Search our database by keyword

Examples

Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 45 out of 45 for Gpr1

0.019s

Type

Details

Score

Gene

424101 | GPR1

Type:	gene
Organism:	chicken

•

Publication

29793502 | J:273922

First Author:	Yang YL
Year:	2018
Journal:	Reprod Biol Endocrinol
Title:	Deficiency of Gpr1 improves steroid hormone abnormality in hyperandrogenized mice.
Volume:	16
Issue:	1
Pages:	50

•

Publication

26363224 | J:236145

First Author:	Rourke JL
Year:	2015
Journal:	Mol Cell Endocrinol
Title:	CMKLR1 and GPR1 mediate chemerin signaling through the RhoA/ROCK pathway.
Volume:	417

Pages:	36-51

•

Publication

24895415 | J:301873

First Author:	Rourke JL
Year:	2014
Journal:	J Endocrinol
Title:	Gpr1 is an active chemerin receptor influencing glucose homeostasis in obese mice.
Volume:	222
Issue:	2
Pages:	201-15

•

Publication

29799787 | J:271709

First Author:	Zheng C
Year:	2018
Journal:	FASEB J
Title:	FAM19A1 is a new ligand for GPR1 that modulates neural stem-cell proliferation and differentiation.


Pages:	fj201800020RRR

•

Publication

30835511 | J:276003

First Author:	Huang B
Year:	2019
Journal:	Am J Physiol Endocrinol Metab
Title:	Impact of GPR1 signaling on maternal high-fat feeding and placenta metabolism in mice.
Volume:	316
Issue:	6
Pages:	E987-E997

•

Publication

10655215 | -

First Author:	Lorenz MC
Year:	2000
Journal:	Genetics
Title:	The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae.
Volume:	154
Issue:	2
Pages:	609-22

•

Publication

9524122 | -

First Author:	Xue Y
Year:	1998
Journal:	EMBO J
Title:	GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p Galpha subunit and functions in a Ras-independent pathway.
Volume:	17
Issue:	7
Pages:	1996-2007

•

Publication

27716822 | -

First Author:	De Henau O
Year:	2016
Journal:	PLoS One
Title:	Signaling Properties of Chemerin Receptors CMKLR1, GPR1 and CCRL2.
Volume:	11
Issue:	10
Pages:	e0164179

•

Protein

Q8K087

Organism:	Mus musculus/domesticus
Length:	353
Fragment?:	false

•

Protein Coding Gene

MGI:2385324 | Cmklr2

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Domain

IPR022596 | GPR1_C

Type:	Domain
Description:	GPR1 associate with GPA2 and acts as G protein-coupled receptor that senses glucose and controls filamentous growth [, ]. This entry represents the conserved C-terminal domain.

•

Publication

7851889 | J:21102

First Author:	Marchese A
Year:	1994
Journal:	Genomics
Title:	Cloning of human genes encoding novel G protein-coupled receptors.
Volume:	23
Issue:	3
Pages:	609-18

•

Publication

22449967 | J:182357

First Author:	Kobayashi H
Year:	2012
Journal:	FEBS Lett
Title:	Imprinted DNA methylation reprogramming during early mouse embryogenesis at the Gpr1-Zdbf2 locus is linked to long cis-intergenic transcription.
Volume:	586
Issue:	6
Pages:	827-33

•

Publication

14968426 | -

First Author:	Paiva S
Year:	2004
Journal:	Yeast
Title:	Ady2p is essential for the acetate permease activity in the yeast Saccharomyces cerevisiae.
Volume:	21
Issue:	3
Pages:	201-10

•

Publication

1349449 | -

First Author:	Kujau M
Year:	1992
Journal:	Yeast
Title:	Characterization of mutants of the yeast Yarrowia lipolytica defective in acetyl-coenzyme A synthetase.
Volume:	8
Issue:	3
Pages:	193-203

•

Publication

12634328 | -

First Author:	Augstein A
Year:	2003
Journal:	Microbiology
Title:	Characterization, localization and functional analysis of Gpr1p, a protein affecting sensitivity to acetic acid in the yeast Yarrowia lipolytica.
Volume:	149
Issue:	Pt 3
Pages:	589-600

