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Search results 1 to 100 out of 104 for Gp5

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Type Details Score
Gene
2814 | GP5
Type: gene
Organism: human
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Gene
741837 | GP5
Type: gene
Organism: chimpanzee
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Gene
522692 | GP5
Type: gene
Organism: cattle
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Gene
707776 | GP5
Type: gene
Organism: macaque, rhesus
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Gene
116411101 | gp5
Type: gene
Organism: frog, western clawed
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Gene
124417079 | GP5
Type: gene
Organism: chicken
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Gene
25259 | Gp5
Type: gene
Organism: rat
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Protein Coding Gene
MGI:1096363 | Gp5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0020645 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0022711 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0022674 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0022648 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0022678 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0022443 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1096363 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0023127 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0021971 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0022413 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0022546 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0022521 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0022613 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0022540 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0023139 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0021710 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0022015 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016349 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0021541 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9129030 | J:40027
First Author: Ravanat C
Year: 1997
Journal: Blood
Title: Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage.
Volume: 89
Issue: 9
Pages: 3253-62
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Publication
10590056 | J:59008
First Author: Kahn ML
Year: 1999
Journal: Blood
Title: Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype.
Volume: 94
Issue: 12
Pages: 4112-21
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Publication
11493449 | J:115611
First Author: Moog S
Year: 2001
Journal: Blood
Title: Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation.
Volume: 98
Issue: 4
Pages: 1038-46
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Publication
11435305 | J:70418
First Author: Ni H
Year: 2001
Journal: Blood
Title: Increased thrombogenesis and embolus formation in mice lacking glycoprotein V.
Volume: 98
Issue: 2
Pages: 368-73
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Publication
9783673 | J:50652
First Author: Katsutani S
Year: 1998
Journal: Thromb Res
Title: Cloning and characterization of the gene encoding the murine glycoprotein V: the conserved thrombin-cleavable protein on platelet surface.
Volume: 92
Issue: 1
Pages: 43-51
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GXD Expression
GXD Expression
 
Probe: MGI:5784652
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5784660
Age: embryonic day 9.5
Note: Expression in diploid platelet-forming cells in the placental vasculature.
Specimen Label: 1B Placenta
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5784652
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5784660
Age: embryonic day 10.5
Note: Expression in diploid platelet-forming cells in the placental vasculature.
Specimen Label: 2Aiii
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:5784652
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608517
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5784660
Age: embryonic day 10.5
Note: Expression in megakaryocytes and platelets.
Specimen Label: 5Ci
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:5784652
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608517
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5784660
Age: embryonic day 10.5
Note: Expression in megakaryocytes.
Specimen Label: 5Ciii Nfe2-/-
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:5784652
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608517
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5784660
Age: embryonic day 10.5
Note: Expression in megakaryocytes and platelets.
Specimen Label: 6C Mpl-/-
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:5784652
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684715
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:5784660
Age: embryonic day 9.5
Note: Expression occasionally within the mesenchyme of the developing liver bud.
Specimen Label: 1B embryo proper
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5784652
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684715
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:5784660
Age: embryonic day 9.5
Note: Expression occasionally within the mesenchyme of the developing liver bud.
Specimen Label: S2
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:5784652
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185817
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5784660
Age: embryonic day 10.5
Note: Expression in diploid platelet-forming cells in the head vasculature.
Specimen Label: 2Ai
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5784652
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185815
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:5784660
Age: embryonic day 9.5
Note: Expression in diploid platelet-forming cells in the head vasculature,
Specimen Label: S2
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:5784652
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5784660
Age: embryonic day 10.5
Note: Expression in diploid platelet-forming cells occasionally within the mesenchyme of the developing liver bud.
Specimen Label: 2Ai
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5784652
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5784660
Age: embryonic day 10.5
Note: Expression in diploid platelet-forming cells occasionally within the mesenchyme of the developing liver bud.
Specimen Label: 2Aii
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:5784652
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:5784660
Age: embryonic day 13.5
Note: Expression in megakaryocytes.
Specimen Label: 3H
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:5784652
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1641115
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:5784660
Age: embryonic day 9.5
Note: Expression in diploid platelet-forming cells in the splanchnic mesenchyme.
