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Search results 1 to 100 out of 100 for Gpr18

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Hits by Category

Type Details Score
Gene
2841 | GPR18
Type: gene
Organism: human
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Gene
738311 | GPR18
Type: gene
Organism: chimpanzee
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Gene
540038 | GPR18
Type: gene
Organism: cattle
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Gene
100858263 | GPR18
Type: gene
Organism: chicken
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Gene
556711 | gpr18
Type: gene
Organism: zebrafish
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Gene
698714 | GPR18
Type: gene
Organism: macaque, rhesus
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Gene
105946540 | gpr18
Type: gene
Organism: frog, western clawed
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Gene
485531 | GPR18
Type: gene
Organism: dog, domestic
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Gene
679957 | Gpr18
Type: gene
Organism: rat
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Protein Coding Gene
MGI:107859 | Gpr18
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR028335 | GPR18
Type: Family
Description: Several 7TM receptors have been cloned but their endogenous ligands are unknown; these have been termed orphan receptors. However, recent research has identified certain pharmacological targets that could be investigated to find, for example, new potential cannabinoid receptors or channels [, , ]. GPR18 [, ], GPR55 [, ], GPR119 []show little structural similarity to CB1 and CB2 receptors, but they respond to endogenous agents analogous to the endogenous cannabinoid ligands, as well as some natural/synthetic cannabinoid receptor ligands []. However, because they do not fulfill all of the cannabinoid receptor criteria defined by IUPHAR, the classification of these proteins remains a contentious issue due to conflicting pharmacological results. As a result, they remain classified as putative endogenous agonists by IUPHAR [].This entry represents G protein-coupled receptor 18, also known as N-arachidonyl glycine receptor. It has been found to be a receptor for endogenous lipid neurotransmitters, several of which also bind to cannabinoid receptors [, , , ]. Recent research also supports the hypothesis that GPR18 is the abnormal cannabidiol receptor and N-arachidonoyl glycine, the endogenous lipid metabolite of anandamide, initiates directed microglial migration in the CNS through activation of GPR18 []. However, the pairing of GPR18 with N-arachidonoylglycine (NAGly) and tetrahydrocannabinol (THC) was not reproduced in two studies based on beta-arrestin assays [, ]. So, until further research allows a more definitive decision the function and nomenclature GPR18 is still being debated [, ].
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Publication
22014123 | -
First Author: Alexander SP
Year: 2012
Journal: Br J Pharmacol
Title: So what do we call GPR18 now?
Volume: 165
Issue: 8
Pages: 2411-3
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Publication
26197390 | J:233534
First Author: Becker AM
Year: 2015
Journal: PLoS One
Title: GPR18 Controls Reconstitution of Mouse Small Intestine Intraepithelial Lymphocytes following Bone Marrow Transplantation.
Volume: 10
Issue: 7
Pages: e0133854
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Publication
25348153 | J:219661
First Author: Wang X
Year: 2014
Journal: J Exp Med
Title: GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment.
Volume: 211
Issue: 12
Pages: 2351-9
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Publication
36389671 | J:331442
 
First Author: Dicker M
Year: 2022
Journal: Front Immunol
Title: CD4(+)-mediated colitis in mice is independent of the GPR183 and GPR18 pathways.
Volume: 13
Pages: 1034648
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Publication
27893106 | J:254677
First Author: Miller S
Year: 2016
Journal: Invest Ophthalmol Vis Sci
Title: Evidence for a GPR18 Role in Diurnal Regulation of Intraocular Pressure.
Volume: 57
Issue: 14
Pages: 6419-6426
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Publication
8995768 | J:37412
First Author: Samuelson LC
Year: 1996
Journal: Mamm Genome
Title: Mapping of the novel G protein-coupled receptor Gpr18 to distal mouse chromosome 14.
Volume: 7
Issue: 12
Pages: 920-1
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Publication
21595653 | -
First Author: McHugh D
Year: 2012
Journal: Br J Pharmacol
Title: Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.
Volume: 165
Issue: 8
Pages: 2414-24
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Publication
16844083 | -
First Author: Kohno M
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.
Volume: 347
Issue: 3
Pages: 827-32
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Publication
18187165 | -
First Author: Burstein S
Year: 2008
Journal: Neuropharmacology
Title: The elmiric acids: biologically active anandamide analogs.
Volume: 55
Issue: 8
Pages: 1259-64
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Publication
19379823 | -
First Author: Bradshaw HB
Year: 2009
Journal: Prostaglandins Other Lipid Mediat
Title: Orphan endogenous lipids and orphan GPCRs: a good match.
Volume: 89
Issue: 3-4
Pages: 131-4
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Publication
23396314 | -
First Author: Southern C
Year: 2013
Journal: J Biomol Screen
Title: Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors.
Volume: 18
Issue: 5
Pages: 599-609
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Publication
19286662 | -
First Author: Yin H
Year: 2009
Journal: J Biol Chem
Title: Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay.
Volume: 284
Issue: 18
Pages: 12328-38
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Publication
23686350 | -
First Author: Davenport AP
Year: 2013
Journal: Pharmacol Rev
Title: International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands.
Volume: 65
Issue: 3
Pages: 967-86
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Publication
20346144 | -
 
