenger receptor SREC-I.
Volume: 219
Issue: 12
Pages: 924-31
Protein Domain
Type: Homologous_superfamily
Description: This entry represents RNA polymerase inhibitor, including Gp2 from T7-like viruses. Bacterial RNA polymerase inhibitor, which is expressed in the late stage of lytic development, is also essential for continuous synthesis of phage DNA and functions in the packaging of the viral genome into the mature phage particle []. It inhibits the bacterial host RNA polymerase by interacting with the RpoC subunit and inhibiting the formation of a promoter complex [, ].Gp2 folds into a compact globular domain consisting of a three-stranded beta sheet that packs against an alpha-helix with a beta1beta2alpha1beta3 topology. The central beta2 strand is flanked by antiparallel beta1 and beta3 strands. Positive and negative charges are at opposite sides on the surface of the molecule. Two conserved arginine residues located on one side are important for binding to and inhibition of host RNA polymerase [].
Publication
First Author: Gall VA
Year: 2017
Journal: Cancer Res
Title: Trastuzumab Increases HER2 Uptake and Cross-Presentation by Dendritic Cells.
Volume: 77
Issue: 19
Pages: 5374-5383
Publication
First Author: Côté M
Year: 2011
Journal: Nature
Title: Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection.
Volume: 477
Issue: 7364
Pages: 344-8
Publication
First Author: Chandrakesan P
Year: 2014
Journal: Oncogene
Title: Utility of a bacterial infection model to study epithelial-mesenchymal transition, mesenchymal-epithelial transition or tumorigenesis.
Volume: 33
Issue: 20
Pages: 2639-54
Protein Domain
Type: Family
Description: The class F scavenger receptors (SCARFs or SRECs) have two isoforms, SCARF1/SREC-I and SCARF2/SREC-II. Similar to SREC-I, SREC-II contains multiple epidermal growth factor-like repeats in its extracellular domain. However, in contrast to SREC-I, SREC-II had little activity to internalize modified low density lipoproteins (LDL). SREC-II and SREC-I display strong heterophilic trans-interaction through the extracellular domains []. They are expressed in a specific temporal and spatial pattern during epidermal development [].Mutations in the SCARF2 gene cause Van den Ende-Gupta syndrome (VDEGS), a syndrome characterised by craniofacial and skeletal abnormalities []. The class F scavenger receptor 1 (SCARF1/SREC-I) contains epidermal growth factor (EGF)-like repeats in its extracellular domain, followed by a long C-terminal cytoplasmic tail composed of serine and proline-rich regions. SCARF1 is an endocytic receptor for acetylated low density lipoprotein, HSP70, HSP90, calreticulin, gp96, and GP2 [, , , , ]. Dendritic cells (DCs), macrophages and endothelial cells use SCARF1 to recognize and engulf apoptotic cells via the complement component C1q; this mediates apoptotic cells clearance, antigen clearance and prevents autoimmunity [].
Publication
First Author: Ishii J
Year: 2002
Journal: J Biol Chem
Title: SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain.
Volume: 277
Issue: 42
Pages: 39696-702
Publication
First Author: Will C
Year: 1993
Journal: J Virol
Title: Marburg virus gene 4 encodes the virion membrane protein, a type I transmembrane glycoprotein.
Volume: 67
Issue: 3
Pages: 1203-10
Publication
First Author: Shimojima M
Year: 2006
Journal: J Virol
Title: Tyro3 family-mediated cell entry of Ebola and Marburg viruses.
Volume: 80
Issue: 20
Pages: 10109-16
Publication
First Author: Marzi A
Year: 2006
Journal: J Virol
Title: The signal peptide of the ebolavirus glycoprotein influences interaction with the cellular lectins DC-SIGN and DC-SIGNR.
Volume: 80
Issue: 13
Pages: 6305-17
Publication
First Author: Ito H
Year: 2001
Journal: J Virol
Title: Ebola virus glycoprotein: proteolytic processing, acylation, cell tropism, and detection of neutralizing antibodies.
Volume: 75
Issue: 3
Pages: 1576-80
Publication
First Author: Sui J
Year: 2002
Journal: Virology
Title: Evidence against Ebola virus sGP binding to human neutrophils by a specific receptor.
Volume: 303
Issue: 1
Pages: 9-14
Publication
First Author: Wahl-Jensen VM
Year: 2005
Journal: J Virol
Title: Effects of Ebola virus glycoproteins on endothelial cell activation and barrier function.
Volume: 79
Issue: 16
Pages: 10442-50
Publication
First Author: Wahl-Jensen V
Year: 2005
Journal: J Virol
Title: Role of Ebola virus secreted glycoproteins and virus-like particles in activation of human macrophages.
Volume: 79
Issue: 4
Pages: 2413-9
Publication
First Author: Hwang M
Year: 2005
Journal: Gene Expr Patterns
Title: The temporal and spatial expression of the novel Ca++-binding proteins, Scarf and Scarf2, during development and epidermal differentiation.
Volume: 5
Issue: 6
Pages: 801-8
Publication
First Author: Anastasio N
Year: 2010
Journal: Am J Hum Genet
Title: Mutations in SCARF2 are responsible for Van Den Ende-Gupta syndrome.
Volume: 87
Issue: 4
Pages: 553-9
Protein Domain
Type: Family
Description: Proteins in this family include the envelope glycoprotein and the pre-small/secreted glycoprotein from Filoviridae []. The envelope glycoprotein can be cleaved into 3 chains: GP1, GP2 and GP2-delta.GP1 is responsible for binding to the receptor(s), such as CD209 and CLEC4M, on target cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by dendritic cells (DCs) and subsequent transmission to susceptible cells without DCs infection (trans infection) [].GP2 acts as a class I viral fusion protein. It is responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane []. GP1,2 peplomers mediates endothelial cell activation and decreases endothelial barrier function. It mediates activation of primary macrophages. At terminal stages of the viral infection, when its expression is high, GP1,2 down-modulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion [].GP2delta is part of the complex GP1,2delta released by host ADAM17 metalloprotease. This secreted complex may play a role in the pathogenesis of the virus by efficiently blocking the neutralizing antibodies that would otherwise neutralize the virus surface glycoproteins GP1,2. Might therefore contribute to the lack of inflammatory reaction seen during infection in spite the of extensive necrosis and massive virus production. GP1,2delta does not seem to be involved in activation of primary macrophage [].pre-small/secreted glycoprotein sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha. It might therefore contribute to the lack of inflammatory reaction seen during infection in spite the of extensive necrosis and massive virus production. It does not seem to be involved in activation of primary macrophages. It does not seem to interact specifically with neutrophils [, , , ].
Protein
Organism: Mus musculus
Length: 474  
Fragment?: false
Protein
Organism: Mus musculus
Length: 820  
Fragment?: false
Protein
Organism: Mus musculus
Length: 478  
Fragment?: false
Protein
Organism: Mus musculus
Length: 833  
Fragment?: false
Protein
Organism: Mus musculus
Length: 833  
Fragment?: false
Publication
First Author: Mural RJ
Year: 2002
Journal: Science
Title: A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
Volume: 296
Issue: 5573
Pages: 1661-71
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63