Specimen Label: 1B embryo proper
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5784652
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1641115
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:5784660
Age: embryonic day 9.5
Note: Expression in diploid platelet-forming cells in the splanchnic mesenchyme.
Specimen Label: S2
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:5784652
Assay Type: Immunohistochemistry
Annotation Date: 2016-07-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3604017
Pattern: Widespread
Stage: TS17
Assay Id: MGI:5784660
Age: embryonic day 10.5
Note: Expression in cells distributed throughout the conceptus.
Specimen Label: 2Ai
Detected: true
Specimen Num: 3
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Publication
10557321 | J:58516
First Author: Ramakrishnan V
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Increased thrombin responsiveness in platelets from mice lacking glycoprotein V.
Volume: 96
Issue: 23
Pages: 13336-41
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Publication
15691827 | J:143685
First Author: Rabie T
Year: 2005
Journal: J Biol Chem
Title: Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V.
Volume: 280
Issue: 15
Pages: 14462-8
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Publication
18187573 | J:131290
First Author: Suva LJ
Year: 2008
Journal: Am J Pathol
Title: Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease.
Volume: 172
Issue: 2
Pages: 430-9
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Publication
22101895 | J:181795
First Author: Jansen AJ
Year: 2012
Journal: Blood
Title: Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice.
Volume: 119
Issue: 5
Pages: 1263-73
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Publication
21037087 | J:168396
First Author: Cosemans JM
Year: 2011
Journal: Blood
Title: Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow.
Volume: 117
Issue: 2
Pages: 651-60
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Publication
23336709 | J:320061
First Author: Li R
Year: 2013
Journal: J Thromb Haemost
Title: The organizing principle of the platelet glycoprotein Ib-IX-V complex.
Volume: 11
Issue: 4
Pages: 605-14
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Publication
16179345 | J:143683
First Author: Aktas B
Year: 2005
Journal: J Biol Chem
Title: Aspirin induces platelet receptor shedding via ADAM17 (TACE).
Volume: 280
Issue: 48
Pages: 39716-22
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Publication
25995324 | J:225923
First Author: Potts KS
Year: 2015
Journal: Blood
Title: Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL.
Volume: 126
Issue: 6
Pages: 807-16
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Publication
- | J:193309
       
First Author: Mouse Genome Informatics Scientfic Curators
Year: 2013
Title: Curated associations of genes in MGI and UniProt sequence records
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
16709746 | -
First Author: Lander GC
Year: 2006
Journal: Science
Title: The structure of an infectious P22 virion shows the signal for headful DNA packaging.
Volume: 312
Issue: 5781
Pages: 1791-5
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Protein Domain
IPR024659 | Phage_coat_Gp5
Type: Family
Description: This family of proteins includes Gp5 from bacteriophage P22 and related proteins. Gp5 is involved in the formation of the pro-capsid shells in the bacteriophage. In total, there are 415 molecules of the coat protein which are arranged in an icosahedral shell [].
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Publication
10893147 | -
First Author: Dea S
Year: 2000
Journal: Arch Virol
Title: Current knowledge on the structural proteins of porcine reproductive and respiratory syndrome (PRRS) virus: comparison of the North American and European isolates.
Volume: 145
Issue: 4
Pages: 659-88
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Protein Domain
IPR001332 | Arteri_GP5
Type: Family
Description: Arterivirus such as porcine reproductive and respiratory syndrome virus (PRRSV) contain four glycoproteins on the virion envelope: the major glycoprotein GP5 and minor glycoproteins GP2a, GP3, and GP4. GP5, previously known as Gl, is encoded in ORF5 and is 30- 45kDa in size []. Gl is heterogeneously glycosylated with N-acetyllactosamine in a cell-type-specific manner. It is the most abundant envelope glycoprotein and a key target for neutralising antibodies [, ].
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Publication
21793574 | -
First Author: Nishima W
Year: 2011
Journal: J Am Chem Soc
Title: Screw motion regulates multiple functions of T4 phage protein gene product 5 during cell puncturing.