First Author: McHugh D
Year: 2010
Journal: BMC Neurosci
Title: N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor.
Volume: 11
Pages: 44
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Publication
17876302 | -
First Author: Ryberg E
Year: 2007
Journal: Br J Pharmacol
Title: The orphan receptor GPR55 is a novel cannabinoid receptor.
Volume: 152
Issue: 7
Pages: 1092-101
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Publication
17876300 | -
First Author: Pertwee RG
Year: 2007
Journal: Br J Pharmacol
Title: GPR55: a new member of the cannabinoid receptor clan?
Volume: 152
Issue: 7
Pages: 984-6
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Publication
20117132 | -
First Author: Izzo AA
Year: 2010
Journal: Pharmacol Ther
Title: Cannabinoids and the gut: new developments and emerging concepts.
Volume: 126
Issue: 1
Pages: 21-38
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Publication
17906678 | -
First Author: Brown AJ
Year: 2007
Journal: Br J Pharmacol
Title: Novel cannabinoid receptors.
Volume: 152
Issue: 5
Pages: 567-75
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Protein
Q8K1Z6
Organism: Mus musculus/domesticus
Length: 331  
Fragment?: false
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Publication
21079038 | -
First Author: Pertwee RG
Year: 2010
Journal: Pharmacol Rev
Title: International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂.
Volume: 62
Issue: 4
Pages: 588-631
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Publication
29670628 | J:272224
 
First Author: Sumida H
Year: 2018
Journal: Front Immunol
Title: G-Protein Coupled Receptor 18 Contributes to Establishment of the CD8 Effector T Cell Compartment.
Volume: 9
Pages: 660
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Publication
26195725 | J:226433
First Author: Chiang N
Year: 2015
Journal: J Exp Med
Title: Identification of resolvin D2 receptor mediating resolution of infections and organ protection.
Volume: 212
Issue: 8
Pages: 1203-17
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Publication
37717941 | J:343270
First Author: Fitzgerald H
Year: 2023
Journal: Am J Pathol
Title: Resolvin D2-G-Protein Coupled Receptor 18 Enhances Bone Marrow Function and Limits Steatosis and Hepatic Collagen Accumulation in Aging.
Volume: 193
Issue: 12
Pages: 1953-1968
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Publication
34716330 | J:328125
First Author: Dort J
Year: 2021
Journal: Nat Commun
Title: Resolvin-D2 targets myogenic cells and improves muscle regeneration in Duchenne muscular dystrophy.
Volume: 12
Issue: 1
Pages: 6264
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Protein Coding Gene
MGP_CAROLIEiJ_G0019609 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0021665 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0021625 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0021601 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0021631 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0021409 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_107859 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0022071 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020924 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0021377 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0021500 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0021478 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0021568 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0021505 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0022094 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0020668 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020980 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0030626 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0020506 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
27994074 | J:252814
First Author: Chiang N
Year: 2017
Journal: J Immunol
Title: Novel Resolvin D2 Receptor Axis in Infectious Inflammation.
Volume: 198
Issue: 2
Pages: 842-851
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Publication
29559341 | J:266182
First Author: Hellmann J
Year: 2018
Journal: J Invest Dermatol
Title: Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair.
Volume: 138
Issue: 9
Pages: 2051-2060
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Publication
27507404 | J:244452
First Author: Zhang MJ
Year: 2016
Journal: Circulation
Title: Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation.
Volume: 134
Issue: 9
Pages: 666-680
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Publication
32385136 | J:291565
First Author: Joffre J
Year: 2020
Journal: J Immunol
Title: Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury.
Volume: 204
Issue: 12
Pages: 3339-3350
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Publication
- | J:24194
     