•

Publication

23844911 | -

First Author:	Sá-Pessoa J
Year:	2013
Journal:	Biochem J
Title:	SATP (YaaH), a succinate-acetate transporter protein in Escherichia coli.
Volume:	454
Issue:	3
Pages:	585-95

•

Protein Domain

IPR000791 | Gpr1/Fun34/SatP

Type:

Family

Description:

This family of evolutionary related proteins includes Yarrowia lipolytica (Candida lipolytica)glyxoxylate pathway regulator GPR1 [], Saccharomyces cerevisiae Ady2 and Fun34 (also known as Ato2); fission yeast hypothetical protein SpAC5D6.09c; Escherichia coli SatP (YaaH); and Aspergillus nidulans AcpA (AN5226). They are predicted to contain six transmembrane regions that may be involved in transport.Saccharomyces cerevisiae Ady2 is necessary for the expression of an acetate permease []. Gpr1p affects sensitivity to acetic acid in the yeast Yarrowia lipolytica []. AcpA may be a acetate transporter that is essential for acetate permease activity in the hyphal fungus Aspergillus nidulans []. SatP is involved in the uptake of acetate and succinate [].

•

Publication

25659101 | J:223525

First Author:	Banas M
Year:	2015
Journal:	PLoS One
Title:	The expression and regulation of chemerin in the epidermis.
Volume:	10
Issue:	2
Pages:	e0117830

•

Publication

23764515 | J:306229

First Author:	Kobayashi H
Year:	2013
Journal:	Epigenetics
Title:	Epigenetic and transcriptional features of the novel human imprinted lncRNA GPR1AS suggest it is a functional ortholog to mouse Zdbf2linc.
Volume:	8
Issue:	6
Pages:	635-45

•

Publication

7811287 | -

First Author:	Marchese A
Year:	1994
Journal:	Biochem Biophys Res Commun
Title:	Mapping studies of two G protein-coupled receptor genes: an amino acid difference may confer a functional variation between a human and rodent receptor.
Volume:	205
Issue:	3
Pages:	1952-8

•

Protein Domain

IPR002275 | CML2

Type:

Family

Description:

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The rhodopsin-like GPCRs (GPCRA) represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [, , ].Chemerin-like receptor 2 (CML2, also known as GPCR1), is a receptor for chemoattractant adipokine chemerin/RARRES2 that may have a role for in the regulation of inflammation and energy homeostasis [, ]. This protein also acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway []. In humans, GPR1 is expressed in the human hippocampus []. By contrast, the rat GPR1 gene is not expressed in hippocampus, demonstrating a functional variation for this receptor in these species [].

•

Protein Domain

IPR003910 | GPR1/GPR3/GPR5

Type:

Family

Description:

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The secretin-like GPCRs include secretin [], calcitonin [], parathyroid hormone/parathyroid hormone-related peptides []and vasoactive intestinal peptide [], all of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. These receptors contain seven transmembrane regions, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins (however there is no significant sequence identity between these families, the secretin-like receptors thus bear their own unique '7TM' signature). Their N-terminal is probably located on the extracellular side of the membrane and potentially glycosylated. This N-terminal region contains a long conserved region which allows the binding of large peptidic ligand such as glucagon, secretin, VIP and PACAP; this region contains five conserved cysteines residues which could be involved in disulphide bond. The C-terminal region of these receptor is probably cytoplasmic. Every receptor gene in this family is encoded on multiple exons, and several of these genes are alternatively spliced to yield functionally distinct products. Several 7TM receptors have been cloned but their endogenous ligands are unknown; these have been termed orphan receptors. GPR1 (formerly GPR56) was isolated from a human heart cDNA library using oligonucleotide primers corresponding to TM domains 4 and 7 of the secretin-like receptor family. The mRNA transcript is widely distributed throughout most tissues, the highest levels being found in thyroid, brain and heart. Within the brain, the hippocampus and hypothalamic nuclei express GPR1 in particularly high levels. This entry also include other orphan receptors, such as human adhesion G-protein coupled receptor G3 and G5 (AGRG3/5).