Volume: 133
Issue: 34
Pages: 13571-6
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Publication
3157805 | -
First Author: Nakagawa H
Year: 1985
Journal: J Virol
Title: Isolation and characterization of the bacteriophage T4 tail-associated lysozyme.
Volume: 54
Issue: 2
Pages: 460-6
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Publication
16956798 | -
First Author: Kumar Sarkar S
Year: 2006
Journal: Biochim Biophys Acta
Title: Association and dissociation of the cell puncturing complex of bacteriophage T4 is controlled by both pH and temperature.
Volume: 1764
Issue: 9
Pages: 1487-92
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Protein Domain
IPR046397 | NEEDLE_T4
Type: Family
Description: This entry includes the pre-baseplate central spike protein Gp5 from bacteriophage T4 which is a baseplate central spike complex-associated lysozyme, essential for the localized hydrolysis of bacterial cell wall. This allows the tail tube to penetrate to the host inner membrane, through which the phage DNA is ejected [, , , ].
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Protein Domain
IPR038288 | Gp5_sf
Type: Homologous_superfamily
Description: This superfamily represents the P5 murein endopeptidase from Pseudomonas phage phi6. P5 murein endopeptidase has lytic activity against several Gram-negative bacteria []. It is thought that the enzyme cleaves the cell wall peptide bridge formed by meso-2,6-diaminopimelic acid and D-Alanine.
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Publication
8553578 | -
First Author: Balasuriya UB
Year: 1995
Journal: Virology
Title: Phylogenetic analysis of open reading frame 5 of field isolates of equine arteritis virus and identification of conserved and nonconserved regions in the GL envelope glycoprotein.
Volume: 214
Issue: 2
Pages: 690-7
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Publication
1390911 | -
First Author: Caldentey J
Year: 1992
Journal: Biochim Biophys Acta
Title: The lytic enzyme of the Pseudomonas phage phi 6. Purification and biochemical characterization.
Volume: 1159
Issue: 1
Pages: 44-50
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Publication
19939927 | -
First Author: Das PB
Year: 2010
Journal: J Virol
Title: The minor envelope glycoproteins GP2a and GP4 of porcine reproductive and respiratory syndrome virus interact with the receptor CD163.
Volume: 84
Issue: 4
Pages: 1731-40
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Publication
21129200 | -
 
First Author: Leiman PG
Year: 2010
Journal: Virol J
Title: Morphogenesis of the T4 tail and tail fibers.
Volume: 7
Pages: 355
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Protein Domain
IPR009590 | Gp5_OB_N
Type: Domain
Description: This domain is found at the N terminus of the Gp5 baseplate protein of Bacteriophage T4. The baseplate is located at the end of the phage tail. Gp5 is a lysozyme essential for localised hydrolysis of bacterial cell wall, which is necessary for viral DNA injection []. This domain binds to the Gp27 protein []. It has the common OB fold [].
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Publication
7745690 | -
First Author: de Vries AA
Year: 1995
Journal: J Virol
Title: The small envelope glycoprotein (GS) of equine arteritis virus folds into three distinct monomers and a disulfide-linked dimer.
Volume: 69
Issue: 6
Pages: 3441-8
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Publication
8938984 | -
First Author: Lepage N
Year: 1996
Journal: Virus Genes
Title: Comparison of nucleic and amino acid sequences and phylogenetic analysis of the Gs protein of various equine arteritis virus isolates.
Volume: 13
Issue: 1
Pages: 87-91
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Publication
14645556 | -
First Author: Wieringa R
Year: 2003
Journal: J Virol
Title: Intra- and intermolecular disulfide bonds of the GP2b glycoprotein of equine arteritis virus: relevance for virus assembly and infectivity.
Volume: 77
Issue: 24
Pages: 12996-3004
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Protein Domain
IPR001913 | Equi_arteri_GP2b
Type: Family
Description: Equine arteritis virus (EAV) is an enveloped, positive-strand RNA virus belonging to the family Arteriviridae. EAV virions contain six different envelope proteins. GP5 (previously named GL) and the unglycosylated membrane protein M are the major envelope proteins, while the glycoproteins GP2b (previously named Gs), GP3, and GP4 are minor structural proteins []. GP2b is a class I transmembrane protein which adopts a number of different conformations [, ].