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
29870711 | J:319830
 
First Author: Reyes-Resina I
Year: 2018
Journal: Biochem Pharmacol
Title: Molecular and functional interaction between GPR18 and cannabinoid CB2 G-protein-coupled receptors. Relevance in neurodegenerative diseases.
Volume: 157
Pages: 169-179
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Publication
19805329 | J:153225
First Author: Whyte LS
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo.
Volume: 106
Issue: 38
Pages: 16511-6
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Protein Domain
IPR028334 | GPR55
Type: Family
Description: Several 7TM receptors have been cloned but theirendogenous ligands are unknown; these have been termed orphan receptors. However, recent research has identified certain pharmacological targets that could be investigated to find, for example, new potential cannabinoid receptors or channels [, , ]. GPR18 [, ], GPR55 [, ], GPR119 []show little structural similarity to CB1 and CB2 receptors, but they respond to endogenous agents analogous to the endogenous cannabinoid ligands, as well as some natural/synthetic cannabinoid receptor ligands []. However, because they do not fulfill all of the cannabinoid receptor criteria defined by IUPHAR, the classification of these proteins remains a contentious issue due to conflicting pharmacological results. As a result, they remain classified as putative endogenous agonists by IUPHAR [].This entry represents G protein-coupled receptor 55. It is thought to play a role in bone physiology by regulating osteoclast number and function [].
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Publication
30550613 | J:268346
First Author: Miller S
Year: 2018
Journal: Invest Ophthalmol Vis Sci
Title: Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Regulate Intraocular Pressure.
Volume: 59
Issue: 15
Pages: 5904-5911
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Publication
26033291 | J:336368
 
First Author: Taylor L
Year: 2015
Journal: Sci Rep
Title: Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Independently of the CB2 Receptor.
Volume: 5
Pages: 10682
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Publication
15607732 | J:94969
First Author: Soga T
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor.
Volume: 326
Issue: 4
Pages: 744-51
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Publication
17289847 | J:174048
First Author: Chu ZL
Year: 2007
Journal: Endocrinology
Title: A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release.
Volume: 148
Issue: 6
Pages: 2601-9
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Publication
16517404 | -
First Author: Overton HA
Year: 2006
Journal: Cell Metab
Title: Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents.
Volume: 3
Issue: 3
Pages: 167-75
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Publication
18724386 | -
First Author: Ning Y
Year: 2008
Journal: Br J Pharmacol
Title: Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells.
Volume: 155
Issue: 7
Pages: 1056-65
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Publication
19009545 | -
First Author: Swaminath G
Year: 2008
Journal: Arch Pharm (Weinheim)
Title: Fatty acid binding receptors and their physiological role in type 2 diabetes.
Volume: 341
Issue: 12
Pages: 753-61
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Publication
19282326 | J:244912
First Author: Lan H
Year: 2009
Journal: J Endocrinol
Title: GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis.
Volume: 201
Issue: 2
Pages: 219-30
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Publication
18037923 | -
 
First Author: Overton HA
Year: 2008
Journal: Br J Pharmacol
Title: GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity.
Volume: 153 Suppl 1
Pages: S76-81
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Publication
19901198 | -
First Author: Chu ZL
Year: 2010
Journal: Mol Endocrinol
Title: N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119.
Volume: 24
Issue: 1
Pages: 161-70
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Protein Domain
IPR028336 | GPR119
Type: Family
Description: Several 7TM receptors have been cloned but their endogenous ligands are unknown; these have been termed orphan receptors. However, recent research has identified certain pharmacological targets that could be investigated to find, for example, new potential cannabinoid receptors or channels [, , ]. GPR18 [, ], GPR55 [, ], GPR119 []show little structural similarity to CB1 and CB2 receptors, but they respond to endogenous agents analogous to the endogenous cannabinoid ligands, as well as some natural/synthetic cannabinoid receptor ligands []. However, because they do not fulfill all of the cannabinoid receptor criteria defined by IUPHAR, the classification of these proteins remains a contentious issue due to conflicting pharmacological results. As a result, they remain classified as putative endogenous agonists by IUPHAR [].This entry represents glucose-dependent insulinotropic receptor, also known as G protein-coupled receptor 119. It is expressed predominantly in the pancreas and gastrointestinal tract in rodents and humans, as well as in the brain in rodents []. It has been shown to be involved in the control of glucose-dependent insulin release and glucagon-like peptide 1 release, respectively [, ], which caused a reduction in food intake and body weight gain in rats []. GPR119 has also been shown to regulate incretin and insulin hormone secretion [, , ], behaving as a glucose-dependent insulinotropic receptor. As a result, new drugs acting on the receptor have been suggested as novel treatments for obesity and diabetes [, , ]. Although GPR119 is phylogenetically related to cannabinoid receptors, only fatty acid amides interact with GPR119 [, , , ]. The potency order is N-oleoyl dopamine >oleoyl ethanolamide >palmitoyl ethanolamide >anandamide [, ]. However, because only N-oleoyl dopamine and oleoyl ethanolamide have reasonably high (low micromolar) affinity for GPR119, and because neither of these lipids interacts with CB1 or CB2 receptors, GPR119 cannot currently be viewed as a cannabinoid receptor [].
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Protein
Q7TQP3
Organism: Mus musculus/domesticus
Length: 335  
Fragment?: false
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Protein
Q3UJF0
Organism: Mus musculus/domesticus
Length: 327  
Fragment?: false
•
•
•
•
•
Protein
Q14BW0
Organism: Mus musculus/domesticus
Length: 327  
Fragment?: false
•
•
•
•
•
Protein
Q14BV9
Organism: Mus musculus/domesticus
Length: 327  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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