•

Publication

18302536 | -

First Author:	Robellet X
Year:	2008
Journal:	Biochem J
Title:	AcpA, a member of the GPR1/FUN34/YaaH membrane protein family, is essential for acetate permease activity in the hyphal fungus Aspergillus nidulans.
Volume:	412
Issue:	3
Pages:	485-93

•

Protein

Q3V3Z3

Organism:	Mus musculus/domesticus
Length:	524
Fragment?:	false

•

Protein

Q8K209

Organism:	Mus musculus/domesticus
Length:	687
Fragment?:	false

•

Protein

Q8R0T6

Organism:	Mus musculus/domesticus
Length:	542
Fragment?:	false

•

Protein

Q3U3P6

Organism:	Mus musculus/domesticus
Length:	542
Fragment?:	false

•

Protein

Q8CB00

Organism:	Mus musculus/domesticus
Length:	310
Fragment?:	false

•

Protein

Q66JT4

Organism:	Mus musculus/domesticus
Length:	486
Fragment?:	false

•

Publication

1646711 | -

First Author:	Ishihara T
Year:	1991
Journal:	EMBO J
Title:	Molecular cloning and expression of a cDNA encoding the secretin receptor.
Volume:	10
Issue:	7
Pages:	1635-41

•

Publication

1314625 | -

First Author:	Ishihara T
Year:	1992
Journal:	Neuron
Title:	Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide.
Volume:	8
Issue:	4
Pages:	811-9

•

Publication

1658940 | -

First Author:	Lin HY
Year:	1991
Journal:	Science
Title:	Expression cloning of an adenylate cyclase-coupled calcitonin receptor.
Volume:	254
Issue:	5034
Pages:	1022-4

•

Publication

1658941 | -

First Author:	Jüppner H
Year:	1991
Journal:	Science
Title:	A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide.
Volume:	254
Issue:	5034
Pages:	1024-6

•

Publication

12679517 | J:83410

First Author:	Vassilatis DK
Year:	2003
Journal:	Proc Natl Acad Sci U S A
Title:	The G protein-coupled receptor repertoires of human and mouse.
Volume:	100
Issue:	8
Pages:	4903-8

•

Publication

8170923 | -

First Author:	Attwood TK
Year:	1994
Journal:	Protein Eng
Title:	Fingerprinting G-protein-coupled receptors.
Volume:	7
Issue:	2
Pages:	195-203

•

Publication

8081729 | -

First Author:	Kolakowski LF Jr
Year:	1994
Journal:	Receptors Channels
Title:	GCRDb: a G-protein-coupled receptor database.
Volume:	2
Issue:	1
Pages:	1-7

•

Publication

15914470 | -

First Author:	Foord SM
Year:	2005
Journal:	Pharmacol Rev
Title:	International Union of Pharmacology. XLVI. G protein-coupled receptor list.
Volume:	57
Issue:	2
Pages:	279-88

•

Publication

18948278 | -

First Author:	Harmar AJ
Year:	2009
Journal:	Nucleic Acids Res
Title:	IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.
Volume:	37
Issue:	Database issue
Pages:	D680-5

•

Publication

16753280 | J:115055

First Author:	Bjarnadóttir TK
Year:	2006
Journal:	Genomics
Title:	Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse.
Volume:	88
Issue:	3
Pages:	263-73

•

Publication

23020293 | -

First Author:	Civelli O
Year:	2013
Journal:	Annu Rev Pharmacol Toxicol
Title:	G protein-coupled receptor deorphanizations.
Volume:	53

Pages:	127-46

•

Publication

2111655 | -

First Author:	Birnbaumer L
Year:	1990
Journal:	Annu Rev Pharmacol Toxicol
Title:	G proteins in signal transduction.
Volume:	30

Pages:	675-705

•

Publication

2830256 | -

First Author:	Casey PJ
Year:	1988
Journal:	J Biol Chem
Title:	G protein involvement in receptor-effector coupling.
Volume:	263
Issue:	6
Pages:	2577-80

•

Publication

8386361 | -

First Author:	Attwood TK
Year:	1993
Journal:	Protein Eng
Title:	Design of a discriminating fingerprint for G-protein-coupled receptors.
Volume:	6
Issue:	2
Pages:	167-76

•

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/keywordSearchResults.do?searchTerm=Gpr1

MouseMine

Search our database by keyword

Examples

Search results 1 to 45 out of 45 for Gpr1

Categories

Hits by Pathway

Hits by Category