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Publication
19251641 | -
First Author: Leiman PG
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
Volume: 106
Issue: 11
Pages: 4154-9
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Publication
17873062 | -
First Author: Pukatzki S
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin.
Volume: 104
Issue: 39
Pages: 15508-13
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Protein Domain
IPR006531 | Gp5/Vgr_OB
Type: Domain
Description: This domain occurs in a family of phage (and bacteriocin) proteins related to the phage P2 V gene product, which forms the small spike at the tip of the tail []. Homologs in general are annotated as baseplate assembly protein V. At least one member is encoded within a region of Pectobacterium carotovorum (Erwinia carotovora) described as a bacteriocin, a phage tail-derived module able to kill bacteria closely related to the host strain.It is also found in Vgr-related proteins. Genes encoding type VI secretion systems (T6SS) are widely distributed in pathogenic Gram-negative bacterial species. In Vibrio cholerae, T6SS have been found to secrete three related proteins extracellularly, VgrG-1, VgrG-2, and VgrG-3. VgrG-1 can covalently cross-link actin in vitro, and this activity was used to demonstrate that V. cholerae can translocate VgrG-1 into macrophages by a T6SS-dependent mechanism. VgrG-related proteins likely assemble into a trimeric complex that is analogous to that formed by the two trimeric proteins gp27 and gp5 that make up the baseplate "tail spike"of Escherichia coli bacteriophage T4. The VgrG components of the T6SS apparatus might assemble a "cell-puncturing device"analogous to phage tail spikes to deliver effector protein domains through membranes of target host cells [].Gp5 is an integral component of the virion baseplate of bacteriophage T4. T4 Gp5 consists of 3 domains connected via long linkers: the N-terminal oligosaccharide/oligonucleotide-binding (OB)-fold domain, the middle lysozyme domain, and the C-terminal triplestranded-helix. The equivalent of the Gp5 OB-fold domain in the structure of VgrG is the domain of unknown function comprising residues 380-470 and conserved in all known VgrGs. This entry represents the OB-fold domain which consists of a 5-stranded antiparallel-barrel with a Greek-key topology [].
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Protein Domain
IPR037026 | Vgr_OB-fold_dom_sf
Type: Homologous_superfamily
Description: This domain occurs in a family of phage (and bacteriocin) proteins related to the phage P2 V gene product, which forms the small spike at the tip of the tail []. Homologs in general are annotated as baseplate assembly protein V. At least one member is encoded within a region of Pectobacterium carotovorum (Erwinia carotovora) described as a bacteriocin, a phage tail-derived module able to kill bacteria closely related to the host strain.It is also found in Vgr-related proteins. Genes encoding type VI secretion systems (T6SS) are widely distributed in pathogenic Gram-negative bacterial species. In Vibrio cholerae, T6SS have been found to secrete three related proteins extracellularly, VgrG-1, VgrG-2, and VgrG-3. VgrG-1 can covalently cross-link actin in vitro, and this activity was used to demonstrate that V. cholerae can translocate VgrG-1 into macrophages by a T6SS-dependent mechanism. VgrG-related proteins likely assemble into a trimeric complex that is analogous to that formed by the two trimeric proteins gp27 and gp5 that make up the baseplate "tail spike"of Escherichia coli bacteriophage T4. The VgrG components of the T6SS apparatus might assemble a "cell-puncturing device"analogous to phage tail spikes to deliver effector protein domains through membranes of target host cells [].Gp5 is an integral component of the virion baseplate of bacteriophage T4. T4 Gp5 consists of 3 domains connected via long linkers: the N-terminal oligosaccharide/oligonucleotide-binding (OB)-fold domain, the middle lysozyme domain, and the C-terminal triplestranded-helix. The equivalent of the Gp5 OB-fold domain in the structure of VgrG is the domain of unknown function comprising residues 380-470 and conserved in all known VgrGs. This entry represents the OB-fold domain which consists of a 5-stranded antiparallel-barrel with a Greek-key topology [].
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